• 한국산학기술학회논문지
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• 제19권1호
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• pp.368-378
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• 2018

본 연구를 통하여 적대성과 강박증상의 관계를 알아보고, 특히 외현적 적대성과 내현적 적대성이 강박증상에 대해 차별적인 영향을 갖는지 밝히고자 하였다. 아울러 적대성이 강박증상에 대해 끼치는 영향에 있어서 충동성이 조절효과를 갖는지도 검증하고자 했다. 150명의 온라인 학생을 대상으로 Buss Durkee Hostility 척도, 강박증상 척도 개정판, 바렛 충동성 척도를 실시하여 적대성, 강박증상, 충동성을 각각 측정하였다. 150명의 온라인 대학생의 자료를 수집하여 이 자료에 대해 상관과 조절다중회귀 모형을 분석하였다. 그 결과 외현적 적대성과 강박행동간의 상관이 유의미하였고 강박사고는 외현적 적대성 및 내현적 적대성과 모두 유의미한 상관을 나타냈다. 회귀분석을 한 결과 내현적 적대성이 강박사고와 강박행동을 증진시키는 효과가 있었다. 내현적 적대성이 강박증상에 영향을 끼치는 관계에 있어서 충동성이 조절 변수로서 기여하는 역할을 확인한 분석 결과, 충동성은 내현적 적대성이 강박 사고에 미치는 영향에 있어서만 조절역할을 하였고 외현적 적대성의 영향에서는 유의미한 조절역할을 하지 않는 것으로 나타났다. 이러한 결과를 바탕으로 하여 연구의 함의와 제한점에 대해 논하였다.

• 대한불안의학회지
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• 제19권1호
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• pp.10-18
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• 2023

Objective : The 18-item Obsessive-Compulsive Inventory-Revised (OCI-R) is widely employed to assess symptoms of obsessive-compulsive disorder (OCD). However, this instrument's factor structure does not align with contemporary dimensional models of OCD. Therefore, the objective of this study was to examine psychometric properties of the 12-item Korean OCI (OCI-12) on four obsessive-compulsive symptom dimensions, in patients with OCD. Methods : A total of 157 patients with OCD and 51 healthy controls completed psychological measures, including the OCI-R, Dimensional Obsessive-Compulsive Scale (DOCS), and scales evaluating anxiety and depressive symptoms. Pychometric characteristics of the OCI-12 with three neutralizing and three hoarding items eliminated from the OCI-R, were analyzed. Results : All OCI-12 items registered excellent internal consistency at 0.83. Confirmatory factor analysis revealed strong association between individual items and their proposed latent factors (i.e., subscales). Convergent validity was appropriate. A high correlation was particularly observed for the DOCS score (r=0.71, p<0 .001). Moreover, the OCI-12 was as sensitive as the OCI-R for determining effects of empirically supported treatment for OCD. Conclusion : The OCI-12 is a 12-item measure that adheres to the prevailing 4-factor model of OCD dimensions. Like OCI-R, it possesses good to excellent psychometric properties, including reliability, validity, and sensitivity to treatment.

• 대한불안의학회지
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• 제11권1호
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• pp.33-37
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• 2015

Objective : Impaired response inhibition has been suggested to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibition in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms. Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale. Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with commission errors and omission errors. Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contribute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in patients with OCD.

• 정신신체의학
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• 제22권2호
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• pp.130-137
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• 2014

Objectives : Obsessive-compulsive(OC) symptoms have yet to be directly studied in neurodegenerative conditions involving behavioral changes. To examine regional abnormalities in the brains of dementia patients with OC symptoms, we assessed the gray matter density using voxel-based morphometry(VBM). Methods : We performed brain magnetic resonance imaging(MRI) with VBM analysis in 106 dementia patients with OC behaviors. In this study, OC behaviors were investigated in patients with neurodegenerative disease using the modified Manchester Behavior Questionnaire. Results : The OC behavior scores were correlated with structural brain volume using VBM. The total OC symptom score correlated negatively with the volume of both putamens, the right middle orbitofrontal gyrus, both anterior cingulate cortices, and the left insula(p<0.001, uncorrected). No gray matter reductions were associated specifically with the OC symptom sub-categories. Conclusions : Our results suggest that abnormalities in these brain regions may play an important role in the pathophysiology of OCD in neurodegenerative disease. This is the first lesion study to investigate the neural basis of OCD behaviors in neurodegenerative disease.

• 대한불안의학회지
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• 제4권1호
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• pp.11-18
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• 2008

Obsessive-compulsive disorder (OCD) affects approximately 2-3% of the adult population. OCD is associated with impairments in social and occupational functioning. Although there are effective treatments for OCD, many individuals who suffer from OCD go undiagnosed and untreated. Thus, improvements in the assessment and diagnosis of OCD are needed. This paper provides a review of the instruments used to assess and diagnose patients with OCD. We reviewed clinician-administered inventories and self-report questionnaires. The characteristics, strengths, weaknesses, reliability and validity of each instrument are discussed. We also reviewed the psychometric properties of the Korean version of each instrument.

