• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3845-3848
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• 2016

This study was undertaken to determine the incidence of subsequent oophorectomy due to ovarian pathology or ovarian cancer in women with prior hysterectomy for benign gynecologic conditions at Chiang Mai University Hospital. Medical records of women who underwent hysterectomy for benign gynecologic diseases and precancerous lesions between January 1, 2004 and December 31, 2013 at Chiang Mai University Hospital were retrospectively reviewed. The incidence and indications of oophorectomy following hysterectomy were analyzed. During the study period, 1,035 women had hysterectomy for benign gynecologic conditions. Of these, 590 women underwent hysterectomy with bilateral salpingo-oophorectomy and 445 hysterectomy with bilateral ovarian preservation or unilateral salpingo-oophorectomy. The median age was 47 years (range, 11-75 years). Ten women (2.45 %) had subsequent oophorectomy for benign ovarian cysts. No case of ovarian cancer was found. The mean time interval between hysterectomy and subsequent oophorectomy was 43.1 months (range, 2-97 months) and the mean follow-up time for this patient cohort was 51 months (range, 1.3-124.9 months). According to our hospital-based data, the incidence of subsequent oophorectomy in women with prior hysterectomy for benign gynecologic conditions is low and all represent benign conditions.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.133-137
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• 2013

Background: To investigate the impact of ovarian transposition (OT) on survival rates of the patients with stage Ib squamous cell cervical cancer. Materials and Methods: Ninety-two subjects who underwent a radical hysterectomy including oophorectomy were evaluated. For nineteen (20.7%), OT was performed. Patients were divided into two groups, OT versus oophorectomy alone. The primary end-point of this study was to investigate the impact of OT on tumor recurrence rate and time, 5-year disease-free survival (DFS) and overall survival (OS). These comparisons were performed for subgroups including patients who received radiotherapy versus who did not. Statistical analyses were conducted using the Chi-square test, T-test and Mann-Whitney test. OS was examined using the Kaplan-Meier method. $P{\leq}0.05$ was considered to be statistically significant. Results: The median follow-up period was 89 months for OT and 81 months for the oophorectomy group (p>0.05). Both groups experienced similar recurrence rates (31.6% vs. 26.4%, p=0.181). The median duration from surgery to recurrence, and surgery to death were also similar between the groups (p>0.05). The 5-year DFS and OS rates were both 68.4% for the OT group, and 73.6% and 77.8% for the oophorectomy group (p=0.457 and p=0.307, respectively). While the 5-year DFS rate was not statistically significant between the OT and oophorectomy groups who did not receive radiotherapy (p=0.148), the 5-year OS rate was significantly higher in the oophorectomy group (95.4% vs 66.7%, respectively) without radiotherapy (p=0.05). The 5-year DFS and OS rates were statistically similar between the groups who received adjuvant radiotherapy (p>0.05). Conclusions: Ovarian transposition has not significantly negative effect on the survival rates when adjuvant radiotherapy will be applied, while 5-year OS may be less in OT group if radiotherapy is not mandatory.

• Journal of Yeungnam Medical Science
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• v.16 no.1
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• pp.137-140
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• 1999

Adnexal torsion is not a common surgical emergency in obstetrics and gynecology, and is not observed frequently during pregnancy with its incidence being one out of about 5,000 pregnancies: pregnancy is a factor that encourages torsion. The traditional treatment for ischemic and twisted adnexa consists of oophorectomy or salpingo-oophorectomy. With early diagnosis. a conservative approach is recommended in cases of young women to assure future fertility. With a brief review of literature, we report a case of unilateral salphingo-oophorectomy during pregnancy due to adnexal torsion with the delivery of a normal baby.

• Advances in pediatric surgery
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• v.1 no.2
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• pp.115-121
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• 1995

We reviewed 45 cases of ovarian tumors treated at Seoul National University Children's Hospital from 1983 to 1993. Forty-five patients were operated upon for 52 ovarian tumors. The most common pathologic diagnosis was mature teratoma. The next were functional cyst, the tumors of epithelial cell origin, and those of stromal origin in order of frequency. Six patients(13%) had malignant tumor. There were one malignant teratoma, two dysgerminomas, one endodermal sinus tumor, and two granulosa cell tumors. Four cases were diagnosed as torsion of ovarian cyst preoperatively, and emergency exploratory laparotomy were performed. There were three cases of ovarian tumors associated with precocious puberty. The most widely used diagnostic tool was ultrasonography. In the treatment of these 45 patients, unilateral oophorectomy was done in 38 cases, unilateral oophorectomy with wedge resection of contralateral ovary was done in 5 cases, unilateral oophorectomy with contralateral simple cystectomy was done in one case and total abdominal hysterectomy with bilateral salpingooophorectomy was done in one case. Of the six cases of malignancy, five patients are alive 2 to 6 years after operation and one case was lost to be followed up.

