• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
• /
• 제16권10호
• /
• pp.980-984
• /
• 2010

microRNA (miRNA)와 mRNA 조절 상호작용 탐색은 다양한 생물학적 현상에 있어 새로운 시야를 제공해 줄 수 있다. 최근 생물학적 프로세스에서 miRNA는 유전자 발현을 제어하고 세포를 기능적으로 조절하는 중요한 역할을 하는 요소로 밝혀졌다. 이에 복잡한 생물학 시스템에서 miRNA의 기능적 활동을 이해하기 위해서는 miRNA와 mRNA간 상호작용 분석은 필수적이다. 그러나 아직까지 복잡한 miRNA와 mRNA간 상호작용 관계를 추론하는 것은 어려운 문제이기 때문에 많은 연구자들이 실험적, 전산학적 접근 방법을 제안하며 활발한 연구를 진행하고 있다. 본 논문에서는 이종의 발현 데이터로부터 기능적으로 상호작용하는 miRNA-mRNA 조합을 탐색하기 위한 진화 연산 기반의 새로운 하이퍼네트워크 모델을 제안한다. 이에 실험결과로 제안하는 방법을 인간 암 관련 miRNA와 mRNA 발현 데이터에 적용하여 암 특이적 miRNA-mRNA 상호작용 집합을 탐색하고 발견한 miRNA-mRNA 상호작용 관계가 생물학적으로 유의함을 제시한다.

• 한국음향학회지
• /
• 제15권6호
• /
• pp.110-116
• /
• 1996

본 논문에서는 자동음성응답장치(ARS)에서의 복합주파수(DTMF)톤 수신의 정확도를 높이기 위한 방법을 제안한다. ARS시스템의 음성안내를 송출하는 동안 이용자가 DTMF신호를 발생할 경우, ARS시스템의 망접속부에 위치한 하이브리드에 의해 수신측으로 궤환된 음성신호가 이용자가 송신한 DTMF신호와 중첩이 되어, ARS시스템에서 DTMF신호음을 제대로 검출하지 못하는 경우가 발생한다. 제안하는 방법은 ARS의 음성안내신호에서 DTMF 신호의 주파수 대역 부분을 노치필터(notch filter)로 제거함으로써 여파된 음성안내신호가 하이브리드를 통해 수신측으로 궤환되어도 DTMF신호에 해당하는 주파수 성분이 없게 된다. DTMF수신기의 전단에는 노치필터에서 사용된 필터의 역필터특성을 갖는 대역통과필터를 설치하면, 하이브리드를 통해 수신측으로 궤환되는 신호는 DTMF수신기에 입력되지 않게 되며, 이용자가 송신하는 DTMF신호를 효과적으로 검출할 수 있다. 또한, 노치필터링된 음성신호의 음질저하는 무시할만하여 음성 안내어를 사용하는데 문제가 없다.

• Journal of Microbiology and Biotechnology
• /
• 제22권11호
• /
• pp.1457-1466
• /
• 2012

Antimicrobial peptides (AMPs) exert antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and viruses by various mechanisms. AMPs commonly possess particular characteristics by harboring cationic and amphipathic structures and binding to cell membranes, resulting in the leakage of essential cell contents by forming pores or disturbing lipid organization. These membrane disruptive mechanisms of AMPs are possible to explain according to the various structure forming pores in the membrane. Some AMPs inhibit DNA and/or RNA synthesis as well as apoptosis induction by reactive oxygen species (ROS) accumulation and mitochondrial dysfunction. Specifically, mitochondria play a major role in the apoptotic pathway. During apoptosis induced by AMPs, cells undergo cytochrome c release, caspase activation, phosphatidylserine externalization, plasma or mitochondrial membrane depolarization, DNA and nuclei damage, cell shrinkage, apoptotic body formation, and membrane blebbing. Even AMPs, which have been reported to exert membrane-active mechanisms, induce apoptosis in yeast. These phenomena were also discovered in tumor cells treated with AMPs. The apoptosis mechanism of AMPs is available for various therapeutics such as antibiotics for antibiotic-resistant pathogens that resist to the membrane active mechanism, and antitumor agents with selectivity to tumor cells.

• Journal of Communications and Networks
• /
• 제10권3호
• /
• pp.316-330
• /
• 2008

This paper proposes a novel method for transporting various types of user traffic effectively over the next generation network called integrated services digital network 3 (ISDN3) (or quantum network) using quantum packets. Basically, a quantum packet comprises one or more 53-byte quanta as generated by a "quantumization" process. While connection-oriented traffic is supported by fixed-size quantum packets each with one quantum to emulate circuit switching, connectionless traffic (e.g., IP packets and active packets) is carried by variable-size quantum packets with multiple quanta to support store-and-forward switching/routing. Our aim is to provide frame-like or datagram-like services while enabling cell-based multiplexing. The quantum packet method also establishes a flexible and extensible framework that caters for future packetization needs while maintaining backward compatibility with ATM. In this paper, we discuss the design of the quantum packet method, including its format, the "quantumization" process, and support for different types of user traffic. We also present an analytical model to evaluate the consumption of network resources (or network costs) when quantum packets are employed to transfer loss-sensitive data using three different approaches: cut-through, store-and-forward and ideal. Close form mathematical expressions are obtained for some situations. In particular, in terms of network cost, we discover two interesting equivalence phenomena for the cut-through and store-and-forward approaches under certain conditions and assumptions. Furthermore, analytical and simulation results are presented to study the system behavior. Our analysis provides valuable insights into the. design of the ISDN3/quantum network.

