• Journal of Yeungnam Medical Science
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• 제37권3호
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• pp.194-201
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• 2020

Background: Dietary polyunsaturated fatty acids (PUFA) are thought to modify systemic inflammation. The present study aimed to evaluate the relationship between PUFA intake, lung function, and health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). Methods: In this study, we used the dataset of 6th Korea National Health and Nutrition Examination Survey, in which, a total of 22,948 individuals including 573 participants with a high probability of developing COPD were enrolled. Participants with missing data for the investigated variables were excluded. Linear regression analyses were used to evaluate the association between PUFA intake (omega-3 [N3], omega-6 [N6], and total) with lung function, and HRQoL. HRQoL was determined according to the European Quality of Life-5 Dimensions (EQ-5D). Subgroup analysis of older patients was performed. Age, sex, body mass index, smoking, alcohol, education, residence, total calorie intake, and predicted FEV₁% were adjusted in all analyses. Results: Although lung function was not associated with PUFA intake, EQ-5D index was remarkably associated with N3, N6, and total PUFA intake in a dose-dependent manner. This association was more pronounced in elderly COPD patients. Mean levels of N3, N6, and total PUFA intake were significantly higher in patients having better HRQoL with respect to mobility, self-care, and usual activities. Conclusion: Our results suggest that N3, N6, and total PUFA intake are associated with HRQoL in COPD patients. This association may be attributed to mobility, self-care, and usual activities. Further longitudinal study is required to clarify this relationship.

• Journal of Microbiology and Biotechnology
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• 제21권7호
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• pp.697-702
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• 2011

A strain of the cyanobacterium Arthrospira was isolated from Lake Chahannaoer in northern China and was characterized according to microscopic morphology, photosynthetic oxygen-evolving activity, growth rate, and nutritional profile. Compared with thermophilic Arthrospira species occurring naturally in tropical and subtropical lakes, this isolate is mesophilic and grows optimally at ${\sim}20^{\circ}C$. The total protein, fatty acid, phycocyanin, carotenoid, and chlorophyll a contents were 67.6, 6.1, 4.32, 0.29, and 0.76 grams per 100 grams of dry weight, respectively. The strain is rich in polyunsaturated fatty acids (PUFAs). An essential omega-3 fatty acid, docosahexaenoic acid (DHA), was detected, and ${\gamma}$-linolenic acid (GLA) and DHA accounted for 28.3% of the total fatty acid content. These features of this newly isolated strain make it potentially useful in commercial mass culture in local areas or as a biofuel feedstock. It is also an alternative resource for studying the metabolic PUFA pathways and mechanisms of cold stress tolerance in cyanobacteria.

• 한국가금학회지
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• 제26권4호
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• pp.217-236
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• 1999

Among polyunsaturated fatty acids (PURAs) targeted for manipulation in animal tissues (poultry eggs and meat), omega-3 PUFAs(n-3 PUFAs) are discussed in this review. 3 or 5% dietary menhaden oil (MO) supplemented layer diets was reported to increase docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) contents in the egg. MO at 1.5% also increased the deposition of up to 180mg total omega-3 fatty acids / yolk. Utilization of 5% ground flax seed (FS) resulted in similar total omega-3 fatty acid (FA) deposition as 1.5% MO. However, the basic feed formulations used in the Canadian feed industry usually include 10 to 20% FS in the egg laying diets. Recently several studies reported that addition of tocopherols in layer diets increased the tocopherol content more in the egg than any other tissue. One of reports said that 3.5% dietary oil with added tocopherols resulted in increasing tocopherol deposition and FA composition of the egg and other tissues. In the poultry meat, redfish meal (RM;4, 8, 12, 15 and 30% of diet) or redfish oil (RO;2.1 or 4.2% of diet) added to the practical corn-wheat-soybean based diets resulted in an increase in omega-3 FA and docosapentaenoic acid (DPA) contents in broiler meat lipids. Linseed oil (LO;1.0, 2.5, and 5.0% of broiler diet) supplemented in broiler diets also resulted in omega-3 FA and the ratio of omega-6 being significantly higher in poultry meat lipid than MO. Concern about fish flavor resulted in research about fish oil (FO) supplementation in broiler diets. Without the use of antioxidants, no more than 1.5% FO should be fed to broilers due to unacceptable orders from the chicken carcasses. One recent research project found that over 50mg/kg of vitamin E was required for maintaining the stability of unsaturated lipids in the meat. In regards to 'fishy'or 'crabby'taint in the eggs and poultry meat, poultry products remained acceptable when dietary fish oils were stabilized with antioxidants.

