• Journal of Ginseng Research
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• v.39 no.2
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• pp.141-147
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• 2015

Background: Adipocytes, which are the main cellular component of adipose tissue, are the building blocks of obesity. The nuclear hormone receptor $PPAR{\gamma}$ is a major regulator of adipocyte differentiation and development. Obesity, which is one of the most dangerous yet silent diseases of all time, is fast becoming a critical area of research focus. Methods: In this study, we initially aimed to investigate whether the ginsenoside Rf, a compound that is only present in Panax ginseng Meyer, interacts with $PPAR{\gamma}$ by molecular docking simulations. After we performed the docking simulation the result has been analyzed with several different software programs, including Discovery Studio, Pymol, Chimera, Ligplus, and Pose View. All of the programs identified the same mechanism of interaction between $PPAR{\gamma}$ and Rf, at the same active site. To determine the drug-like and biological activities of Rf, we calculate its absorption, distribution, metabolism, excretion, and toxic (ADMET) and prediction of activity spectra for substances (PASS) properties. Considering the results obtained from the computational investigations, the focus was on the in vitro experiments. Results: Because the docking simulations predicted the formation of structural bonds between Rf and $PPAR{\gamma}$, we also investigated whether any evidence for these bonds could be observed at the cellular level. These experiments revealed that Rf treatment of 3T3-L1 adipocytes downregulated the expression levels of $PPAR{\gamma}$ and perilipin, and also decreased the amount of lipid accumulated at different doses. Conclusion: The ginsenoside Rf appears to be promising compound that could prove useful in antiobesity treatments.

• Journal of Welding and Joining
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• v.34 no.6
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• pp.42-46
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• 2016

Hydrogen assisted cracking (HAC) is one of the most complicated problem in welding. Huge amount of studies have been done for decades. Based on them, various standards have been established to avoid HAC. But it is still a chronic problem in industrial field. It is well known that the main causes of the hydrogen crack are residual stress, crack susceptible micro structures and a certain critical level of hydrogen concentration. Even though the exact generating mechanism is unclear till today, it has been reported that the hydrogen level in the weld metal should be managed less than a certain amount to prevent it. Matsuda studied that the residual hydrogen level in the weld metal can be varied even if the initial hydrogen content is same. It is also insisted in this report that the residual hydrogen concentration is in stronger correlation with hydrogen crack than the initial hydrogen content. But, in practical point of view, the residual hydrogen is still hard to consider because measuring hydrogen level is time and cost consuming process. In this regard, numerical analysis is the only solution for considering the residual hydrogen content. Meanwhile, Takahashi showed the possibility of predicting the residual hydrogen by a rigorous FE analysis. But, few commercial software suitable for solving the weld metal hydrogen has been reported yet. In this study, two dimensional thermal - hydrogen coupled analysis was developed by using the commercial FE software MARC. Since the governing equation of the hydrogen diffusion is similar to the heat transfer, it is shown that the heat transfer FE analysis in association with hydrogen diffusion property can be used for hydrogen diffusion analysis. A series of simulation was performed to verify the accuracy of the model. For BOP (Bead-On-Plate) and the multi-pass butt welding simulations, remaining hydrogen contents in the weld metal is well matched with measurements which are referred from Kim and Masamitsu.

• Journal of Korea Water Resources Association
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• v.39 no.4 s.165
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• pp.321-334
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• 2006

The need for economical and accurate presentations of equivalent radar reflectivity( $Z_e$) data in an orthogonal coordinate system has existed for some time. So, in this study, a fast and efficient procedure has been developed which allows the systematic interpolation of digital reflectivity data from radar space into Cartesian space. At first, QC(Quality Control) of radar data has been executed for extracting uncontaminated Constant Altitude Plan Position Indicator(CAPPI) data. The algorithm is designed so that only one ordered pass through the original Plan Position Indicator(PPI) scan data is necessary to complete the interpolation process. The model can calculate various resolution and altitude reflectivity data for many kinds of hydrological usage.

