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Bootstrapped Malmquist 지수를 이용한 국내 의약품산업의 생산성 변화 요인 분석에 관한 연구 (An Analysis of the Productivity Changes of Korean Pharmaceutical Industry Using Bootstrapped Malmquist Index)

  • 소순후
    • 경영과정보연구
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    • 제35권4호
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    • pp.141-153
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    • 2016
  • 본 연구는 Bootstrapped Malmquist 지수를 이용하여 국내 의약품산업의 생산성 변화 추이를 측정하고 이러한 변화를 기술효율성 변화와 기술변화 요인으로 분해함으로써 의약품산업의 생산효율성을 제고하기 위한 시사점을 제시하고자 한다. 특히 기존의 연구들과 달리 투입 및 산출요소의 여분을 반영하여 투입최소화와 산출최대화를 측정할 수 있는 투입산출지향 비방사적 Malmquist 지수를 분석에 활용한다. 또한 평활부트스트랩 방법을 적용하여 Malmquist 지수와 그 구성요인의 통계적 신뢰구간을 추정한다. 실증분석을 위해 2005년에서 2014년까지 10개년의 균형패널자료를 수집하였으며, 분석에 사용된 투입요소는 종사자수, 유형자산, 주요생산비를 선정하였고, 생산액을 산출요소로 사용하였다. 분석 결과, 의약품산업의 생산성은 분석기간 동안 하락한 것으로 나타났으며, 이러한 생산성 하락은 기술진보의 둔화에 기인한 것으로 나타났다. 또한 의약품산업의 기술적 효율성은 순수효율성보다는 규모효율성에 보다 많은 영향을 받은 것으로 분석되었다. 따라서 향후 의약품산업의 경쟁력 강화를 위해서는 효율적 R&D 투자와 산업구조의 선진화를 통해 기술혁신역량을 강화하는 정책적 지원이 요구된다.

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제주도 민간요법에 관한 조사연구 (Survey on Personal Medicines in Cheju Island)

  • 이경희
    • 동서간호학연구지
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    • 제2권1호
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    • pp.37-53
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    • 1997
  • The purpose is to inspect the personal medicines in Cheju island that are used traditionally and to get their characteristics. The subjectives are 39 Cheju people, men 10, women 29, who were horned, grown up in Cheju and agreed with this study. The ranges of age are 10 persons(m : 1, w: 9) over 40 less 50 years old, 14(m : 7, w : 7) over 50 less 60, 5(m : 1, w : 4) over 60 less 70, 6(m : 0, w : 6) over 70 less 80, and 4(m : 1, w : 3) over 80. The average age is 64.5 years old. The method to collect the data is 20 structured opening questionaires that are based on references. The duration to collect datas is 11days from 4th, Aprill 1997 to 14th, Aprill 1997. The workers who are trainned the interview methods went their villages and got answers after explaining the purpose and contents to them. Somtimes they used to record the answers. The analysis was identified the subjectives to four regions of Cheju, arranged answers with items, rearranged the same answers, counted with number and percentage. And classified the materials and characteristics. The results of this study are followed: The things that is used as personal medicines are the effects through experiences ans misteries that have hand down by word of mouth, even though they are not scientific. People used the materials arround their circumference. It is an accumulation of experiences. The ways used in eating, doing acupuncture or sting, exposing to smoke, wheedling, fixing after pounding. Almost materials are plants. Mugwort is effective in fever, gastritis, hemorrhoid, diarrhea, edematous hands or feet and dermatitis. Citron and Arrowroot in fever, gastritis. Seeds of Pumpkin in indigestive, hemorrhoid, edematous hands or feet. Gallic in fever, diarrhea, frostbite, dermatitis, and toothache. Motherwort in diarrhea, gastritis. Radish juice in indigestive, jaundice. Bean paste in burn, wound. Acupuncture in fever, gastritis, indigestive, back pain, edematous hands or feet. Sting as similar with it in fever, indigestive, edematous hands or feet. Cigarrette in hemorrhoid, wound, toothache. Cowstools in edematous hands or feet, wound. Sault is usded a lot in fever, gastritis, indigestive, hemorrhoid, uneffective voiding, edematous hands or feet, dermatitis, having a boil around the mouth, toothache, and eye disease. Japanese Parsley in fever, gastritis. Egg Apple in diarrhea, edematous hands or feet, frostbite. And Wild Chrysanthemum is effective in jaundice. In the conclusion, people used the things arround. A things is effective in several symptoms. If these are not effective, they would used the magic as god's anger. As locally, they used the grasses and fruits in the middle of Mt. Halla and seafood on the sea village.

