• KIISE Transactions on Computing Practices
• /
• v.22 no.5
• /
• pp.246-251
• /
• 2016

Recently, the influence of SNS and online media is rapidly growing with a consequent increase in the interest of marketing using these tools. Blog marketing can increase the ripple effect and information delivery in marketing at low cost by prioritizing keyword search results of influential portal sites. However, because of the tough competition to gain top ranking of search results of specific keywords, long-term and proactive efforts are needed. Therefore, we propose a new method that recommends associated keyword groups with the possibility of higher exposure of the blog. The proposed method first collects the documents of blog including search results of target keyword, and extracts and filters keyword with higher association considering the frequency and location information of the word. Next, each associated keyword is compared to target keyword, and then associated keyword group with the possibility of higher exposure is recommended considering the information such as their association, search amount of associated keyword per month, the number of blogs including in search result, and average writhing date of blogs. The experiment result shows that the proposed method recommends keyword group with higher association.

• Journal of Environmental Science International
• /
• v.27 no.11
• /
• pp.957-966
• /
• 2018

This study intend to induce citizen's voluntary preliminary disaster prevention activity to reduce damage of typhoon that occurs every year. For this purpose, a survey was conducted to develop Typhoon information contents. The number of samples used in the survey was set to 500 people, and citizens living in Jeju, Busan, and Jeonlanam-do were surveyed for areas with high typhoon disasters in order to develop practical and efficient information. The survey consisted of perception about natural disaster, how to get and use weather information, satisfaction with typhoon information and requirements. The general public perceived the typhoon as the first natural disaster. As a result of responding to the method of obtaining and utilizing weather information, the frequency of collecting weather information at the time of issuance of typhoon special report is higher than usual. The purpose of using weather information is clear and the response rate is high for the purpose of disaster prevention. The medium mainly collecting weather information is Internet portal site and mobile phone besides television. The current satisfaction with typhoon weather information is 34.8%, in addition to the accuracy of prediction, it is necessary to improve the information (that is content) provided. Specific responses to the content were investigated not only for single meteorological factors, but also for possible damage and potential countermeasures in the event of a disaster such as a typhoon. As can be seen from the above results, people are requested to provide information that can be used to detect and cope with disasters. The development of new content using easy accessible media will contribute to the reduction of damages caused by the typhoon that will occur in the future, and also to the disaster prevention activity.

• Journal of Korean Medicine Rehabilitation
• /
• v.33 no.1
• /
• pp.61-75
• /
• 2023

Objectives The purpose of this study is to find out what diseases or treatments the Korean Medicine Rehabilitation department is dealing with. Methods For data collection, papers published from 2012 to 2021 were searched and collected on the website of the Korean Society of Rehabilitation Medicine (https://www.ormkorea.org/). After that, reconfirmed data at the Oriental Medicine Advanced Searching Integrated System (OASIS) Traditional Medicine Portal (https://oasis.kiom.re.kr/). The searched papers were classified by year and classified according to format based on thesis and abstract. In addition, the papers were classified by subject, focusing on diseases and treatments. Results Total 557 studies were classified. The format of a total of 557 papers was distributed in 129 preclinical studies (23.2%), 136 literature studies (24.4%), 153 clinical studies (27.5%), 112 case reports (20.1%), and 27 other studies (4.8%). While preclinical studies and clinical studies are gradually decreasing over the years, case reports and literature studies are gradually increasing. Conclusions The number of papers in Journal of Korean Medicine Rehabilitation is gradually decreasing. Papers on more diverse topics is needed for the qualitative growth of journals and Department of Korean Medicine Rehabilitation.

• Korean Journal of Veterinary Service
• /
• v.26 no.4
• /
• pp.345-359
• /
• 2003

A number of toxicants have been incriminated as a causing hepatic disease. Among many detrimental injury, alcohol has been noted for hepatitis, fatty liver, fibrosis, and hepatic cirrhosis. The purpose of this study was to develop animal model for hepatic fibrosis in pigs fed ethanol, and to search for a new anti-fibrogenic agent via this model. Twelve male Landrace pigs were divided into 3 groups of 4 animals each. Group 1, 2 and 3 were fed with active ceramic water only, ceramic water + liquid diet containing 15% ethanol and normal tap water + liquid diet containing 15% ethanol for 12 weeks, respectively. At week 12, all pigs were immediately sacrificed for collection each tissue and blood. Serologically, serum ALT and AST levels were significantly reversed in group 2, as compared to group 3. They were normal range in pigs of group 1. Microscopically, macrovesicular lipid droplets and moderate hepatocellular necrosis were evident in the tap water + ethanol fed group 3. However, the active ceramic water treated group 1 showed normal architecture. Moreover, in group 2, mild fatty changes and necrosis were observed in hepatocytes. Collagen fibers were increased in spaces surrounding periportal and interlobular connective tissues in the group 3 of tap water + ethanol, but collagen synthesis and its thickness of fibrotic septa connecting portal tracts were markedly reduced in the group 2 of ceramic water + ethanol. Myofibroblasts were detected mainly in the interlobular connective tissues of pig liver of group 3 treated ethanol and tap water. Few to no myofibroblasts were observed in groups 1 and 2. CYP2E1 was not or rarely detected in group 1 fed ceramic water. However, group 2 showed slightly activation of CYP2E1 in the area of pericentral vein, while CYP2E1 was significantly activated in group 3 fed tap water and ethanol. Based on the above data, we believe that we have developed a unique alcohol induced fibrosis model in pig, which will be useful in developing anti-fibrotic agents and drugs. Furthermore, the active ceramic water used in our study had an inhibitory and may be protective against ethanol induced hepatic toxicity and fibrosis.

