• Journal of Korean Ophthalmic Optics Society
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• v.5 no.1
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• pp.73-81
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• 2000

This review on ocular toxicology concentrates on the effects on ocular health and contact lens wear induced by systemically used drugs, including alcohol. Many systemically administered drugs produce ocular adverse effects. Fortunately, relatively few are capable of causing significant, irreversible visual impairment. The visual symptoms of acute intoxication are as follows : Drop in vision/visual acuity, diplopia, poor dark adaptation, increase in time for glare recovery, early cataract, decreased depth perception, blue-yellow or red-green colour defect and visual hallucinations. Blinking pattern, tear production, and discoloration of contact lenses can be affected by some systemic or local ocular medications. The cornea, conjunctiva, or eyelids may react to some systemic medications and to some preservatives used in contact lens solutions. The hydrogel contact lens act as a drug reservoir that emits the drug over time. I discuss management of contact lens-induced infectious and inflammatory conditions.

• Journal of Environmental Science International
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• v.26 no.2
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• pp.249-256
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• 2017

In this study, we evaluated the potential of 70% ethanol extract from Persicaria nepalensis (PNE) as a cosmetic ingredient by primary skin irritation, ocular irritation, and maximization tests for delayed hypersensitivity in New Zealand white rabbits and Hartley guinea pig. Skin safety study was performed to evaluate the potential toxicity of PNE using the primary irritation test. In the primary irritation test, 50% PNE was applied to the skin, and no adverse reactions such as erythema and edema were observed at the intact skin sites. Therefore, PNE was classified as a practically non-irritating material based on a primary irritation index of "0.0.". In the ocular irritation test, the 50% PNE applied did not show any adverse reactions in the different parts of rabbit eyes, including the cornea, iris, and conjunctiva. Thus, PNE was classified as a practically non-irritating material based on an acute ocular irritation index of "0.0.". Skin sensitization was tested by the Guinea Pig Maximization Test (GPMT) and Freund's Complete Adjuvant (FCA) using an intradermal injection of 10% PNE. Edema and erythema were not observed 24 and 48 h after the topical application of PNE in skin sensitization test, which exhibited a sensitization score of "0.0.". Therefore, it can be suggested that P. nepalensis could be used as potential candidates for cosmoceutical ingredients, without any major side effects.

• Journal of Clinical Otolaryngology Head and Neck Surgery
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• v.29 no.2
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• pp.198-203
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• 2018

Background and Objectives : Pediatric orbital blowout fractures occur in discreet patterns, in reference to the characteristic developmental anatomy of the facial skeleton at the time of injury. The purpose of this study was to investigate the clinical characteristics, ocular symptom, fracture type and postoperative results of orbital blowout fractures in the pediatric population. Material and Methods : A retrospective study was conducted from January 2009 to June 2015 in 116 patients with orbital floor fractures ; all less than 18 years old. Patients were divided into 3 groups by age : 0 to 6, 7 to 12, and 13 to 18 years of age. The cause of fracture, fracture site and type, preoperative and postoperative ocular symptoms, timing of surgery were reviewed from their records. Results : Medial wall fractures were the most common site in the 0 to 6 years old group, and floor fractures were the most common site in other age groups. However, floor fracture was the most common site of the need for surgery in all age groups. Trapdoor type of fractures occurred more frequently than open door type of fractures in all age groups. Preoperative symptoms did not differ among the 3 age groups. In case of need surgery, frequency of preoperative ocular symptoms increased with age. However, as age group was young, rate of residual postoperative ocular symptoms were increased. Conclusions : The younger patients are more to have trapdoor type fracture and residual postoperative ocular symptom. Earlier surgical intervention more needed for children with entrapment results.

• Journal of Korea Multimedia Society
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• v.19 no.2
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• pp.271-279
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• 2016

The recent development of the HD (High Definition) and UHD (Ultra High Definition) technology allowed the growth of 3D contents market. Yet the majority of the 3D contents in the market are strictly for 6.5 cm inter-ocular distance, causing various visual discomforts for the viewers who have different inter-ocular distance. Moreover, because the 3D contents are created for a fixed viewing distance, the change of the viewing distances when watching 3D contents can also cause visual conflicts. To solve this problem, we devised techniques that consider the environmental information of the viewer watching 3D contents. By analyzing the relationship between viewing distance, inter-ocular distance, and perceived depth, we created an adaptive content viewing system that reflects the viewer's environment to minimize any conflicts in watching 3D contents. From our experiments, we found that the performance of our adaptive content viewing system was reasonable.