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병원 급식 및 영양 서비스를 개선하기 위한 정보시스템 구축 (An Information System Building to Improve the Food and Nutrition Services in Hospitals)

  • 이재선;신해웅;김성태
    • 한국컴퓨터산업학회논문지
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    • 제3권1호
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    • pp.9-18
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    • 2002
  • 최근 의료환경의 변화와 함께 병원 간 경쟁이 더욱 심화되어 병원경영의 목표가 새로 정립되고 있다. 이러한 목표를 달성하기 위해 진료지원부서인 병원 급식 및 영양 서비스 분야에서도 혁신적인 방안을 모색하고 있다. 모색된 여러 가지 방안들을 구체적으로 실행하는데 있어 전산화를 기반으로 한 정보시스템의 구축은 필수적이다. 본 연구에서는 병원 급식 및 영양서비스분야에서 사용하고 있는 각종 정보의 통합적 관리를 위한 정보시스템을 구축하고자 하였다. 기존의 단순 반복적인 업무들을 전산화하는 것은 물론이고, 병원 정보시스템과 유기적으로 연계할 수 있는 정보시스템 구축을 통해 급식분야의 생산성을 향상시키고, 비용 절감의 효과를 얻고자 하였다. 이는 병원 경영의 효율성을 제고하고 타 병원에 대한 경쟁력을 확보할 뿐 아니라 궁극적으로는 최고의 환자 식사 서비스 만족을 도모하는데 큰 역할을 할 것이다. 본 연구를 통해 구축된 병원 급식 및 영양서비스 분야의 정보시스템을 TASTY(Time-based Advanced Service Technology for Yong-Dong Severance Hospital, Nutrition Department)라 명명하였다. TASTY는 식단관리, 구매관리, 임상영양서비스관리, 작업관리, 급식경영분석의 5가지 업무 분야와 이들의 바탕이 되는 기본 정보관리 업무를 수행한다.

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대학시설물 관리W떠 PDA기반의 실시간 Mobile GIS 도입 타당성 평가 (Validity Evaluation of Real Time Mobile GIS combined with PDA in University Building Facility Management)

  • 정지훈;엄정섭
    • Spatial Information Research
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    • 제11권1호
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    • pp.41-60
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    • 2003
  • 책자형태의 대학시설물 도면에서 공간정보의 부정확, 도면의 유지보수의 한계, 현장에서 유지보수 등 작업과 GIS-DB구축간에 이원화된 작업으로 인한 경제적 비효용 등이 문제점으로 지적되어왔다 본 연구에서는 이러한 문제에 대한 대안을 제시하기 위해 시설물 도면을 현장 실무자가 작업현장에서 실시간으로 입·출력하는 시스템의 도입가능성을 평가하고자 하였다. 제안된 기법은 무선 네트워크, 이동 컴퓨팅 등의 최근 정보 통신 환경의 변화 동향을 바탕으로 PDA를 기반으로 하여 작업현장에서 도면을 수정·갱신할 수 있는 실시간 Mobile GIS를 상정하였다. 구축된 시스템을 평가하기 위한 기준에는 다양한 관점이 있을 수 있으나 본 연구에서는 대학시설물 관리자가 기존의 시스템에서 직면한 문제를 해소할 수 있는 지 여부에 주안점을 두고 3종류의 품질 평가기준이 도출되었다: (1) 데이터 검색 (2) 공간분석 (3) 실시간 데이터 갱신. 실제 서비스를 수행하면서 평가기준에 의거 시스템의 가능성을 검증하여 보았다. 본시스템을 이용함으로써 현지 작업인력이 시설물 점검 등 관련업무에서 보다 정확한 위치정보를 확보할 수 있게 되었다. 아울러 작업과정에서 다양한 도면을 실시간으로 직접 확인하여 현재 시설물 상황과 비교함으로서 시설물의 시·공간적 변화 추이를 반영한 공간분석이 이루어질 수 있었다. 또한 이동 컴퓨팅에 의거한 시스템을 통해 작업현장에서 실시간으로 GIS 데이터베이스를 구축할 수 있게 되었다. 본 연구는 실제적인 실시간 Mobile GIS 도입을 위한 개념 및 요구 사항, 구조, 동작 모델에 대해 향후 무선통신 등 관련 기술이 일반화되었을 경우를 대비한 기초연구를 수행하였다는데 큰 의의가 있을 것이다. 본 연구가 전통적인 책자도면 기반의 대학시설물 관리의 한계를 극복할 수 있는 계기가 되어 적은 인력과 예산으로도 대학시설물에 대하여 표준화된 실시간 GIS구축에 중요한 참고자료가 될 수 있을 것으로 사료된다.

