• 대한약리학회지
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• 제29권1호
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• pp.1-8
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• 1993

뇌의 허혈-재관류 손상에 있어서 혈소판 활성인자 (PAF, platelet activating factor)의 관련을 증명하기 위하여 흰쥐와 생쥐에서 양측 총경동맥을 10분간 결찰하고 그후 6시간동안 재관류시켜 허혈-재관류 손상을 야기시켰다. 생쥐에 PAF 길항제인 BN52021과 CV6209 (각각 1 mg/kg, i.p.)를 총경동맥결찰 10분전 또는 재관류 시작 1시간 후에 투여시 McGram stroke index는 심하게 억제되었다. 흰쥐와 생쥐에서 뇌허혈-재관류에 의한 뇌수분함량의 증가는 BN52021 또는 CV6209 전처치에 의하여 유의하게 억제되었다. BN52021 전처치는 허혈 후의 혈압변동을 개선시켰을 뿐만 아니라 뇌연막동맥의 확장지연에 대하여도 효과가 있었다. 이러한 실험결과로 보아 PAF가 뇌허혈-재관류 손상의 발생에 내인성 인자로서 중요한 역할을 하는 것으로 사료된다. 나아가 PAF 길항제가 뇌허혈후의 병리학적 후휴증의 개선 내지는 예방에 사용 될 수 있을 것으로 기대된다.

• 대한핵의학회지
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• 제29권1호
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• pp.22-30
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• 1995

저자들은 두개 기저나 경부종괴 또는 내경동맥의 동맥류등으로 인하여 내경동맥의 결찰이 필요한 환자에 있어서 객관적인 관점에서 수술전에 영구적인 내경동맥의 결찰의 안전성에 관하여 $^{99m}Tc$-HMPAO 뇌 SPECT를 이용하여 보고자 하였다. 내경동맥의 결찰이 고려되는 24명의 두개기저나 경부종괴 환자를 대상으로 하였다. 저자들은 풍선 시험 결찰술 시행전과 시행중의 양측 중대뇌동맥 영역의 섭취정도를 $^{99m}Tc$-HMPAO 뇌 SPECT를 이용하여 비교해보았고 이러한 결과를 신경학적 검사, 경동맥 스텀프압 고리고 뇌전도검사등과 비교해 보았다. 대상환자중 19명의 환자에서는 풍선 시험 결찰술 동안 신경학적 이상등의 문제들을 경험하지 않았고 이들에 있어 중대뇌동맥영역의 섭취정도는 결찰술 시행전에 비교하여 95-101%에 해당하였다. 나머지 5명의 환자에서는 일과성 반신마비와 의식소실등의 심한 신경학적 증상을 보였고 이들에 있어 중대뇌동맥 영역의 섭취정도는 시행전에 비하여 77-85%에 해당하였으며 다른 검사결과와도 잘 부합되었다. 결론적으로 풍선시험결찰술 시행전과 시행중의 $^{99m}Tc$-HMPAO 뇌 SPECT는 중대뇌동맥영역의 섭취가 시행전에 비교하여 85%이하인 경우 영구적인 신경학적 결손을 예측할 수 있는 간단하고 객관적인 방법이 될 수 있을 것으로 생각한다.

• 대한한방내과학회지
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• 제22권4호
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• pp.503-512
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• 2001

Objective : This study was carried out to investigate the effects of DDT on the brain damage and hypertension. Methods : We observed the effect of Dodamtang(DDT) extract on KCN-induced coma, focal brain ischemia by MCA occlusion, cytotoxicity and protection of PC12 cells and B103 cells induced by amyloid ${\beta}$ protein(25-35). To prove the effect of DDT as a blood pressure depressant, we measured aldosterone, renin activity, catecholamine, sodium and NO density using the seperated blood plasma. Results : DDT showed a protective effect on cytotoxicity of PC12 cells and B103 cells induced by amyloid ${\beta}$ protein(25-35) in a dose dependent manner and proved the significant abridgement of brain ischemic area and edema induced by MCA occlusion, a critical decrease of neurologic deficitic grade in the fore-limbs. DDT didn't reduce the duration of KCN(1.87mg/kg iv.)-induced coma and prolonged the survival rate in the case of KCN(3.0mg/kg iv.)-induced coma by the ratio of 20%. While DDT increased the value of NO in SHR, it significantly decreased the blood pressure of SHR and the value of aldosterone& epinephrine in SHR. Conclusions : These results suggested that DDT might be usefully applied for treatment of hypertension, cerebral infarction, and brain damage.

