• Journal of Korean Neurosurgical Society
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• 제63권6호
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• pp.821-826
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• 2020

Objective : Hyperostosis in meningiomas can be present in 4.5% to 44% of cases. Radical resection should include aggressive removal of invaded bone. It is not clear however to what extent bone removal should be carried to achieve pathologically free margins, especially that in many cases, there is a T2 hyperintense signal that extends beyond the hyperostotic bone. In this study we try to investigate the perimeter of tumour cells outside the visible nidus of hyperostotic bone and to what extent they are present outside this nidus. This would serve as an initial step for setting guidelines on dealing with hyperostosis in meningioma surgery. Methods : This is a prospective case series that included 14 patients with convexity meningiomas and hyperostosis during the period from March 2017 to August 2018 in two university hospitals. Patients demographics, clinical, imaging characteristics, intraoperative and postoperative data were collected and analysed. In all cases, all visible abnormal bone was excised bearing in mind to also include the hyperintense diploe in magnetic resonance imaging (MRI) T2 weighted images after careful preoperative assessment. To examine bony tumour invasion, five marked bone biopsies were taken from the craniotomy flap for histopathological examinations. These include one from the centre of hyperostotic nidus and the other four from the corners at a 2-cm distance from the margin of the nidus. Results : Our study included five males (35.7%) and nine females (64.3%) with a mean age of 43.75 years (33-55). Tumor site was parietal in seven cases (50%), fronto-parietal in three cases (21.4%), parieto-occipital in two cases (14.2%), frontal region in one case and bicoronal (midline) in one case. Tumour pathology revealed a World Health Organization (WHO) grade I in seven cases (50%), atypical meningioma (WHO II) in five cases (35.7%) and anaplastic meningioma (WHO III) in two cases (14.2%). In all grade I and II meningiomas, bone biopsies harvested from the nidus revealed infiltration with tumour cells while all other bone biopsies from the four corners (2 cm from nidus) were free. In cases of anaplastic meningiomas, all five biopsies were positive for tumour cells. Conclusion : Removal of the gross epicentre of hyperostotic bone with the surrounding 2 cm is adequate to ensure radical excision and free bone margins in grade I and II meningiomas. Hyperintense signal change in MRI T2 weighted images, even beyond visible hypersototic areas, doesn't necessarily represent tumour invasion.

• Asian-Australasian Journal of Animal Sciences
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• 제30권10호
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• pp.1471-1477
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• 2017

Objective: Since athletic performance is a most importance trait in horses, most research focused on physiological and physical studies of horse athletic abilities. In contrast, the molecular analysis as well as the regulatory pathway studies remain insufficient for evaluation and prediction of horse athletic abilities. In our previous study, we identified AXL receptor tyrosine kinase (AXL) gene which was expressed as alternative spliced isoforms in skeletal muscle during exercise. In the present study, we validated two AXL alternative splicing transcripts (named as AXLa for long form and AXLb for short form) in equine skeletal muscle to gain insight(s) into the role of each alternative transcript during exercise. Methods: We validated two isoforms of AXL transcripts in horse tissues by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned the transcripts to confirm the alternative locus and its sequences. Additionally, we examined the expression patterns of AXLa and AXLb transcripts in horse tissues by quantitative RT-PCR (qRT-PCR). Results: Both of AXLa and AXLb transcripts were expressed in horse skeletal muscle and the expression levels were significantly increased after exercise. The sequencing analysis showed that there was an alternative splicing event at exon 11 between AXLa and AXLb transcripts. 3-dimentional (3D) prediction of the alternative protein structures revealed that the structural distance of the connective region between fibronectin type 3 (FN3) and immunoglobin (Ig) domain was different between two alternative isoforms. Conclusion: It is assumed that the expression patterns of AXLa and AXLb transcripts would be involved in regulation of exercise-induced stress in horse muscle possibly through an $NF-{\kappa}B$ signaling pathway. Further study is necessary to uncover biological function(s) and significance of the alternative splicing isoforms in race horse skeletal muscle.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1061-1065
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• 2013

