• 대한임상검사과학회지
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• 제45권2호
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• pp.54-59
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• 2013

NonHDL cholesterol values have been suggested as a risk marker for cardiovascular disease. NonHDL cholesterol values were calculated, using a very simple measurement [nonHDL cholesterol=serum total cholesterol-HDL cholesterol]. This formula is very useful as a screening tool for identifying dyslipoproteinemias, risk assessment, and assessing the results of hypolipidemic therapy. The data from the 2009 Korean National Health and Nutrition Examination Survey were used. Analysis was done for 1,992 subjects with lipid panels (Cholesterol, HDL, LDLdirect and Triglycerides) results. We studied the relationship between nonHDL cholesterol and LDL cholesterol. As a result, nonHDL cholesterol values were plotted against the LDL direct and calculated values. The linear regression equation for nonHDL cholesterol and direct LDL cholesterol was $nonHDLchol=23.60+1.03{\times}LDLdirect$ (p<0.0001, $r^2=0.80$) in all subjects. The subjects were classified into triglyceride values. When triglycerides are below 400 mg/dL, the linear fit to LDL direct is found to be $[nonHDLchol=17.34+1.07{\times}LDLdirect]$ (p<0.0001, $r^2=0.88$) and to the Friedewald LDL calculation is $[nonHDLchol=23.10+1.02{\times}LDLcalc]$ (p<0.0001, $r^2=0.82$). For triglycerides above 400 mg/dL, the linear fit equation is $[nonHDLchol=87.57+0.92{\times}LDLdirect]$ (p<0.0001, $r^2=0.50$) and to the LDL calculated, it is $[nonHDLchol=142.70+0.50{\times}LDLcalc]$ (p<0.0001, $r^2=0.32$). This study provides examples of the utility of nonHDL cholesterol concentrations in clinical medicine.

• 한국산학기술학회논문지
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• 제13권5호
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• pp.2251-2258
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• 2012

본 연구는 잠재적 위험요인을 탐색하는 방법으로 단순임의추출분석(unweighted sample design), 빈도 가중치를 적용한 단일표본분석(frequency weighted sample design), 가중치를 층화하여 적용한 복합표본분석(complex sample design)을 비교하고, 도출된 결과에 통계적인 차이가 있는지를 파악하고자 수행되었다. 자료원은 2009 국민건강영양조사의 이비인후과 검진 자료를 이용하였다. 분석 방법은 피어슨의 교차검정(Pearson chi-square test)과 라오-스콧교차검정(Rao-scott chi-square test)을 이용하였다. 분석 결과, 빈도 가중치만을 적용한 단일표본분석의 경우에는 모든 변수가 유의한 위험요인으로 과대 예측 되었고, 가중치를 적용하지 않은 단순임의추출 분석과 복합표본분석은 유의수준 및 결과에 차이가 있었다. 국가통계자료를 이용할 때, 연구의 결과가 전체 인구집단을 대표할 수 있도록 의미를 부여하기 위해서는 층화변수와 집락변수를 사용하여 가중치를 적용하는 복합표본분석이 필요하다. 나아가, 빈도 가중치만을 적용하는 경우에는 연구 결과에 대한 과잉해석의 가능성이 높기 때문에 각별한 주의가 요구된다.

• 대한영양사협회학술지
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• 제26권1호
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• pp.14-29
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• 2020

Dietary nitrate supplementation from green leafy vegetables and beetroot is involved in the 'nitrate-nitrite-nitric oxide (NO) pathway' and is reported to have important vascular impacts. This study evaluated the blood parameters and blood flow change subsequent to a raw juice diet program. The 28 subjects who voluntarily participated in the raw juice diet program at Sahmyook University were instructed to drink the juice composed of fruits and vegetables instead of partaking the usual meal, at a scheduled time daily. The study was approved by the research ethics council of the Sahmyook University (SYUIRB 2014-043). Evaluation of the participants after the required duration revealed decreased levels of soft lean mass (P<0.05), skeletal muscle mass (P<0.001), body fat mass (P<0.001), body mass index (P<0.001) and circulating levels of total cholesterol (P<0.001), triglycerides (P<0.05), HDL-cholesterol (P<0.01), LDL-cholesterol (P<0.01), and blood urea nitrogen (P<0.001). Conversely, circulating levels of creatinine (P<0.001), hemoglobin (P<0.001), and hematocrit (P<0.01) were increased after the intervention. The blood flow levels were also increased after the program (P<0.001). Our results indicate that a short-term raw juice diet contributes to the improvement of vascular blood flow and blood lipid parameters, and decreases the lean muscle mass related to dehydration.

