• Title/Summary/Keyword: O'Neill

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Case Study on Design of Axially Loaded Drilled Shafts in Intermediate Geomaterials(I) (IGM에 근입된 현장타설말뚝의 설계사례 연구(I))

  • Kim, Won-Cheul;Hwang, Young-Cheol;Lee, Jung-Hoon
    • Journal of the Korean GEO-environmental Society
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    • v.6 no.2
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    • pp.61-73
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    • 2005
  • In Korea, none of the design methods, which can consider the properties of hard soil, weathered rock and the condition of construction, are suggested. Therefore, the properties of geomaterial are simply classified into three categories such as sand, clay and rock for the resistance estimation of axially loaded drilled shafts in Korea. However, in America, O'Neill et al.(1996) presented design methods for a new category of geomaterial which is between soil and rock termed "intermediate geomaterials, IGM's". And FHWA(1999) adapted above most complete classification of geomaterials in its design manual. However, in Korea, these properties are depended on the engineer's judgement, the weathered rocks may be counted as soils, although they may be referred to as IGM's in America. In this study, the applicability of IGM method was investigated through the two construction sites in Korea. For the comparison, two geomaterial properties are applied, respectively. The one was sound soil condition and the other was IGM condition and classical design method and IGM method were applied, respectively. The results showed that the predicted bearing capacities of drilled shafts with IGM's were larger than the predicted values by the classical design method with sound soil condition.

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Literary Study in Representation of City Images in Contemporary Theater: A Comparative study of Modern American and Modern European Theater

  • Yang, Gi-Chan
    • Lingua Humanitatis
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    • v.7
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    • pp.227-246
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    • 2005
  • The difference between presentation of cities in the European modern drama and its counterpart the American modern drama denotes and comes from two very different images of cities. While the European modern drama presented cities that were desolate and fantastic to certain measure, the American modern drama presented the images of actual cities that can be identified by the spectators and readers. Although one cannot 'actually' identify any actual representation of cities in both the European and the American dramas, the images of cities can be discerned in the dialogues of the characters in the plays themselves. In this perspective the images of cities that are represented in any work of modern drama are actually represented through metaphors and connotations. The images in this instance rests and can only be identified within the boundaries of psychology. The dialogues are means through which the author communicates with the spectators. Because drama is above all categorized as being a work of text before representation, deciphering drama also falls in to same cadre as any other literary texts. Through the means of 'decontextualisation' the reader/spectator identifies with the associated images that the text proposes.

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Determination of Shear Strength Modification Factors in Drilled Shaft (현장타설말뚝의 전단강도 조정계수 결정법)

  • Kim, Myung-Hak;Michael W. O'Neill
    • Proceedings of the Korean Geotechical Society Conference
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    • 1999.03a
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    • pp.193-200
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    • 1999
  • An experimental study is described in which a 305-mm-diameter instrumented drilled shaft was installed in a moderately expansive clay soil during the dry season and monitored over a period of about 18 months. The purpose of the study was In investigate the effects of seasonal moisture changes in the soil on the shear stresses imposed on the sides of the drilled shaft and movements of the shaft head. The soil in the vicinity of the test shaft was instrumented to measure suction and ground surface movement and the relation between suction, total stress and shear strength of the soil at the test site was determined through laboratory triaxial compression testing. Daily rainfall and temperatures were also monitored at the test site, the National Geotechnical Experimentation Site at the University of Houston, where control on surface grading and vegetation existed. Over the course of the study induced unit side shear values of up to 54 kPa were measured in the test shaft. A simple computational model was developed that related observed suction changes to unit side shear induced by the expansion of the soil through the use of the laboratory suction-total stress-shear strength relation.

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Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

  • Alegre, Melissa Marie;Knowles, McKay Hovis;Robison, Richard A.;O'Neill, Kim Leslie
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.4
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    • pp.2207-2212
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    • 2013
  • Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.