Objective: To investigate the treatment effect of additional information obtained by single photon emission computed tomography (SPECT) lung perfusion imaging (LPI) in the radiotherapy planning process for patients with stage III non-small cell lung cancer (NSCLC). Methods: 39 patients with stage III NSCLC were enrolled. Gross tumor volume (GTV) was outlined by SPECT/CT images, SPECT-LPIs being used to define functional lung (FL) and non-functional lung (NFL) regions. Two sets of IMRT plans were designed to deliver 64Gy to PTV. One was a regular IMRT plan using CT images only (Plan 1), and the other was a corresponding IMRT plan using co-registered images (Plan 2). $FL_{Vx}$ (the % volume of functional lung receiving ${\geq}$x Gy) and $WL_{Vx}$ (% volume of whole lung to receive ${\geq}$x Gy) were compared by paired Student's t test. Kendalls correlation was used to analyze the factor (s) related with the FLV20 decrease. Results: Compared with plan 1, both $WL_{Vx}$ and $FL_{Vx}$ were decreased in plan 2. $WL_{V10}$, $WL_{V15}$, $WL_{V20}$, $WL_{V25}$, $WL_{V30}$ and $WL_{V35}$ decreased 9.7%, 13.8%, 17.2%, 12.9%, 9.8% and 9.8%, and $FL_{V10}$, $FL_{V15}$, $FL_{V20}$, $FL_{V25}$, $FL_{V30}$ and $FL_{V35}$ decreased 10.8%, 14.6%, 17.3%, 14.5%, 14.5% and 10.5%. $FL_{Vx}$ decreased significantly compared with $WL_{Vx}$. There were significant differences in $WL_{V10}$, $WL_{V15}$, $WL_{V20}$, $WL_{V25}$, $WL_{V3}$ and $FL_{V10}$, $FL_{V15}$, $FL_{V20}$, $FL_{V25}$, $FL_{V30}$ between plan 1 and plan 2 (P=0.002, 0.000, 0.000, 0.005, 0.027 and 0.002, 0.000, 0.000, 0.006, 0.010). According to Kendall correlation analysis, NFL had a negative relation with the percentage FLV20 decrease (r=-0.559, P<0.01), while the distance of PTV and NFL center had a significantly positive relation with the percentage of FLV20 decrease (r=0.768, P<0.01). Conclusion: Routine use of SPECT-LPI for patients undergoing radiotherapy planning for stage III NSCLC appears warranted.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권3호
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• pp.167-173
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• 2013

Purpose: The aim of this study is to analyze the series of panoramic radiograph of implant patients using the system to measure peri-implant crestal bone loss according to the elapsed time from fixture installation time to more than three years. Methods: Choose 10 patients having 45 implant fixtures installed, which have series of panoramic radiograph in the period to be analyzed by the system. Then, calculated the crestal bone depth and statistics and selected the implant in concerned by clicking the implant of image shown on the monitor by the implemented pattern recognition system. Then, the system recognized the x, y coordination of the implant and peri-implant alveolar crest, and calculated the distance between the approximated line of implant fixture and alveolar crest. By applying pattern recognition to periodic panoramic radiographs, we attained the results and made a comparison with the results of preceded articles concerning peri-implant marginal bone loss. Analyzing peri-implant crestal bone loss in a regression analysis periodic filmed panoramic radiograph, logarithmic approximation had highest $R^2$ value, and the equation is as shown below. $y=0.245Logx{\pm}0.42$, $R^2=0.53$, unit: month (x), mm (y) Results: Panoramic radiograph is a more wide-scoped view compared with the periapical radiograph in the same resolution. Therefore, there was not enough information in the radiograph in local area. Anterior portion of many radiographs was out of the focal trough and blurred precluding the accurate recognition by the system, and many implants were overlapped with the adjacent structures, in which the alveolar crest was impossible to find. Conclusion: Considering the earlier objective and error, we expect better results from an analysis of periapical radiograph than panoramic radiograph. Implementing additional function, we expect high extensibility of pattern recognition system as a diagnostic tool to evaluate implant-bone integration, calculate length from fixture to inferior alveolar nerve, and from fixture to base of the maxillary sinus.

• 대한치과교정학회지
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• 제39권6호
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• pp.354-361
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• 2009

본 연구는 전산화 단층촬영 영상으로 상악동의 형태를 파악하여 교정용 미니스크류를 안전하게 식립할 수 있는 위치를 찾고자 시행되었다. 남자 20명, 여자 20명의 3차원 전산화 단층촬영 사진을 촬영한 후 3차원 영상프로그램을 이용하여 상악동의 형태를 계측하여 통계 분석하였으며 다음과 같은 결과를 얻었다. 상악동저에서 백악법랑경계까지의 골두께는 제1대구치와 제2대구치 사이에서 유의하게 얇았고, 제1소구치와 제2소구치 사이에서 유의하게 두꺼웠다. 상악동저에서 협측 상악골 외연까지의 두께는 제1대구치와 제2대구치에서 유의하게 두꺼웠으며, 제1소구치와 제2소구치 사이에서 유의하게 얇았다. 이상의 결과를 바탕으로 안전하게 미니스크류를 식립하여 교정치료의 영역을 넓힐 수 있을 것이다.

