• Title/Summary/Keyword: OKLAHOMA

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Mechanosensitive β-catenin signaling regulates lymphatic vascular development

  • Cha, Boksik;Srinivasan, R. Sathish
    • BMB Reports
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    • v.49 no.8
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    • pp.403-404
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    • 2016
  • The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development.

The impact of continuous positive airway pressure on radiation dose to heart and lung during left-sided postmastectomy radiotherapy when deep inspiration breath hold technique is not applicable: a case report

  • Kil, Whoon Jong;Pham, Tabitha;Hossain, Sabbir;Casaigne, Juan;Jones, Kellie;Khalil, Mohammad
    • Radiation Oncology Journal
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    • v.36 no.1
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    • pp.79-84
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    • 2018
  • Deep inspiration breathing hold (DIBH) compared to free-breathing (FB) during radiotherapy (RT) has significantly decreased radiation dose to heart and has been one of the techniques adopted for patients with breast cancer. However, patients who are unable to make suitable deep inspiration breath may not be eligible for DIBH, yet still need to spare the heart and lung during breast cancer RT (left-sided RT in particular). Continuous positive airway pressure (CPAP) is a positive airway pressure ventilator, which keeps the airways continuously open and subsequently inflates the thorax resembling thoracic changes from DIBH. In this report, authors applied CPAP instead of FB during left-sided breast cancer RT including internal mammary node in a patient who was unable to tolerate DIBH, and substantially decreased radiation dose the heart and lung with CPAP compared to FB.

Isolate Virulence and Cultivar Response in the Winter Wheat: Pyrenophora tritici-repentis (Tan Spot) Pathosystem in Oklahoma

  • Kader, Kazi A.;Hunger, Robert M.;Payton, Mark E.
    • The Plant Pathology Journal
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    • v.37 no.4
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    • pp.339-346
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    • 2021
  • Prevalence of tan spot of wheat caused by the fungus Pyrenophora tritici-repentis has become more prevalent in Oklahoma as no-till cultivation in wheat has increased. Hence, developing wheat varieties resistant to tan spot has been emphasized, and selecting pathogen isolates to screen for resistance to this disease is critical. Twelve isolates of P. tritici-repentis were used to inoculate 11 wheat cultivars in a greenhouse study in splitplot experiments. Virulence of isolates and cultivar resistance were measured in percent leaf area infection for all possible isolate x cultivar interactions. Isolates differed significantly (P < 0.01) in virulence on wheat cultivars, and cultivars differed significantly in disease reaction to isolates. Increased virulence of isolates detected increased variability in cultivar response (percent leaf area infection) (r = 0.56, P < 0.05) while increased susceptibility in cultivars detected increased variance in virulence of the isolates (r = 0.76, P < 0.01). A significant isolate × cultivar interaction indicated specificity between isolates and cultivars, however, cluster analysis indicated low to moderate physiological specialization. Similarity in wheat cultivars in response to pathogen isolates also was determined by cluster analysis. The use of diverse isolates of the fungus would facilitate evaluation of resistance in wheat cultivars to tan spot.

Assessment of Subsurface Damage in Ultraprecision Machined Semiconductors

  • Lucca, D.A.;Maggiore, C.J.;Rhorer, R.L.;Wang, Y.M.;Seo, Y.W.
    • Tribology and Lubricants
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    • v.11 no.5
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    • pp.156-161
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    • 1995
  • The subsurface damaged layer in ultraprecisison machined single crystal Ge was examined by ion channeling. Single crystal Ge surfaces were prepared by chemo-mechanical polishing, mechanical polishing with 1/4 gm diamond abrasive, single point diamond turning and ultraprecision orthogonal flycutting. The extent of subsurface lattice disorder was compared to the crystal's orginal surface quality. Ion channeling is seen to be useful for quantitative measure of lattice disorder in finely finished surfaces.

