• Journal of Korea Society of Industrial Information Systems
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• v.12 no.4
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• pp.41-54
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• 2007

To make most out of Order Review/Release(ORR) models, they are to be analyzed and classified according to their prospective users' requirements. To this end, we discuss ORR functions and so-called "ORR paradox", and propose an ORR model classification scheme named "COMPACT(COMplexity-imPACT) Matrix". Under the scheme, the complexity and impact levels of each ORR model are rated one after another in order to position it across the matrix. We explore the process and present the results, insisting that a DSS should suggest ORR models to its users on the complexity-impact basis.

• Korea-Australia Rheology Journal
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• v.13 no.3
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• pp.109-123
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• 2001

A stress jump, defined as the instantaneous gain or loss of stress on startup or cessation of a deformation, has been predicted by various models and has relatively recently been experimentally observed. In 1993, Liang and Mackay measured shear stress jump data of xanthan gum solutions, and in 1996, Orr and Sridhar reported extensional stress jump data of Boger fluids. Shear stress jumps of suspensions and liquid crystal polymers have also been observed. In this contribution, experimental work as well as a variety of theoretical models, which are able to predict a stress jump, are reviewed.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5177-5182
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• 2012

Purpose: To compare the efficacy and safety of epidermal growth factor receptor tyrosine kinase inhibitormonotherapy (EFGR-TKIs: gefitinib or erlotinib) with standard second-line chemotherapy (single agent docetaxel or pemetrexed) in previously treated advanced non-small-cell lung cancer (NSCLC). Methods: We systematically searched for randomized clinical trials that compared EGFR-TKI monotherapy with standard second-line chemotherapy in previously treated advanced NSCLC. The end points were overall survival (OS), progression-free survival (PFS), overall response rate (ORR), 1-year survival rate (1-year SR) and grade 3 or 4 toxicities. The pooled hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: Eight randomized controlled trials (totally 3218 patients) were eligible. Our meta-analysis results showed that EGFR-TKIs were comparable to standard second-line chemotherapy for advanced NSCLC in terms of overall survival (HR 1.00, 95%CI 0.92-1.10; p=0.943), progression-free survival (HR 0.90, 95%CI 0.75-1.08, P=0.258) and 1-year-survival rate (RR 0.97, 95%CI 0.87-1.08, P=0.619), and the overall response rate was higher in patients who receiving EGFR-TKIs(RR 1.50, 95%CI 1.22-1.83, P=0.000). Sub-group analysis demonstrated that EGFR-TKI monotherapy significantly improved PFS (HR 0.73, 95%CI: 0.55-0.97, p=0.03) and ORR (RR 1.96, 95%CI: 1.46-2.63, p=0.000) in East Asian patients, but it did not translate into increase in OS and 1-year SR. Furthermore, there were fewer incidences of grade 3 or 4 neutropenia, febrile neutropenia and neutrotoxicity in EGFR-TKI monotherapy group, excluding grade 3 or 4 rash. Conclusion: Both interventions had comparable efficacy as second-line treatments for patients with advanced NSCLC, and EGFR-TKI monotherapy was associated with less toxicity and better tolerability. Moreover, our data also demonstrated that EGFR-TKImonotherapy tended to be more effective in East Asian patients in terms of PFS and ORR compared with standard second-line chemotherapy. These results should help inform decisions about patient management and design of future trials.

• Nuclear Engineering and Technology
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• v.45 no.7
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• pp.895-910
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• 2013

The reflood test data from the rod bundle heat transfer (RBHT) test facility showed that the grids in the upper portion of the rod bundle could become wet well before the arrival of the quench front and that the sizes of liquid droplets downstream of a wet grid could not be predicted by the droplet breakup models for a dry grid. To investigate the water droplet generation from a wet grid spacer, a viscous linear temporal instability model of the water sheet issuing from the trailing edge of the grid with the surrounding steam up-flow is developed in this study. The Orr-Sommerfeld equations along with appropriate boundary conditions for the flow are solved using Chebyshev series expansions and the Tau-Galerkin projection method. The effects of several physical parameters on the water sheet oscillation are studied by determining the variation of the temporal growth rate with the wavenumber. It is found that a larger relative steam velocity to water velocity has a tendency to destabilize the water sheet with increased dynamic pressure. On the other hand, a larger ratio of steam boundary layer to the half water sheet thickness has a stabilizing effect on the water sheet oscillation. Droplet diameters downstream of the spacer grid predicted by the present model are found to compare reasonably well with the data obtained at the RBHT test facility as well as with other data recently reported in the literature.