• Journal of Genetic Medicine
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• v.18 no.2
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• pp.132-136
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• 2021

Maturity-onset diabetes of the young (MODY) is caused by autosomal dominant pathogenic variants in one of 14 currently known monogenic genes. Characteristics of patients with MODY include early-onset clinical disease with a family history of diabetes and negative autoantibodies and may present with heterogeneous phenotypes according to the different subtypes. Here, we report a patient with early-onset diabetes who presented asymptomatic mild fasting hyperglycemia with the absence of autoantibodies. She was diagnosed with glucokinase (GCK)-MODY caused by a GCK variant, c.1289T>C (p.L430P), identified by targeted gene-panel testing, and the affected father had the same variant. We interpreted this rare missense variant as a likely pathogenic variant and then she stopped taking oral medication. This case highlights the usefulness of gene-panel testing for accurate diagnosis and appropriate management of MODY. We also note the importance of familial genetic testing and genetic counseling for the proper interpretation of MODY variants.

• Nuclear Engineering and Technology
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• v.31 no.6
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• pp.548-560
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• 1999

An experimental investigation has been peformed to examine the effects of various geometrical parameters and an initial operating condition on the air-water countercurrent How limitation (CCFL) in a simulated PWR hot leg. A total of 118 experimental data for the onset of CCFL and zero liquid penetration were obtained for various combinations of test parameters. It was observe that the CCFL can be classified into three different categories: (the onset of CCFL, (the partial liquid delivery, and (r) the zero liquid penetration. The observed mechanisms of the onset of CCFL were different depending on the inlet water flow rate. The parametric effects of pipe diameter, horizontal pipe length, horizontal pipe length-to-diameter (L/D) ratio, and initial water level in the horizontal pipe of the test section on the onset of air-water CCFL were also examined. An empirical correlation for the onset of CCFL in a horizontal pipe connected to an inclined riser was developed in terms of Wallis flooding parameters for the low inlet water flow rate region. Comparisons of the present empirical correlation with the air-water CCFL data of large pipe diameters show that the present correlation agrees more closely with the experimental data than the existing CCFL correlations.

• Nuclear Engineering and Technology
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• v.31 no.6
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• pp.618-630
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• 1999

An analytical model that includes the steam condensation effect has been derived and a parametric study has been performed. In addition, a series of experiments were performed and a total of 34 experimental data for the onset of CCFL in nearly horizontal countercurrent two-phase How have been obtained for various flow rates of water. Comparisons of the present CCFL data with slug formation models show that the agreement between the present as well as the existing model and the data is about the same. However, the deviation between the Taitel and Dukler's model predictions and the data is the largest when if j$_{f}$<0.04 m/s. A parametric study of the effect of the steam condensation using the present model shows that, when all local conditions are similar, the model predicted local gas velocities that cause the onset of flooding are slightly lower when condensation occurred. Based on the visual observation and the evaluation of the present work, it has been concluded that the criterion derived for the onset of slug flow can be directly used to predict the onset of inner flooding in nearly horizontal two-phase flow within the experimental ranges of the present work.

• PNF and Movement
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• v.15 no.3
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• pp.291-302
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• 2017

Purpose: The purpose of this study was to describe the effects of neck and trunk stabilization exercise on the onset time of trunk muscle contraction in the elderly. Methods: Elderly subjects were divided into 2 groups: a neck and trunk stabilization exercise group (NTSG) and a control group (CG). The NTSG performed both neck and trunk stabilization exercises and the CG performed gait training on a treadmill, at 30 min per session, 3 times per week, over 8 weeks. Surface electromyography was employed to measure the onset times of trunk muscle contractions in the right anterior deltoid, rectus abdominis, external oblique abdominis, internal oblique abdominis, and erector spinae muscles. Results: The NTSG subjects showed earlier and statistically significant onset of contraction in trunk muscles as compared to the CG. Conclusion: The combination of neck and trunk stabilization exercises may more effectively improve the onset of muscle contractions in the elderly than other types of exercise. The present study's findings may be used as basic data for the development of exercise programs suitable to the elderly, specifically for the design of home exercise programs.

• The Journal of Korean Physical Therapy
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• v.24 no.1
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• pp.7-14
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• 2012

Purpose: The purpose of this study was to investigate the effect of motor imagery on the onset time of the leg muscle and ankle injury score of patients with functional ankle instability. Methods: The study included 16 patients with ankle instability after their ankle sprains. Motor imagery was performed 3 times a week for 4 weeks. The onset time of leg muscles was measured by using the surface EMG in one leg standing position on tibialis anterior, peroneous longus and medial, lateral gastrocnemius. The pre- and post-intervention was measured by using the ankle injury score. Data was analyzed by a paired t-test. Results: The onset time was reduced but there was no significant difference (p>0.05). The order of muscle recruitment was changed. Anke injury score increased significantly after motor imagery (p<0.05). Conclusion: The results suggest that motor imagery was effective by showing delayed onset time of peroneal muscle in patients with functional ankle instability. In future studies, various conditions and disorders should all be considered for the effective analysis of motor imagery.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.87.2-87.2
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• 2011

