• Journal of Biomedical Engineering Research
• /
• v.28 no.3
• /
• pp.377-386
• /
• 2007

Mechanical loading to bone cells using simple sine wave or constant wave fluid flow has been widely used for in vitro experiments. Human gait is characterized by a complex loading to bones of lower extremities which results from a series of events consisting of heel strike, foot flat and push-off during the stance phase of the gait cycle. Telemetric force analyses have shown that human femora are subject to multiphasic loading. Therefore, it would be ideal if the physiologic loading conditions during human walking can be used for in vitro mechanotransduction studies. Here, for a mechanotransduction study, we develop it fluid flow system (FFS) in order to simulate human physiologic mechanicalloading on bone cells. The development methods of the FFS including the COR (Center for Orthopedic Research), monitor program are presented. The FFS could generate various multiphasic loading conditions of human gaits with output flow. Wall shear distribution was very uniform, with 81 % of the effective loading area of the culture on a glass slide. Our results demonstrated that the FFS, provide a new translational approach for unveiling molecular mechanotransduction pathways in bone cells.

• Smart Structures and Systems
• /
• v.14 no.4
• /
• pp.617-641
• /
• 2014

The energy constraint is still a common issue for the practical application of wireless sensors, since they are usually powered by batteries which limit their lifetime. In this paper, a practical compound energy efficiency strategy is proposed and realized in the implementation of a real time wireless sensor platform. The platform is intended for wireless structural monitoring applications and consists of three parts, wireless sensing unit, base station and data acquisition and configuration software running in a computer within the Matlab environment. The high energy efficiency of the wireless sensor platform is achieved by a proposed adaptive radio transmission power control algorithm, and some straightforward methods, including adopting low power ICs and high efficient power management circuits, low duty cycle radio polling and switching off radio between two adjacent data packets' transmission. The adaptive transmission power control algorithm is based on the statistical average of the path loss estimations using a moving average filter. The algorithm is implemented in the wireless node and relies on the received signal strength feedback piggybacked in the ACK packet from the base station node to estimate the path loss. Therefore, it does not need any control packet overheads. Several experiments are carried out to investigate the link quality of radio channels, validate and evaluate the proposed adaptive transmission power control algorithm, including static and dynamic experiments.

• Journal of Power System Engineering
• /
• v.12 no.5
• /
• pp.34-39
• /
• 2008

The combustion purpose of diesel engine is to reduce the emission of green gas and to produce high output. Generally, the regulation matter of emission gas is largely diveded by 'THC', 'NOx', 'CO' and 'PM'. Among those matters, the most problem is to disgorge into 'PM', the character of diesel combustion. Diesel PM can be controlled using Diesel Particulate Filter, which can effectively reduce the level of soot emissions to ambient background levels. $NO_2$ generated by the DOC is used to combust the carbon collected in the DPF at low temperature. To certificate DPF device that is suitable to domestic circumstances, it is necessary to exactly evaluate the DPF devices according to the regulation of DPF certificate test procedure fur retrofit. To do carry out the above-mentioned description the understanding of that regulation like the standard of PM reduction is needed. In this study the test procedure including test cycle and BPT test condition was examined, and also the test result for specific DPF was analyzed. In every test like field test, PM reduction efficiency test and Seoul-10 mode test, no defect was showed.

• Biomolecules & Therapeutics
• /
• v.26 no.1
• /
• pp.39-44
• /
• 2018

In 1923, Dr. Warburg had observed that tumors acidified the Ringer solution when 13 mM glucose was added, which was identified as being due to lactate. When glucose is the only source of nutrient, it can serve for both biosynthesis and energy production. However, a series of studies revealed that the cancer cell consumes glucose for biosynthesis through fermentation, not for energy supply, under physiological conditions. Recently, a new observation was made that there is a metabolic symbiosis in which glycolytic and oxidative tumor cells mutually regulate their energy metabolism. Hypoxic cancer cells use glucose for glycolytic metabolism and release lactate which is used by oxygenated cancer cells. This study challenged the Warburg effect, because Warburg claimed that fermentation by irreversible damaging of mitochondria is a fundamental cause of cancer. However, recent studies revealed that mitochondria in cancer cell show active function of oxidative phosphorylation although TCA cycle is stalled. It was also shown that blocking cytosolic NADH production by aldehyde dehydrogenase inhibition, combined with oxidative phosphorylation inhibition, resulted in up to 80% decrease of ATP production, which resulted in a significant regression of tumor growth in the NSCLC model. This suggests a new theory that NADH production in the cytosol plays a key role of ATP production through the mitochondrial electron transport chain in cancer cells, while NADH production is mostly occupied inside mitochondria in normal cells.