• 한국수자원학회논문집
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• 제49권1호
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• pp.19-28
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• 2016

본 연구의 목적은 TOPLATS 지표해석모형으로부터 생산된 격자 수문기상성분과 통계적 돌발홍수지수모형을 이용하여 격자 돌발홍수지수를 생산하고 그 적용성을 평가하는데 있다. 대상유역은 2009~2012년동안 38건의 돌발홍수 구조요청 사례가 발생한 수도권 지역을 선정하였다. 지표해석모형의 시공간 해상도는 1 h, 1 km 이며 동일한 해상도의 모의를 위해 필요한 격자 기상자료는 기상청 AWS (automatic weather stations)의 시단위 자료를 역거리법을 이용하여 구축하였다. 돌발홍수 피해사례 38건에 대해 대응되는 모의격자의 수문성분을 분석하였으며 27건(71%)에서 구조요청시점에 대해 강우량, 지표유출량, 토양수분량, 지하수면깊이가 적절하게 모의되는 것을 확인하였다. 강우조건에 따른 격자 돌발홍수지수의 정확도는 구조요청시점 기준 선행시간 4~6시간까지 71~87%, 구조요청시점으로 한정된 0시간에서 42~52%로 나타났다. 이상의 결과로부터 지표해석모델을 이용한 격자 수문성분과 통계적 돌발홍수지수모형으로부터 산정된 격자 돌발홍수지수는 산지 돌발홍수를 예측하는데 활용될 수 있을 것으로 판단된다.

• 대한한의학회지
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• 제23권2호
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• pp.88-96
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• 2002

Objective : This study attempted to evaluate the ultrasonographic diagnosis of sinusitis compared to X-ray diagnosis and further to help the diagnosis and treatment of sinusitis through oriental medicine. Methods : Both A-mode ultrasonography and X-ray were taken of 30 symptom-positive patients and 10 symptom-negative controls. Nasal obstruction, rhinorrhea, postnasal drip, headache (facial pain), hyposmia (anosmia), throat discomfort and chronic cough were included in the symptoms of sinusitis. Both ultrasonographic and X-ray findings were divided into four groups (clear, mucosal thickening, air-fluid level and cystic shape) according to severity. Results : 1. The symptoms of patients (n=30) were as follows: nasal obstruction (83.3%), rhinorrhea (70.0%), postnasal drip (60.0%), chronic cough (53.3%), headache (40.0%), throat discomfort (40.0%), hyposmia (26.7%). 2. There was a significant correlation between symptoms and ultrasonographic findings (n=40, ${\gamma}=0.550$, P=0.001). 3. There was a significant correlation between symptoms and X-ray findings (n=40, ${\gamma}=0.555$, P=0.001). 4. There was a significant whole coincidence between ultrasonographic and X-ray findings (n=60, ${\gamma}=0.335, P=0.00l). Moreover, there was a significant coincidental trend between the two findings as they became severe (n=60, ${\gamma}=6.284$, P=0.012). 5. The distance of the ultrasonographic echoes was as follows: clear echo (n=9, from transducer pulse to air mucosa echo) $0.90{\pm}0.19cm$, mucosal thickening echo (n=23, from transducer pulse to air mucosa echo) 1.85{\pm}0.14cm, air-fluid level echo (n=26, from transducer pulse to back wall echo) $3.70{\pm}0.16cm$. 6. The highest diagnostic reliability of the ultrasonographic findings compared to X-ray findings was as follows: over-diagnosis in clear finding 77.3%, matched diagnosis in mucosal thickening finding 62.0%, matched diagnosis in air-fluid level finding 86.7%, matched diagnosis and under-diagnosis in cystic shape finding 50.0%. 7. In mucosal thickening, air-fluid level and cystic shape finding, there was a significant individual coincidence between the ultrasonographic and X-ray findings. In clear finding, there was no significant individual coincidence between the two findings. Conclusion : The ultrasonographic diagnosis significantly reflects the symptoms of sinusitis like X-ray diagnosis and is a valuable tool to screen prognostic factors such as mucosal thickening, air-fluid level and cyst. Therefore the ultrasonography will be useful for the diagnosis and treatment of sinusitis in oriental medicine.