• 한국해양바이오학회지
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• 제9권2호
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• pp.22-29
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• 2017

A unicellular green alga was axenically isolated from the Port of Jeongja, Ulsan, Korea. Morphological, molecular, and biochemical analyses revealed that the isolate belonged to Heterochlorella luteoviridis. This is the first report of this species in Korea. The microalgal strain was named as H. luteoviridis MM0014 and its growth, lipid composition, and biomass properties were investigated. The strain thrived over a wide range of temperatures ($5-30^{\circ}C$) and withstood up to 0.5 M NaCl. The results of gas chromatography/mass spectrometry analysis showed that the isolate was rich in nutritionally important polyunsaturated fatty acids. Its major fatty acids were linoleic acid (35.6%) and ${\alpha}$-linolenic acid (16.2%). Thus, this indigenous marine microalga is a potential alternative source of ${\omega}3$ and ${\omega}6$ polyunsaturated fatty acids, which are currently obtained from fish and plant oils. Ultimate analysis indicated that the gross calorific value was $19.7MJ\;kg^{-1}$. In addition, the biomass may serve as an excellent animal feed because of its high protein content (51.5%). Therefore, H. luteoviridis MM0014 shows promise for applications in the production of microalgae-based biochemicals and biomass feedstock.

• 한국수산과학회지
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• 제20권2호
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• pp.146-151
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• 1987

정어리유의 산화 안정성과 지질추출시에 첨가한 BHA에 의한 저장중의 산화방지효과를 정토하고 산화로 인한 지방산 조성의 면화를 조사한 결과를 요약하면 다음과 같다. 1. BHA는 유리 지방산의 생성을 현저히 억제하는 효과가 있었다. 2. BHA는 과산화물 생성을 억제하였으며 특히 카르보닐 화합들의 생성을 아주 강하게 억제하였다. 즉 BHA는 과산화을 분해를 억제하는 작용이 있었다. 3. 정어리유는$C_{20:5}$와 $C_{22:6}$의 함량이 $23\%$ 이상으로서 매우 높았다. 4. 산화에 의한 지방산의 감소는 polyene 산에서 급격하였으며 특히 $C_{20:5}$와 $C_{22:6}$산이 급격히 감소하였다. BHA 첨가는 $C_{22:5}$와 $C_{22:6}$산의 산화를 크게 억제 할수 있었다.

• Preventive Nutrition and Food Science
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• 제6권3호
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• pp.170-175
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• 2001

This study was designed to investigate the effect of different sources of $\omega$3 fatty acid in the diet with a similar polyunsaturated/saturated (P/S) fatty acid ratio and $\omega$6/$\omega$3 fatty acid ratio as well as excess DHA on the plasma fatty acid composition and cholesterol level of rats. Three experimental diets contained 10% (w/w) dietary lipids. The control diet and one treatment diet were corn oil-based diets with different $\omega$-3 fatty acid sources: perilla (CO) or fish oil (CF), respectively. In order to examine the effect of excess DHA, the other treatment diet (FO) was a fish oil-based diet with corn oil to supply essential fatty acids at the level of 1.8% (w/w) of the diet. Female Sprague Dawley rats were fed the experimental diets for 2 weeks prior to mating and throughout gestation and lactation. Pups were weaned to the same diet of dams at 21 days of age. Plasma fatty acid compositions and cholesterol contents were analyzed for pups at 3th, 7th and 10th week after birth. Plasma DHA concentrations increased significantly as the level of fish oil supplementation increased. Three-, seven- and ten-week old rats fed on CO diet which contained only $\alpha$-lino1enic acid as a $\omega$-3 fatty acid Source had Plasma DHA levels of 4.85%, 3.15% ana 2.47%, respectively, suggesting that rats at this period of development can convert $\alpha$-linolenic acid to DHA. But the ability to form DHA might be limited, since dietary DHA showed to be more effective in raising the plasma level of DHA. There was a significant negative correlation between DHA and cholesterol concentration of the rat plasma at 7th week (r=0.34, p<0.05) and l0th week after birth (r=036, p<0.05), proving the hypocholesterolemic effect of DHA.

• 한국수산과학회지
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• 제22권2호
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• pp.102-108
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• 1989

[ $\omega3$ ] 고도불포화지방산의 투여가 체중변화, 단백질, 인지질 및 콜레스테롤 함량에 미치는 영향을 비교하기 위하여 정어리유에서 분리한 $\omega3$ 고도불포화지방산, 식물유 및 동물성지방 (대조군)을 $10\%$가 되도록 첨가한 사료로써 실험동물에 6주간 투여하였다. 체중변화는 어유 투여군이 대조군에 비해 $11.1\%\~14.4\%$로 감소하였고, 또 식물유인 옥수수기름 투여군에 비해서는 $16.4\%\~23.3\%$로 감소하였다. 간장에서의 단백질 함량은 $\omega3$ 고도불포화지방산과 정어리 기름 투여군에 비해 $6.78\%\~8.51\%$로 약간 증가하였지만, 뇌 및 혈청에서는 유의성이 없었다. 간장의 마이크로좀에서의 인지질함량은 $\omega3$ 고도불포화지방산과 정어리 기름 투여군이 대조군에 비해 감소하는 경향을 나타내고 있었다. 더우기 이들 어유 투여군은 대조군에 비해 혈청 콜레스테롤 함량이 효과적으로 감소되었다. 따라서 $\omega3$ 고도불포화지방산을 포함한 어유는 단백질 합성을 촉진함은 물론 체중 증가와 인지질 함량을 감소시킬 뿐만 아니라 콜레스테롤 함량을 효과적으로 감소시킴을 알 수 있었다.

