• Archives of Pharmacal Research
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• v.23 no.4
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• pp.418-423
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• 2000

Oka strain VR-795 (Varicella Zoster Virus, VZV) of American Type Culture Collection (ATCC) has been used for chickenpox vaccine production. In order to use this strain for vaccine production, the strain must be identified and its stability must be confirmed. The identification of the Oka strain has been confirmed using Restriction Fragment Length Polymorphism (RFLP) and DNA sequence analysis of glycoprotein-II (gp-II). The amino acid sequences of Oka deduced from the DNA sequence of gp-II have changed at three amino acids against Ellen and at one amino acid against Webster. To prove the stability of the Oka strain during the passage, RFLP and DNA sequence analyses were also used with 11, 15 and 23 times of virus passage. We found that the Oka strain was stable at passages of up to 23 times, based on the RFLP and DNA sequence analyses. The confirmed Oka strain was renamed as BR-Oka for the purposes of chickenpox vaccine production.

• Natural Product Sciences
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• v.5 no.2
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• pp.107-111
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• 1999

To investigate less toxic antiviral agents from Basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (pers.) Karst. Anti-varicella zoster virus (Oka strain; anti-VZV/Oka) activity of EA was examined in MRC-5 cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with nucleoside anti-VZV agents, acyclovir and vidarabine, were examined on the multiplication of VZV/Oka. EA exhibited a concentration-dependent reduction in the plaque formation of VZV/Oka with a 50% effective concentration $(EC_{50})$ of $464.14\;{\mu}g/ml$. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combination of EA with acyclovir showed more potent synergism with CI values of $0.18{\sim}0.62$ for $50{\sim}90%$ effective levels than that of EA with vidarabine with CI values of $0.67{\sim}1.04$.

• East Asian mathematical journal
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• v.16 no.1
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• pp.27-31
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• 2000

• The Korean Journal of Mycology
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• v.27 no.3 s.90
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• pp.237-241
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• 1999

To search for less toxic antiviral agents from Basidiomycetes, the water soluble components (=EA), were isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-varicella zoster virus (Oka strain; anti-VZV/Oka) activity of EA was examined in MRC-5 cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha or IFN gamma were examined on the multiplication of VZV/Oka. EA exhibited a dose-dependent reduction in the plaque formation of VZV/Oka with 50% effective concentration $(EC_{50})$ of $464.14\;{\mu}g/ml$. The results of the combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combination of EA with IFN alpha showed partially synergistic or additive effects with CI values of $0.83{\sim}1.09$ for 50%, 70%, 90% effective levels, and those with IFN gamma showed antagonism with CI values of $1.20{\sim}1.24$.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08a
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• pp.1039-1042
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• 2007

Motion blur of LCD displays has been measured subjectively by using Gabor patch radiusese. Gabor radiuses at a normalized scroll speed, Scroll speed times Fc, to be unity, indicate motion blur strengths, which are named a perceived motion blur strength measured by a Gabor patch. The results are compared with eye perception, PBET and EBET.

• Bulletin of the Korean Mathematical Society
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• v.32 no.2
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• pp.259-263
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• 1995

The following classical Oka-Weil approximation theorem on pseudoconvex domains in $C^n$ is well-known. Suppose that $M \subseteq C^n$ is pseudoconvex and that K is a compact subset of M with K = K, where K is the usual holomorphic hull of K in M. Then any function holomorphic in a neighborhood of K can be approximated uniformly on K by functions holomorphic on M (see [5], [6]).

• Proceedings of the Korea Water Resources Association Conference
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• 1990.07a
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• pp.137-137
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• 1990

하천의 각종 용수 수요급증지역에서의 저수및 갈수시에는 한정된 수자원의 공급능력에 비해 각종용수의 수요가 크게 증가하므로 수자원을 적정 배분하는 데에는 물의 부족으로 인하여 많은 문제가 발생하고 있다. 이러한 저수및 갈수시 각 수요점 별로 필요한 용수를 확보하기 위하여 용수사용의 우선권을 고려한 수자원 최적배분 모형을 개발할 필요성이 있다. 본연구의 목적은 Out of Kilter Algorithm(OKA)를 이용하여 저수및 갈수시 용수사용의 우선순위에 따른 수자원 배분을 실시하기 위한 알고리즘을 구성하고, 이를 실제 유역에 적용하므로서 그 유용성과 신뢰성을 입증하고자 한다.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.18 no.1
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• pp.213-225
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• 1988

This study was to compare the quality of image by different screen and film combinations. Using the sensitometer measured the speed and average gradient of blue sensitive films and orthochromatic films. The films was combined with rare earth screen LR, LM, LF and conventional screen OM, OH, XOR, OKa and exposed the step wedge to impulse 2, 3, 4, 6, 10, 15, 24,3 8, 60 and measured the density. The following results were obtained: 1. The density of film and film-screen combinations showed significant difference, then in film-screen combinations was significantly different by the screens than films. 2. The speed of blue sensitive films was little different, the TMG of orthochromatic films produced high speed, and the AX film was high average gradient. 3. The relative speed of film-screen combinations showed significant difference, and was high in the OKa of the conventional screens and in the LR of the rare earth screens, especially that of LR screen in the combination with blue sensitive films was high. 4. The average gradient of film-screen combinations showed no significant difference, and was high in the OKa screen and LR/OG combination, and that of OKa/AX combination was highest. 5. The latitude of film-screen combinations showed significant difference by screens, and was high in the LM screen in combination with blue sensitive films and in the OM screen in combination with orthochromatic films. 6. The subject contrast of film-screen combinations showed significant difference by screen, and was high in the LR screen in combination with blue sensitive AX film and orthochromatic TMG film.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.13-13
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• 2003

• Journal of Sericultural and Entomological Science
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• v.37 no.2
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• pp.244-246
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• 1995