• Journal of Korean Ophthalmic Optics Society
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• v.5 no.2
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• pp.139-144
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• 2000

In this study, anterior corneal radius of curvature in korean subjects aged between 16 to 79 year-olds were measured using a keratometer. Refractive power was also measured without cyloplegia. A-mode Ultrasonography was used to measure anterior chamber depth, crystalline lens thickness, vitreous chamber depth & axial length. Measurements of anterior chamber depth of subjects in their 20s were between 3.0 mm & 4.0 mm, 70s age group were between 2 mm & 3.50 mm, showing a decrease with age. Crystalline lens thickness of 20s age group was 2.64 mm while 70s age group was 4.62 mm showing an increase with age. Vitreous chamber depth, unaffected by age, was about 17 mm. Axial length was 24.47 mm in subjects below 40s age groups decreasing to 24.11 mm in above 40s age groups. Corneal radius of curvature was 7.79 mm and 7.72 mm in younger and older age groups respectively, showing a decrease with age.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.381-389
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• 2004

To investigate changes of multi-purpose solutions for soft contact lens(MPS) depending on using period or keeping temperature, we evaluate four brands of MPS. No significant difference was seen in protein deposit removing efficacy after samples had used for 24 weeks and kept at $4^{\circ}C$, $20^{\circ}C$ or $30^{\circ}C$. The pH values of the samples of 4 brands measured weekly over the 24 week testing period. The initial average pH value of samples were 7.0, 7.5, 7.6 or 8.2. One brand of MPS was in the range of the threshold for ocular awareness, which is outside the zone of 6.6 ~ 7.8. During the testing period, the pH value were decreased in using period-dependent manner. At the 24th week, the average pH values of samples turned to 6.6, 7.2, 7.2 or 7.7. However, the difference of keeping temperature was not associated with decreased levels of pH values. After 24 weeks, one of total 36 samples was contaminated by bacteria. Furthermore, the change of components was shown after 24 weeks in the analysis using thin layer chromatography and the analysis of UV absorption pattern. The results of our study provides that the keeping temperature of MPS is not the important factor of changes of MPS, but the using period of MPS can cause contact lens wearers discomfort.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.1
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• pp.67-74
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• 2012

Purpose: The purpose of this study to evaluate visual acuity and refractive state and measure and analyze the components of eye's optical system in children and teenagers. Methods: With subjects of 124 (230 eyes) children and teenagers who had no eye diseases, correlation between the correlation between refractive errors and component's of eye's optical system was investigated. The spherical equivalent power of cycloplegic clinical refraction or manifest clinical refraction(SE), corneal power(CP), corneal radius(CR), axial length(AL), anterior chamber depth(ACD) and axial length to corneal radius (AL/CR) ratio were measured and analysed. Results: the SE was negatively correlated with the AL(r = -0.80, p = 0.00), the ACD(r = -0.35, p = 0.00) and the CR(r = -0.11, p=0.00) and positively correlated with the CP(r = +0.11, p=0.00). The AL was positively correlated with the AL/CR ratio (r = +0.84, p = 0.00), the ACD(r = +0.47, p=0.00) and the CR(r = +0.38, p = 0.00) and negatively correlated with the CP(r = -0.38, p=0.00). The CR was negatively correlated with CP(r = -1.00, p = 0.00), the AL/CR ratio(r = -0.19, p = 0.00) and the ACD(r = -0.06, p = 0.39). The CP was positively correlated with the AL/CR ratio(r = +0.19, p = 0.00) and the ACD(r = +0.06, p = 0.39). The ACD was positively correlated with the AL/CR ratio(r = 0.53, p = 0.00). Conclusions: the highest change of refractive errors was shown that the AL/CR ratio was a very important indicator for diagnosing the refractive errors of the children and teenagers.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.3
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• pp.311-319
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• 2012

Purpose: One of the critical aspects on dispensing glasses is to match the center of pupils to the optical center of lenses as the mismatched glasses are able to induce uncomfortable effects called prism which has been known to induce phoria, a main cause for asthenopia in many cases. Therefore, we investigated the induced prism occurred by mismatching centers between the center of pupils and the optical center of lenses. Methods: In this study, total 103 subjects were examined whether the center of pupils and the optical center of lenses are matched in horizontal and vertical directions, and then, the data was categorized into 4 groups based on the structural components of glasses. Total amount of prism was compared to show the effect of the glasses frame on the prism induction, and the value of measured prism was compared with the German RAL-RG 915 regulations. Results: The results in respect to the horizontal component showed that the induced prism was not found in 10.7% of total subjects. 73.8% of total subjects were influenced by induced prism, the range of prism was in a tolerance level. However, the 15.5% of total subjects seemed to be influenced by prism which is out of the criterion of tolerance. In case of vertical component, 23.3% of total subjects showed no effects of prism while early adopting glasses, 54.4% of total subjects showed a little prism effect within the criterion of tolerance, and 22.3% of total subjects showed the prism effect out of the tolerance range. This data indicates that group A and B that are less likely adjustable by fitting induce more prism than group C and D in horizontal and vertical components. Conclusions: In higher refractive error condition, it was found that aligning the optical center of lenses with the center of pupils by pre-fitting of glasses frame minimized prism induction in horizontal and vertical components, which ameliorates ocular fatigue. Therefore, appropriate optometric dispensing through fitting by opticians and precise design about monocular PD and monocular Oh are necessary to improve visual perception.

• Biomolecules & Therapeutics
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• v.27 no.5
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• pp.474-483
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• 2019

Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the therapeutic mechanisms and effects of the tetrapeptide Arg-Leu-Tyr-Glu (RLYE), a VEGFR2 inhibitor, in the development of vascular permeability and choroidal neovascularization (CNV). In cultured human retinal microvascular endothelial cells (HRMECs), treatment with RLYE blocked VEGF-A-induced phosphorylation of VEGFR2, Akt, ERK, and endothelial nitric oxide synthase (eNOS), leading to suppression of VEGF-A-mediated hyper-production of NO. Treatment with RLYE also inhibited VEGF-A-stimulated angiogenic processes (migration, proliferation, and tube formation) and the hyperpermeability of HRMECs, in addition to attenuating VEGF-A-induced angiogenesis and vascular permeability in mice. The anti-vascular permeability activity of RLYE was correlated with enhanced stability and positioning of the junction proteins VE-cadherin, ${\beta}$-catenin, claudin-5, and ZO-1, critical components of the cortical actin ring structure and retinal endothelial barrier, at the boundary between HRMECs stimulated with VEGF-A. Furthermore, intravitreally injected RLYE bound to retinal microvascular endothelium and inhibited laser-induced CNV in mice. These findings suggest that RLYE has potential as a therapeutic drug for the treatment of CNV by preventing VEGFR2-mediated vascular leakage and angiogenesis.