• Archives of Pharmacal Research
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• v.28 no.7
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• pp.823-828
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• 2005

Multidrug resistance (MDR) is one of the most significant obstacles in cancer chemotherapy. One of the mechanisms involved in the development of MDR is the over-expression of P-glycoprotein (P-gp). It is widely known that natural compounds found in vegetables, fruits, plant-derived beverages and herbal dietary supplements not only have anticancer properties, but may also modulate P-gp activity. Therefore, the purpose of this investigation was to examine the effects of naturally occurring products on P-gp function in human breast cancer cell lines, MCF-7 (sensitive) and MCF-7/ADR (resistant). The accumulation of daunomycin (DNM), a P-gp substrate, was greater in the sensitive cells compared to the resistant cells, while the efflux of DNM was higher in the resistant cells compared to the sensitive cells over a period of 2h. The $IC_{50}$ value of DNM in the resistant cells was about 22 times higher than that in the sensitive cells, indicating an over-expression of P-gp in the resistant cells, MCF-7/ADR. All of the compounds tested, with the exception of fisetin, significantly decreased the $IC_{50}$ value of DNM. Biochanin A showed the greatest increase in $[^3H]-DNM$ accumulation, increasing by $454.3{\pm}19.5%$ in the resistant cells, whereas verapamil, the positive control, increased the accumulation by $229.4{\pm}17.6%$. Also, the accumulation of $[^3H]-DNM$ was increased substantially by quercetin and silymarin while it was reduced by fisetin. Moreover, biochanin A, silymarin, and naringenin significantly decreased DNM efflux from MCF-7/ADR cells compared with the control. These results suggest that some flavonoids such as biochanin A and silymarin may reverse MDR by inhibiting the P-gp function.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.8
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• pp.1926-1933
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• 2013

Many localization algorithms have been proposed for Wireless Sensor Networks (WSNs). The IEEE 802.15.4a-based location-aware-system can provide precise ranging distance between two mobile nodes. The mobile nodes can obtain their exact locations by using accurate ranging distances. However, the indoor environments contain various obstacles which cause non-line-of-sight (NLOS) conditions. In NLOS condition, the IEEE 802.15.4a-based location-aware system has a large scale location error. To solve the problem, we propose location error compensation in indoor environment by using MST-based topology control. Experimental and simulation results show that the proposed algorithm improves location accuracy in NLOS conditions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.10a
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• pp.668-670
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• 2017

Visible Light Communication, which is promising as a next generation near field wireless communications, has been increased study and application case due to the development of LED technology. However, there are few application cases to IoT service due to the necessity of separate equipment for communication and limitation of light transmission to obstacles. In this paper, it propose a portable VLC transceiver module that can be connected to USB OTG and dedicated application for control to realization position possible necessary technique. The string input from the dedicated application is sent to the VLC module via USB OTG to transmit and receive data between the modules. As string transmission experiment result, it is confirmed that ASCII code transmission between VLC transceiver modules is possible through control of the implemented dedicated application.

• Journal of the Korean Institute of Navigation
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• v.20 no.2
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• pp.1-13
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• 1996

Most of the ShipHandling Simulators of full-mission-bridge system need vast area to install and even PC-based maneuvering simulators are often equipped with Steering Wheel or Engine Telegraphe etc. of data input interface, which necessarily makes the user face with excessive financial burden. These have been one of the obstacles for the officers, captains, pilots and students in access to maneuvering simulation whenever they want to try it in advance prior to actual ship maneuvering. Subsequently, all the officers and captains come to have little chances to train themselves until they arualified as a pilot after a long period of time of realship maneuvering practice on board, which means they have to control they have to control their own ship at sea without clear understanding on her maneuverability when they are forced to do it on the way. And these lack of capability for maneuvering have used so often to result in marine casualties of collision with other ships or pier facilities while maneuvering in harbor. To prevent those accidents by means of enhancing their maneuvering ability, PC-based DeskTop Simulator that allows anyong to access readily at anytime is needed and in conformation to such demand this simulator has been developed. The Software this simulator written in Turbo Pascal Ver. 5.0 has adopted MMG mathmatical model theoretically in part and also it was designed to make it possible that all numeric data inputs and outputs with graphic presentation for maneuvering operation be carried out just only with keyboard and monitor console. With the Simulation software, all the officers, captains, pilots and even students who has a proper computer at hand are expected to be able to make an attempt to simulate the maneuvering of their ownship or any other types of them at any port in which they want to do it.

• International Journal of Stem Cells
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• v.11 no.2
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• pp.177-186
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• 2018

Background and Objectives: Glial scarring and inflammation after spinal cord injury (SCI) interfere with neural regeneration and functional recovery due to the inhibitory microenvironment of the injured spinal cord. Stem cell transplantation can improve functional recovery in experimental models of SCI, but many obstacles to clinical application remain due to concerns regarding the effectiveness and safety of stem cell transplantation for SCI patients. In this study, we investigated the effects of transplantation of human mesenchymal stem cells (hMSCs) that were genetically modified to express Olig2 in a rat model of SCI. Methods: Bone marrow-derived hMSCs were genetically modified to express Olig2 and transplanted one week after the induction of contusive SCI in a rat model. Spinal cords were harvested 7 weeks after transplantation. Results: Transplantation of Olig2-expressing hMSCs significantly improved functional recovery in a rat model of contusive SCI model compared to the control hMSC-transplanted group. Transplantation of Olig2-expressing hMSCs also attenuated glial scar formation in spinal cord lesions. Immunohistochemical analysis showed that transplanted Olig2-expressing hMSCs were partially differentiated into Olig1-positive oligodendrocyte-like cells in spinal cords. Furthermore, NF-M-positive axons were more abundant in the Olig2-expressing hMSC-transplanted group than in the control hMSC-transplanted group. Conclusions: We suggest that Olig2-expressing hMSCs are a safe and optimal cell source for treating SCI.

