• YAKHAK HOEJI
• /
• v.56 no.6
• /
• pp.401-406
• /
• 2012

Previously, we identified that Cirsium japonicum (CJ) extract posses antidepressant properties. In order to look for the optimal hebal preparation, CJ extracts collected from Koheung, Yesan, Cheju, Pyungchang and Pocheon were compared. The psychopharmacological activities of each extract were investigated using the open field test, the rota-rod test and the forced swimming test. Effect of each extract on $Cl^-$ influx in neuroblastoma cells were also identified. All of the extracts were orally administered at dosages of 50, 100, 200, 400 mg/kg of body weight. Supplementation of CJ did not significantly alter psychomotor behaviors such as movement, rearing frequency and total turn angle on the open field. Supplementation of CJ's extract from Pyungchang (100 mg/kg, p.o.), Cheju (200 and 400 mg/kg p.o.) and Yesan (100 and 200 mg/kg, p.o.) significantly decreased immobile duration and increased mobile duration in the forced swimming test. All of extracts have no influence on NE uptake in HEK-293 cells, but increased $Cl^-$ influx in neuroblastoma cell. The extract from Yesan demonstrated the most potent effect on $Cl^-$ influx. These results indicate that CJ's extracts from Pyungchang, Cheju and Yesan may alleviate depression, and the extract from Yesan may be the most effective preparation.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2023.04a
• /
• pp.79-79
• /
• 2023

With the development of digital technology, the size of the smart agriculture market at home and abroad is rapidly expanding. It is necessary to establish a foundation for sustainable precision agriculture in order to respond to the aging of rural areas and labor shortages. This study was conducted to establish an automated digital agricultural test bed for soybean production management using data suitable for agricultural environmental conditions in Korea and to demonstrate the field of leading complexes. In order to manage water smartly, we installed a subsurface drip irrigation system in the upland field and an underground water level control system in the paddy field. Based on data collected from sensors, water management was controlled by utilizing an integrated control system. Irrigation was carried out when the soil moisture was less than 20%. For effective water management, soil moisture was measured at the surface, 15cm, and 30cm depth. The main growth characteristics and yield, such as stem length, number of branches, and number of nodes of the main stem, were investigated during the main growth period. During the operation of the test bed, drought appeared during the early vegetative growth period and maturity period, but in the open field smart agriculture test bed, water was automatically supplied, reducing labor by 53% and increasing yield by 2%. A test bed was installed for each field digital farming element technology, and it is planned to verify it once more this year. In the future, we plan to expand the field digital farming technology developed for leading farmers to the field.

• Proceedings of the KSR Conference
• /
• 2002.10b
• /
• pp.1041-1046
• /
• 2002

A railway open deck plate girder bridge without ballast should support relatively heavier vehicle loads compared with its self-weight. For such a reason, actual dynamic response of the bridge is considerably differing with normal prediction because additional masses added from vehicle to a bridge have an effect on the dynamic characteristics of the bridge. These differences affect to the estimation of a natural frequency change that adopted for one of the evaluation technique of strength decrease, and these make trouble to the analysis of a natural frequency from the field test data that measured at the bridge subjected to a running vehicle. In this study, classification of mass participation ratio for each component of open deck plate girder bridge without ballast and the comparison according to the change of vibration characteristics for the case of subjected to a running vehicle were accomplished.

• Biomolecules & Therapeutics
• /
• v.18 no.2
• /
• pp.219-225
• /
• 2010

We tested whether ginsenosides $Rg_3$-standardized ginseng extract (RGE) has anti-stress effects in restraint-stressed animals. RGE increased time spent in the open arms and open arm entries in the elevated plus-maze test. In addition, RGE blocked the reduction of center zone distance and stereotypes behaviors in the open-field test. RGE also increased head dips in stressed mice, indicating anxiolytic-like effects. Stress decreased movement distance and duration, burrowing, and rearing frequency but increased face washing and grooming. RGE significantly reversed burrowing and rearing activity in stressed mice. In addition, we measured sleep architecture in restraint stressed rats using EEG recorder. Stress increased rapid eye movement (REM) sleep, but total sleep and non-rapid eye movement (NREM) sleep were not changed. RGE did not affect sleep architecture in stressed rats. These behavioral experiments suggest that RGE has anti-stress effects in restraint-stressed animal models.

• Journal of Applied Reliability
• /
• v.12 no.3
• /
• pp.201-213
• /
• 2012

A gear type lubrication pump is an essential component of the powertrain and has a major role for supplying oil to the gears and bearings in automatic transmission with a hydraulic clutch. Therefore, the durability test code design of lubrication pump is very important to ensure the reliability of the entire transmission and the vehicle. In this study, the design process for the life testing of lubrication pump has been generalized by four steps. The four design steps of the life testing of lubrication pump consist of the configuration of load spectrum, rain flow counting and analysis of load level, the equivalent damage assessment and test code generation. In fact, the load spectrum should be obtained from the field operating condition but that kind of data is the top secret of manufacturers. This is not open to the public in general. So we could use the artificially simulated load spectrum instead of field obtained one and focused on the development of the general process for designing the life test of a gear type lubrication pump. Reliability goals for lubrication pump, pressure, torque, temperature and load spectrum, if present, as appropriate for the given test conditions, accelerated life testing for the lubrication pump can be designed by the developed design steps.

