• 운동영양학회지
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• 제23권3호
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• pp.13-21
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• 2019

[Purpose] Chronic stress is a precipitating factor for depression, whereas exercise is beneficial for both the mood and cognitive process. The current study demonstrates the anti-depressive effects of regular exercise and the mechanisms linked to hippocampal neurogenesis. [Methods] Mice were subjected to 14 consecutive days of restraint, followed by 3 weeks of treadmill running, and were then subjected to behavioral tests that included the forced swimming and Y-maze tests. Protein levels were assessed using western blot analysis and newborn cells were detected using 5-bromo-2'-deoxyuridine (BrdU). [Results] Three weeks of treadmill running ameliorated the behavioral depression caused by 14 days of continuous restraint stress. The exercise regimen enhanced BrdU-labeled cells and class III β-tubulin levels in the hippocampal dentate gyrus, as well as those of thioredoxin-1 (TRX-1) and synaptosomal β2-adrenergic receptors (β2-AR) under stress. In vitro experiments involving treatment with recombinant human TRX-1 (rhTRX-1) augmented the levels of phospho-extracellular signal-regulated kinases 1 and 2 (ERK1/2), nuclear β-catenin, and proliferating cell nuclear antigens, which were previously inhibited by U0216 and FH535 (inhibitors of ERK1/2 and β-catenin/T cell factor-mediated transcription, respectively). The hippocampal neurogenesis elicited by a 7-day exercise regimen was abolished by a selective inhibitor of β2-AR, butoxamine. [Conclusion] These results suggest that TRX-1-mediated hippocampal neurogenesis by β2-AR function is a potential mechanism underlying the psychotropic effect of exercise.

• 운동영양학회지
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• 제16권1호
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• pp.51-59
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• 2012

The purpose of this study was to examine the effects of endurance training and prolonged L-arginine supplementation on blood glucose, blood insulin, muscle glycogen, muscle glycogen synthase (GS), muscle nitric oxide (NO), muscle nitric oxide synthase (NOS), endurance performance. We equally divided 36 Sprague-Dawley mice to be distributed into control group, L-NMMA treated group and L-arginine treated group. The L-arginine treated group and L-NMMA treated group consumed 10 mg/kg/day of L-arginine and 5 mg/kg/day of L-NMMA for 6 weeks period. Mice of control group, L-arginine treated group, and L-NMMA treated groups performed swimming exercise training for 60 min once a day, 5 days per week for 6 weeks. Blood glucose had tendency to increase in L-arginine treated group than the control group, and insulin significantly increased in L-arginine treated group than the control group. L-arginine treated group showed significant increase in glycogen, GS, NO and NOS in the gastrocnemius muscle and soleus muscle compared to the control group. Whereas L-NMMA treated group showed the lowest glycogen, GS, NO and NOS in the gastrocnemius muscle and soleus muscle compared to control group and L-arginine treated group. Exhaustive swimming time had tendency to increase in L-arginine treated group compared to the value for control group. These reults indicate that endurance training and prolonged L-arginine supplementation appear to be effective in exhancing nitric oxide production, glycogen concentration and endurance performance.

• 운동영양학회지
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• 제15권4호
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• pp.173-182
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• 2011

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder induced by severe external stressors such as assault, disaster or severe accident. We investigated the effects of treadmill exercise on short-term memory in relation to apoptosis and cell proliferation in the hippocampus following PTSD. Stress to the pregnant rats was induced by exposure of maternal rats to the hunting dog in an enclosed room. Exposure time was 10 min, repeated three times per day, with 1 hour interval. Exposure of maternal rats to the hunting dog was continued 7 days after pregnancy until delivery. The pregnant rats in the exercise groups were forced to run on a treadmill for 30 min once a day for the same duration of stress exposure. Step-down avoidance task for short-term memory, western blot for Bcl-2, Bax, and immunohistochemistry for caspase-3, 5-bromo-2'-deoxyuridine (BrdU), and Ki-67 were conducted. Maternal rats exposed to stress during pregnancy showed short-term memory impairment. Expressions of Bax, Bcl-2, ratio of Bax to Bcl-2, and caspase-3 in the hippocampus were increased in the PTSD rats. Cell proliferation in the hippocampal dentate gyrus was decreased in the PTSD rats. Treadmill exercise alleviated short-term memory impairment and suppressed expressions of Bax, the ratio of Bax to Bcl-2, and caspase-3. Treadmill exercise also increased cell proliferation. The present results indicate that treadmill exercise alleviated PTSD-induced short-term memory impairment by suppressing apoptotic cell death and enhancing cell proliferation in the hippocampus.