• 동아시아식생활학회지
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• 제15권5
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• pp.558-565
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• 2005

In this study, Schizandriae fructus which has been used in oriental medicine and folks remedy, was studied to apply to functional foods and oriental medicinal cuisine. The aim of this experiments was to investigate the effects of Schizandriae fructus water extract(SFE) on the renal function, plasma renin activity, plasma levels of aldosterone and arterial natriuretic peptide(ANP) in rats. Spargue-Dawley rats weigh 200g, were randomly assigned to 3 groups such as basal diet only(BDG), basal diet with $0.5{\mu}L/g$ SFE(LAG) and basal diet with $1.0{\mu}L/g$ SFE(HAG). The results were as follows. Water balance decreased significantly after administration for 2 weeks compared with the control period in HAG. Urine volume increased significantly after administration for 1 week compared with the control period in LAG and HAG. Urinary excretion of sodium increased significantly after administration for 1 week and for 2 weeks compared with the control period in LAG and HAG. Urinary excretion of creatinine increased significantly after administration for 2 weeks compared with the control period in HAG. Plama levels of ANL decreased significantly after administration of $SFE(0.5{\mu}L/g)$. Plasma levels of aldosterone decreased significantly after administration of $SFE(1.0{\mu}L/g)$. There results indicated that Schizandriae fructus can improve the renal function through increased urine volume and sodium excretion. These results imply that SFE could be used as a potent food resource for diet therapy or clinical nutrition.

• 대한한의학방제학회지
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• 제22권2호
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• pp.25-34
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• 2014

Objectives : Excessive nutrition intake and lack of physical activity induce obesity through accumulation of fat in human body. The obesity have been categorized as a disease and known to cause several chronic diseases and cancers. In Japan, Bangpungtongsung-san has been applied as one of the therapies of the obesity and it's pharmacological uses have been studied for a long time. The purpose of this study is reviewing researches of Bangpungtongsung-san related to the obesity. Methods : By searching with the keyword of "Bangpungtongsung-san" or related words such as "Bofutsushosan" and 'TJ-62" from PubMed and off-line libraries, many reports were gathered and reviewed from the perspective of the obesity. Results and Conclusions : It has become evident by reviewing the reports that Bangpungtongsung-san is useful as a therapy of the obesity though some case reports showed side effects. Also, the mechanisms of Bangpungtongsung-san on obesity were reviewed and suggested.

• 디지털융복합연구
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• 제14권9호
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• pp.31-42
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• 2016

본 연구는 치과위생사들의 소진이 직무몰입에 주는 영향에 대해 알아보고자 실시하였다. 조사대상자는 치과위생사 156명이며 구조화된 설문조사를 실시하였다. 소진은 Maslash Burnout Inventory척도, 직무몰입은 강종수의 도구를 사용하였다. 분석결과 치과위생사들의 소진은 정서적 고갈, 성취감 감소, 비인간화의 3요인으로 분류되었고 직무몰입은 조직몰입, 경력몰입, 작업몰입의 3요인으로 분류되었다. 치과위생사들의 소진은 7점 만점 중 3.77점, 몰입은 5점 만점에서 3.53점으로 나타났다. 임상경력이 5년 미만이며 동료 인원이 적을수록 소진이 높았다. 임상경력이 높을수록 경력몰입이 높았으며, 경력과 연봉이 많을수록 조직몰입이 높게 나타났다. 치과위생사의 경력몰입과 작업몰입은 정서적 고갈과, 조직몰입은 성취감 감소와 음의 영향을 받고 있어서 소진이 높을수록 직무몰입 정도가 낮아지고 있었다. 그러므로 치과위생사들의 소진감소와 직무몰입도 증진을 위하여 경력을 유지하고 연봉을 높일 수 있는 방안 마련이 필요하다.

• 대한영양사협회학술지
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• 제7권2호
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• pp.138-143
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• 2001