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국민건강증진을 위한 보건교육확대방안에 관한 연구 (Expanding Health Education Plan For Improving Public Health)

  • 윤기선;박정열
    • 한국콘텐츠학회논문지
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    • 제15권3호
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    • pp.303-317
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    • 2015
  • 본 연구는 국민건강증진을 위해 보건교육기관에서 실시하던 보건교육을 평생교육원의 보건교육으로 확대하여 보건교육의 기회 폭을 넓혀 누구나 쉽게 가까운 장소에서 보건교육을 받을 수 있는 기회를 제공함으로서 보건교육을 증진시키고 의료비용을 절감 할 수 있는 방안을 제시하고자 한다. 즉 국민건강증진향상을 위한 보건교육확대방안에 관한 연구를 분석하고자 20대 이상 보건교육을 필요로 하는 남 여를 대상으로 보건프로그램이나 교육에 참가한 사람 중 무작위 추출법을 사용하여 연구표본을 선정하였다. 수집된 자료의 통계처리는 데이터 코딩과 데이터 크리닝 과정을 거쳐 SPSS 20.0 for Windows 통계 패키지 프로그램을 활용하였고 분석한 결과는 다음과 같다. 국민건강증진의 교육과 질병예방 및 영양개선 그리고 식생활개선은 보건교육확대에 영향을 주는 것으로 조사되었으나, 참가의향에는 영향을 주지 않는 것으로 조사되었으며, 보건교육지원이나 건강보험혜택과 교육장소 확대는 참가의향에 영향을 주는 것으로 조사되었다. 또한 참가의향이 높을수록 의료비절감도 높아지는 것으로 나타났다. 그리고 국민건강증진의 교육과 질병예방은 의료비절감에 영향을 주지 않으나, 영양개선 및 식생활개선, 보건교육지원, 건강보험혜택 그리고 교육장소 확대는 의료비절감에 영향을 주는 것으로 조사되었다.

농촌(農村) 주민(住民)들의 의료필요도(醫療必要度)에 관(關)한 연구(硏究) (A Study Concerning Health Needs in Rural Korea)

