• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.86-86
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• 2003

In a continuous effort to develop novel anticancer agents we newly synthesized and evaluated the antitumor activity of nucleoside analogues. One analogue, 4 - ［2-Chlor-6- (3-iodo- benzy lamino) -purin -9-yl］- 2,3-dihydroxy-cyclopentanecarbo xylic acid methylamide (LJ-331), has been shown to exert a potent inhibition of human cancer cell growth in vitro including human lung (A549), stomach (SNU-638) and leukemia (HL-60) cancer cells. Following mechanism of action study revealed that LJ - 331induces cell cycle arrest at the G1 phase in HL-60 cells and evokes apoptotic phenomena such as an increase in DNA ladder intensity and chromatin condensation by a dose- and time-dependent manner. LJ-331 also activated the caspase-3 activity in HL-60. This result suggests that the growth inhibition of human cancer cells by LJ-331 might be related to the cell cycle arrest and induction of apoptosis.

• Journal of Integrative Natural Science
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• v.13 no.1
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• pp.1-7
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• 2020

This paper proposes a novel fractional frequency reuse(FFR) based on dynamic user distribution. In the FFR, a macro cell is divided into two regions, i.e., the inner region(IR) and outer region(OR). The criterion for dividing the IR and OR is the distance ratio of the radius. However, these distance-based criteria are uncertain in measuring user performance. This is because there are various attenuation phenomena such as shadowing and wall penetration as well as path loss. Therefore, we propose a novel FFR based on dynamic user classification with signal to interference plus noise ratio(SINR) of macro users and classify the FFR into two regions newly. Simulation results show that the proposed scheme has better performance than the conventional FFR in terms of SINR and throughput of macro cell users.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.90.2-90.2
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• 2003

In a continuous effort to develop novel anticancer agents we newly synthesized and evaluated the antitumor activity of nucleoside analogues. One analogue, 4-[2-Chlor-6-(3-iodo-benzylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid methylamide (LJ-331), has been shown to exert a potent inhibition of human cancer cell growth in vitro including human lung (A549), stomach (SNU-638) and leukemia (HL-60) cancer cells. Following mechanism of action study revealed that LJ-331 induces cell cycle arrest at the G$_1$ phase in HL-60 cells and evokes apoptotic phenomena such as an increase in DNA ladder intensity and chromatin condensation by a dose-and time-dependent manner. (omitted)

• International Journal of Advanced Culture Technology
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• v.10 no.2
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• pp.92-97
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• 2022

This study studied the seasons in the novel Snowy Read and the archetypal characteristics in natural phenomena. Summer and winter are the main seasons of Snowy Road. The cycle of the day is the time of dawn and early morning, evening, or night. It is summer now, and memory day is winter. In Snowy Road, 'I' is in sharp conflict with my mom during the summer season. This conflict is resolved and resurfaced with the feeling of 'love' as the story of the day is told in the mother's memory. It was a long time of conflict and trials for winter in the memory of me and my mother. As a result of examining the circular symbols in the Snowy Road, each symbol represents the 'I' and 'the mother's feelings'. 'I' and 'Mom's Emotions' collide, but they confirm each other's sincerity and rebuild their feelings of conflict with 'love'. In Snowy Road, the mother and son's 'love' shows that the mother's son is deeply in love, but the son's mother's love is also very deep.

• International journal of advanced smart convergence
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• v.2 no.2
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• pp.7-9
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• 2013

Current physics-based simulation is an important tool in the fluid animation. However some problems require a new change to current research trends which depend only on the simulation. The ultimate goal of this project is to obtain information of flow example, analyze an example through machine learning and the novel fluid animation reconfigure without physical simulation.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.16 no.4
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• pp.262-269
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• 2016

In this paper, we propose a novel dynamical love model of Romeo and Juliet, which has an external force with a fuzzy membership function. The external force used in the model has the characteristics of a Gaussian function. The chaotic behavior in the model is demonstrated using time series and phase portraits.

• Journal of Information Display
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• v.10 no.2
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• pp.76-79
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• 2009

In Joule-heating-induced crystallization, solid-to-solid or liquid-to-solid phase transformation could occur. It was found that novel physical phenomena that randomly nucleated liquid seeds, followed by rapid solidification in an amorphous matrix, during the Joule-heating-up period play an important role especially in liquid-to-solid transformation. Under some processing conditions, super-grains sized 6-8 ${\um}m$ were produced by the lateral growth from the initial seeds, without any artificially control.

• Journal of Magnetics
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• v.8 no.1
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• pp.60-69
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• 2003

A review of mechanical sensing techniques based on magnetic methods is presented, with special reference to magnetoelastic strain gauges and force sensors. A novel strain sensor based on soft amorphous ribbons is described. Other types of magnetic sensors, for the measurement of torque and displacement are briefly discussed. An overview of magnetic actuators based on giant magnetostrictive materials, with some practical examples, is presented. Recent advances in the development and application of magnetic shape memory materials are discussed, together with the analysis of recent studies for the description of magnetic shape memory phenomena.

• Proceedings of the IEEK Conference
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• 2002.07c
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• pp.1992-1995
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• 2002

This paper presents a novel 4-D chaotic spiking oscillator. The oscillator can generate hyperchaos characterized by two positive Lyapunov exponents. Us-ing a simple test circuit, typical phenomena can be verified in the laboratory.

• Journal of the Korean Ceramic Society
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• v.41 no.8
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• pp.578-581
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• 2004

In this study, we proposed the novel method that can crystallize the amorphous silicon by adjacent Pd-MILC enhanced Ni-MILC. With this method, the MILC rate was about 15 ${\mu}$m/h at 550$^{\circ}C$ which is four times faster than conventional MILC rate. The crystallization rate increased rapidly with the spacing between Ni and Pd decreased. And it was independent on Ni and Pd layer thickness and amorphous silicon active width. However, when Pd was capped by a Ni layer, there's no enhancement on Ni-MILC. This phenomenon implies that the enhancement of Ni-MILC rate comes from not Pd material itself but Pd-MILC induced tensile stress. We can explain these phenomena with a novel MILC mechanism.