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.1 no.1
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• pp.23-35
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• 1983

In its global meaning language translation refers to the process whereby a program which is executable in one computer can be executed in another computer directly to obtain the same result. There are four different ways of approaching translation. The first way is translation by a Translator or a Compier, the second way is Interpretation, the third way is Simulation, the last way is Emulation. This paper introduces the M-C Translator which was designed as the first way of translation. The MUSS 80 language (the subsystem of the UNIVAC Solid State 80 S-4 assembly language system) was chosen as the source language which includes forty-three instructions, using the CYBER COMPASS as the object language. The M-C translator is a two pass translator and is a two pas translator and es written in Fortran Extended language. For this M-C Translation, seven COMPASS subroutines and a set of thirty-five macros were prepared. Each executable source instruction corresponds to a macro, so it will be a macro instruction within the object profram. Subroutines are used to retain and handle the source data representation the same way in the object program as in the source system, and are used to convert the decimal source data into the equivalent binary result into the equivalent USS-80digits before and after arithmetic operations. The source instructions can be classified into three categories. First, therd are some instructions which are meaningless in the object system and are therefore unnecessary to translate, and the remaining instructions should be translated. Second, There are some instructions are required to indicate dual address portions. Third, there are Three instructions which have overflow conditions, which are lacking in the remaining instructions. The construction and functions of the M-C Translator, are explained including some of the subroutines, and macros. The problems, difficulties and the method of solving them, and easier features on this translation are analysed. The study of how to save memory and time will be continued.

• Journal of Biomedical Engineering Research
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• v.43 no.2
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• pp.124-130
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• 2022

In this paper, we proposed a portable electronic cardiogram and stethoscope (ECGS) that can simultaneously perform the electrocardiogram (ECG) and auscultation tests to increase the reliability of diagnosis of heart disease. To measure the ECG and heart sound (HS) at the same time, three ECG electrodes and a microphone sensor were combined into a triangular shape with a width of 90 mm and a height of 97 mm that can be held in one hand. In order to prevent skin problems when they contact the patient's skin, a capacitive coupled electrode was selected as the ECG electrode and a silicone material was used in a chest piece with the microphone sensor. For the signals measured from the electrodes and the chest piece, filters were respectively configured to pass only the signals of 0.01-100 Hz and 20-250 Hz, which are frequency bands for ECG and HS. The filtered ECG and HS analog signals were converted into digital signals and transmitted to a PC using wireless communication for monitoring them. The HS could be auscultated simultaneously using an earphone. The monitored ECG had an SNR of about 34 dB and a P-QRS-T waveform is clearly visible. In addition, the HS had an SNR of about 28 dB and both S₁ and S₂ are clearly visible. It is expected that it can aid doctors' inexperience in analyzing the ECG and HS.

• Journal of Korean Society of Transportation
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• v.24 no.3 s.89
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• pp.63-71
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• 2006

There were many theories to suggest the indicators that evaluate stability and reflect the plan in mixed traffic street in all traffic modes This Paper analyzed residential street of Suwon City adopting time-space occupancy index among these indicates. Three survey street. congregated into apartment house. were selected to analyze this and pictured by video camera over one hour. and the length of these street were 76m, 55m, and 34m each, and major street by each region, comparably high in Pedestrians and pass vehicles, were selected. Basic datum to calculate time-space occupancy index and time-space occupancy index per person was gathered through video analysis. i.e Parameters for pedestrians, cars, bicycles, average speed of bicycles, and parking car. There are some limitation to analyze LOS of mixed traffic street in all traffic modes, not pedestrian mall. Therefore this paper presented evaluation standard of LOS. In conclusion. the aim of this paper is to suggest modeling based on guidelines for evaluating LOS of mixed traffic street in all traffic modes. It is estimated that this will be influencing indicates for improving pedestrian environment, and Planning mixed traffic street in future.