  • 이성관;김두희;정종학;정극수;박상빈;최정헌;홍순호;라진훈
    • Journal of Preventive Medicine and Public Health
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    • 제7권1호
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    • pp.29-94
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    • 1974
  • Today most developed countries provide modern medical care for most of the population. The rural area is the more neglected area in the medical and health field. In public health, the philosophy is that medical care for in maintenance of health is a basic right of man; it should not be discriminated against racial, environmental or financial situations. The deficiency of the medical care system, cultural bias, economic development, and ignorance of the residents about health care brought about the shortage of medical personnel and facilities on the rural areas. Moreover, medical students and physicians have been taught less about rural health care than about urban health care. Medical care, therefore, is insufficient in terms of health care personnel/and facilities in rural areas. Under such a situation, there is growing concern about the health problems among the rural population. The findings presented in this report are useful measures of the major health problems and even more important, as a guide to planning for improved medical care systems. It is hoped that findings from this study will be useful to those responsible for improving the delivery of health service for the rural population. Objectives: -to determine the health status of the residents in the rural areas. -to assess the rural population's needs in terms of health and medical care. -to make recommendations concerning improvement in the delivery of health and medical care for the rural population. Procedures: For the sampling design, the ideal would be to sample according to the proportion of the composition age-groups. As the health problems would be different by group, the sample was divided into 10 different age-groups. If the sample were allocated by proportion of composition of each age group, some age groups would be too small to estimate the health problem. The sample size of each age-group population was 100 people/age-groups. Personal interviews were conducted by specially trained medical students. The interviews dealt at length with current health status, medical care problems, utilization of medical services, medical cost paid for medical care and attitudes toward health. In addition, more information was gained from the public health field, including environmental sanitation, maternal and child health, family planning, tuberculosis control, and dental health. The sample Sample size was one fourth of total population: 1,438 The aged 10-14 years showed the largest number of 254 and the aged under one year was the smallest number of 81. Participation in examination Examination sessions usually were held in the morning every Tuesday, Wenesday, and Thursday for 3 hours at each session at the Namchun Health station. In general, the rate of participation in medical examination was low especially in ages between 10-19 years old. The highest rate of participation among are groups was the under one year age-group by 100 percent. The lowest use rate as low as 3% of those in the age-groups 10-19 years who are attending junior and senior high school in Taegu city so the time was not convenient for them to recieve examinations. Among the over 20 years old group, the rate of participation of female was higher than that of males. The results are as follows: A. Publie health problems Population: The number of pre-school age group who required child health was 724, among them infants numbered 96. Number of eligible women aged 15-44 years was 1,279, and women with husband who need maternal health numbered 700. The age-group of 65 years or older was 201 needed more health care and 65 of them had disabilities. (Table 2). Environmental sanitation: Seventy-nine percent of the residents relied upon well water as a primary source of dringking water. Ninety-three percent of the drinking water supply was rated as unfited quality for drinking. More than 90% of latrines were unhygienic, in structure design and sanitation (Table 15). Maternal and child health: Maternal health Average number of pregnancies of eligible women was 4 times. There was almost no pre- and post-natal care. Pregnancy wastage Still births was 33 per 1,000 live births. Spontaneous abortion was 156 per 1,000 live births. Induced abortion was 137 per 1,000 live births. Delivery condition More than 90 percent of deliveries were conducted at home. Attendants at last delivery were laymen by 76% and delivery without attendants was 14%. The rate of non-sterilized scissors as an instrument used to cut the umbilical cord was as high as 54% and of sickles was 14%. The rate of difficult delivery counted for 3%. Maternal death rate estimates about 35 per 10,000 live births. Child health Consultation rate for child health was almost non existant. In general, vaccination rate of children was low; vaccination rates for children aged 0-5 years with BCG and small pox were 34 and 28 percent respectively. The rate of vaccination with DPT and Polio were 23 and 25% respectively but the rate of the complete three injections were as low as 5 and 3% respectively. The number of dead children was 280 per 1,000 living children. Infants death rate was 45 per 1,000 live births (Table 16), Family planning: Approval rate of married women for family planning was as high as 86%. The rate of experiences of contraception