• Women's Health Nursing
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• v.26 no.4
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• pp.285-299
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• 2020

Purpose: This systematic review aims to identify factors associated with risk-reducing salpingo-oophorectomy (RRSO), including the uptake rate and decision timing, among women at high risk for hereditary breast and ovarian cancer (HBOC). Methods: We found 4,935 relevant studies using MEDLINE, Embase, CINAHL, and PsycINFO on July 6, 2020. Two authors screened the articles and extracted data. Twenty-four studies met the inclusion criteria. Quality assessment of articles was conducted using the Risk of Bias for Nonrandomized Studies tool. Results: Five types of factors were identified (demographic factors, clinical factors, family history of cancer, psychological factors, and objective cancer risk). The specific significant factors were older age, having child(ren), being a BRCA1/2 carrier, mastectomy history, perceived risk for ovarian cancer, and perceived advantages of RRSO, whereas objective cancer risk was not significant. The uptake rate of RRSO was 23.4% to 87.2% (mean, 45.2%) among high-risk women for HBOC. The mean time to decide whether to undergo RRSO after BRCA testing was 4 to 34 months. Conclusion: RRSO decisions are affected by demographic, clinical, and psychological factors, rather than objective cancer risk. Nonetheless, women seeking RRSO should be offered information about objective cancer risk. Even though decision-making for RRSO is a complex and multifaceted process, the psychosocial factors that may influence decisions have not been comprehensively examined, including family attitudes toward RRSO, cultural norms, social values, and health care providers' attitudes.

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.4
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• pp.213-222
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• 2013

Purpose: The purpose of this study is to evaluate the effects of Gyejigabuja-tang on a menopausal female patient complained of excessive sweating after bilateral salpingo-oophorectomy (BSO). Methods: We studied one menopausal female patient complained of excessive sweating who visited OO University Hospital from 10th July 2013 to 23th July 2013. We only treated her with Gyejigabuja-tang. The climacteric symptoms of the patient had been estimated with Numeric Rating Scale (NRS) and Menopause Rating Scale (MRS). Results: After treatment, climacteric symptoms were improved and the score of MRS was reduced from 20 to 10 during 12days. NRS score of sweating was reduced from 10 to 2. NRS scores of fatigue, hot flush, thirst, anorexia, dyspepsia, back pain and cramp of calves also reduced after treatment. Conclusions: This study suggests that Gyejigabuja-tang significantly reduced the climacteric symptoms of patient.

• Journal of Nutrition and Health
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• v.29 no.2
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• pp.166-176
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• 1996

Effect of fish oil feeding was investigated on morphological changes of thoracic aora in female rats after bilateral oophorectomy(OVX). Fifty four healthy female rats of Spraque-Dawley strain, were divided into sham group, OVX group and , OVX and fish oil feeding, group. Experimental animals were sacrificed at the end first, eighth week and sixteenth week after operation, thoracic aorta blood sample were collected. The results obtained were as follows ; 1) Total cholesterol and LDL-cholesterol contents in serum were significantly higher in the sham and OVX groups than fish oil feeding group. Serum HDL-cholesterol levels among three exjperimentnal group were lowest in the OVX group. 2) In the sham operation group, as experimental period prologed the endothelial cells were distorted round shape and enlarged, and the subendothelial layer was widened in tunical intima. The elastic lamina were disrupted in tunica group. In the fish oil feeding group, the endothelial cells and subendothelial layer in tunica intima, and the elastic lamina in tunica media were intance. From the present results, it was suggested that fish oil feeding may prevent the atherosclerotic changes in thoracic aorta and serum cholesterol induced by oophhorectomy in the rats.