• Biomedical Science Letters
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• v.11 no.4
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• pp.555-559
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• 2005

Evaluate the triolein emulsion could disrupt the barriers and to suggest as an experimental model in blood-ocular barrier studies. Triolein emulsion was infused into the carotid artery in the experimental group ten cats. Normal saline was used in another the control group ten cats. Pre contrast and postcontrast T1-weighted MR images were obtained at 30 minutes and 3 hours after embolization. Signal intensities were evaluated in the anterior, posterior chamber and in the vitreus qualitatively and quantitatively. Postembolization 30 minutes MR images were not different from those of the control group. Postembolization 3 hour MR images demonstrated delayed contrast enhancement in the anterior chamber of the ipsilateral and contralateral eyeballs and in the posterior chamber of the ipsilateral eyeball. Delayed contrast enhancement of the posterior chamber of the ipsilateral eyeball was statistically significant (P<0.05). The present study demonstrated significant contrast enhancement in the posterior chamber with infusion of triolein emulsion and can be a model in blood-aqueous barrier studies.

• Journal of Korean Ophthalmic Optics Society
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• v.10 no.3
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• pp.237-240
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• 2005

The cause of poor visual acuity was connected to the damage by the ocular trauma related. Especially the most cause of visual disorder was identified as irregular pupil by ocular damage. Therefore most patients stopped the wearing of the contact lens immediately by the visual decrease effects from irregular pupil disorder. But we had suggested that the contact lens wear was a very intensive visual therapy. We had identified the visual recover from several tests using the contact lens treatment.

• Toxicological Research
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• v.17 no.2
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• pp.91-96
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• 2001

Phthalates are widely used as plasticizers to impart softness and flexibility to normally rigid polyvinylchloride products. However, there are not much studies jar dermal and ocular irritation toxicity of phthalates. So we investigated the skin or eye irritation effect of some phthalates which was not reported. The primary skin irritation of diethyl phthalate (DEP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), dipropyl phthalate (DPP) and dipropyl phthalate (DPrP) was studied. The ocular irritation of dibutyl phthalate(DBP), DIDP, DINP, DPP and DPrP was also studied. DEP, DIDP, DINP, DPP, and DPrP were found to be non-irritating to the skin of the test animals. DBP, DIDP, DINP and DPP were found to be non-irritating to the eye of the rabbits. DPrP caused the slight irritations to the eye in 1 or 2 days after treatment but irritation of the animals was soon recovered.

• Journal of Biomedical Engineering Research
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• v.9 no.2
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• pp.171-178
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• 1988

In this study, we proposed a test to explore the function of Vestibulo-ocular reflex (VOR) which subjected to an angular head acceleration using pseudo random binary stimulus. Resultant eye movements(horizontal vestibular nystagmus) were digitized, filtered and transformed into the frequency domain. At first we evaluated the transfer function of V.0.R(gain and phase) and the coherence function between stimulus and response by linear frequency methods in view of the quantitative analysis since the vestibulo-ocular reflex can be considered as a linear system. at least, in normals. Secondly. with the proposed test, we showed a direct possibility that we could interpret the pathological situation quantitatively as an illustration of clinical application.

• Archives of Plastic Surgery
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• v.42 no.3
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• pp.346-350
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• 2015

Brown syndrome is known as limited elevation of the affected eye during adduction. It is caused by a disorder of the superior oblique tendon, which makes it difficult for the eyeball to look upward, especially during adduction. It is classified into congenital true sheath Brown syndrome and acquired simulated Brown syndrome. Acquired simulated Brown syndrome can be caused by trauma, infection, or inflammatory conditions. The surgical restoration of blowout fractures can also lead to limitations of ocular motility, including Brown syndrome. We report on three patients with acquired simulated Brown syndrome, who complained of diplopia and limitation of ocular motility after operations to treat blowout fractures.

• Journal of Biomedical Engineering Research
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• v.26 no.3
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• pp.133-138
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• 2005

This paper presents a new method for measuring ocular torsion using the optical flow. Images of the iris were cropped and transformed into rectangular images that were orientation invariant. Feature points of the iris region were selected from a reference and a target image, and the shift of each feature was calculated using the iterative Lucas-Kanade method. The feature points were selected according to the strength of the corners on the iris image. The accuracy of the algorithm was tested using printed eye images. In these images, torsion was measured with $0.15^{\circ}$ precision. The proposed method shows robustness even with the gaze directional changes and pupillary reflex environment of real-time processing.