in the past was 51%. The current rate of contraception was 37%. Willingness to use contraception in the future was as high as 86% (Table 17). Tuberculosis control: Number of registration patients at the health center currently was 25. The number indicates one eighth of estimate number of tuberculosis in the area. Number of discharged cases in the past accounted for 79 which showed 50% of active cases when discharged time. Rate of complete treatment among reasons of discharge in the past as low as 28%. There needs to be a follow up observation of the discharged cases (Table 18). Dental problems: More than 50% of the total population have at least one or more dental problems. (Table 19) B. Medical care problems Incidence rate: 1. In one month Incidence rate of medical care problems during one month was 19.6 percent. Among these health problems which required rest at home were 11.8 percent. The estimated number of patients in the total population is 1,206. The health problems reported most frequently in interviews during one month are: GI trouble, respiratory disease, neuralgia, skin disease, and communicable disease-in that order, The rate of health problems by age groups was highest in the 1-4 age group and in the 60 years or over age group, the lowest rate was the 10-14 year age group. In general, 0-29 year age group except the 1-4 year age group was low incidence rate. After 30 years old the rate of health problems increases gradually with aging. Eighty-three percent of health problems that occured during one month were solved by primary medical care procedures. Seventeen percent of health problems needed secondary care. Days rested at home because of illness during one month were 0.7 days per interviewee and 8days per patient and it accounts for 2,161 days for the total productive population in the area. (Table 20) 2. In a year The incidence rate of medical care problems during a year was 74.8%, among them health problems which required rest at home was 37 percent. Estimated number of patients in the total population during a year was 4,600. The health problems that occured most frequently among the interviewees during a year were: Cold (30%), GI trouble (18), respiratory disease (11), anemia (10), diarrhea (10), neuralgia (10), parasite disease (9), ENT (7), skin (7), headache (7), trauma (4), communicable disease (3), and circulatory disease (3) -in that order. The rate of health problems by age groups was highest in the infants group, thereafter the rate decreased gradually until the age 15-19 year age group which showed the lowest, and then the rate increased gradually with aging. Eighty-seven percent of health problems during a year were solved by primary medical care. Thirteen percent of them needed secondary medical care procedures. Days rested at home because of illness during a year were 16 days per interviewee and 44 days per patient and it accounted for 57,335 days lost among productive age group in the area (Table 21). Among those given medical examination, the conditions observed most frequently were respiratory disease, GI trouble, parasite disease, neuralgia, skin disease, trauma, tuberculosis, anemia, chronic obstructive lung disease, eye disorders-in that order (Table 22). The main health problems required secondary medical care are as fellows: (previous page). Utilization of medical care (treatment) The rate of treatment by various medical facilities for all health problems during one month was 73 percent. The rate of receiving of medical care of those who have health problems which required rest at home was 52% while the rate of those who have health problems which did not required rest was 61 percent (Table 23). The rate of receiving of medical care for all health problems during a year was 67 percent. The rate of receiving of medical care of those who have health problems which required rest at home was 82 percent while the rate of those who have health problems which did not required rest was as low as 53 percent (Table 24). Types of medical facilitied used were as follows: Hospital and clinics: 32-35% Herb clinics: 9-10% Drugstore: 53-58% Hospitalization Rate of hospitalization was 1.7% and the estimate number of hospitalizations among the total population during a year will be 107 persons (Table 25). Medical cost: Average medical cost per person during one month and a year were 171 and 2,800 won respectively. Average medical cost per patient during one month and a year were 1,109 and 3,740 won respectively. Average cost per household during a year was 15,800 won (Table 26, 27). Solution measures for health and medical care problems in rural area: A. Health problems which could be solved by paramedical workers such as nurses, midwives and aid nurses etc. are as follows: 1. Improvement of environmental sanitation 2. MCH except medical care problems 3. Family planning except surgical intervention 4. Tuberculosis control except diagnosis and prescription 5. Dental care except operational intervention 6. Health education for residents for improvement of utilization of medical facilities and early diagnosis etc. B. Medical care problems 1. Eighty-five percent of health problems could be solved by primary care procedures by general practitioners. 2. Fifteen percent of health problems need secondary medical procedures by a specialist. C. Medical cost Concidering the economic situation in rural area the amount of 2,062 won per residents during a year will be burdensome, so financial assistance is needed gorvernment to solve health and medical care problems for rural people.