• 한국식생활문화학회지
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• 제13권4호
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• pp.293-305
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• 1998

According to economical status, under-nutrition and over-nutrition coexist in preschool children in Korea. Subjects consumed more than RDA in most nutrients, and children in of the upper income class tended to have more nutrients than those of the low income class. Especially in case of energy, protein, fat, vitamin $B_2$, and P there were significant differences among the different classes. The mean calorie compositions of carbohydrates, protein and fat were $57{\sim}59:\;16{\sim}17:\;26{\sim}27$ and fat calorie percentage was higher than quantity recommended for Korean adults. Energy, protein, Fe, vitamin A, $B_1$ and C intakes were taken mostly from plant food sources. In the upper income class group, intakes of protein and vitamin $B_2$ from animal food sources were higher than in any other income classes. Intakes of iron, vitamin A, $B_1$ and C were largely provided by plant food group. Especially 44-45% of vitamin A were taken from vegetable and fruits group, which indicated that about 50% of vitamin A intake was the form of ${\beta}-carotene$. Also compared with other groups, in the upper income class group, the intakes of energy, protein, Ca, p, vitamin $B_1$ and vitamin $B_2$ from cereal and potatoes were significantly lower, and those of Ca and P from milks and meats, fishes & eggs were significantly higher(p<0.05). The mean fat intake in all subjects was $38{\sim}43g/day$. Regardless of income class, oleic acid($6.6{\sim}8.4g$) and linoleic acid($6.7{\sim}8.1g$) were the most abundant fatty acids contained in the diet. The upper class group consumed significantly more total saturated fatty acids and total monounsaturated fatty acids(p<0.05). In polyunsaturated fatty acids, there were no differences between 3 different income classes, but intakes of total ${\omega}6$ fatty acids in the upper class tended to be higher and those of total o3 fatty acids in low class tended to be higher. Therefore, ${\omega}6/{\omega}3$ tended to be higher in the upper class group. Regardless of income classes, P/M/S and ${\omega}6/{\omega}3$ ratios in all subjects were $0.9{\sim}l.3/1.0{\sim}1.1/1.0$ and $5.2{\sim}7.4/1.0$, respectively and were in a desirable range. Cholesterol intake of subject was 184-218 mg/day, which was comparable to the value of Korean adult intake.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권1호
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• pp.31-38
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• 2016

Pharmacotherapy is considered the first line therapy in attention-deficit hyperactivity disorder (ADHD). Many patients also choose complementary medicine such as dietary supplements. Omega-3 has shown some efficacy for improving ADHD symptoms in several studies. The goal of this review is to integrate the previous research findings on omega-3 and understand the issues worth considering in the treatment of ADHD. The terms "attention deficit disorder with hyperactivity", "omega-3", and "dietary supplements" were searched on PubMed, Cochrane, and Google scholar. The search was further limited to clinical trials, reviews, and meta-analyses. Trials that examined treatments for ADHD, used randomized design, and placebo-controlled trials were included. Eighteen clinical trials with a total of 1,141 participants were included in this review. Fifteen trials had parallel designs, comparing an omega-3/6 polyunsaturated fatty acid (PUFAs) or a combination of both to a placebo and three compared omega-3/6 PUFAs to a placebo and psycho-stimulants. Seven of the included trials showed significant improvements in groups receiving omega-3/6 PUFAs compared to placebo groups, however, 11 trials showed no significant differences. Evidence that PUFAs supplementation provides benefits for ADHD was yet limited. Mixed results were due to selection variability criteria, variability of supplementation, and short follow-up intervals.

• 한국수산과학회지
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• 제22권2호
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• pp.109-114
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• 1989

[ $\omega3$ ] 고도불포화지방산의 투여가 생체내의 과산화지질 생성 및 항산화관련 효소들의 활성에 미치는 영향을 비교하기 위하여 어유에서 분리한 $\omega3$ 고도불포화지방산, 식물유 및 동물성 지방(대조군)을 $10\%$가 되도록 첨가한 사료로써 실험동물에 6주간 투여하였다. 혈청, 뇌 및 간장에서의 과산화지질 생성은 $\omega3$ 고도불포화지방산과 정어리 기름 투여군이 대조군에 비해 유의성 있게 감소하였다. 카탈라아제 및 슈퍼옥사이드 디스뮤타제의 항산화활성은 이들 어유 투여군이 대조군에 비해 $15\%\~20\%$ 정도 높음을 알 수 있었다. 따라서 $\omega3$ 고도불포화지방산을 포함한 어유는 과산화지질 생성을 효과적으로 억제하고 또 노화관련 효소들의 활성을 증가시켜주므로써 생체의 노화 방지에 효과가 있을 것으로 추정된다.