• BMB Reports
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• v.54 no.7
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• pp.335-343
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• 2021

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss of NUMB expression leads to uncontrolled proliferation and amplification of the CSC pool, which promotes the Notch signaling pathway and reduces the expression of the p53 protein. NUMB genes are alternatively spliced to produce six functionally distinct isoforms. An interesting recent discovery is that the protein NUMB isoform produced by alternative splicing of NUMB plays an important role in promoting carcinogenesis. In this review, we summarize the known functions of NUMB and NUMB isoforms related to the proliferation and generation of CSCs.

• Development and Reproduction
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• v.16 no.4
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• pp.371-378
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• 2012

Notch signaling plays fundamental roles in various animal development. It has been suggested that Hr-Notch, a Notch homologue in the ascidian Halocynthia roretzi, is involved in the formation of peripheral neurons by suppressing the neural fates and promoting the epidermal differentiation. However, roles of Notch signaling remain controversial in the formation of nervous system in ascidian embryos. To precisely investigate functions of Notch signaling, we have isolated and characterized Hr-Numb, a Numb homologue which is a negative regulator of Notch signaling, in H. roretzi. Maternal expression of Hr-Numb mRNAs was detected in egg cytoplasm and the transcripts were inherited by the animal blastomeres. Its zygotic expression became evident by the early neurula stage and the transcripts were detected in dorsal neural precursor cells. Suppression of Hr-Numb function by an antisense morpholino oligonucleotide resulted in larvae with defect in brain vesicle and palps formation. Similar results have been obtained by overexpression of the constitutively activated Hr-Notch forms. Therefore, these results suggest that Hr-Numb is involved in Notch signaling during ascidian embryogenesis.

• Journal of Oral Medicine and Pain
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• v.36 no.4
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• pp.253-259
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• 2011

Numb chin syndrome, is a rare neuropathy, characterized by facial and oral numbness restricted to the distribution of the mental nerve. Even though this neuropathy is uncommon, but this still has an important clinical meaning because it can be related with a malignancy. Because orofacial symptoms can even present the first clinical feature of a malignancy, dentists should pay careful attention to their meaning and importance to detect the malignant tumor early. Moreover, patients who present with a sudden numbness on chin should be investigated for the undiagnosed malignancy. In this report, we described a patient with stabbing orofacial pain and numbness of chin who was diagnosed with diffuse large B-cell lymphoma and placed the importance on the diagnosis of NCS.

• Tuberculosis and Respiratory Diseases
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• v.53 no.1
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• pp.46-51
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• 2002

Numb chin syndrome is a rare clinical manifestation, characterized by focal sensory loss and paresthesia of the chin. It is more often associated with cancer than with benign disorders, and can be the first manifestation of a cancer. A 60-year-old man presented with focal numbness of right chin and gingiva for 10 days. Chest computed tomograghy showed a 3 cm sized mass on the distal left main- stem bronchus. Squamous cell carcinoma was diagnosed on bronchoscopic biopsy. However, bony metastasis of mandible was not evident on reontgenogram, CT scan, bone scintigram and positron emission tomography. Despite the chemotherapy with three cycles of paclitaxel and cisplatinum, the cancer was progressed and pain on the right chin was developed 4 months later. Bone scintigram showed multiple bony metastasis including mandible. Here we report this case with a brief review of the appropriate literature.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.42 no.5
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• pp.301-306
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• 2016

The purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate. Numb chin syndrome (NCS), which was associated with this case, is also discussed. Computed tomography (CT) and an intraoral incisional biopsy of the left mandibular area were performed. Urology consultation, hormone therapy, chemotherapy and follow-up radiographic images were administered. Histological examination of the incised specimen revealed moderately differentiated adenocarcinoma. The Gleason score was 8 (primary 4/secondary 4). Immunohistochemical features and radiographic results confirmed the diagnosis of metastasis from prostate adenocarcinoma, moderately differentiated. The patient's prostate-specific antigen (PSA) level was very high. After hormone treatment, the patient's PSA levels dropped gradually. Seventeen months later, in May 2015, the PSA level was elevated. The 18-month follow-up CT image indicated that the patient's condition was aggravated. Docetaxel chemotherapy was started in June 2015 (18 months later), and the sixth cycle of the therapy is in progress. Oral metastases that originate from prostate adenocarcinoma are rare and can induce various periosteal reactions. Hormone therapy, chemotherapy and close follow-up could be additional, appropriate treatment, and were applied in this case. Finally, NCS is a valuable indicator of metastatic disease in the mandible.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.879-892
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• 2003

This thesis makes a review of symptoms and cause of the numbness in the literature. clinical case are studied and classified according to the Hyungsang of the patients. The followings are the conclusions: In case of Dam type persons, numbness is mainly caused by Fire with blood deficiency and so cured by tonifying the Jung and blood. In case of Bang Kwang type persons. it is generally caused by the deficiency of Ki and damp-phlegm and treated by reinforcing Ki and removing dampness. Persons of Jung and Hyal types are apt to be afflicted with numbness of deficiency symptoms which can be cured by tonifying the Jung and blood. Those of Ki and Shin types are inclined to get numb from the congestion and stagnancy and so treated by promotion the flow of Ki, dispelling stagnancy, resolving phlegm and promoting digestion. Numbness is common to the old people and women. The deficiency of blood and primordial energy is a cause of old people's numbness. Women get numb due to the pent-up feelings and emotional disturbance. The function disharmony of five Jang and six Bu makes the body lose the control of heat and cold or deficiency and excessiveness, which can be a cause of numbness. Especially the deficiency of the spleen results in numbness. When the special parts of the body become numb treatment must be decided after due consideration on which of the Jang and Bu or meridians is related to that affected area. In case of person with six meridian types. unbalance of Ki and blood leads the six atmospheric influences(wind, cold, heat, dampness, dryness and fire) get into the body through the most developed meridian and brings in numbness.

