• Title/Summary/Keyword: One-pot

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Synthesis of 1H-Indol-3-ylpyrazole Derivatives from 1,3,5-Triketones and Arylhydrazines: One-Pot Construction of Pyrazole and Indole Rings

  • Kim, Sung Hwan;Lee, Sangku;Kim, Se Hee;Kim, Ko Hoon;Kim, Jae Nyoung
    • Bulletin of the Korean Chemical Society
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    • v.34 no.11
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    • pp.3415-3419
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    • 2013
  • The reaction of 1,3,5-triketones and arylhydrazines provided indolylpyrazole derivatives in a one-pot reaction in good to moderate yields. Both the pyrazole and indole rings were constructed simultaneously with phenylhydrazine, $RCOCH_2CO$- moiety for the pyrazole and the remaining -$CH_2COR$ part for the indole ring.

Expedient One-Pot Synthesis of γ-hydroxybutenolides Starting from Baylis-Hillman Adducts: Lactonization, Isomerization, and Aerobic Oxidation of α-Methylene-γ-hydroxyester

  • Kim, Ko-Hoon;Lee, Hyun-Seung;Kim, Sung-Hwan;Lee, Ka-Young;Lee, Ji-Eun;Kim, Jae-Nyoung
    • Bulletin of the Korean Chemical Society
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    • v.30 no.5
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    • pp.1012-1020
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    • 2009
  • We developed an efficient three-step synthetic protocol of $\gamma$-hydroxybutenolides starting from the Baylis-Hillman adducts: (i) bromination, (ii) Barbier reaction and (iii) one-pot $K_2CO_3$-mediated synthesis of $\gamma$-hydroxybutenolides. In addition, we showed the synthetic applicability of butenolides including self-dimerization, conjugate addition reaction, and alkylations.

Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues (5-Chloroindole계 화합물의 Large Scale 합성)

  • Keetha, Laxminarayana;Palle, Sadanandam;Ramanatham, Vinodkumar;Khagga, Mukkanti;Chinnapillai, Rajendiran
    • Journal of the Korean Chemical Society
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    • v.55 no.2
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    • pp.240-242
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    • 2011
  • A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields.

Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Thiamine Hydrochloride Under Solvent-free Condition

  • Badadhe, Pravin V.;Chate, Asha V.;Hingane, Dattatraya G.;Mahajan, Pravin S.;Chavhan, Namdev M.;Gill, Charansingh H.
    • Journal of the Korean Chemical Society
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    • v.55 no.6
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    • pp.936-939
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    • 2011
  • Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.

Phosphomolybdic Acid-Catalyzed Highly Efficient and Simple One-Pot Synthesis of Quinoxaline (인 몰립덴산을 촉매로 이용한 효과적이고 간단한 퀸옥살린의 One-Pot합성)

  • Chaskar, Atul;Padalkar, Vikas;Phatangare, Kiran;Langi, Bhushan;Naik, Pallavi
    • Journal of the Korean Chemical Society
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    • v.53 no.6
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    • pp.727-730
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    • 2009
  • A series of quinoxaline derivatives were efficiently synthesized in excellent yield using phosphomolybdic acid as a catalyst. The advantages of present methods are ambient reaction temperature, simplicity of operation, high atom economy, recyclability of HPA catalyst and ecofriendly nature of reaction medium.

1-Butyl-3-Methyl Imidazolium Hydrogen Sulphate Promoted One-Pot Three-Component Synthesis of Amidoalkyl Naphthols

  • Sapkal, Suryakant B.;Shelke, Kiran F.;Madje, Balaji R.;Shingate, Bapurao B.;Shingare, Murlidhar S.
    • Bulletin of the Korean Chemical Society
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    • v.30 no.12
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    • pp.2887-2889
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    • 2009
  • An efficient and easy method for one-pot three-component synthesis of amidoalkyl naphthols by the condensation of aromatic/heteroaromatic/aliphatic aldehydes, 2-naphthol and amides or urea under thermal condition at $60^{\circ}C$ in the presence of acidic ionic liquid 1-butyl-3-methylimidazolium hydrogen sulphate ([bmim]$HSO_4$) has been described.

Hydrated Ferric Sulfate [Fe2(SO4)3·xH2O]: An Efficient and Reusable Catalyst for One-Pot Synthesis of 2H-Indazolo[2,1-b]phthalazine-triones

  • Choudhury, Abhik;Ali, Shahzad;Khan, Abu T.
    • Journal of the Korean Chemical Society
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    • v.59 no.4
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    • pp.280-283
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    • 2015
  • Hydrated ferric sulfate can be used as an efficient and reusable catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives via one-pot three-component condensation reaction of phthalhydrazide, aromatic aldehydes and cyclic-1,3-diketones in ethanol under reflux conditions.

Convenient One-Pot Synthesis of 2,4,5-Triaryl-1H-imidazoles from Arylaldehydes, Benzyl Alcohols, or Benzyl Halides with HMDS in the Presence of Molecular Iodine

  • Veisi, Hojat;Khazaei, Ardashir;Heshmati, Leila;Hemmati, Saba
    • Bulletin of the Korean Chemical Society
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    • v.33 no.4
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    • pp.1231-1234
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    • 2012
  • A one-pot efficient procedure for the synthesis of 2,4,5-triaryl-1H-imidazole derivatives in good to excellent yields by reaction between hexamethyldisilazane and arylaldehydes, benzyl alcohols, benzyl halides in the presence of molecular iodine has been developed. The remarkable advantages of this method are the simple workup procedure, high yields of products, and the availability of reagents.