• Explosives and Blasting
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• v.16 no.3
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• pp.69-76
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• 1998

• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1067-1073
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• 2006

Cisplatin, a platinum coordinated complex, is a widely used antineoplastic agent for the treatment of metastatic tumors of the testis, metastatic ovarian tumors, lung cancer, advanced bladder cancer and many other solid tumors. The cytotoxic action of the drug is often thought to be associated with its ability to bind DNA to form cisplatin-DNA adducts. The development of resistance to cisplatin during treatment is common and constitutes a major obstacle to the cure of sensitive tumors. Although to understand the clinically relevant mechanisms of resistance, many studies have been aimed at clarifying the biochemical/molecular alterations of cisplatin-resistance cells, these studies did not conclusively identify the basis of cellular resistance to cisplatin. In this review, cisplatin resistance was discussed in terms of the relevant transporters, such as copper transporters (CTRs), organic cation transporters (OCTs) and multi-drug resistance related transporters (MDRs). These transporters seem to be contributed to cisplatin resistance through the reduction of drug accumulation in the cell. Better understanding the mechanism of cisplatin resistance associated with transporters will provide the useful informations for overcoming the cisplatin resistance.

• Archives of Pharmacal Research
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• v.29 no.7
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• pp.605-616
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• 2006

A wide variety of drugs and endogenous bioactive amines are organic cations (OCs). Approximately 40% of all conventional drugs on the market are OCs. Thus, the transport of xenobiotics or endogenous OCs in the body has been a subject of considerable interest, since the discovery and cloning of a family of OC transporters, referred to as organic cation transporter (OCTs), and a new subfamily of OCTs, OCTNs, leading to the functional characterization of these transporters in various systems including oocytes and some cell lines. Organic cation transporters are critical in drug absorption, targeting, and disposition of a drug. In this review, the recent advances in the characterization of organic cation transporters and their distribution in the small intestine are discussed. The results of the in vitro transport studies of various OCs in the small intestine using techniques such as isolated brush-border membrane vesicles, Ussing chamber systems and Caco-2 cells are discussed, and in vivo knock-out animal studies are summarized. Such information is essential for predicting pharmacokinetics and pharmacodynamics and in the design and development of new cationic drugs. An understanding of the mechanisms that control the intestinal transport of OCs will clearly aid achieving desirable clinical outcomes.

• Korean Journal of Remote Sensing
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• v.15 no.2
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• pp.175-181
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• 1999

A recurring eddy which located at the terminal end of the Korean East Warm Current was captured on ocean color and sea surface temperature imagery from satellite in spring and autumn. During late April, 1997 thermal infrared imagery from the NOAA AVHRR sensor and ocean color data from the Japanese ADEOS-I OCTS sensor, revealed this feature. The cold core had elevated chlorophyll concentrations, based on OCTS estimates, of greater than 3 mg/m$^3$ while the warmer surrounding waters had chlorophyll concentrations of 1 mg/m$^3$ or less. The elevated cholophyll accociated with this eddy has not been previously described. The eddy is also evident in SST images from autumn, but the SST in the core is warmer than in spring, and the warm jet flowing to the west of the eddy is also warmer is autumn compared to spring. A reccurring eddy and the high chlorophyll_a concentration area which surround around the eddy show on NOAA and SeaWiFS images in March 2, 1998. The eddy forms at the northern extent of the Korean East Warm Current as those waters collide with the cold, south-flowing Liman Current over a topographic shelf about 1500 m deep. This region of the eddy formation appears to have a strong connection with the dynamics of the western part of the polar front eddy field that dominates surface mesoscale structure in the central East (Japan) Sea. Interaction of the eddy with ARGOW tracked drifters, and evidence for its persistence are discussed.

• Proceedings of the KSRS Conference
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• 2009.03a
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• pp.151-154
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• 2009

MODIS Aqua에 의한 한반도 주변 해역의 관측은 엽록소의 변동을 관측하여 해양환경변화를 관측하는데 주로 연구되었다. 그러나 황해는 Case II 해역으로 해양의 엽록소 관측에 오차가 크기 때문에 동해와 남해, 동중국해역을 관측한 연구가 발표되어 왔다. 특히 적조와 같은 이상변동을 관측하는데 해색자료의 활용은 매우 활발한 연구가 이루어졌다. 하지만 K490(Diffuse attenuation coefficient for downwelling irradiance at 490nm)은 OCTS, SeaWiFS, MODIS, MERIS 등의 해색자료에 의해 많은 자료가 생산되고 있으나 이를 이용한 한반도 주변 해역의 해양환경변동에 관한 연구는 부족한 실정이다. 본 연구에서는 2008년 한반도 주변해역에서 관측된 MODIS 자료를 처리하여 K490에 의한 시-공간적 변화를 분석하였다. 특히 K490에 의한 월 변화(monthly)와 통계처리 결과를 분석하여 기후변화의 주요 분석인자인 해양의 일차생산력을 판단하는데 중요한 영향을 미치는 K490의 공간 특성을 제시하였다. 한반도 주변 해역의 K490에 의한 시-공간적 특성은 육상의 주요 하천에서 기인하는 부유사와 서남해역의 재부유 물질에 의한 영향이 시-공간적으로 뚜렷하게 나타나는 것을 파악할 수 있었다.

• The Journal of the Korea Contents Association
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• v.7 no.4
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• pp.39-48
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• 2007

Ad hoc network is a wireless network without fixed base stations or any wired backbone infrastructure. In the DUDMAC protocol, ORTS and OCTS in control channel solve the problem of deafness and DDATA and DACK in data channel improve spatial reuse by using the efficient blocking algorithm for directional antennas. In this paper, we propose the PCDUDMAC (Power Controlled DUDMAC) protocols. In the PCDUDMAC protocol, the power control of DATA/DACK in data channel saves transmission power and improves spatial reuse. We confirm the throughput performance of the proposed MAC protocol by computer simulations using Qualnet ver.3.8 simulator.