• Journal of Korean Neurosurgical Society
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• 제53권6호
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• pp.337-341
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• 2013

Objective : After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was performed to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, in the brain following thoracic contusive SCI in a mouse model. Methods : Eight-week-old female imprinting control region mice (n=60; 30-35 g) were used in this study. We analyzed the expression levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. Results : The expression of BDNF levels were elevated significantly compared with control group at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 2, 4 weeks compared with control group, but these difference were not significant (p>0.05). The GDNF levels were elevated at 2 week compared with control group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared with control group (p>0.05). Conclusion : These results demonstrate that the upregulation of BDNF may play on important role in brain reorganization after SCI.

• International Journal of Computer Science & Network Security
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• 제22권5호
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• pp.215-219
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• 2022

Bankruptcy is one of the major areas that have attracted the interest of many researchers in the American system, particularly in terms of the laws that oversee it. It provides a plan of reorganization that enables the debtor or the proprietor to discharge liabilities to the creditors through dividing the assets to settle debts. This activity is carried out under supervision to fairly protect the interests of the creditors. Bankruptcy protection systems are dynamic and complex in nature, in line with the economic sector, ensuring the protection of affected individuals from falling into huge losses. Some bankruptcy procedures give the debtor the opportunity to stay in operation or business activity and benefit from revenues until the debt is settled. This law allows some debtors to be relived from any financial burden after the distribution of assets, even if the debt is not paid in full. In light of the above information, this research paper seeks to explore the nature of the complexity of bankruptcy protection laws, their characteristics, and the justice system that regulate them. It also sheds more light on the decision-making powers on bankruptcy cases. There are specialized courts that cover bankruptcy cases located in district courts in every state.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권5호
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• pp.2674-2697
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• 2019

Identity authentication is a crucial line of defense for network security, and passwords are still the mainstream of identity authentication. So far trawling password attacking has been extensively studied, but the research related with personal information is always sporadic. Probabilistic context-free grammar (PCFG) and Markov chain-based models perform greatly well in trawling guessing. In this paper we propose a systematic targeted attacking model based on structure partition and string reorganization by migrating the above two models to targeted attacking, denoted as TG-SPSR. In structure partition phase, besides dividing passwords to basic structure similar to PCFG, we additionally define a trajectory-based keyboard pattern in the basic grammar and introduce index bits to accurately characterize the position of special characters. Moreover, we also construct a BiLSTM recurrent neural network classifier to characterize the behavior of password reuse and modification after defining nine kinds of modification rules. Extensive experimental results indicate that in online attacking, TG-SPSR outperforms traditional trawling attacking algorithms by average about 275%, and respectively outperforms its foremost counterparts, Personal-PCFG, TarGuess-I, by about 70% and 19%; In offline attacking, TG-SPSR outperforms traditional trawling attacking algorithms by average about 90%, outperforms Personal-PCFG and TarGuess-I by 85% and 30%, respectively.

• BMB Reports
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• 제57권2호
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• pp.104-109
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• 2024

Gefitinib exerts anticancer effects on various types of cancer, such as lung, ovarian, breast, and colon cancers. However, the therapeutic effects of gefitinib on cervical cancer and the underlying mechanisms remain unclear. Thus, this study aimed to explore whether gefitinib can be used to treat cervical cancer and elucidate the underlying mechanisms. Results showed that gefitinib induced a caspase-dependent apoptosis of HeLa cells, which consequently became round and detached from the surface of the culture plate. Gefitinib induced the reorganization of actin cytoskeleton and downregulated the expression of p-FAK, integrin β1 and E-cadherin, which are important in cell-extracellular matrix adhesion and cell-cell interaction, respectively. Moreover, gefitinib hindered cell reattachment and spreading and suppressed interactions between detached cells in suspension, leading to poly (ADP-ribose) polymerase cleavage, a hallmark of apoptosis. It also induced detachment-induced apoptosis (anoikis) in C33A cells, another cervical cancer cell line. Taken together, these results suggest that gefitinib triggers anoikis in cervical cancer cells. Our findings may serve as a basis for broadening the range of anticancer drugs used to treat cervical cancer.