• 대한불안의학회지
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• 제9권1호
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• pp.3-9
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• 2013

Intolerance of uncertainty (IU) is defined as the tendency to react negatively on an emotional, cognitive, and behavioral level to uncertain situations and events. However, this definition is somewhat categorical and does not explain the phenomenology of IU. Intolerance of uncertainty scale (IUS), the standard measure of IU, was considered to have two factors : 'unacceptability and avoidance of uncertainty' and 'uncertainty leading to the inability to act'. IU may be a cognitive vulnerability factor for clinical worry and generalized anxiety disorder (GAD). A number of moderators and mediators including cognitive avoidance, experiential avoidance and rumination influence the relationship between IU, worry, obsessive-compulsive symptoms, anxious and depressive symptoms. IU may be more strongly related to the symptoms of GAD than to symptoms of other anxiety disorders including obsessive-compulsive disorder (OCD), and major depressive disorder. IU may serve as an important transdiagnostic feature across anxiety and depressive disorders. Incorporating IU-specific treatment components into therapeutic protocols may result in pervasive benefits, and not only for those with GAD or OCD, but for people with any anxiety disorder or with depression.

• 생물정신의학
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• 제25권2호
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• pp.31-37
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• 2018

Objectives The aim of this study was to evaluate the psychopathological features such as depression and anxiety in schizophrenics with obsessive-compulsive symptoms (OCS) as well as the severity of OCS according to duration of schizophrenia. Methods We randomly selected sixty four inpatients with schizophrenia. We classified the patients into two groups (OCS group, non-OCS group) according to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Clinical and demographic features were evaluated. To assess OCS, Y-BOCS were performed. The Korean version of the Positive and Negative Syndrome Scale(K-PANSS), the Brief Psychiatric Rating Scale (BPRS), the Korean version of the Calgary Depression Scale for Schizophrenia (K-CDSS), the Beck Anxiety Inventory (BAI) and the Satisfaction With Life Scale (SWLS) were conducted. Independent t-test and chi-square test were conducted to compare the two groups. Pearson correlation analysis was performed to examine the relationship between the duration of schizophrenia and the Y-BOCS score. Results The Y-BOCS, K-CDSS, and BAI scores were higher in the OCS group. There was a significant correlation between the duration of schizophrenia and the Y-BOCS score. Conclusions Anxiety and depression symptoms were severe in the OCS group. In addition, the results of this study indicate that the longer duration of schizophrenia, the more severe the OCS. Therefore, the evaluation of OCS in schizophrenics should be accompanied by treatment intervention.

• 생물정신의학
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• 제12권2호
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• pp.151-158
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• 2005

Background:Clozapine is a unique atypical antipsychotic medication. It is considered to be superior, even amongst the newer agents, in treatment-resistant schizophrenia. However, de novo emergence or exacerbation of obsessive-compulsive(OC) symptoms during treatment with clozapine has been reported. We prospectively evaluated 19 cases which newly developed OC symptoms during clozapine treatment and discussed the treatment of OC symptoms induced by it. Methods:We recruited 19 patients(8 males, 11 females) with a DSM-IV diagnosis of schizophrenia and schizoaffective disorder who had developed OC symptoms during clozapine treatment. OC symptoms were assessed using the Padua-ICMA and YBOCS on a monthly basis over three months. Results:Eleven female and eight male patients were enrolled and the average age of patients was 32.8 years. At baseline, no patients showed OC symptoms. Moderate to severe OC symptoms appeared with mean daily dose of 298.68 mg of clozapine. There were no significant differences in improving OC symptoms between the clozapine dose reduction group and the OC treatment group. Conclusion:We noticed the possibility that the appearance of OC symptoms is connected with the effect of clozapine. The clozapine-induced OC symptoms were improved both by reducing clozapine daily doses, and by adding OC treatment drugs. With other atypical antipsychotics now available, to know and treat the side effects of clozapine would be of considerable value, offering clinical guidance in making a decision on treatment-resistant schizophrenia.

• 대한불안의학회지
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• 제2권1호
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• pp.22-27
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• 2006

Objectives : There is a paucity of data on the long-term course of obsessive-compulsive disorder (OCD) and chronological relationship between OC symptoms and their related symptoms such as anxiety and depression. The purpose of this study was to investigate the longitudinal course of OC symptoms as well as anxiety and depression which are believed to be associated with OC symptoms. Methods : Data for 155 patients with OCD who completed general evaluation for OCD were used. Forty four were excluded to minimize the effect of the different age of onset on the clinical course. One hundred eleven patients finally participated in the analysis. Cross-sectional correlations between each symptom as well as between such symptoms and the duration of illness were analyzed. Further correlation analysis was done within two groups that were divided by 7 years of the duration of illness. Results : There were significant correlations not only between the severity of OC symptoms and anxiety but also between anxiety and depressive symptom, regardless of the duration of illness. These correlations between such symptoms were also found within patients with the duration of illness below 7 years, whereas these were not within the group with the duration of illness above 8 years. Conclusion : Patients with OCD in this study shows the moderate to severe level of OC symptoms irrespective of the duration of illness. Our finding also suggests that the OC symptoms, especially obsessions are closely related to anxiety and depressive symptoms and these relationships might be pronounced in relatively early phase of the OCD after onset.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권2호
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• pp.89-94
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• 2011

Objectives : The purpose of this study was to assess the factor structures related to the Maudsley Obsessive-Compulsive Inventory (MOCI) in middle school students. Methods : A total of 1,175 7th grade students from four middle schools in Paju city completed the MOCI, Center for Epidemiological Studies-Depression scale (CES-D), and Self Esteem Scale (SES). An exploratory factor (maximum likelihood method with oblique rotation) and correlation analyses were subsequently performed. Results : The two main factors related to the MOCI were 'intrusive thought' and 'contamination'. 'Intrusive thought' was positively correlated with the CES-D and negatively associated with the SES. 'Contamination' had a negative correlation with self-esteem as measured by the SES. Conclusion : The results of this study revealed a two-factor structure of obsessive and compulsive symptoms in middle school students.