3D SIMULATIONS OF RADIO GALAXY EVOLUTION IN CLUSTER MEDIA

  • O'NEILL SEAN M.;SHEARER PAUL;TREGILLIS IAN L.;JONES THOMAS W.;RYU DONGSU
    • Journal of The Korean Astronomical Society
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    • v.37 no.5
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    • pp.605-609
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    • 2004
  • We present a set of high-resolution 3D MHD simulations exploring the evolution of light, supersonic jets in cluster environments. We model sets of high- and low-Mach jets entering both uniform surroundings and King-type atmospheres and propagating distances more than 100 times the initial jet radius. Through complimentary analyses of synthetic observations and energy flow, we explore the detailed interactions between these jets and their environments. We find that jet cocoon morphology is strongly influenced by the structure of the ambient medium. Jets moving into uniform atmospheres have more pronounced backflow than their non-uniform counterparts, and this difference is clearly reflected by morphological differences in the synthetic observations. Additionally, synthetic observations illustrate differences in the appearances of terminal hotspots and the x-ray and radio correlations between the high- and low-Mach runs. Exploration of energy flow in these systems illustrates the general conversion of kinetic to thermal and magnetic energy in all of our simulations. Specifically, we examine conversion of energy type and the spatial transport of energy to the ambient medium. Determination of the evolution of the energy distribution in these objects will enhance our understanding of the role of AGN feedback in cluster environments.

Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal

  • Putker, Marrit;O'Neill, John Stuart
    • Molecules and Cells
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    • v.39 no.1
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    • pp.6-19
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    • 2016
  • Redox signalling comprises the biology of molecular signal transduction mediated by reactive oxygen (or nitrogen) species. By specific and reversible oxidation of redoxsensitive cysteines, many biological processes sense and respond to signals from the intracellular redox environment. Redox signals are therefore important regulators of cellular homeostasis. Recently, it has become apparent that the cellular redox state oscillates in vivo and in vitro, with a period of about one day (circadian). Circadian timekeeping allows cells and organisms to adapt their biology to resonate with the 24-hour cycle of day/night. The importance of this innate biological timekeeping is illustrated by the association of clock disruption with the early onset of several diseases (e.g. type II diabetes, stroke and several forms of cancer). Circadian regulation of cellular redox balance suggests potentially two distinct roles for redox signalling in relation to the cellular clock: one where it is regulated by the clock, and one where it regulates the clock. Here, we introduce the concepts of redox signalling and cellular timekeeping, and then critically appraise the evidence for the reciprocal regulation between cellular redox state and the circadian clock. We conclude there is a substantial body of evidence supporting circadian regulation of cellular redox state, but that it would be premature to conclude that the converse is also true. We therefore propose some approaches that might yield more insight into redox control of cellular timekeeping.

Modular reactors: What can we learn from modular industrial plants and off site construction research

  • Paul Wrigley;Paul Wood;Daniel Robertson;Jason Joannou;Sam O'Neill;Richard Hall
    • Nuclear Engineering and Technology
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    • v.56 no.1
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    • pp.222-232
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    • 2024
  • New modular factory-built methodologies implemented in the construction and industrial plant industries may bring down costs for modular reactors. A factory-built environment brings about benefits such as; improved equipment, tools, quality, shift patterns, training, continuous improvement learning, environmental control, standardisation, parallel working, the use of commercial off shelf equipment and much of the commissioning can be completed before leaving the factory. All these benefits combine to reduce build schedules, increase certainty, reduce risk and make financing easier and cheaper.Currently, the construction and industrial chemical plant industries have implemented successful modular design and construction techniques. Therefore, the objectives of this paper are to understand and analyse the state of the art research in these industries through a systematic literature review. The research can then be assessed and applied to modular reactors.The literature review highlighted analysis methods that may prove to be useful. These include; modularisation decision tools, stakeholder analysis, schedule, supply chain, logistics, module design tools and construction site planning. Applicable research was highlighted for further work exploration for designers to assess, develop and efficiently design their modular reactors.

Effects of Photoperiod, Temperature, and Fish Size on Oxygen Consumption in the Black Porgy Acanthopagrus schlegeli