• The Journal of Korean Medicine
• /
• v.16 no.2 s.30
• /
• pp.365-385
• /
• 1995

In order to prove the antitumor effect of Wekyungtang(WKT) that was originated in Bigeubchunkeumyobang(備急千金要方), Wekyungtang with Houttuyniae Herba(WKT-I) and Wekyungtang with Oldenlandiae diffusae Herba(WKT-II) experimentally, the studies were done, We evaluated the cytotoxic activity against B16- Fo as well as the synergistic effects with anticancer drugs such as cyclophophamide (CPM), cisplatin(CPT) and 5-fluorouracil (5-FU) in vitro and measured body weight, survival time, hematological changes, changes of tissues in G57BL／6 implanted with B16-Fo. The results were obtained as follows: 1. In vitro cytotoxic effect against B16-Fo was shown in all groups as compared with control group, but the concentrations showing inhibitory growth rate below 55% of control was recognized in all concentrations of Wekyungtang(WKT) against B16-Fo and also concentration of $10^4$g／ml above in all group with cyclophophamide (CPM), concentration of $10^3$g／ml in Wekyungtang(WKT-l) with cisplatin(CPT) in synergistic effect, 2. In vivo body and tumor weight were significantly suppressed in all groups as compared with control group 3. The number of platelet, WBC, RBC were significantly increased in all groups, platelet aggregation was significantly increased in WKT-I and WKT-II as compared with control group. 4. In changes of tissues heavy infiltration oh cancer was shown in portal vein, pulmonary tissue, vein, peribronchiole, aveoli, while WKT-I was effective in antihepatic metastasis and WKT-II in pulmonary matastasis. From above results it was concluded that wekyungtang(WKT), wekyungtang with Houttuyniae Herba(WKT-I) and wekyungtang with Oldenlandiae diffusae Herba(WKT -II) had antitumor effect, and also wekyungtang combined with Houttuyniae Herba or Oldenlandiae diffusae Herba were more effective than wekyungtang only and also cyclophophamide (CPM), cisplatin(CPT) showed the more synergistic effect which suggests the necessity of continuous study on the mechanism of antitumor action of Houttuyniae Herba or Oldenlandiae diffusae Herba.

• The Korea Journal of Herbology
• /
• v.26 no.3
• /
• pp.65-73
• /
• 2011

Objectives : The present study was evaluated the protective roles of Spatholobi Caulis in hepatotoxic rats due to APAP overdose. Methods : In experiments, rats were orally administrated with the aqueous extract of Spatholobi Caulis (SCE; 50, 100 mg/kg) for 4 days and then, orally gavage with APAP (1.2 g/kg) to induce acute liver damage. Results : Oral injection of APAP caused severe hepatic injury. Plasma ALT, AST and LDH levels were significantly elevated, but SCE significantly decreased ALT, AST and LDH to the normal level. In histopathological analysis, peripheral hemorrhage around portal triads and central necrosis around central veins were founded after APAP treatment. However, these histopathological changes were recovered by SCE pretreatment. SCE also decreased the percentage of generative hepatic regions (%/$mm^2$ hepatic parenchyma), the numbers of inflammatory cells (cells/$mm^2$ hepatic parenchyma) and the number of degenerative hepatic cells (N/100 hepatic cellls) which were significantly elevated after APAP injection. Furthermore, SCE down-regulated the contents of hepatic MDA and up-regulated hepatic GSH. SCE also inhibited the decrease in the expression of pro-caspase-3 by APAP treatment. Conclusions : Collectively, these data indicate that SCE protected APAP-induced hapatic damages through antioxidative and anti-apoptotic process. These findings the significant therapeutic potential of SCE during APAP-induced liver injury.