Economic and Fast-track Rehabilitation of Concrete Pavements and Bridge Decks

  • Ramseyer, Chris;Chancellor, Brent;Kang, Thomas H.K.
    • International Journal of Concrete Structures and Materials
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    • v.2 no.2
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    • pp.107-113
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    • 2008
  • The last 10 years have seen considerable growth in the use of proprietary and special repair cements for concrete pavements in the state of Oklahoma. Many of these products lend themselves to "fast track" construction techniques that allow reopening to traffic within 12 hours or less. These products achieve high early strengths by accelerating the Portland cement hydration process for both Type I and Type III cements. In this paper, the important features of a durable repair which include strength, compatibility and bond or adhesion are first discussed. Then the development, testing and field implementation of the aforementioned materials are discussed including the learning curve required to implement a repair system, not just install a new material. Some of the materials discussed, while expensive on a cost per unit basis, hold great promise for economical use on fast track project.

Effect of stocker management program on beef cattle skeletal muscle growth characteristics, satellite cell activity, and paracrine signaling impact on preadipocyte differentiation

  • Vaughn, Mathew A.;Lancaster, Phillip A.;Roden, Kelly C.;Sharman, Evin D.;Krehbiel, Clinton R.;Horn, Gerald W.;Starkey, Jessica D.
    • Journal of Animal Science and Technology
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    • v.61 no.5
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    • pp.260-271
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    • 2019
  • The objective of this study was to determine the effect of different stocker management programs on skeletal muscle development and growth characteristics, satellite cell (SC) activity in growing-finishing beef cattle as well as the effects of SC-conditioned media on preadipocyte gene expression and differentiation. Fall-weaned Angus steers (n = 76; $258{\pm}28kg$) were randomly assigned to 1 of 4 stocker production systems: 1) grazing dormant native range (NR) supplemented with a 40% CP cottonseed meal-based supplement ($1.02kg{\cdot}steer^{-1}{\cdot}d^{-1}$) followed by long-season summer grazing (CON, 0.46 kg/d); 2) grazing dormant NR supplemented with a ground corn and soybean meal-based supplement fed at 1% of BW followed by short-season summer grazing (CORN, 0.61 kg/d); 3) grazing winter wheat pasture (WP) at high stocking density (3.21 steers/ha) to achieve a moderate rate of gain (LGWP, 0.83 kg/d); and 4) grazing winter WP at low stocking density (0.99 steers/ha) to achieve a high rate of gain (HGWP, 1.29 kg/d). At the end of the stocker (intermediate harvest, IH) and finishing (final harvest, FH) phases, 4 steers / treatment were harvested and longissimus muscles (LM) sampled for cryohistological immunofluorescence analysis and SC culture assays. At IH, WP steers had greater LM fiber cross-sectional area than NR steers; however, at FH, the opposite was observed (p < 0.0001). At IH, CORN steers had the lowest Myf-5+:Pax7+ SC density (p = 0.020), while LGWP steers had the most Pax7+ SC (p = 0.043). At FH, CON steers had the highest LM capillary density (p = 0.003) and their cultured SC differentiated more readily than all other treatments (p = 0.017). At FH, Pax7 mRNA was more abundant in 14 d-old SC cultures from HGWP cattle (p = 0.03). Preadipocytes exposed to culture media from proliferating SC cultures from WP cattle isolated at FH had more $PPAR{\gamma}$ (p = 0.037) and less FABP4 (p = 0.030) mRNA expression compared with NR cattle. These data suggest that different stocker management strategies can impact skeletal muscle growth, SC function, and potentially impact marbling development in growing-finishing beef cattle.

Early-Age Properties of Polymer Fiber-Reinforced Concrete

  • Myers, Daniel;Kang, Thomas H.K.;Ramseyer, Chris
    • International Journal of Concrete Structures and Materials
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    • v.2 no.1
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    • pp.9-14
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    • 2008
  • The cracking problem in concrete is widespread and complex. This paper reviews the problem and focuses on those parts of the problem that are more readily solved. Polymer fibers are shown to have promise in several important areas of the cracking problem. To investigate one of these areas of the cracking problem more completely, an experimental research program focusing on the early-age properties of fibers was carried out. This study researched the properties of four polymer fibers; two of the fibers were macrofibers, and two were microfibers. Each fiber was tested at several dosage rates to identify optimum dosage levels. Early-age shrinkage, long-term shrinkage, compressive strength, and tensile strength were investigated. Long-term shrinkage and strength impacts from the polymer fibers were minimal; however, the polymer fibers were shown to have a great impact on early-age shrinkage and a moderate impact on early-age strength.