• 한국정보기술응용학회:학술대회논문집
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• 한국정보기술응용학회 2002년도 추계공동학술대회 정보환경 변화에 따른 신정보기술 패러다임
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• pp.350-362
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• 2002

높은 가용성 확장성, 시스템 성능의 요구를 만족시키기 위해 SAN(Storage Area Network)이 등장했다. SAN을 보다 효과적으로 활용할 수 있도록, 대부분의 SAN 운영체제들은 SAN에 부착된 물리적 저장장치들을 가상적으로 하나의 커다란 볼륨으로 보이게 하는 저장장치 가상화 개념을 지원한다. 저장장치 가상화의 핵심적인 역할을 하는 것이 바로 논리볼륨 관리자이다. 논리볼륨 관리자는 논리 주소를 물리 주소로 매핑시킴으로서 저장장치 가상화를 실현한다. 이 논문에서는 논리볼륨 관리자를 위한 효율적이고 유연한 매핑 기법을 설계하고 구현한다. 이 논문의 매핑 기법은 특정 시점의 볼륨이미지를 유지할 수 있는 스냅샷과 시스템을 정지시키지 않고 SAN에 디스크를 추가 또는 삭제할 수 있는 온라인 재구성 기능을 지원한다.

• 한국산업정보학회:학술대회논문집
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• 한국산업정보학회 2002년도 추계공동학술대회
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• pp.350-362
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• 2002

높은 가용성, 확장성, 시스템 성능의 요구를 만족시키기 위해 SAN(Storage Area Network)이 등장했다. SAN을 보다 효과적으로 활용할 수 있도록, 대부분의 SAN 운영체제들은 SAN에 부착된 물리적 저장장치들을 가상적으로 하나의 커다란 볼륨으로 보이게 하는 저장장치 가상화 개념을 지원한다. 저장장치 가상화의 핵심적인 역할을 하는 것이 바로 논리볼륨 관리자이다. 논리볼륨 관리자는 논리 주소를 물리 주소로 매핑 시킴으로서 저장장치 가상화를 실현한다. 이 논문에서는 논리볼륨 관리자를 위한 효율적이고 유연한 매핑 기법을 설계하고 구현한다. 이 논문의 매핑 기법은 특정 시점의 볼륨이미지를 유지할 수 있는 스냅 샷과 시스템을 정지시키지 않고 SAN에 디스크를 추가 또는 삭제할 수 있는 온라인 재구성 기능을 지원한다.

• 건축역사연구
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• 제29권6호
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• pp.41-56
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• 2020

This study attempted to clarify the modern transition process of the urban space through the construction and change of the Imperial Palace as a central facility in Seoul. The road renovation of Seoul, which started in 1895, has established a modern, circular transportation system centered on Gyeongun-gung Palace, the Imperial Palace along with the tram line. In this urban structure, the imperial palace as a central facility of the former monarchy, unlike the previous palaces, could not be located at the top of a road with a longitudinal axis, and it expanded its territory around foreign legionaries and placed a new government office around the perimeter. However, the royal palace was moved to Changdeokgung Palace in 1907 with the throne of Sunjong. With the creation of Changdeokgung, which is the periphery of Seoul, as new royal palace, the status of the imperial palace in the city was remarkably weakened, and Gyeongun-gung, located in the center of Seoul, was also reduced to the current Deoksugung area, turning into an urban facility facing a modern street.

• 한국문헌정보학회지
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• 제32권2호
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• pp.211-232
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• 1998