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한국제조업에서의 외부통제에 관한 공간적 분석 (The geography of external control in Korean manufacturing industry)

  • 백영기
    • 대한지리학회지
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    • 제30권2호
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    • pp.146-168
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    • 1995
  • 본 연구는 기업의 외부통제에 관한 개념적인 논의와 함께, 한국의 제조업에서 80년 대 중반 이후(1986-1992)에 나타난 통제의 공간적 변화를 경험적으로 조사하였다. 15개의 지역 사이에 다입지 기업의 소유연계에 대한 자료가 외부통제의 대체척도로 이용되었다. 이 자료를 근거로 생산과정의 특성에 따른 세가지 유형의 제조업 부문별로 통제의 변화를 지도 화하여 분석하였다. 전반적인 외부통제의 지리적 특징은 서울이 탁월한 통제의 중심지로서, 서울의 영향력은 수도권과 동남권의 산업발달 지역에 집중되었지만, 최근에 그 영향력은 산 업이 낙후된 지역까지 확산되어 전국적이다. 또한 새로운 통제의 중심지로 수도권과 동남권 의 중심인 대도시가 서서히 부각되고 있다. 이러한 특징에도 불구하고, 제조업 유형별로 상 이한 외부통제의 공간적 패턴은 생산의 조직구조가 생산과정에서 필요로 하는 자본과 노동 은 물론 부문이 처한 외부환경에 따라 변화됨을 보여준다. 이러한 결과는 상이한 생산과정 을 채택하는 다입지 기업의 공간적 영향에 차별적 분석을 요구한다.

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요통환자들의 성생활 행태와 영향 요인 조사 (A survey on sex life behavior and factors of low back pain)

  • 남철현;우광석
    • 대한물리치료과학회지
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    • 제9권3호
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    • pp.31-49
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    • 2002
  • The purpose of this study was to investigate discomforts and sexual life and to identify the relation between the discomforts and sexual life with low back pain. The data were collected from March 2 through July 31, 2001. Four hundred forty-two questionnaires were returned (response rate=88.0%). Analysis of the data was done with SPSS PC+ and use descriptive statistics, $x^2$-test, t-test, ANOVA. regression. The statistics shows that over than 80% of the adults experienced lumbago at least one time in their life, and Back pain is known as one of the most common complaints made by the patients of all ages in the general hospital or local medical clinics throughout. However, in certain case it leads to a chronic condition which can cause a great deal of problems in management and in financial burden to individuals and society. The result of this study was summarized as follows: 1) It appeared that regarding the distribution of gender, male was the higher(63.6%) then that of female, the portion of forties was 28.5%. Sitting for long time was 23.1% in men and 21.7% in women. Unknown reason including sexual behaviour was 12.9% in men and 15.5% in women. Patients treated medicine and physical therapy were 36.4%. In level of educational background, the rate of high school was 31.0%, technical college was 28.5%. The highest proportion by occupation was 18.3% of office workers, occupation posture was 41.9% of sitting. 2) Men(26.0%) and most of women(34.8%) were not satisfied in the explanation satisfaction rate of sex life concerned disease. 23.8% in men and 23.6% in women considered flexibility of waist good. Man(33.3%) and most of woman(35.0%) considered that Health education is necessary. 32.7% in men and 27.3% in women did't mind educator is whoever. Preventing of lower back pain(LBP) and proper Health education of sex life are demanded in daily life. 3) 58.0% of man and 64.0% of woman mostly had a posture which is man over woman. 28.5% in men and 27.8% in women considered that proper information finding of LBP and sex life was very few and few. 37.7% in men and 42.7% in women have acquired information about sex life flung their friends. 4) The number of sex life was decreased from 2.96 0.98 to 2.61 1.63 and also the time of sex life was decreased from 3.65 1.89 to 226 1.64. The satisfaction rate of sex life changed from 3.60 0.86 to 2.77 1.10. In the number of sex life, The non correct group was 2.62 1.91 and the correct group was higher in 2.68 1.65. In the time of sex life, The non correct group was 2.02 1.47 and the correct group was higher in 229 1.65. The satisfaction rate of sex life was 2.76 0.86 in non correct group and 2.88 1.10 in correct group. So there was a difference. 5) In the satisfaction rate of sex life, Men who have a lower back pain were higher than women and no attack group was higher than attack group. As they had many sex life, the satisfaction rate was higher significantly in statistics. As the time of sex life was short, the satisfaction rate was lower significantly in statistics. As the age was low, the demand rate of Health education was high and as means of patient who had a lower back pain was high, the demand rate of Health education was high. As the patient who had a lower back pain had a long married life, the demand rate of Health education was high and as education level was high, the demand rate of Health education was high. It is necessary to provide patients with conservative treatment, educational teaching, and training to prevent further injuries in the future. In general, it is important to educate the public how to prevent back injuries and how to treat themselves in an onset period to prevent further injuries sliding into a chronic state. Sexuality is an integral part of normal and healthy relationships, but patients are unable to enjoy sex because they are riot able to get into a comfortable position due to back pain. Many conditions of the spine can make certain positions uncomfortable. Health educator should make the education program of the discomforts and the sexual pattern for low back pain in workplace and/or hospital. Further study Is needed on how to integrate the educational program on sexuality into the total rehabilitation program.