Proper motion of sunspots in several active regions was studied to detect their indicator on flare onset, using data from the Solar Flare Telescope at Mitaka (four flaring active regions), TRACE (e.g. NOAA 0424, M1.7 flare on 5 Aug. 2003) and Hinode (e.g. NOAA 10930, X3.4 flare on 13 Dec. 2006). The proper motion of individual sunspots was derived using a local correlation tracking method. As a result, we found that the sunspots that are located under or close to a part of chromospheric flaring patches showed a change in their moving direction prior to the flare onset. The change in their movements took place a half to two hours before the flare onset. On the other hand, sunspots in non-flaring areas or non-flaring active regions did not show this kind of change. It is likely, therefore, that if a sunspot shows the particular movement, a chromospheric flare is to occur in its nearby region. In the most active regions, the part of flare ribbons was located on an emerging bipolar pair of sunspots. The disturbance in the usual motion of the bipolar sunspots and in other sunspots as well can be interpreted as a sign of magnetic shear development leading to final magnetic energy buildup before its sudden release. We suggest that the change in sunspot motion in a short time scale prior to the flare onset can be regarded as a good indicator in predicting the onset timing and location of chromospheric flares.

• The Journal of Korean Physical Therapy
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• v.11 no.3
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• pp.37-44
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• 1999

Delayed onset muscle soreness is a sensation of discomfort that occurs 24h after exercise, and it is associated with the performance of unfamiliar and high force muscle wor, such as eccentric contractions. The injury to the muscle has been well described but the mechanism underlying the injury is not fully understood. Although the pathophysiological processes underlying delayed onset muscle soreness are not completely understood, many researchers have investigated various treatments in a attempt to reduce the soreness. These treatments have focused on reducing the inflammation, or edema, consequent to tissue damage, and breaking up the cycle which is thought provoke tonic muscle spasm or pain. Physical therapy is the most importance thechniques to reduce delayed onset muscle soreness. Physical therapy on delayed onset muscle soreness includes massage, exercise, therapeutic ultrasound, TENS, stretching and cryotherapy, this investigation should encourage physical therapists to experiment further with various techniques to reduce delayed onset muscle soreness.

• Atmosphere
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• v.24 no.2
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• pp.189-196
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• 2014

The definition of onset date of Changma is revisited in this study using a quality controlled Ieodo ocean research station data. The Ieodo station has great importance in terms of its southwest location from Korean Peninsula and, hence, makes it possible to predict Changma period in advance with less impact of continents. The onset date of Changma using the Ieodo station data is defined by the time that meridional wind direction changes and maintains from northerly to southerly, and then the zonal wind changes from easterly to westerly after first June. This definition comes from a recognition that the establishment and movement of the western North Pacific subtropical high (WNPSH) cause Changma through southwesterly flow. The onset data of Changma has been determined by large-scale dynamic-thermodynamic characteristics or various meteorological station data. However, even the definition based on circulation data at the Ieodo station has a potential for the improved prediction skill of the onset date of Changma. The differences between before and after Changma, defined as Ieodo station data, are also found in synoptic chart. The convective instability and conspicuous circulations, corresponding low-level southwesterly flow related to WNPSH and strong upper-level zonal wind, are represented during Changma.

• Safety and Health at Work
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• v.12 no.1
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• pp.108-113
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• 2021

Background: This study aimed to investigate the relationship between changes in employment status and new-onset depressive symptoms through a one-year follow-up of permanent waged workers. Methods: We analyzed the open-source data from the Korea Welfare Panel Study. Using the 2017 data, we selected 2,314 permanent waged workers aged 19 to 59 years without depressive symptoms as a base group. The final analysis targeted 2,073 workers who were followed up in 2018. In 2018, there were five categories of employment status for workers who were followed up: permanent, precarious, unemployed, self-employed, and economically inactive. Multiple logistic regression was used to determine the association between employment status change and new-onset depressive symptoms. Results: Adjusted multiple logistic regression analysis showed that among male workers, workers who went from permanent status to being unemployed (odds ratio: 4.50, 95% confidence interval: 1.19 to 17.06) and from permanent status to being precarious workers (odds ratio: 3.15, 95% confidence interval: 1.30 to 7.65) had significantly high levels of new-onset depressive symptoms compared with those who retained their permanent employment status. There were no significant increases in new-onset depressive symptoms of male workers who went from permanent status to being self-employed or economically inactive. On the other hand, no significant differences were found among female workers. Conclusion: Our study suggests that the change of employment status to precarious workers or unemployment can cause new-onset depressive symptoms in male permanent waged workers.

• PNF and Movement
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• v.11 no.1
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• pp.55-62
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• 2013

Purpose : This study was assessed muscle activity and onset time in trunk and upper extremity on functional reaching. Methods : The participant was 18 female(young 10, old 8). As functional reaching, we collection data by using EMG(MP150) on transverse abdominis, external oblique, erector spinae, deltoid middle and serratus anterior. Results : 1) In functional reaching, transverse abdominis, external oblique, erector spinae and deltoid middle muscle activity was augmented on old female(p>.05). Serratus anterior was augmented on young female(p>.05). 2) In functional reaching, transverse abdominis and erector spinae muscle onset time is significantly faster old female than young female(p<.05). External oblique and serratus anterior muscle onset time is faster old female than young female(p>.05). 3) As increase of age muscle activity of external oblique was more increased that we found .511 a coefficient correlation and onset time more faster on transverse abdominis and erector spinae were each -.492 and -.554 coefficient correlation. Conclusion : The muscle activity and onset time was difference in functional reaching according to ageing and task context. It is necessary concentration and attention to old female than young female. Therefore, these results suggest that importance of anticipatory postural control and selective strategy of postural control.