• Safety and Health at Work
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• 제14권3호
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• pp.267-271
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• 2023

Background: The objective of this study is to identify the working conditions and health status of Vietnamese male migrant workers in Republic of Korea, in comparison to the Korean general population. Methods: We conducted our survey through the Migrant People Center, and we received completed questionnaires from 87 male Vietnamese migrant workers. The questionnaire employed was identical to those used in the Korean Working Conditions Survey and the 2020 Korea National Health and Nutrition Examination Survey. The collected data from the Vietnamese migrant workers was then compared with the Korean reference population using indirect age-standardization. Results: Vietnamese male workers demonstrated a higher prevalence of health problems including hearing problems (age-standardized prevalence ratio (aSPR) 13.22, 95% confidence interval [CI]: 8.07-20.4), skin problems (aSPR 13.49, 95% CI: 8.07-20.4), and low back pain (aSPR 8.40, 95% CI: 6.50-10.69). Elevated exposure to workplace hazards such as chemicals (aSPR 2.36, 95% CI: 1.51-3.51), organic solvents (aSPR 2.22, 95% CI: 1.44-3.28), handling of heavy objects (aSPR 1.67, 95% CI: 1.24-2.21), and high temperatures (aSPR 1.96, 95% CI: 1.46-2.57) was observed among them. Additionally, they faced a higher risk of no personal protective equipment (aSPR 2.53, 95% CI: 1.26-4.52) and a greater prevalence of unmet medical needs (aSPR 7.14, 95% CI: 4.74-10.32). Conclusion: Our findings highlight the elevated workplace hazards, health problems, and unmet medical needs among Vietnamese male workers compared to the Korean reference population. These findings underscores the urgency for enhanced scrutiny over working conditions and protective equipment provision, coupled with efforts to improve healthcare accessibility and worker education.

• Animal Bioscience
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• 제37권1호
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• pp.116-122
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• 2024

Objective: This research was conducted to evaluate the effects of citrus fiber (CF) as a natural alternative to sodium tripolyphosphate (STPP) in marinated broiler boneless chicken breast and inside beef skirt on overall retention rate, shear force, and consumer sensory attributes. Methods: Five different marinade formulations were targeted to include 0.9% salt, either 0.25% or 0.50% STPP or CF and water on a finished product basis. Water and salt only were considered the negative control (CON). Chicken breasts (n = 14) and inside beef skirt (n = 14) were randomly assigned to a treatment, raw weights recorded and then placed in a vacuum tumbler. Marinated weights were recorded, individually packed, and randomly assigned to either retail display for 10-day retention rate, shear force analysis, cook loss, or consumer sensory panel. Results: Pickup percentage, and overall retention was similar among treatments for chicken breast and inside beef skirt. Citrus fiber treatments resulted in higher cooking loss compared to the CON in chicken breast; though, CF050 resulted in similar cooking loss compared to STPP025 in inside beef skirt. No differences were found in sensory attributes for chicken breast, however, WBSF data showed CF025 was tougher than CF050, STPP050, and CON. Inside beef skirt with CF050 were least liked overall by the consumer panel. Conclusion: Citrus fiber included in marinades at a lower percentage rate can produce similar texture characteristics, and sensory properties compared with those marinated with STPP.

• 한국응용과학기술학회지
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• 제40권4호
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• pp.890-896
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• 2023

본 연구는 혈중 엽산농도와 대사증후군의 관련성을 살펴보고자 한다. 분석에 사용한 자료는 국민건강영양조사 2018년도 자료(제7기 3차)를 사용하였으며 본 연구는 만 19세 이상인 성인을 대상으로 혈중 엽산농도를 측정한 대상자 중 남자 495명, 여자 706명, 총 1,201명을 최종 분석하였다. 자료의 분석은 일반적 특성에 따른 혈중 엽산 차이는 Chi-square와 t- test로, 대사증후군 하부요인들간의 관계는 Pearson 상관관계, 혈중엽산농도와 대사증후군 지표는 로지스틱 회귀분석을 사용하였다. 본 연구 결과에 의하면 혈중 엽산농도와 대사증후군의 하부요인인 허리둘레(r=-0.113, p<0.05), 중성지방(r=-0.086, p<0.05)과 유의미한 음의 상관관계, HDL-cholesterol(r=0.086, p<0.05)은 유의미한 양의 상관관계를 보였으며 회귀분석결과 HDL-cholesterol의 경우 혈중엽산농도가 정상인 군이 낮은 군에 비하여 유의미하게 높았다(p<0.05). 따라서 본 연구를 통하여 대사증후군 예방을 위한 적절한 식습관 및 건강 교육프로그램 개발을 제안한다.