• International Journal of High-Rise Buildings
• /
• v.11 no.4
• /
• pp.287-300
• /
• 2022

Unconventional structures are getting more popular in recent days. Large-span roofs are used for many structures, such as airports, stadiums, and conventional halls. Identifying the pressure distribution and wind load acting on those structures is essential. This paper offers a collaborative study of computational fluid dynamics (CFD) simulations and wind tunnel tests for assessing wind pressure distribution for a building with a combined slender curved roof. The hybrid turbulence model, Improved Delayed Detached Eddy Simulation (IDDES), simulates the open terrain turbulent flow field. The wind-induced local pressure coefficients on complex roof structures and the turbulent flow field around the structure were thus calculated based upon open terrain wind flow simulated with the FLUENT software. Local pressure measurements were investigated in a boundary layer wind tunnel simultaneous to the simulation to determine the pressure coefficient distributions. The results predicted by CFD were found to be consistent with the wind tunnel test results. The comparative study validated that the recommended IDDES model and the vortex method associated with CFD simulation are suitable tools for structural engineers to evaluate wind effects on long-span complex roofs and plan irregular buildings during the design stage.

• Tunnel and Underground Space
• /
• v.21 no.3
• /
• pp.181-191
• /
• 2011

It is very difficult to prepare a lab. test specimen from weak rock masses affected by faults, highly fractured zone or weathered zone. In conventional method of in situ direct shear test a rock block is sheared inside galleries, where reactions for the hydraulic jacks are available. A new in situ direct shear test apparatus has been developed in this study to perform the test inside galleries as well as open pit conditions. The apparatus is composed of normal and shear reaction plates including load transfer plates, hydraulic cylinder systems, load cells, multistage shear boxes with fixing devices, and needle rollers. Maximum size of the test block is $400{\times}400{\times}460$ mm, and procedures of the test block preparation has been suggested. To explore the field applicability of in situ direct shear test apparatus, proper test block site was investigated by extensive geological field survey. In situ direct shear test has been successful in producing most of information related to strength and deformability of the weak rock.

• Journal of Oriental Neuropsychiatry
• /
• v.31 no.3
• /
• pp.149-156
• /
• 2020

Objectives: The purpose of this study was to experimentally assess the effects of Chengsimyeonjatanggagam extracts in the animal model regarding ADHD related symptoms and indicators. Methods: The experimental group was classified into the normal group (WKY rat) in 7, the control group (SHR rat) in 7, the low-concentration group of herbal medicines (SHR rat) in 7, and the high-concentration group of herbal medicines (SHR rat) in 7 by random sampling. The open field test was conducted three times on the 7th, 14th, and 21st days during the oral medication. After that, Y-maze test, intestinal permeability verification (L/M ratio), and Western blotting (CDK expression in the cerebral cortex) were performed in sequence. Results: The Chengsimyeonjatang-gagam extracts reduced the activity distance in the SHR rat at 21 days in the low and high concentration groups by the open field test. It also reduced the cross-action rate in the low and high concentration groups by the Y-maze test. And the low concentration group showed 52.3% decrease in the L/M ratio compared to the SHR group. Finally, the CDK5 protein significantly increased in the low and high concentration groups. Conclusions: This study suggests that the Chengsimyeonjatang-gagam extracts have potential to be used for the treatment of ADHD.

• Journal of Ginseng Research
• /
• v.44 no.4
• /
• pp.644-654
• /
• 2020

Background: Posttraumatic stress disorder (PTSD), a mental disorder induced by traumatic stress and often accompanied by depression and/or anxiety, may involve an imbalance in the neurotransmitters associated with the fear response. Korean Red Ginseng (KRG) has long been used as a traditional medicine and is known to be involved in a variety of pharmacological activities. We used the open field test and forced swimming test to examine the effects of KRG on the depression-like response of rats after exposure to single prolonged stress (SPS), leading to activation of the serotonergic system. Methods: Male rats received KRG (30, 50, and 100 mg/kg, intraperitoneal injection) once daily for 14 days after exposure to SPS. Results: Daily KRG administration significantly improved depression-like behaviors in the forced swimming test, increased the number of lines crossed and time spent in the central zone in the open field test, and decreased freezing behavior in contextual and cued fear conditioning. KRG treatment attenuated SPS-induced decreases in serotonin (5-HT) tissue concentrations in the hippocampus and medial prefrontal cortex. The increased 5-HT concentration during KRG treatment may be partially attributable to the 5-hydroxyindoleacetic acid/5-HT ratio in the hippocampus of rats with PTSD. These effects may be caused by the activation of hippocampal genes encoding tryptophan hydroxylase-1 and 2 mRNA levels. Conclusion: Our findings suggest that KRG has an antidepressant effect in rats subjected to SPS and may represent an effective use of traditional medicine for the treatment of PTSD.

• Journal of Positioning, Navigation, and Timing
• /
• v.1 no.1
• /
• pp.35-43
• /
• 2012

The UGV is one of the special field robot developed for mine detection, surveillance and transportation. To achieve successfully the missions of the UGV, the accurate and reliable navigation data should be provided. This paper presents design and implementation of multi-sensor-based open architecture integrated navigation for localization of UGV. The presented architecture hierarchically classifies the integrated system into four layers and data communications between layers are based on the distributed object oriented middleware. The navigation manager determines the navigation mode with the QoS information of each navigation sensor and the integrated filter performs the navigation mode-based data fusion in the filtering process. Also, all navigation variables including the filter parameters and QoS of navigation data can be modified in GUI and consequently, the user can operate the integrated navigation system more usefully. The conventional GPS/INS integrated system does not guarantee the long-term reliability of localization when GPS solution is not available by signal blockage and intentional jamming in outdoor environment. The presented integration algorithm, however, based on the adaptive federated filter structure with FDI algorithm can integrate effectively the output of multi-sensor such as 3D LADAR, vision, odometer, magnetic compass and zero velocity to enhance the accuracy of localization result in the case that GPS is unavailable. The field test was carried out with the UGV and the test results show that the presented integrated navigation system can provide more robust and accurate localization performance than the conventional GPS/INS integrated system in outdoor environments.