Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지
DOI QR코드

DOI QR Code

Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report

  • Kim, Il-Kyu (Division of Oral and Maxillofacial Surgery, Department of Dentistry, Inha University School of Medicine) ;
  • Lee, Dong-Hwan (Division of Oral and Maxillofacial Surgery, Department of Dentistry, Inha University School of Medicine) ;
  • Cho, Hyun-Young (Division of Oral and Maxillofacial Surgery, Department of Dentistry, Inha University School of Medicine) ;
  • Seo, Ji-Hoon (Division of Oral and Maxillofacial Surgery, Department of Dentistry, Inha University School of Medicine) ;
  • Park, Seung-Hoon (Department of Oral and Maxillofacial Surgery, Catholic Kwandong University International St. Mary's Hospital) ;
  • Kim, Joon-Mee (Department of Pathology, Inha University School of Medicine)
  • Received : 2016.04.20
  • Accepted : 2016.08.17
  • Published : 2016.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate. Numb chin syndrome (NCS), which was associated with this case, is also discussed. Computed tomography (CT) and an intraoral incisional biopsy of the left mandibular area were performed. Urology consultation, hormone therapy, chemotherapy and follow-up radiographic images were administered. Histological examination of the incised specimen revealed moderately differentiated adenocarcinoma. The Gleason score was 8 (primary 4/secondary 4). Immunohistochemical features and radiographic results confirmed the diagnosis of metastasis from prostate adenocarcinoma, moderately differentiated. The patient's prostate-specific antigen (PSA) level was very high. After hormone treatment, the patient's PSA levels dropped gradually. Seventeen months later, in May 2015, the PSA level was elevated. The 18-month follow-up CT image indicated that the patient's condition was aggravated. Docetaxel chemotherapy was started in June 2015 (18 months later), and the sixth cycle of the therapy is in progress. Oral metastases that originate from prostate adenocarcinoma are rare and can induce various periosteal reactions. Hormone therapy, chemotherapy and close follow-up could be additional, appropriate treatment, and were applied in this case. Finally, NCS is a valuable indicator of metastatic disease in the mandible.

Keywords

References

  1. Shen ML, Kang J, Wen YL, Ying WM, Yi J, Hua CG, et al. Metastatic tumors to the oral and maxillofacial region: a retrospective study of 19 cases in West China and review of the Chinese and English literature. J Oral Maxillofac Surg 2009;67:718-37. https://doi.org/10.1016/j.joms.2008.06.032
  2. Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity: pathogenesis and analysis of 673 cases. Oral Oncol 2008;44:743-52. https://doi.org/10.1016/j.oraloncology.2007.09.012
  3. Aksoy S, Orhan K, Kursun S, Kolsuz ME, Celikten B. Metastasis of prostate carcinoma in the mandible manifesting as numb chin syndrome. World J Surg Oncol 2014;12:401. https://doi.org/10.1186/1477-7819-12-401
  4. Daley T, Darling MR. Metastases to the mouth and jaws: a contemporary Canadian experience. J Can Dent Assoc 2011;77:b67.
  5. Menezes JD, Cappellari PF, Capelari MM, Gonçalves PZ, Toledo GL, Toledo Filho JL, et al. Mandibular metastasis of adenocarcinoma from prostate cancer: case report according to epidemiology and current therapeutical trends of the advanced prostate cancer. J Appl Oral Sci 2013;21:490-5. https://doi.org/10.1590/1679-775720130148
  6. Saijo H, Chikazu D, Mori Y, Hikiji H, Yonehara Y, Takato T. Metastasis of prostate cancer to the mandibular condyle. Asian J Oral Maxillofac Surg 2008;20:86-8. https://doi.org/10.1016/S0915-6992(08)80016-7
  7. Tchan MC, George M, Thomas M. Metastatic prostate cancer mimicking primary osteosarcoma of the jaw: an infrequent clinical case. South Med J 2008;101:657-9. https://doi.org/10.1097/SMJ.0b013e318172f6dc
  8. Soares EC, Costa FW, Rocha-Filho FD, Ferreira FV, Alves AP. Metastatic prostate adenocarcinoma associated with numb chin syndrome. J Craniofac Surg 2011;22:2366-8. https://doi.org/10.1097/SCS.0b013e318231e5a1
  9. Zaheer F, Hussain K, Rao J. Unusual presentation of 'numb chin syndrome' as the manifestation of metastatic adenocarcinoma of the lung. Int J Surg Case Rep 2013;4:1097-9. https://doi.org/10.1016/j.ijscr.2013.08.024
  10. Narendra H, Ray S. Numb chin syndrome as a manifestation of metastatic squamous cell carcinoma of esophagus. J Cancer Res Ther 2009;5:49-51. https://doi.org/10.4103/0973-1482.48771
  11. Evans RW, Kirby S, Purdy RA. Numb chin syndrome. Headache 2008;48:1520-4. https://doi.org/10.1111/j.1526-4610.2008.01302.x
  12. Wenaden AE, Szyszko TA, Saifuddin A. Imaging of periosteal reactions associated with focal lesions of bone. Clin Radiol 2005;60:439-56. https://doi.org/10.1016/j.crad.2004.08.017
  13. Reyes Court D, Encina S, Levy I. Prostatic adenocarcinoma with mandibular metastatic lesion: case report. Med Oral Patol Oral Cir Bucal 2007;12:E424-7.

Cited by

  1. Prognosis of hepatocellular carcinoma metastasizing to the oral cavity vol.43, pp.1, 2016, https://doi.org/10.1186/s40902-021-00294-7