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급성(急性) 기아(饑餓)마우스의 간단백질(肝蛋白質), 핵산(核酸) 및 Guanine Deaminase 활성(活性)에 관(關)한 연구(硏究) (A Study on The Content of Liver Protein, Nucleic Acids, and Guanine Deaminase Activity of Mouse During Acute Starvation)

  • 박승희;김승원
    • Journal of Nutrition and Health
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    • 제1권2호
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    • pp.107-115
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    • 1968
  • Number of aspects, not only nutritional but social as well as political involved in human starvation pose nowadays global problems. In order to help establish the minimum nutritional requirements in the daily life of a man and to free people as well from either undernourishment, malnutrition or even starvation many workers have devoted themselves so far on the research programs to know what and how number of metabolic events take place in animals in vivo. It is the purpose of the present paper to examine in effect to what extent both of the protein and nucleic acids (DNA & RNA) together with an enzyme, guanine deaminase, which converts guanine into xanthine and in turn ends up to uric acid as an end product, undergo changes, quantitatively during acute starvation, using the mouse as an experimental animal. The mouse was strictly inhibited from taking foods except drinking water ad libitum and was sacriflced 24, 48, and 72 hours following starvation thus acutely induced. The animals consisted of two experimental groups, one control and another starvation groups, each being consisted of 6-24 mice of whose body weights ranged in the vicinity of 10 g. The animals were sacriflced by a blow on the head, followed by immediate excision of their livers into ice-cold distilled water, washing adherent blood and other contaminant tissues. The liver was minced foramin, by an all-glass homogenizer immersing it in an ice-bath, followed by subsequent fractionatin of the homogenate (10% W/V in 0.25M sucrose solution made up with 0.05M phosphate buffer of pH 7.4). For the liver protein and guanine deaminase assay, the 10% homogenate was centrifuged at 600 x g for 10 minutes to eliminate the nuclear fraction; and for the estimation of DNA and RNA, the homogenate was prepared by the addition of 10% trichloroacetic acid in order to free the homogenate from the acid-soluble fraction, the remaining residue being delipidate by the addition of alcohol and dried in vacuo for later KOH (IN) hydrolysis. The changes in body and liver wegihts during acute starvation were checked gravimetrically. Protein contents in the liver were monitored by the method of Lowry et al; and guanine deaminase activities were followed by the assay of liberated ammonia from the substrate utilizing the Caraway's colorimetry. The extraction of both DNA and RNA was performed by the Schmidt-Thannhauser's method, which was followed by Marmur's method of purification for DNA and by Chargaff's method of purification for RNA. The determinations of both DNA and RNA were carried out by the diphenylamine reaction for the former and by the orcinol reaction for the latter. The following resume was the results of the present work. 1. It was observed that the body as well as liver weights fall abruptly during starvation, and that the loss of body weight showed no statistical correlation with the decreases in the content of liver protein. 2. The content of liver protein and activity of liver guanine deaminase activity as well decline dramatically, and the specific activities of the enzyme (activity/protein), however, decreased gradually as starvation proceeded. 3. Both of the nucleic acids, DNA and RNA, showed decrements in the liver of mouse during acute starvation; the latter, however, being more striking in the decline as compared to the former. 4. The decreases in the liver protein content as resulted from the acute starvation had no statistically significant correlation with the decrements of DNA in the same tissue, but had regressed with a significant statistical correlation with the fall of RNA in the tissue. 5. The decrease in the activity of guanine deaminase in the liver of mouse during acute starvation was functionally more proportional to the decrease in RNA than DNA, and moreover correlated with the changes in the content of the liver protein. 6. The possible mechanisms involved during in this acute starvation as bring the decreases in the contents of DNA, protein, and guanine deaminase were discussed briefly.