  • Chang Young Jin;Jeong Min Hwan;Min Byung Hwa;Neill William H.;Fontaine Lance P.
    • Fisheries and Aquatic Sciences
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    • v.8 no.3
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    • pp.142-150
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    • 2005
  • The effects of photoperiod, temperature, and fish size on oxygen consumption (OC) in the black porgy Acanthopagrus schlegeli, a euryhaline marine teleost, were studied using a closed recirculating seawater system with a respiratory chamber. Fish reared in indoor recirculating seawater tanks were divided into two groups: small (15.7-55.8 g, mean 38.1$\pm$15.9 g) and large (108.7-238.8 g, mean 181.8$\pm$54.9 g) fish. The OC of the fish showed a clear diel rhythm, with higher values in the daytime and lower values at night, in accordance with light (09:00-20:59 h) and dark (21:00-08:59 h) cycles. The OC of the fish increased linearly with the water temperature. The OC was the highest at 10:00 h, one hour after the onset of daylight and was the lowest at 03:00 h, six hours after dusk. The average OC at $20^{\circ}C$ during the light period was as high as 219.8 mg $O_2$/kg/h in the small fish and 156.3 mg $O_2$/kg/h in the large fish, while during the dark period it was as low as 130.5 and 110.4 mg $O_2$/kg/h, respectively. The OC during the dark period, which showed limited variation, could be regarded as the resting OC, and was 107.6, 130.5, and 219.8 mg $O_2$/kg/h at 15, 20, and $25^{\circ}C$, respectively, in small fish, and 52.3, 110.4, and 171.0 mg $O_2$/kg/h in large fish. As the body weight of black porgy increased, the OC decreased exponentially and the relationship was expressed as OC=1,222.8$BW^{-0.567}$, OC=1,113.2$BW^{-0.448}$, and OC=1,495.3$BW^{-0.468}$ at 15, 20, and $25^{\circ}C$, respectively. At a fish density of 14.5 g/L at $20^{\circ}C$, black porgy had the highest OC per breath compared to fish at the same density at 15 or $25^{\circ}C$. This suggests that the black porgy responds to the stocking density (15 kg/$m^3$) and water temperature ($20^{\circ}C$) conditions commonly observed in intensive aquaculture with the deepest breath and the highest metabolic activity.

Modeling of Space Radiation Exposure Estimation Program for Pilots, Crew and Passengers on Commercial Flights

  • Hwang, Junga;Dokgo, Kyunghwan;Choi, Enjin;Park, Jong-Sun;Kim, Kyung-Chan;Kim, Hang-Pyo
    • Journal of Astronomy and Space Sciences
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    • v.31 no.1
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    • pp.25-31
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    • 2014
  • There has been a rapid increase of the concern on the space radiation effect on pilots, crew and passengers at the commercial aircraft altitude (~ 10 km) recently. It is because domestic airline companies, Korean Air and Asiana Airlines have just begun operating the polar routes over the North Pole since 2006 and 2009 respectively. CARI-6 and CARI-6M are commonly used space radiation estimation programs which are provided officially by the U.S. federal aviation administration (FAA). In this paper, the route doses and the annual radiation doses for Korean pilots and cabin crew were estimated by using CARI-6M based on 2012 flight records. Also the modeling concept was developed for our own space radiation estimation program which is composed of GEANT4 and NRLMSIS00 models. The GEANT4 model is used to trace the incident particle transports in the atmosphere and the NRLMSIS00 model is used to get the background atmospheric densities of various neutral atoms at the aircraft altitude. Also presented are the results of simple integration tests of those models and the plan to include the space weather variations through the solar proton event (SPE) prediction model such as UMASEP and the galactic cosmic ray (GCR) prediction model such as Badhwar-O'Neill 2010.

Mechanism study on DNA damage and Apoptosis induced by heak shock using Comet Assay

  • Seo, Young-Rok;Han, Sung-Sik;Kim, L. O′Neill;Ryu, Jae-Chun
    • Proceedings of the Korea Society of Environmental Toocicology Conference
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    • 1997.12a
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    • pp.101-101
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    • 1997
  • Comet assay, single cell gel electrophoresis has been known as useful, rapid, simple, visual, and sensitive technique for measuring the DNA breakage in mammalian ce1ls. For evaluation of DNA damage using comet assay, early studies reported a change in comet length and intensity with DNA damage using simple visual technique, such as fluorescence microscopy with eyespiece. In recent, some workers are observing and analyzing nucleotide of comets using quantitative fluorescence image analysis system to estimate 'tail moment', which is defined as the product of the tail length and the fraction of total DNA in tail. Our laboratory also adopted the image analysis software for qualification. In addition, many of the practical features of comet assay render it potentially attractive as useful tool for molecular toxicology and carcinogenesis, because the system is already showing considerable promise as rapid predictor in both in vitro and in vivo experimental designs. Recently, the comet assay becomes a attractive technique to study of apoptosis, because apoptotic fragmentation of nuclear DNA into nucleosomal sizes can be evaluated by the comet assay. So, we attempted to apply the comet assay to studying the effect of various stress on the apoptosis-sensitive cell lines. Particularly, focusing on the hyperthermic apoptosis, we could find that heat shock(44˚C for 60 minutes) was sufficient to induced apoptosis in these cell lines. But using the highly sensitive comet assay, we could not detect DNA breaks immediately after heat shock.

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