• Journal of agricultural medicine and community health
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• v.19 no.1
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• pp.5-13
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• 1994

To investigate the cause of Farmers' Syndrome, this study was done in some rural areas of Kyoungsangam Province, from July to August of 1993. 117 men and 112 women were completed interview, medical examination and laboratory examination. The results were as follows. 1. The prevalence of Farmers' Syndrome in women was 509 per 1,000 and it was significantly higher than that in men, 329 per 1,000(p=0.0026). Prevalence of age adjusted with rural population of Kyungsangnam Province of 1985 was 204 per 1,000 in men and 383 per 1,000 in women. The average age of subjects with Farmers' Syndrome, 58.9 was significantly higher than that of subjects without Farmers' Syndrome, 53.2(p<0.001). 2. The most frequent symptom was lumbago(27.7%), and the second was numb limbs(21.6%), and the third was shoulder stiffness(20.9%). Less than 10% of study subjects complained of breathlessness, sleeplessness, dizziness. Women complained of shoulder stiffness(p<0.001), lumbago(p<0.001), numb limbs(p<0.05), dizziness(p<0.001), abdominal fullness(p<0.001) significantly frequently than men. 3. Those aged 50 or more complained of shoulder stiffness(p<0.001), lumbago(p<0.01), numb limbs(p<0.001), nocturia(p<0.001), breathlessness(p<0.05), sleeplessness (p<0.05) and dizziness(p<0.05) significantly frequently than those aged less than 50. 4. By logistic regression, the risk factors significantly associated with Farmers' Syndrome were age(odds ratio(OR)=1.05, 95% confidence interval(CI) 1.02-1.07), sex(OR of 75,95% CI 0.58-0.97), and mental stress(OR=1.39, 95% CI 1.03-1.86). 5. By logistic regression, the risk factors significantly associated with each component symptom of Farmers' Syndrome were as follows. There were significant associations between sex(OR of male=0.51) with shoulder stiffness, age(OR=1.04) and mental stress(OR=1.72) with lumbago, age(OR=1.06), regular exercise(OR=0.35) and mental stress(OR=1.63) with numb limbs, age(OR=1.06) and abnormal LFT(OR=1.59) with nocturia, age(OR=1.08) with breathlessness, sex(OR of male=0.56) with dizziness respectively.

• Asian Oncology Nursing
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• v.9 no.2
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• pp.145-154
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• 2009

Purpose: The purpose of this study was to obtain information about the experiences of sensations after breast cancer surgery characterized by prevalence, frequency, and severity, distresses, and disturbances in ADL using the BSAS (Breast Sensation Assessment Scale) and to develop the standardized Korean BSAS. Methods: Thirty two women from 3 to 100 days after breast cancer surgery (BCS) completed Roberta's BSAS. The 18 sensations of BSAS were translated using the references of Lee's Korean Pain Rating Scale and English-English, English-Korean dictionaries and the consultation from two native Americans, one bilingual permanent resident of the States, and one nursing professor. The Korean-translated BSAS has high reliability in test-retest. Likert type 4-point scale and 100 mm VAS were used for assessment. Results: Certain sensations remained prevalent (tender, pull, pain), frequent (numb, nag, throb), severe (throb, shoot, numb), causing distress (throb, penetrate, shoot), and influencing on ADL (throb, penetrate, nag). The most frequently experienced sensation other than BSAS was itching. There was little difference in the prevalence of symptom experiences between sentinel lymph node biopsy and axillary lymph node dissection. Conclusion: The women after BCS are suffering from neuropathic sensations. The Korean- translated BSAS could be used in effectively assessing breast sensations after BCS in Korean women.

• Journal of Oral Medicine and Pain
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• v.41 no.4
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• pp.200-204
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• 2016

Numb chin syndrome, or mental neuropathy is a rare sensory neuropathy characterized by abnormal sensation such as hypoesthesia, paresthesia, or dysesthesia in the chin and lower lip innervated by the mental nerve. Sensory neuropathy of mental nerve is somewhat familiar to dentists because it can occur following nerve damage by trauma or dental treatment such as implant surgery or third molar extraction. It can also result from dental causes including abscess or osteomyelitis. However, it can be the first sign of the systemic disease or malignancy if it is not related to dental causes. In this study, we present the case of a patient who present with hypoesthesia and pain in chin area without other symptoms and is later diagnosed with diffuse large B-cell lymphoma.

• Korean Journal of Mathematics
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• v.22 no.3
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• pp.501-516
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• 2014

We define the class of almost ${\omega}_1-p^{\omega+n}$-projective abelian p-primary groups and investigate their basic properties. The established results extend classical achievements due to Hill (Comment. Math. Univ. Carol., 1995), Hill-Ullery (Czech. Math. J., 1996) and Keef (J. Alg. Numb. Th. Acad., 2010).