• Journal of Navigation and Port Research
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• v.39 no.3
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• pp.209-215
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• 2015

Miraculous victory of Myeongnyang sea battle turned the tide of the Joseon's entire war against Japan and it is regarded as one of the most remarkable sea victories in the world history. In the sea battle of Myeongnyang, on September 16, 1597(lunar calender), the Joseon navy with 13 battle ships, led by Admiral Yi Sun-sin, won the Japanese navy with their fleet of 133 warships. There were several reasons why Admiral Yi decided on this location for battle. Myeongnyang strait is so narrow and had currents so powerful that many ships could not pass strait simultaneously. Therefore, despite being vastly outnumbered, Admiral Yi used terrain and tidal current advantage to defeat Japanese navy's numerical advantage. In order to find out the tidal state of Myeongnyang strait on September 16, 1597, topological phase of sun and moon was studied by orbital period of earth and moon. The tidal state of Myeongnyang strait on September 16, 1597 is estimated based on the theories of tide and tide tables. As a result of this study, time of slack water were found to be 0636, 1248, 1906 and time/speed of maximum tidal current were found to be 0930/8.3kts(NW), 1612/9.9kts(SE).

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.6
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• pp.11-51
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• 1993

This study is focused on the problems and the suggestions of proper ideas for solving them which are arisen from appling CIF, Incoterms 1990 into the contract of sale after reviewing of the contents of traditional CIF contract and the main changes of CIF, Incoterms 1990. This study summerized as follows: First, when the seller provide the buyer with non-negotiable sea waybill or inland waterway document instead of negotiable bill of lading, it is my feeling that the essence of symbolic delivery in traditional CIF contract is fading. And if the buyer has paid for the goods in advance, or a bank wishes to use the goods as security for a loan extended to the buyer, it is not sufficient that the buyer or the bank be named as consignee in a non-negotiable document. This is true because the seller by new instractions to the carrier could replace the named consignee with someone else. To protect the buyer or the bank it is therefore necessary that the original instructions from the seller to the carrier to deliver the goods to the named consignee be irrevocable. Second, CIF term can only be used for sea and inland waterway transport. When the ship's rail serves no practical purposes such as in the case of roll-on/roll-off or container traffic, CIP term instead of CIF term is more appropriate to use. Third, the EDI method still contains many legal and technical problems to be solved in order to be used thoroughly' in the international sale of goods. Therefore, the parties wishing to replace the traditional paper-based trade documents by electronic messages must exchange the agreement on EDI each other in order to prevent and sol ye unexpected problems. Forth, it may be that the goods are to be carried in bulk without such marking or naming of consignee as would amount to appropriation. Then the risk will not pass until effective appropriation has been made. Therefore, the seller needs to appropriate by issuing of separate bills of lading or delivery orders for parts of the bulk cargo. And in case the goods are bought while they are carried at sea, some problems on the passing of risk would arise. One possibility is that the buyer might have to assume risks which have already occured at the time when the contract of sale is entered into force. The other possibility would be to let the pissing of the risk concide with the time when the contract of sale is concluded. The parties are advised to ascertain the applicable law and any solution which might follow there form. Finally, Incoterms are restricted to deal with the main principles for the division of functions, costs and risks between the parties and the rest is left to their individual contract as supplemented by the custom of the trade, the individual terms of the contract of sale and the applicable law. Thus, the parties are advised to ascertain the applicable law on their individual contract of sale in order to solve the problems on the transfer of property, the remedy and so on.

• (The)Study of the Eastern Classic
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• no.37
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• pp.33-61
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• 2009