• Journal of IKEEE
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• v.25 no.3
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• pp.437-444
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• 2021

In this paper, we propose an autonomous driving algorithm that allows a robot to explore various terrains, and implement an application that can monitor the robot's movement path during terrain search. The implemented application consists of a status unit that indicates the position, direction, speed, and motion of the mobile robot, a map unit that displays terrain information obtained through terrain search, and a control unit that controls the movement of the mobile robot. In order to control the movement of the robot, only the start and stop of the search/return is commanded by the application, and all driving for the search is performed autonomously. The basic algorithm for terrain search uses an infrared sensor to check for obstacles in the order of left, front, right, and rear, and if there is no obstacle and the path traveled is a dead end, it returns to the previous position and moves in the other direction to continue the search. Repeat the process to explore the terrain.

• Journal of Practical Engineering Education
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• v.9 no.1
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• pp.7-13
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• 2017

This study will provide a practical plan of engineering education through the study of major activities connected with the production of works to accomplish the graduation conditions by completing the comprehensive design subject and the result of the performance. The designed subject is to measure the minimum safety distance during driving using the obstacle detection function of the ultrasonic sensor and to perform the avoidance algorithm based on the measurement value of the acceleration gyro sensor. It is proposed an access surveillance system that minimizes the damage of drones, surrounding objects, and people, and improves air mobility. Experimental results show that the obstacles around the drone are detected by five ultrasonic sensors and the difference of output value is applied to each motor of the drone and obstacle avoidance is confirmed. In addition, the content and level of the data for measuring the achievement of learning achievement in the engineering education certification program were used and the results were confirmed to be consistent with the description of the engineering problem level required for the graduates of 4-year engineering college.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.22 no.1
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• pp.155-167
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• 2012

Cloud computing service is a next generation IT service which has pay-per-use billing model and supports elastically provisioning IT infra according to user demand. However it has many potential threats originating from outsourcing/supporting service structure that customers 'outsource' their own data and provider 'supports' infra, platform, application services, the complexity of applied technology, resource sharing and compliance with a law, etc. In activation of Cloud service, we need objective assessment standard to ensure safety and reliability which is one of the biggest obstacles to adopt cloud service. So far information security management system has been used as a security standard for a security management and IT operation within an organization. As for Cloud computing service it needs new security management and assessment different from those of the existing in-house IT environment. In this paper, to make a Information Security Management System considering cloud characteristics key components from threat management system are drawn and all control domain of existing information security management system as a control components are included. Especially we designed service security management to support service usage in an on-line self service environment and service contract and business status.

• The Journal of Korean Academic Society of Nursing Education
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• v.28 no.4
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• pp.433-443
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• 2022

Purpose: This qualitative study was to understand the awareness of epidemiological investigation tasks for nurses who were in charge of coronavirus disease 2019 (COVID-19) epidemiological investigations. Methods: Before data collection, written consent was obtained from 13 participants, and the data were then collected from September 1 to December 31, 2021. Individual interviews were conducted and recorded by video interview using Zoom, and data were transcribed verbatim. Four themes were derived by using the qualitative thematic analysis method. Results: The participants perceived that epidemiological investigations were burdensome but that the field work was important, and that expertise and collaboration were required. The participants started work without preparation due to the explosive increase in the number of confirmed COVID-19 cases, and they recognized work conflicts, unstable employment, and exhaustion as obstacles to their work performance. On the other hand, the participants took pride in contributing to the national epidemiological investigation and control and felt a sense of responsibility as nursing professionals. Finally, participants mentioned that the training of infectious disease practitioner was important for work improvement. Conclusion: Further research is needed on the development of standardized manuals for the training of nursing personnel as infectious disease specialists through the job analysis of epidemiological investigators.

• Advances in materials Research
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• v.11 no.2
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• pp.147-164
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• 2022

This study aims to investigate the influence of scoria aggregate (SA) and silica fume (SF) as a replacement of conventional aggregate and ordinary Portland cement (OPC), respectively. Three types of concrete were prepared namely normal weight concrete (NWC) using limestone aggregate (LSA) and OPC (control specimen), lightweight concrete (LWC) using SA and OPC, and LWC using SA and partial SF (SLWC). The representative workability and compressive strength properties of the developed concrete were evaluated, and the results were correlated with non-destructive ultrasonic pulse velocity and Schmidt hammer tests. The LWC and SLWC yielded compressive strength of around 30 MPa and 33 MPa (i.e., 78-86% of control specimens), respectively. The findings indicate that scoria can be beneficially utilized in the development of structural lightweight concrete. Present renewable sources of aggregate will preserve the natural resources for next generation. The newly produced eco-friendly construction material is intended to break price barriers in all markets and draw attraction of incorporating scoria based light weight construction in Saudi Arabia and GCC countries. Findings of the SWOT analysis indicate that high logistics costs for distributing the aggregates across different regions in Saudi Arabia and clients' resistant to change are among the major obstacles to the commercialized production and utilization of lightweight concrete as green construction material. The findings further revealed that huge scoria deposits in Saudi Arabia, and the potential decrease in density self-weight of structural elements are the major drivers and enablers for promoting the adoption of lightweight concrete as alternative green construction material in the construction sector.