• 한국안광학회지
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• 제19권1호
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• pp.79-85
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• 2014

목적: 정상군과 폭주부족군을 대상으로 양안개방형 자동굴절검사기(Nvision-K5001, shin-nippon, Japan)를 이용하여 시교정 상태에 따른 조절 반응량을 측정하여 조절의 변화량을 조사하였다. 방법: 피검자는 등가구면 굴절력 평균이 우안은 $-2.28{\pm}2.03$ D이고, 좌안은 $-2.18{\pm}2.01$ D인 19~29세(평균연령 $21.59{\pm}2.53$세)의 대학생 74명(남 54명, 여 20명)을 타각적자각적 굴절검사를 실시하여 완전교정과 플러스 렌즈를 임의적으로 +0.25 D, +0.50 D, +0.75 D로 부가한 저교정 상태에서 조절 반응량을 측정하여 그 변화를 비교 분석하였다. 결과: 정상군과 폭주부족군 모두에서 주시거리가 짧을수록 조절래그가 커지는 경향을 보였다. 폭주부족군은 정상군보다 조절 반응량의 값이 낮게 나타났으나 조절폭은 조금 크게 나타났다. 정상군에서는 저교정(+0.50 D) 상태와 폭주부족군의 완전교정의 조절 반응량이 비슷한 값을 보였다. 시교정 상태에 따른 주시거리와 조절 반응량의 상관관계는 저교정 정도가 클수록 상관계수가 작아지는 것으로 분석 되었다. 결론: 근시와 정시안인 경우 장시간 근거리 작업 시 +0.50 D 정도의 저교정은 조절기능에 영향을 주어 안정피로 증상을 해소하는데 도움이 된다.

• 한국안광학회지
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• 제18권3호
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• pp.341-346
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• 2013

목적: 머리위치와 사위의 관련성, 습관적인 머리위치 평가의 유용성을 평가하고자 하였다. 방법: 무작위 참여자 중 사위가 있는 22명(남자 20명, 여자 2명, 평균나이 $23.6{\pm}2.7$세)을 대상으로 하였다. 모든 대상자는 문진, 차폐검사, 굴절검사, 사위 및 융합여력검사를 실시하였다. 습관적인 머리위치(머리기울임과 얼굴돌림)는 Impression IST에 의한 타각적 측정과 검사자에 의한 주관적 관찰로 평가하였다. 결과: 사위가 있는 대상자에서 습관적인 머리위치가 드러날 수 있다는 것을 확인할 수 있었다. 프리즘 처방이 필요한 15명의 대상자에서 원거리 사위도와 얼굴돌림에서 유의한 Spearman 상관관계를 보였다($\rho$ = 0.524, p = 0.045). 사위 이상 대상자에서 머리위치와 사위도의 상관성은 없었다. 타각적 측정과 자각적 관찰의 상관성은 없었으나 타각적 측정은 정밀하고 자각적 관찰은 판별력이 있는 방법으로 평가되었다. 결론: 사위에서 이상두위 현상이 나타났으며, 이러한 결과들은 사위에서 모든 주 주시방향에서 습관적인 머리위치를 관찰할 필요가 있음을 암시한다.

• 한국작물학회지
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• 제60권1호
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• pp.85-90
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• 2015

바이오 디젤용 원료작물인 카멜리나를 중국 지역에서 대량 상용재배 하기 위해서 길림성 연길 지역에서 재식 밀도, 비료 시비, 파종 시기 등이 종자 생산량에 미치는 영향을 실험하였다. 재식 밀도와 증수량의 상관 관계를 알아보기 위해서 단위면적당 다른 두 가지의 파종량을 적용했다. 0.1 ha 당 카멜리나 종자 0.23 kg을 파종한 시험구가 0.56 kg을 파종한 시험구보다 60.6 g이 증대되는 결과를 보였다. 또한 비료 시비량과 증수량의 상관관계를 알아보기 위해서 0.1ha당 질소 1.97 kg과 인 12.3 kg을 시용한 시험구, 질소 2.8 kg과 인 17.5 kg을 시용한 시험구, 그리고 무시비구를 이용해서 증수량을 분석한 결과 재배지역에 따라 상이한 결과를 보였다. 다른 실험 결과와 비교하면 상당히 낮은 시비량에도 증수량이 포화되는 결과를 보이는 것으로 봐서 시험구 포장 자체가 상당한 양의 비료 성분을 포함하는 것으로 추정되며 통상적인 농경지 재배에서는 추가적인 시비 효과가 크지 않을 것으로 여겨진다. 파종 시기에 따른 종자수확량은 동일한 생육 기간을 거치더라도 5월 4일에 파종을 한 후 수확을 하는 것이 5월 29일 파종한 것보다 높은 생산량을 보였다. 이 결과는 빠른 파종 시기가 종자 생산량에 긍정적인 영향을 미친다는 것을 의미하므로 최대한 파종 시기를 앞당기는 것이 종자의 생산량을 늘리는데 도움이 될 것이라고 판단 된다.