In the late Koryo period, until 14th century, there had been at least two groups of Manchurians who were conferred citizenships; one group was living as an original inhabitant in the coastal area of north­eastern part of Korean peninsular, long time ago, and they were over one thousand households. The other was coming down from inland, eastern part of Yoha River, to the area of Tuman River to settle down and they were at least around one hundred and sixty households, including such tribes as Al-tha-ry, Ol-lyang-hap, Ol-jok-hap and others. They were treated courteously, from the early days of Choson dynasty, with governmental policies in an economic, political, and social ways. They were given, for instance, a house, a land, household furniture, and clothes. They were allowed to get marry with a native Korean to settle down. They were educated how to cultivate their lands. It was also possible for them to be given an official position politically or allowed to take a National Civil Official Examination. The fact they could take such an Examination, in particular, means they were treated fairly and equally, because they also had a privilege to improve their social positions through the formal system as much as common people. Two typical families were scrutinized, in this paper, family Chong-hae Lee and family Chon-ju Ju. All of them were successful to settle down with different backgrounds each other. The former were from a headman, Lee Jee-ran, who controlled his tribe, over five hundred households. He was given three titles of a meritorious retainer at the founding of Chosun dynasty, at the retrieval of armies, and an enshrined retainer. His son, Lee Wha-yong, was also given a vassal of merit who kept a close tie successfully with the king's family through a marriage. Upon the foundation of their ancestors, their grandsons, family Lee Hyo-yang and family Lee Hyo-gang, each, had taken solid root as an aristocratic Yang-ban class. The former became a high officer family, generation by generation, while the latter changed into a civil official family through Civil Official Examinations. They lived mainly around Seoul, Kyong-gi Province and some lived in their original places, Ham-kyong Province. Chu-man, the first ancestor, was given a meritorious retainer at the founding of the dynasty and Chu-in was also given a high officer position from the government. They kept living at the original place, Ham-heung, Ham-kyong Province, and then became an outstanding local family there. They began to pass the Civil Official Examinations. After 17th century on the passers were 17 in Civil Official Examinations and 40 were passed in lower civil examinations. The positions in government they attained usually were remonstrance which position was prohibited particularly to North­Western people at that time. The Chosun dynasty was open to Machurians widely through the system of envoy, convoy, and naturalization. It was intended to build up an enclosure policy through a friendly diplomatic relation with them against any possible invasion from outside. This is one reason why they were supported fully that much in a various way.

• The Journal of Korean Society for Radiation Therapy
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• v.30 no.1_2
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• pp.107-116
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• 2018

Purpose : Intensity-modulated radiation therapy(IMRT) has been widely used for radiation therapy of Prostate Cancer because it can reduce radiation adverse effects on normal tissues and deliver more dose to the Prostate than 3D radiation therapy. Volumetric modulated arc therapy(VMAT) has been widely used due to recent advances in equipment and treatment techniques. VMAT can reduce treatment time by up to 55 % compared to IMRT, minimizing motion error during treatment. Materials and Methods : In this study, compared the MU and DVH values of 10 patients with prostate cancer by classifying them into 4 groups with 5 LN-Prostate groups and 5 Only-Prostate. And DQA measurements were performed using ArcCHECK and MapCHECK. Results : The results of Target and OAR dose distribution of Prostate patients are as follows. $D_{max}$ was in the range of 100~110 % in 4 groups, and more than 110 % of hot spot was not seen. Only-Prostate ($P_1$, $P_2$) without LN had a satisfactory dose distribution for the target dose, but slightly better for 2 arc plan($P_2$) than 1 arc plan($P_1$). The target dose $D_{98%}$ distribution in the LN-Prostate ($P_{L1}$, $P_{L2}$) group showed better 2 arc plan($P_{L2}$) than 1 arc plan($P_{L1}$), But in the case of 1 arc plan($P_{L1}$), the target dose $D_{98%}$ value was not enough. In OAR, the dose distribution of 1 Arc($P_1$) Plan and 2 Arc($P_2$) Plan in the Only-Prostate ($P_1$, $P_2$) Group satisfied the prescribed dose value. But, The dose distribution of 1 arc($P_1$) was slightly higher. In LN-Prostate OAR, 1 Arc($P_{L1}$) Plan showed higher dose than the prescribed dose. The Gamma evaluation pass rate of ArcCHECK and MapCHECK calculated from the DQA measurements was slightly higher than 99 % and the mean error range of the point dose measurements using the CC04 ion chamber was less than 1 %. Conclusion : In this study, Only-Prostate ($P_1$, $P_2$) group, the dose of 2 Arc plan was better. However, considering the treatment time and MU value, 1 Arc treatment method was more suitable. In the LN-Prostate ($P_{L1}$, $P_{L2}$) group, 2 Arc($P_{L2}$) treatment method showed better results and satisfied with Target $D_{98%}$ and OAR prescription dose.