본 연구의 목적은 직면하고 있는 기술과 시스템 환경변화에 적합한 정보전문가 양성을 위한 문헌정보학 교육의 내용을 규명해보는데 있다. 그 중에서 현재 정보환경 변화에 따라 요구되는 최신정보기술인 인공지능과 전문가시스템이 필요함을 인식하여 인공지능과 전문가시스템의 어떤 교육내용이 문헌정보학에 도입해야 할 것인가에 대한 해결방안을 모색하고 기본적 자료를 얻어내는데 그 목적이 있다. 본 연구 결과에 따른 내용을 정리하면 다음과 같다. 첫째, 고도의 정보기술과 컴퓨터의 발전으로 인하여 문헌정보학의 전통적인 핵심내용이 새로운 내용 즉 네트워크를 통한 정보원 탐색, 온라인데이터베이스 검색, 정보시스템 분석과 설긴 컴퓨터활용능력, 정보검색전략 개발순으로 나타났다. 둘째. 인공지능과 전문가시스템 교육내용 중에서 문헌정보학 교육에 중요한 내용으로는 데이터베이스처리 시소러스 자연언어처리, 지식표현으로 나타났다. 셋째, 문헌정보학 교수들은 인공지능과 전문가시스템 교과목 주제가 대다수 학생들에게 유용한 주제라고 인식하고 있음이 나타났다. 넷째, 앞으로 사서/정보전문가를 돕는 인공지능과 전문가시스템의 역할이 참고봉사, 편목${\cdot}$ 분류, 정보검색${\cdot}$ 문헌전달 업무에서 더 중요하게 인식하고 있음이 나타났다. 다섯째, 문헌정보학과 교수들이 인공지능과 전문가시스템 교과목 주제를 중요하게 인식함에 따라 앞으로 인공지능과 전문가시스템 교육과정이 국내 문헌정보학 교육과정에 개설될 것으로 나타났으며 인공지능과 전문가시스템 교육내용 중에서 중요하다고 조사된 데이터베이스처리. 시소러스 자연언어처리. 지식표현의 과목은 앞으로 문헌정보학 교육과정에 도입하여야 할 것이다.

• 보건행정학회지
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• 제2권2호
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• pp.57-89
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• 1992

This study is aimed both to reorient the Health net-works focused to Health Subcenters in times of development of local autonomy in Korea and to collect the fundamental data such as attitude and practice of the directors of Health Subcenter. The materials are collected from 134 out of 258 sampling directors of Health Subcenters with a questionaire by mailing(respond rate 51.9%). The major findings of this fundamental data are as follows. 1. Current average number of outpatients cared by a director of Health Subcenter is found to be 21.6. 2. The directors of Health Subcenter have little deducted hours for Public Health Programme. 3. Number of the Preventive Health Programme worked by a director of Health Subcenter is from 0 to 3. The most major group worked only 1 programme marked at 69.4%. 4. The directors of Health Subcenter express approval opinin marked at 80.2% that their qualification to appoint has to finish intern course. 5. The average diagnosis allowance a month is approximately twenty hundred thousand won. 6. Most of Health Subcenter(market at 94%) adopted a self-supporting account system. 7. The most complaining subject of directors of Health Subcenter is their working environment. The second complaining subject is governmental officier's interference. 8. The average number of outpatients cared by a director of Health Subcenter is found to be certain differentials by their marriage and the duration of employment. Some proposals of development on Health Subcenter based on the result of this research is as follows : 1. The reorganization on Health Subcenter under line of National Health Center Net-work 2. The psychological reorientation of directors of Health Sucenter and officers. 3. Autonomy management of Health Subcenter. 4. Reorientation of status on directors of Health Subcenter.

• 한국실내디자인학회논문집
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• 제12호
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• pp.10-17
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• 1997

The lastest art is being characterised by an ever active exchange between different genre. This is a study on the installation aspect in deconstruction architectured and interior design. The progressive and aggressive nature of installatation art embodies uncatagorized genre, the freedom of material application, introduction of the notion of time in space, the reversion of subject and object, the union of art and every experience, understanding of object through deconstruction, enlargement of concept of space, collage-style composition and layer technique. I can conclude that the installation aspect in Tshumi's Parc de la Villette is its call upon the audience to actively participate, the introduction of a coincidental conjunction, its challenge on the conventional idea of park and its flexibility caused by human activity and time. In Hadid's Hong Kong Peak Club the installation aspect is the application of layer technique using four enormous beams horizontally laid out on a man-made moutain. Furthermore, Libeskind's pursuit of the mental in Berlin Museum Extension through the penetration of an invisible line into a void creates a new interpretation of the role of a museum and thus relates itself to installation art. The installation aspect in Himmelblau's Vienna Roof Renovation is the literal deconstruction of the roof of an old building in the old section of Wien and the expression of time and space through the interrelationship between interior and exterior environment by the use of juxtaposition technique. Finally, I note that the installation aspect in Gehry's Santa Monica Residence is the reorganization of cheap material as a form of 'object', that creates spon-taneity, movement as well as flow of time in space and ex-hibit the double-sidedness of the visible world.