• 한방안이비인후피부과학회지
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• 제19권2호
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• pp.223-232
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• 2006

Background : Many doctors are under a bias toward clinical severity in patients with atopic dermatitis. But the various studios show that atopic dermatitis may produce a range of impacts on the qualify of lift . Nevertheless there is much to be desired about the association between the quality of lift and atopic dermatitis in the department of Dermatology in Korean medicine. Objective : This study was conducted to investigate the impact of the atopic dermatitis on quality of life and explore prognostic factors that influence outcomes. Methods : 70 patients were recruited in this study rho write out more than 90% of Skindex-29 questionnaires. The function of total scores and three domain scores and SCORAD index was investigated and the correlation of each domain scores also . Result : The total scores, showed significant correlation with three domain scores in atopic dermatitis. The correlation of each three domain scores were significant. SCORAD index showed significant correlation with three domain scores and total scores. Conclusion : In this study atopic dermatitis efface of the quality of life in physical, social, and psychological factors. So we considered to the quality of life as well as clinical severity in patient with atopic dermatitis.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 1999년도 추계학술대회-지능형 정보기술과 미래조직 Information Technology and Future Organization
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• pp.121-130
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• 1999

The objective of this paper is to apply Extended AND-OR Graph (EAOG)-related techniques to extract knowledge from a specific problem-domain and perform analysis in complicated decision making area. Expert systems use expertise about a specific domain as their primary source of solving problems belonging to that domain. However, such expertise is complicated as well as uncertain, because most knowledge is expressed in causal relationships between concepts or variables. Therefore, if expert systems can be used effectively to provide more intelligent support for decision making in complicated specific problems, it should be equipped with real-time inference mechanism. We develop two kinds of EAOG-driven inference mechanisms(1) EAOG-based forward chaining and (2) EAOG-based backward chaining. and The EAOG method processes the following three characteristics. 1. Real-time inference : The EAOG inference mechanism is suitable for the real-time inference because its computational mechanism is based on matrix computation. 2. Matrix operation : All the subjective knowledge is delineated in a matrix form, so that inference process can proceed based on the matrix operation which is computationally efficient. 3. Bi-directional inference : Traditional inference method of expert systems is based on either forward chaining or backward chaining which is mutually exclusive in terms of logical process and computational efficiency. However, the proposed EAOG inference mechanism is generically bi-directional without loss of both speed and efficiency.

• 농촌계획
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• 제18권2호
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• pp.1-11
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• 2012

Eco-village has been regarded as an alternative to accomplish sustainable development for rural village. This study has intended to develop comprehensive planning indicators to establish an eco-village based on such aspects of sustainable development as economy, environment, and society. To reach this objective, this study has set up six goals as follows: 1) ecological production activities for agriculture, 2) resource circulation and energy independence in the economic domain; 3) building cultural and historical succession and community activation, and 4) living together with surrounding regions in social domain; and 5) maintaining environmental habitat, and 6) restoring natural ecosystem in environmental domain. Based on these goals, this study has developed the planning indicators to build an eco-village through case study, literature review, survey for suitability, and factor analysis. This study has found 17 strategies and 47 planning indicators in accordance with the six goals.

• 한국자동차공학회논문집
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• 제10권3호
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• pp.237-244
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• 2002

Analyzing acoustic-structural systems such as automobiles and aircraft, the FRF-based substructuring (FBS) method is one of the most powerful tools. In this paper, a general procedure for the parametric sensitivity analysis of vibro-acoustic problems has been presented using the multi-domain FRF-based substructuring formulation. For an acoustic-structural system sub-structured by multiple domains, the substructuring formulation gives the reaction farces on the interface boundaries. The design sensitivity formula is obtained from the direct differentiation of the reaction force expression with respect to the design vector. As a practical application, the proposed design sensitivity formula is applied to an engine mount system of passenger car. An objective of the problem is to identify the most effective engine mounts and bushes in minimizing the interior noise over the concerned rpm range. The comparison of the sensitivity results with those of the finite difference method shows excellent agreement. In addition, stiffness modifications of the mounts and bushes identified through the design sensitivity analysis lead to a successful decrease of the interior noise. This results show usefulness of the present method very well.

• Journal of Korean Neurosurgical Society
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• 제42권3호
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• pp.205-210
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• 2007

Objective : Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels mediate the hyperpolarization-activated currents (Ih) that participate in regulating neuronal membrane potential and contribute critically to pacemaker activity, promoting synchronization of neuronal networks. However, distinct regional and cellular localization of HCN channels in the brain have not been precisely defined. Aim of this study was to verify the precise cellular location of HCN1 channels in rat cerebellum to better understand the physiological role these channels play in synaptic transmission between CNS neurons. Methods : HCN1 expression in rat brain was analyzed using immunohistochemistry and electron-microscopic observations. Postsynaptic density-95 (PSD-95), otherwise known as locating and clustering protein, was also examined to clarify its role in the subcellular location of HCN1 channels. In addition, to presume the binding of HCN1 channels with PSD-95, putative binding motifs in these channels were investigated using software-searching method. Results : HCN1 channels were locally distributed at the presynaptic terminal of basket cell and exactly corresponded with the location of PSD-95. Moreover, nine putative SH3 domain of PSD-95 binding motifs were discovered in HCN1 channels from motif analysis. Conclusion : Distinct localization of HCN1 channels in rat cerebellum is possible, especially when analyzed in conjunction with the SH3 domain of PSD-95. Considering that HCN1 channels contribute to spontaneous rhythmic action potentials, it is suggested that HCN1 channels located at the presynaptic terminal of neurons may play an important role in synaptic plasticity.