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핵의학과 전용화장실에서 측정된 표면오염도 및 공간선량율에 대한 연구 (A Study on the Surface Contamination Level and Spatial Dose Rate Measured from NM Patients-Only Bathroom)

  • 문재승;정희일;정해성;신민용;김수근;박대성;김현기;김화산;이형남;안병필;이동호
    • 핵의학기술
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    • 제16권1호
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    • pp.38-43
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    • 2012
  • 목적 : $^{18}F$-FDG 방사성핵종이 투여된 환자가 사용하는 전용화장실의 표면오염도 및 공간선량율을 측정하여 같은 구역 내에 근무하고 있는 작업종사자들에 미치는 영향에 대하여 고찰해 보고자 한다. 대상 및 방법 : 2011년 1월부터 2011년 6월까지 $^{18}F$-FDG 370 MBq (10 mCi) 방사성핵종이 투여된 후 전용화장실을 1회 사용한 대상 환자는 본원이 60case(그룹1), 부천성모병원은 일평균 환자 수에 따라 50case(그룹2)와 10case(그룹3)으로 분류하였다. 방사선 측정기를 이용한 측정시간은 08:00, 10:00, 13:00, 15:00, 17:00이었으며 측정부위는 좌변기 4부위, 세면대, 휴지통이었다. 병원별 전용화장실의 3개월간 피폭누적량을 측정하였으며 PET/CT를 운영하는 병원을 대상으로 설문조사를 실시하여 전용화장실 유무 및 종사자들의 이용현황에 대하여 알아보았다. 결과 : 그룹1, 그룹2, 그룹3에 대한 일평균 환자 수는 $12.18{\pm}1.33$명, $6.62{\pm}2.21$명, $10.5{\pm}1.58$명이었다. 그룹1, 그룹2, 그룹3에 대한 좌변기의 평균 표면오염도($Bq/cm^2$)는 $8.38{\pm}4.56$, $2.64{\pm}3.90$, $4.59{\pm}4.38$로 그룹1에서의 표면오염도가 그룹2, 그룹3보다 높은 것으로 나타났으나($p$<0.05) 1 m 높이에서의 표면오염도 및 공간선량율에서는 그룹3, 그룹2, 그룹1순으로 높게 나타났다($p$<0.05). 그룹1에서의 세면대 및 휴지통의 표면오염도($Bq/cm^2$)는 $0.12{\pm}0.12$, $25.26{\pm}22.55$이었다. 표면오염도 수준을 단계별로 구분하여 제시하여 보았을 때 측정시간별 표면오염도 차이는 그룹1이 그룹2, 그룹3보다 높게 나타났다($p$<0.05). 개인피폭선량계를 이용하여 측정된 피폭누적량은 본원이 0.78 mSv/3개월, 부천성가병원이 0.37 mSv/3개월이었다. 전용화장실의 공동사용에 대한 설문조사에서 조사대상 31개 병원 중에 16.12%인 5개병원에서 환자와 함께 이용하는 것으로 나타났다. 결론 : 일평균 환자수가 많을수록 전용화장실의 표면오염도가 높아지는 것으로 나타났다. 특히 휴지통의 표면오염도는 원자력법에서 고시하고 있는 기준값인 $4Bq/cm^2$를 훨씬 초과한 것으로 나타났으나 화장실 전체공간에 대한 피폭누적량은 작게 나타났다. 설문조사 결과를 참조해 볼 때 환자들과 같이 사용하는 기관들이 있었음으로 전용화장실 이용에 대한 특별한 주의와 적절한 제염이 필요할 것으로 사료된다.

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