Microalbuminuria is a strong predictor of diabetic nephropathy and is also associated with increased mortality in people with non-insulin-dependent diabetes mellitus(NIDDM) patients. Improved glycemic control and dietary protein restriction are recommended to retard and avoid developing microalbuminuria. The purpose of this study was to measure the dietary counseling effects for diabetes mellitus patients with microalbuminuria. To investigate the effects of the dietary counseling effect, thirty NIDDM patients with microalbuminuria were selected from outpatient diabetic clinic of Seoul National University Hospital for this study. None of them had evidence of renal and heart complications. For 24 weeks, they received individualized dietary counseling 3 times. The results of this study can be summarized as follows 1) Dietary protein and calorie intake decreased significantly from 79.8$\pm$29.9g/d to 66.6$\pm$16.5g/d, from 1845.4$\pm$631.9kcal to 1515.7$\pm$392.7kcal after dietary counseling, respectively (p<0.05). 2)The glycosylate hemoglobin level showed significantly decreased after dietary counseling(p<0.05). However there were no change in lipid profiles and blood pressure after counseling. 3) There was a significant correlation between the duration of disease and the amount of microalbuminuria. Any other cardiovascular risk factors, such as duration of diabetes, total cholesterol level and systolic blood pressure were not correlated with microalbuminuria. These results shown that dietary counseling can be used as an effective therapy to control blood sugar levels for NIDDM patients who are poorly controlled with microalbuminuria.

• 디지털융복합연구
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• 제13권9호
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• pp.531-540
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• 2015

귤피가 비습을 제거하는 효능을 가지 수 있어 과도한 단맛의 식품 섭취에 의해 증가되는 비습을 제거하여 소화기능을 증진시키는데 기여할 수 있고 또한 초콜릿의 향에도 기여할 것으로 판단되어 초콜릿의 기능성과 귤피의 기능성이 복합적으로 작용하여 생리활성을 기대할 수 있는 초콜릿을 개발가능성을 타진해보고자 하였다. 이에 따라 귤피가루를 첨가한 초콜릿의 일반성분과 무기질 조성, 물리적 특성, 항산화 활성 및 관능적 특성을 분석하였다. 약식 동원의 개념과 질병 예방의 중요성 및 현대인의 생활형태 등을 고려할 때 올바른 식생활은 매우 중요한 부분이다. 이에 오감을 고려한 관능적 특징을 가지고 경제적이면서 손쉽게 섭취할 수 있는 식품의 개발은 꾸준히 이루어져야 할 것이다. 이는 한방 재료를 이용하여 그 기능성을 전통적인 효능에 의한 접근이 이루어져야하며 그 기능성에 관한 동서 융복합적 연구의 기초자료로 사용하고자 함이다.

• 셀메드
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• 제2권2호
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• pp.17.1-17.5
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• 2012

Ayurveda is a nearly 3000 years old traditional medical system of India. Most of the time, people turn to ayurvedic physicians in desperate conditions. Here clinical practices of Ayurveda were initially found effective in the management of migraine among few patients. Later, it was developed as an ayurvedic treatment protocol (ATP) which consists of four herbo-mineral formulations (HMF), three meals and three snacks in a day with eight hours sleep at night. ATP brought significant relief in reducing the frequency, intensity of pain and associated symptoms in the migraine patients. IHS diagnostic criteria was followed to establish the diagnosis of migraine and uniform ATP was prescribed to each patient who were primarily treated by the ayurvedic physicians at their respective clinics. Such observations were presented at appropriate international forums. In an effort to validate the above, the present study carries the details of nine migraine patients who were first diagnosed and treated for migraine by a leading headache expert at Mumbai in India and were then referred to receive ATP. A total number of nine subjects volunteered to this program. Out of those, seven subjects completed 120 days of ATP. Five subjects reported significant improvement in overall symptoms of migraine. All subjects were followed up periodically for four years. No Grade II side effects were observed in any treated case. HMF has also been proved to be safe in experimental studies. Further pharmacological and randomized controlled clinical studies are in progress at the respective departments of a premier medical institute in India.

• Journal of Acupuncture Research
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• 제22권2호
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• pp.147-154
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• 2005

Objective: In this study, the effects of Liriope Platyphylla against LPS-induced inflammation was investigated. Methods: Cell viability was determined using the MTT assay. To identify expressions of COX-2 and iNOS mRNA, RT-PCR was performed. Assessment of PGE2 synthesis was performed using the PGE2 immunoassay. Measurement of NO synthesis was performed using the NO detection. Result : The MTT assay revealed that Liriope Platyphylla exerted no significant cytotoxicity in the microglial BV2 cells. RT-PCR analysis revealed that the mRNA levels of COX-2 and iNOS were significantly decreased in the LPS- and 5 mg/ml Liriope Platyphylla treated group. From the PGE2 immunoassay and NO detection, PGE2 and NO synthesis was significantly suppressed in the LPS- and 5 mg/ml Liriope Platyphylla treated group. Conclusion : In these study, Liriope Platyphylla was shown to suppress PGE2 and NO production by inhibiting LPS-stimulated enhancement of COX-2 enzyme activity and iNOS expression. It is very possible that Liriope Platyphylla can offer a valuable mode of therapy for the treatment of brain inflammatory diseases.