• BMB Reports
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• 제57권2호
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• pp.98-103
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• 2024

The mammalian sirtuin family (SIRT1-SIRT7) has shown diverse biological roles in the regulation and maintenance of genome stability under genotoxic stress. SIRT7, one of the least studied sirtuin, has been demonstrated to be a key factor for DNA damage response (DDR). However, conflicting results have proposed that Sirt7 is an oncogenic factor to promote transformation in cancer cells. To address this inconsistency, we investigated properties of SIRT7 in hepatocellular carcinoma (HCC) regulation under DNA damage and found that loss of hepatic Sirt7 accelerated HCC progression. Specifically, the number, size, and volume of hepatic tumor colonies in diethylnitrosamine (DEN) injected Sirt7-deficient liver were markedly enhanced. Further, levels of HCC progression markers and pro-inflammatory cytokines were significantly elevated in the absence of hepatic Sirt7, unlike those in the control. In chromatin, SIRT7 was stabilized and colocalized to damage site by inhibiting the induction of γH2AX under DNA damage. Together, our findings suggest that SIRT7 is a crucial factor for DNA damage repair and that hepatic loss-of-Sirt7 can promote genomic instability and accelerate HCC development, unlike early studies describing that Sirt7 is an oncogenic factor.

• 문화기술의 융합
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• 제10권3호
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• pp.121-130
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• 2024

건강한 노년을 위하여 중년의 건강을 관리하는 것이 필요하다. 본 연구는 주관적 건강인지와 건강관련 삶의 질에 영향을 미치는 요인을 2020년 국민건강영양조사(KNHANES) 제8기 자료를 이용하여 40-59세 중년 여성 1068명의 데이터를 분석하였다. 연구방법은 STATA 15.0을 이용하여 복합표본 평균과 표준편차, 복합표본 가중치 백분율, 복합표본 t-test, 다중회귀분석을 수행 하였다. 주관적 건강과 건강관련 삶의 질에 영향을 미치는 복합공통요인은 교육수준, 가구원수, 우울증, 스트레스이었다. 연령, 폭음, 신체활동은 주관적 건강인지, 보험유형, 취업여부, 수면장애는 건강관련 삶의 질에 영향을 미치는 요인이었다. 중년기는 노년기로 넘어가는 전 단계로 중년의 주관적 건강 및 건강 관련 삶의 질을 향상시킬 수 있는 보건정책 프로그램을 개발하여야 할 것이다.

• 대한물리의학회지
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• 제19권1호
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• pp.23-30
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• 2024

PURPOSE: The purpose of this study is to identify the incidence of chronic obstructive pulmonary disease (COPD) and risk factors for diseases in adults over 40 years of age in Korea, and to provide basic data for the prevention of COPD incidence through management. METHODS: Based on the 2019 data of the Korea National Health and Nutrition Examination Survey (KNHANES), 1,788 adults over the age of 40 who participated in pulmonary function test and health survey were selected as subjects. COPD incidence risk factors were analyzed using complex sample multiple logistic regression analysis. RESULTS: As a result of the analysis, the incidence of COPD in Korea was 11.5%, and the risk of developing COPD was higher in men, age, and current smokers. Compared to women, men had an increased risk of developing COPD by 2.369 times (95% CI 1.289-4.355). In age, the risk of COPD incidence increased by 3.702-fold (95% CI 1.923-7.124) in their 50s, 11.238-fold (95% CI 6.009-21.017) in their 60s, and 28.320-fold (95% CI 14.328-55.977) in their 70s compared to those in their 40s. In the smoking state, 2.302 times (95% CI 1.373-3.860) of past smokers and 4.542 times (95% CI 2.694-7.658) of current smokers were found to have a higher risk of developing COPD than non-smokers. CONCLUSION: To reduce the incidence of COPD, interventions are required to prevent disease development through lifestyle and smoking cessation education in subjects with COPD risk factors.

• 미래기술융합논문지
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• 제3권2호
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• pp.1-7
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• 2024

본 연구는 중장년의 가구형태에 따른 질병이환과 건강관련 삶의 질 영향요인을 비교하기 위해 시도되었다. 본 연구는 제8기 3차년도인 2021년 국민건강영양조사 대상자 중 40-64세 2380명을 대상으로 하였으며, 일반적 특성, 질병이환, 신체적 요인들을 분석하였다. 자료는 spss 25.0프로그램을 이용하여 가중치를 부여한 복합표본계 획파일을 생성한 후 분석하였으며 유의수준은 .05로 하였다. 본 연구결과 1인 가구에 영향을 주는 요인은 교육수준과 활동제한여부, 우울증 진단이었으며, 다인가구에 영향을 주는 요인은 성별, 흡연, 활동제한, 이상지혈증, 우울증이었다. 건강관련 삶의 질에 주관적 건강상태는 양의 상관관계를, 불안과 스트레스는 음의 상관관계를 나타냈다. 본 연구 결과를 바탕으로 가구유형에 맞는 각각의 영향요인을 고려한 개별적 삶의 질 향상 중재가 요구된다.