• Childhood Kidney Diseases
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• v.15 no.2
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• pp.125-137
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• 2011

Purpose : Men are generally more prone to chronic renal disease and progression to end stage renal disease than women. The purpose of this study is to prove the effect of gender and sex hormone on renal fibrosis in mice with unilateral ureteral obstruction (UUO) and to elucidate the specific underlying mechanisms. Methods :We compared the expression of ${\alpha}$-smooth muscle actin (${\alpha}$-SMA) in female and male mice with complete UUO (day 7). After this, we estimated the changes of renal fibrosis in the female mice with oophorectomy and in the female mice with oophorectomy and replacement of $17{\beta}$-estradiol, respectively. Results : The level of ${\alpha}$-SMA in the female kidney with UUO was significantly lower than that in the male kidney with UUO. oophorectomy and replacement of $17{\beta}$-estradiol did not change the expression of angiotensin II type 1 (AT1) receptor in the female kidney with UUO, whereas the expression of angiotensin II type 2 (AT2) receptor was significantly more elevated in the intact female (IF) and the oophorectomized female with estrogen (OF+E) than that in the oophorectomized female (OF). The expressions of inducible nitric oxide synthase (iNOS) in the IF and OF+E mice were significantly more elevated than that in the OF mice, which was similar to the expression of AT2 receptor. Conclusion : The female gender is associated with resistance to renal fibrosis in obstructive uropathy and this gender difference may originate from the existence of $17{\beta}$-estradiol, which has an anti-fibrotic effect via upregulation of the AT2 receptor and iNOS.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7237-7242
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• 2015

Background: Epithelial ovarian cancer (EOC) is the commonest malignancy involving the ovaries. Maximum surgical cytoreduction (MCR) followed by adjuvant taxane-platinum chemotherapy are the standard of care treatments. Aims: To study treatment outcomes of EOC patients that were maximally cyto-reduced and received adjuvant paclitaxel-carboplatin (PC) chemotherapy. Materials and Methods: This retrospective cohort study included 174 patients with EOC treated at the Egyptian National Cancer Institute between 2006 and 2010. For inclusion, they should have had undergone MCR with no-gross residual followed by adjuvant PC chemotherapy. MCR was total abdominal hysterectomy/bilateral salpingo-oophorectomy [TAH/BSO] or unilateral salpingo-oophorectomy [USO] plus comprehensive staging. Results: The median age was 50 years. Most patients were married (97.1%), had offspring (92.5%), were postmenopausal (53.4%), presented with abdominal/pelvic pain and swelling (93.7%), had tumors involving both ovaries (45.4%) without extra-ovarian extension i.e. stage I (55.2%) of serous histology (79.9%) and grade II (87.4%). TAH/BSO was performed in 97.7% of cases. A total of 1,014 PC chemotherapy cycles were administered and were generally tolerable with 93.7% completing 6 cycles. Alopecia and numbness were the commonest adverse events. The median follow up period was 42 months. The 2-year rates for disease free survival (DFS) and overall survival (OS) were 70.7% and 94.8%, respectively. The respective 5-year rates were 52.6% and 81.3%. Advanced stage and high-grade were significantly associated with poor DFS and OS (p<0.001). Age >65 years was associated with poor OS (p =0.008). Using Cox-regression, stage was independent predictor of poor DFS and OS. Age was an independent predictor of poor OS.

• The Journal of Korean Academy of Prosthodontics
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• v.30 no.4
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• pp.526-540
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• 1992

Osteoporosis, a well known metabolic bone disease, occurs due to imbalance of bone formings and resorptions. In an attempt investigate if postmenopausal osteoporosis would have influence on the mandible, histomorphometric analysis was performed in the mandible and the femur of the albino rats. Osteoporosis was induced by bilateral oophorectomy. To determine the effect of calcitonin, calcitonin(Asahi Chemical Co., Japan) was injected in the oophorectomized rats. The results were as follows : 1. The width of cortical bone of the femur was decreased in the oophorectomized group compared to the normal control and calcitonin injected groups and the porosity of cortical bone of the femur was increased in the oophorectomized group compared to the normal control and calcitonin injected groups. 2. The osteoid tissue and resorption lacuna of the femur was increased in both oophorectormized and calcitonin injected groups than the normal control group. 3. The width of cortical bone of the mandible was decreased in the oophorectomized group compared to the normal control and calcitonin injected groups. 4. The porosity of cortical bone of the mandible was decreased in both oophorectomized and calcitonin injected groups than the normal control group. 5. The relative volume of trabecular bone of the mandible was decreased in the oophorectomized group compared to the normal control and calcitonin injected groups. 6. The osteoid tissue of the mandible was increased in the calcitonin injected group than the normal control and oophorectomized groups. 7. The resorption lacuna of the mandible was increased in both oophorectomized and calcitonin injected groups, particularly in the oophorectomized group.