The Effect of Dodamtang(DDT) on Brain damage and Hypertension

도담탕(導痰湯)이 뇌손상(腦損傷) 및 고혈압(高血壓)에 미치는 영향(影響)

  • Lim, Seong-Min (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • An, Joung-Jo (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Choi, Young (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Kim, Yong-Jin (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Yoo, Ho-Ryoung (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Park, Yang-Chun (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Seol, In-Chan (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Hwang, Chi-Won (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Cho, Hyun-Kyung (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dae-jeon University)
  • 임승민 (대전대학교 한의과대학 심계내과학교실) ;
  • 안정조 (대전대학교 한의과대학 심계내과학교실) ;
  • 최영 (대전대학교 한의과대학 심계내과학교실) ;
  • 김용진 (대전대학교 한의과대학 심계내과학교실) ;
  • 유호룡 (대전대학교 한의과대학 심계내과학교실) ;
  • 박양춘 (대전대학교 한의과대학 심계내과학교실) ;
  • 설인찬 (대전대학교 한의과대학 심계내과학교실) ;
  • 황치원 (대전대학교 한의과대학 심계내과학교실) ;
  • 조현경 (대전대학교 한의과대학 심계내과학교실)
  • Published : 2001.12.30

Abstract

Objective : This study was carried out to investigate the effects of DDT on the brain damage and hypertension. Methods : We observed the effect of Dodamtang(DDT) extract on KCN-induced coma, focal brain ischemia by MCA occlusion, cytotoxicity and protection of PC12 cells and B103 cells induced by amyloid ${\beta}$ protein(25-35). To prove the effect of DDT as a blood pressure depressant, we measured aldosterone, renin activity, catecholamine, sodium and NO density using the seperated blood plasma. Results : DDT showed a protective effect on cytotoxicity of PC12 cells and B103 cells induced by amyloid ${\beta}$ protein(25-35) in a dose dependent manner and proved the significant abridgement of brain ischemic area and edema induced by MCA occlusion, a critical decrease of neurologic deficitic grade in the fore-limbs. DDT didn't reduce the duration of KCN(1.87mg/kg iv.)-induced coma and prolonged the survival rate in the case of KCN(3.0mg/kg iv.)-induced coma by the ratio of 20%. While DDT increased the value of NO in SHR, it significantly decreased the blood pressure of SHR and the value of aldosterone& epinephrine in SHR. Conclusions : These results suggested that DDT might be usefully applied for treatment of hypertension, cerebral infarction, and brain damage.

Keywords

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