• International Journal of Advanced Culture Technology
• /
• v.10 no.1
• /
• pp.274-283
• /
• 2022

Korea is facing a number difficulties arising from rising housing prices. As 'housing' takes the lion's share in personal assets, many difficulties are expected to arise from fluctuating housing prices. The purpose of this study is creating housing price prediction model to prevent such risks and induce reasonable real estate purchases. This study made many attempts for understanding real estate instability and creating appropriate housing price prediction model. This study predicted and validated housing prices by using the LSTM technique - a type of Artificial Intelligence deep learning technology. LSTM is a network in which cell state and hidden state are recursively calculated in a structure which added cell state, which is conveyor belt role, to the existing RNN's hidden state. The real sale prices of apartments in autonomous districts ranging from January 2006 to December 2019 were collected through the Ministry of Land, Infrastructure, and Transport's real sale price open system and basic apartment and commercial district information were collected through the Public Data Portal and the Seoul Metropolitan City Data. The collected real sale price data were scaled based on monthly average sale price and a total of 168 data were organized by preprocessing respective data based on address. In order to predict prices, the LSTM implementation process was conducted by setting training period as 29 months (April 2015 to August 2017), validation period as 13 months (September 2017 to September 2018), and test period as 13 months (December 2018 to December 2019) according to time series data set. As a result of this study for predicting 'prices', there have been the following results. Firstly, this study obtained 76 percent of prediction similarity. We tried to design a prediction model of real estate transaction price with the LSTM Model based on AI and Bigdata. The final prediction model was created by collecting time series data, which identified the fact that 76 percent model can be made. This validated that predicting rate of return through the LSTM method can gain reliability.

• BMB Reports
• /
• v.54 no.10
• /
• pp.497-504
• /
• 2021

EGR1 (early growth response 1) is dysregulated in many cancers and exhibits both tumor suppressor and promoter activities, making it an appealing target for cancer therapy. Here, we used a systematic multi-omics analysis to review the expression of EGR1 and its role in regulating clinical outcomes in breast cancer (BC). EGR1 expression, its promoter methylation, and protein expression pattern were assessed using various publicly available tools. COSMIC-based somatic mutations and cBioPortal-based copy number alterations were analyzed, and the prognostic roles of EGR1 in BC were determined using Prognoscan and Kaplan-Meier Plotter. We also used bc-GenEx-Miner to investigate the EGR1 co-expression profile. EGR1 was more often downregulated in BC tissues than in normal breast tissue, and its knockdown was positively correlated with poor survival. Low EGR1 expression levels were also associated with increased risk of ER+, PR+, and HER2- BCs. High positive correlations were observed among EGR1, DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC tissue. This systematic review suggested that EGR1 expression may serve as a prognostic marker for BC patients and that clinicopathological parameters influence its prognostic utility. In addition to EGR1, DUSP1, FOS, FOSB, CYR61, and JUN can jointly be considered prognostic indicators for BC.

• Journal of the Korea Society of Computer and Information
• /
• v.16 no.11
• /
• pp.153-161
• /
• 2011

As the problem of GOSST building belongs to NP compete domain, heuristics for the problem ask for immense amount execution time and computations in large scale inputs. In this paper, we propose an efficient mechanism for GOSST construction using space locality PTAS. For 40,000 input nodes with maximum weight 100, the proposed space locality PTAS GOSST with 16 unit areas can reduce about 4.00% of connection cost and 89.26% of execution time less than weighted minimum spanning tree method. Though the proposed method increases 0.03% of connection cost more, but cuts down 96.39% of execution time less than approximate GOSST method (SGOSST) without PTAS. Therefore the proposed space locality PTAS GOSST mechanism can work moderately well to many useful applications where a greate number of weighted inputs should be connected in short time with approximate minimum connection cost.

• Journal of The Korean Society of Agricultural Engineers
• /
• v.61 no.6
• /
• pp.41-53
• /
• 2019

Recently, the damage caused by climate change has been distinguished in the world. The Korean Peninsula is also suffering from drought, so it is necessary to study the vulnerability assessment to identify and predict the state of the irrigation facility, which is a irrigation facility. As the damage caused by drought is occurring in the Korean peninsula, it is necessary to study the vulnerability assessment to know the condition of the irrigation facility, and to predict it. The target areas were Yeongdong-gun, Cheonan-si, Mungyeong-si, Geochang-gun, Muju-gun, and Yeonggwang-gun. The survey items were selected as positive impacts survey items, including precipitation, groundwater level, and pumping capacity per groundwater well. The negative impacts were selected as the cultivation acreage, Number of days without rain, and the ratio of private underground wells. The survey method was investigated by various methods such as "weather data portal", "groundwater level status information", "agricultural drought management system", "groundwater survey yearbook". The results of vulnerability assessment were expressed by the score by conducting survey and standardization. As a result, Yeonggwang-gun showed normal vulnerability, and other areas showed "vulnerable" or "very vulnerable".