• 구강회복응용과학지
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• 제16권3호
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• pp.221-227
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• 2000

Provisional fixed partial dentures(FPDs) are an important part of many prosthodontic treatment procedures. These provisional fixed prostheses must fulfill biologic, mechanical, and esthetic requirements to be considered successful. Consideration of all these factors and requirements are important because provisional resin restorations may be worn over a long period to assess the results of periodontal and endodontics therapies, and also during the restorative phase of implant reconstructive procedures. This in vitro study examined flexual strength of four resins commonly used for fixed provisional prostheses. The effects of polymerization conditions were also evaluated. The four resins tested were : Caulk Temporary bridge resin(L.D. Caulk Co. Dentsply International Millford), Jet(Lang Dental Mfg. Co. Chicago. ILL. U.S.A), Alike (Coe Laboratories. Inc. Chicago. ILL. U.S.A) and Tokuso Curefast (Coe Laboratories. Inc. Chicago. ILL. U.S.A) The test specimens were 65mm long, 14mm wide, and 3.5mm thickness. 10 specimens of four resins were cured for 15 minutes at atmospheric pressure and 10 specimens of four resins were cured at an additional pressure of approximately 20 psi. A total of 80 specimens were prepared. The flexual strength was determined by three-point bending test. Data were analysed with the Paired samples T-test and Tukey student-range test Within the limitations imposed in this study, the following conclusions can be drawn : 1. Under the condition of bench curing, Caulk Temporary bridge resin showed the highest flexual strength. In decreasing order, the flexual strength of the other materials was as follows : Jet, Tokuso Curefast, Alike, and Caulk Temporary bridge resin demonstrated significantly higher strength than other resins. 2. Under the condition of pressure curing, Jet showed the highest flexual strength. In decreasing order, the flexual strength of the other materials was as follows : Caulk Temporary bridge resin, Tokuso Curefast, and Alike. There were all statistically significant differences among four resins 3. There was a statistically significant difference between bench- and pressure-cured specimens in all four materials.

• 대한치과보철학회지
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• 제52권4호
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• pp.346-351
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• 2014

흡착 의치는 의치상연 주위 전체를 가동 점막으로 봉쇄하여 연하나 교합 시 의치상 내면에 일시적으로 음압을 형성하여 의치의 유지와 안정을 강화한다. 본 증례의 환자는 81세의 남자 환자로 새로운 의치를 제작하고 싶다는 주소로 내원하였다. 의치의 유지와 저작 효율에 대한 환자의 높은 요구도를 고려하여 흡착 의치를 통한 총의치 제작을 계획하였다. 하악 후구치 융기 부위를 가압하지 않은 채로 예비 인상을 채득 후 상하악 진단모형을 제작하였다. 이후 개인 트레이 제작 후 최종 인상 채득과 동시에 고딕 아치 기록을 시행하여 중심위 및 수직 고경을 채득하였으며, 상악에는 해부학적 치아, 하악에는 비해부학적 치아를 배열하여 설측 교합을 형성하였다. 이상과 같이 완전 무치악 환자에서 하악 흡착 의치를 통한 총의치 수복은 만족스러운 유지와 기능을 회복할 수 있었기에 본 증례를 보고하고자 한다.

• Journal of Chest Surgery
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• 제13권4호
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• pp.405-413
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• 1980

A total of 63 patients [42 males and 21 females] underwent multiple valve replacement with artificial valves between January 1975 and August 1980 at Seoul National University Hospital. There were 38 patients with aortic and mitral valve replacement, 22 with mitral and tricuspid, and 3 with aortic, mitral and tricuspid valve replacement. The valve lesions varied from trivial to severe and most aortic and mitral valves had mixed stenosis and insufficiency, while tricuspid valves had only insufficiency. The patients were severely symptomatic in majority of the cases, and belonged to the Classes III and IV [III:45, IV:16] of the NYHA functional criteria. Hemodynamic studies were performed on all the patients. The mean pulmonary wedge pressure was remarkably increased to 19.8 mmHg in aortic and mitral valve lesions and 18.0 mmHg in mitral and tricuspid valve lesions. The mean pulmonary arterial pressure was also increased, while the cardiac index was reduced. In 1977, the average perfusion time was 245.5 minutes for aortic and mitral valve replacement and 181.6 minutes for mitral and tricuspid valve replacement. It has progressively declined to 169.2 minutes for aortic and mitral valve replacement and 123 minutes for mitral and tricuspid valve replacement in 1980. The average period of aortic occlusion also declined after the use of cardioplegic solution. Twenty deaths occurred among the 63 patients operated upon, an overall mortality rate of 30.8%. The operative mortality has declined with successive year from a level of 66.7% before 1977 to 21.1% in 1980. Fourteen patients suffered from a list of postoperative complications, which eventually resolved with adequate treatment. All the survivors were enjoying the levels of daily life activities greater than those existing before the operation.

• 동의생리병리학회지
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• 제27권4호
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• pp.446-452
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• 2013

This study was designed to investigate the effects of Angelicae Gigantis and Cynanchum wilfordii Hemsley extract (AAC) on the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and in the rats with cerebral ischemia induced by middle cerebral artery occlusion, and further to determine the mechanisms. The results were as follows. AAC significantly increased rCBF but significantly decreased MABP in a dose-dependent manner in normal rats. The increase of AAC-induced rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, i.p.), an inhibitor of guanylate cyclase, and AAC-induced MABP was decreased by pretreatment with methylene blue. In cerebral ischemics, rCBF was stably improved by AAC (10 mg/kg, i.p.) during the period of cerebral reperfusion, which was contrasted with the findings of rapid and marked increase in the control group. These results suggest that AAC can increase rCBF in the normal state, as well as improve the stability of rCBF in cerebral ischemic state.