• Land and Housing Review
• /
• v.8 no.4
• /
• pp.267-274
• /
• 2017

Since LID design process for the urban regeneration has not yet been established in Korea, this study was extablished in LID design process through reterauture reviews and expert opinions. But the extablished LID design processes have many limitations to be applied to proper LID facilities to the site because of not considering characteristics and water flow of the site. To solve the limitations of existing design processes, it is necessary for analysis of water flow through GIS analysis at the site. After analysis of water flow, it is important to find areas cut off water flow and to install LID facilities at those points. Through these considerations, this study present the improved LID design process to apply to urban regeneration.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.19 no.7
• /
• pp.485-490
• /
• 2007

The LNG BOG re-liquefaction system for LNG carriers was designed based on the Claude refrigeration cycle and the thermodynamic analysis was carried out in order to find the design point of the three heat exchangers constituting the system. The thermodynamic analysis revealed that the system state could be defined by the three cold endpoint temperatures of the three-pass heat exchanger. Hence the iso-lines of the specific liquefaction work, taken as the performance indicator, were presented in terms of those three temperatures and discussed. The system was found most economical when those three temperatures approached a single temperature of $-140^{\circ}C$ and thus this system state could be taken as the design point for the heat exchangers.

• KIEE International Transactions on Power Engineering
• /
• v.5A no.2
• /
• pp.138-143
• /
• 2005

During faults, the voltage and current signals available to the relay are affected by the decaying dc component and harmonics. In order to make appropriate and accurate decisions, most of the relaying algorithms require the fundamental frequency phasor information that is immune to decaying dc effect and harmonics. The conventional Fourier ph as or estimation algorithm is affected by the presence of decaying-exponential transients in the fault signal. This paper presents a modified Fourier algorithm, which effectively eliminates the decaying dc component and the harmonics present in the fault signal. The decaying dc parameters are estimated by means of an out-of-band filtering technique. The decaying dc offset and harmonics are removed by means of a simple computational procedure that involves the design of two sets of Orthogonal digital OFT filters tuned at different frequencies and by creating three off-line look-up tables. The technique was tested for different decay rates of the decaying dc component. It was also compared with the conventional mimic plus the full cycle OFT algorithm. The results indicate that the proposed technique has a faster convergence to the desired value compared to the conventional mimic plus OFT algorithms over a wide range of decay rates. In all cases, the convergence to the desired value was achieved within one cycle of the power system frequency.

• Proceedings of the KIPE Conference
• /
• 2018.07a
• /
• pp.198-200
• /
• 2018

In this paper a single-stage single-phase differential type isolated AC-DC converter is proposed. This converter eliminates the requirement to use bulky electrolytic capacitor from the system and at the same time provides DC charging by employing the AC Power Decoupling waveform control method. All the switches of the converter achieve ZVS turn on during half line cycle and all diodes achieve ZCS turn off during entire line cycle. A conventional controller is implemented for PFC control and output regulation, whereas a power decoupling controller is added to compensate $2^{nd}$ harmonic ripple power. In addition, an interleaving technique is applied to increase the power range of the converter and reduce the input inductor size. In the end simulation verification is performed and results are obtained for 6.6KW.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.20 no.3
• /
• pp.1106-1113
• /
• 1996

The phase criterion of the feedback cycle of low-speed edgetones has been obtained using the jet-edge interaction model which is based on the substitution of an array of dipoles for the reaction of the wedge to the impinging jet. The edgetone is produced by the feedback loop between the downstream-convected sinuous disturbance and upstream-propagating waves generated by the impingement of the disturbance on the wedge. By estimation of the phase difference between the downstream and the upstream disturbances, the relationship between the edge distance and the wavelength is obtained according to the phase-locking condition at the nozzle lip. With a little variation depending on the characteristics of jet-edge interaction, the criterion can be approximated as follows: h/.LAMBDA. + h/.lambda. = n - 1/4, where h is the stand-off distance between the nozzle lip and the edge tip, .LAMBDA. is the wavelength of downstream-convected wave, .lambda. is the wavelength of the upstream-propagating acoustic wave and n is the stage number for the ladder-like characteristics of frequency. The present criterion has been confirmed by estimating wavelengths from available experimental data and investigating their appropriateness. The above criterion has been found to be effective up to 90.deg. of wedge angle corresponding to the cavitytones.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.23 no.1
• /
• pp.18-24
• /
• 2015

In this study, a $CO_2$ air-conditioning system was investigated with different types of electrically driven compressors, parallel flow type gas cooler, four-pass type evaporator, internal heat exchanger integrated with accumulator, and electric expansion valve. The experimental study was conducted under various operating conditions (ie., different rotational compressor speeds, air inlet temperatures and air velocity coming into heat exchangers). The experimental results showed the cooling capacity was 3.5kW at $35^{\circ}C$ ambient temperature when the vehicle was idle (ie., the worst condition for cooling off the gas cooler). In terms of performance effect of the compressor, the e-RP model had a slightly better cooling capacity and coefficient of performance than the e-GR model under the same test conditions. An experimental equation for optimum cooling-performance control was also suggested based on the results. A high-pressure control algorithm for the super critical cycle was determined to achieve both maximum cooling performance and efficient energy consumption. The results from the experimental equation coincided with those of previous experimental studies.