• 한국환경과학회지
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• 제15권9호
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• pp.881-886
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• 2006

The purpose of this research is to examine the beach erosion prevention capability of submerged breakwaters under wave energy condition. To accomplish this objective, the computational domain was divided into two do-mains : the large and the detailed domain for the Song-Do beach. For each computational domain, numerical models for calculating transformation, wave induced current and beach erosion were used and also these numerical models were carefully applied to three experimental cases such as 1) the present beach condition, 2) the condition for which submerged breakwaters are installed about 240m from the shoreline of beach enlarged by artificial nourishments. The results of this research show that if storm waves attack the present beach, the erosion occurs widely all over the beach. However, when the submerged breakwaters are installed in addition to the artificial nourishments, storm waves can be adequately controlled and strong wave induced currents occur only around the submerged breakwaters resulting in the beach evolution appearing locally only at the western end of the beach.

• 한국정밀공학회지
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• 제22권11호
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• pp.59-63
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• 2005

Since human listening is very sensitive when the sound hit him, the subjective index of sound quality is required. Therefore, at each situation of sound evaluation its composed with the sound quality factor. But, when substituting the level of one frequency band we could not see the tendency of substitution at whole frequency band during the sound quality evaluation. In this study a design of experiment is used. The frequency domain is divided into an equally 12 parts and each level of domain whether is given increase or decrease due to the change of frequency band based on 'sharp' and 'annoy' of the sound quality is analyzed. By using the design of experiment the number of test is reduce very effectively by the number of experiment and each band the main effect will be as a solution. The case of sound quality for 'sharp' and 'annoy' at each band, the change of band (increase or decrease of sound pressure or keep maintain) which will be the most effects on the characteristics of sound quality can be identify and this will be able to us to select the objective frequency band. Through these obtained results the physical changes of level at arbitrary frequency domain sensitivity can be adapted.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2007년도 Proceedings of The Convention of The Korean Society of Applied Pharmacology
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• pp.25-44
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• 2007

The glucocorticoid receptor (GR) is an intracellular protein that is widely distributed throughout hippocampal and neocortical brain tissue. Mifepristone (RU486) is a potent GR antagonist that has also been shown to exhibit partial agonist-like effects. The precise location of the GR domain involved in the agonist-like activity of RU486 is unknown. Here, we examine this aspect of GR signaling by comparing human GR (hGR) construct with a Guyanese squirrel monkey GR (gsmGR) construct in which nuclear translocation and transactivation are known to be impaired. Using an objective translocation scoring method, we found that both hGR and gsmGR are translocated by RU486, and that nuclear translocation of hGR is significantly increased compared to gsmGR at 10 nM, 100 nM and 1000 nM RU486 in transiently transfected COS1 cells. While addition of RU486 to the cells transfected with hGR results in a 16-fold dose-dependent increase in transactivation compared to non-treated cells, no significant change in transactivation is observed with gsmGR at doses up to 100 nM RU486. Further experiments using six GR chimeras indicate that replacement of the hGR carboxyl-terminus of tau-1 transactivation domain (C-AF1, amino acids 132-428) with that from gsmGR diminishes hGR transactivation by RU486. These results demonstrate that RU486-induced transactivation of GR is determined in part by amino acids in the C-AF1 domain.

• 전산구조공학
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• 제10권4호
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• pp.185-193
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• 1997

대형 건축물의 진동과 같은 초저주파 진동특성의 해석을 수행하기 위해서는 측정대상 및 측정조건, 그리고 목적으로 하는 측정요소에 적합한 측정시스템이 구축되어야 하며, 구축된 측정시스템으로부터 얻어진 극히 제한된 유한량의 데이터로부터 목적하는 특성요소를 추출하기 위한 정밀한 데이터분석기술이 요구된다. 따라서, 본 연구에서는 고신뢰성을 저주파진동 특성의 분석을 위한 효과적인 데이터처리기법의 개발을 목표로, 측정조건에 따른 저주파진동 해석의 문제점을 분석하고, FFT법과 MEM법의 저주파응답 특성을 비교하였으며, 비교결과를 토대로 저주파진동 해석에 적합한 알고리즘을 결정하였다. 또한, 결정된 분석 알고리즘의 성능을 명확히 하여 정밀분석을 위한 측정데이터의 최적조건을 제시하였다.

• Structural Engineering and Mechanics
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• 제22권2호
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• pp.185-195
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• 2006

Nowadays it is very necessary to generate artificial accelerograms because of lack of adequate earthquake records and vast usage of time-history dynamic analysis to calculate responses of structures. According to the lack of natural records, the best choice is to use proper artificial earthquake records for the specified design zone. These records should be generated in a way that would contain seismic properties of a vast area and therefore could be applied as design records. The main objective of this paper is to present a new method based on wavelet theory to generate more artificial earthquake records, which are compatible with target spectrum. Wavelets are able to decompose time series to several levels that each level covers a specific range of frequencies. If an accelerogram is transformed by Fourier transform to frequency domain, then wavelets are considered as a transform in time-scale domain which frequency has been changed to scale in the recent domain. Since wavelet theory separates each signal, it is able to generate so many artificial records having the same target spectrum.