• 동의생리병리학회지
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• 제27권2호
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• pp.173-182
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• 2013

This Study was designed to investigate the effects of Sibjeondaebo-tang (SDT) and Gamy-Sibjeondaebo-tang (GST, Sibjeondaebo-tang adding Cervi Pantotrichum Cornu) on the improvement in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and in the rats with cerebral ischemia induced by middle cerebral artery occlusion, and further to determine the mechanisms. And, It was to investigate the effects of the SDT and GST with the change of histologic examination through the BDNF in the hippocampus CA1. In changes of cerebral hemodynamics, SDT and GST significantly increased rCBF in a dose-dependent manner but decreased MABP in normal rats. In mechanism of cerebral hemodynamics, Increase of GST-induced rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, i.p.), an inhibitor of guanylate cyclase, and Decrease of GST-induced MABP was significantly increased by pretreatment with methylene. These results suggested that the action of GST was mediated by guantlate cyclase pathway. In cerebral ischemics, the rCBF was stably improved by SDT (10 mg/kg, i.p.) significantly and stably increased by GST (10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrast with the findings of rapid and marked increase in Control group. These results suggested that GST had anti-ischemic action in cerebral ischemic state. In histological examination through TTC stain, Sample A group and Sample B group decreased discoloration in the cortical part at $28^{th}$ day after MCAO induction. In immunohistochemistric response of BDNF, Sample A group and Sample B group increased respondent effect at $28^{th}$ day after MCAO induction. These results suggest that GST can Increase rCBF in normal state, as well as improve the stability of rCBF in cerebral ischemic state. Furthermore, methylene blue inhibitor study suggested the mechanism of blood flow enhancement by GST may be mediated by guanylate cyclase pathway.

• 사상체질의학회지
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• 제13권2호
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• pp.165-176
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• 2001

This study demonstrates the effects of Yanggyuksanhwa-Tang, Sasang constitutional herb prescription reported its clinical effect on the stroke of the So-yang In(少陽人), on the cerebral blood flow changes induced by nitro L-arginine methyl ester (L-NAME) treatment and ischemic brain damage induced by the middle cerebral artery occlusion (MCAO) in the rats. The changes of the arterial blood pressure, cerebral blood flow, and the diameter of the pial artery were measured in rats treated with L-NAME. And the changes of the infarct size, volume, and plasma tumor necrosis factor alpha ($TNF-{\alpha}$) levels were measured in the rats that the middle cerebral artery has been occluded by the intraluminal suture thread method. Yanggyuksanhwa-Tang was administered by the i.v. injection on the L-NAME treated rats, by the i.o. administration on the MCAO rats. The results is 1. The changes of the arterial blood pressure was not different statistically between in the L-NAME treated control group and in the Yanggyuksanhwa-Tang administered group. 2. Increase in the cerebral blood flow induced by L-NAME treatment was attenuated in the Yanggyuksanhwa-Tang administered group significantly (P<0.05) as compared with the L-NAME treated control group. 3. Decrease in the diameter of the pial artery induced by L-NAME treatment was attenuated about 18% in the Yanggyuksanhwa-Tang administered group as compared with the L-NAME treated control group. 4. Ischemic damaged infarct areas were decreased significantly (P<0.05) in the interaural 12mm, 10mm, and 6mm brain sections of the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group. 5. Total ischemic infarct volume was decreased significantly (P<0.05) in the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group. 6. Plasma $TNF-{\alpha}$ levels were decreased significantly (P<0.01) in the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group.

• 대한치과보철학회지
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• 제16권1호
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• pp.7-11
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• 1978

The author attempted to observe the histological changes of the periodontal structures induced by trauma from occlusion. Eighteen healthy rabbits were devided into two groups; control and experimental group. Three rabbits were kept as control group, while metal crowns were seated on unilateral lower molar teeth of fifteen rabbits were kept as experimental group. And the interocc1usal distance of the incisal edge was kept 1.5mm from begining to the end of the experimental period. Rabbits of each group consisting with three rabbits were killed at the intervals of three days, one week, two weeks, four weeks, eight weeks. The antagonistic teeth of maxilla including periodontal teeth were excised and decalcified for histologic preparation. The results obtained were as follows. 1. Destructions and ulcer formation of the sulcular epithelium and gingival epithelium occurred and persisted from the beginning of the experiment to the four weeks after experiment. The epithelal attachment were proliferated apically. 2. The pressure site were observed at the apical protion, where they showed compression of the periodontal ligament, thrombosis and congestion of blood vessels and hemorrhages. 3. At the pressure site, there appeared osteoclasts and bone resorption from the first week of experiment and it became more prominent at the second week with the extend into the marrow spaces adjacent to the periodontal membrane. 4. The phenomenon of bone apposition and resorption occurred at the fourth week of experiment. The reverse line of bone trabecular were more prominent. And the reactions were ceased at the eighth week of experiment.