• Wind and Structures
• /
• 제18권6호
• /
• pp.693-715
• /
• 2014

Stochastic processes are used to represent phenomena in many diverse fields. Numerical simulation method is widely applied for the solution to stochastic problems of complex structures when alternative analytical methods are not applicable. In some practical applications the stochastic processes show non-Gaussian properties. When the stochastic processes deviate significantly from Gaussian, techniques for their accurate simulation must be available. The various existing simulation methods of non-Gaussian stochastic processes generally can only simulate super-Gaussian stochastic processes with the high-peak characteristics. And these methodologies are usually complicated and time consuming, not sufficiently intuitive. By revealing the inherent coupling effect of the phase and amplitude part of discrete Fourier representation of random time series on the non-Gaussian features (such as skewness and kurtosis) through theoretical analysis and simulation experiments, this paper presents a novel approach for the simulation of non-Gaussian stochastic processes with the prescribed amplitude probability density function (PDF) and power spectral density (PSD) by amplitude modulation and phase reconstruction. As compared to previous spectral representation method using phase modulation to obtain a non-Gaussian amplitude distribution, this non-Gaussian phase reconstruction strategy is more straightforward and efficient, capable of simulating both super-Gaussian and sub-Gaussian stochastic processes. Another attractive feature of the method is that the whole process can be implemented efficiently using the Fast Fourier Transform. Cases studies demonstrate the efficiency and accuracy of the proposed algorithm.

• 한국환경과학회지
• /
• 제22권6호
• /
• pp.651-666
• /
• 2013

This study introduces a novel approach to the differentiation of two phenomena, Asian Dust and haze, which are extremely difficult to distinguish based solely on comparisons of PM10 concentration, through use of the Optical Particle Counter (OPC), which simultaneously generates PM10, PM2.5 and PM1.0 concentration. In the case of Asian Dust, PM10 concentration rose to the exclusion of PM2.5 and PM1.0 concentration. The relative ratios of PM2.5 and PM1.0 concentration versus PM10 concentration were below 40%, which is consistent with the conclusion that Asian Dust, as a prime example of the coarse-particle phenomenon, only impacts PM10 concentration, not PM2.5 and PM1.0 concentration. In contrast, PM10, PM2.5 and PM1.0 concentration simultaneously increased with haze. The relative ratios of PM2.5 and PM1.0 concentration versus PM10 concentration were generally above 70%. In this case, PM1.0 concentration varies because a haze event consists of secondary aerosol in the fine-mode, and the relative ratios of PM10 and PM2.5 concentration remain intact as these values already subsume PM1.0 concentration. The sequential shift of the peaks in PM10, PM2.5 and PM1.0 concentrations also serve to individually track the transport of coarse-mode versus fine-mode aerosols. The distinction in the relative ratios of PM2.5 and PM1.0 concentration versus PM10 concentration in an Asian Dust versus a haze event, when collected on a national or global scale using OPC monitoring networks, provides realistic information on outbreaks and transport of Asian Dust and haze.

• 한국지능시스템학회논문지
• /
• 제22권4호
• /
• pp.527-531
• /
• 2012

본 논문에서는 종래의 PSO 알고리즘 성능저하의 주요 원인들 중 하나인 입자들의 조기수렴 현상을 개선한 DPSO-QI (Distributed PSO with quantum-infusion mechanism) 기법을 제안한다. DPSO-QI 알고리즘은 다음과 같은 두 가지 특징을 지닌다. 첫째, 분산형 구조의 PSO 기법을 도입한다. 이는 먼저 적절한 수의 입자들로 소그룹을 형성하고, 최적해 탐색에 필요한 다양한 정보의 교환이 각 소그룹 내에서만 이루어지도록 한 기법이다. 이러한 기법을 바탕으로 입자들의 탐색 다양성을 증대시킴으로서 조기수렴 현상을 감소시키는 효과를 달성할 수 있다. 둘째, 상기의 입자 소그룹에 Quantum-infusion (QI) 메커니즘에 기반 한 기법을 도입시킨다. 이를 통해 입자들의 전역 최적해 탐색 정밀도를 보다 향상시킬 수 있다. 끝으로 다양한 수치예제를 통하여 제안하는 새로운 PSO 기법이 종래의 방식들에 비해 매우 뛰어난 성능을 구현할 수 있음을 입증하고자 한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1253-1259
• /
• 2012

The 14-3-3 proteins are highly conserved, ubiquitous molecules involved in a variety of biologic phenomena, such as cell cycle control, and apoptosis. However, their expression in cholangiocarcinoma has not been previously characterized. In this paper, immunohistochemistry using specific anti-14-3-3 monoclonal antibodies was performed on formalin-fixed;, paraffin embedded archival tissue from 86 patients of cholangiocarcinoma. We also examined the correlation between expression and survival rate and clinicopathologic factors such as tumor location, tumor size, pathologic differentiation, lymphatic permeation, lymph node metastasis, and tumor stage. Positive 14-3-3 proteins expression was observed for 6 isoforms (${\beta}$, ${\sigma}$, ${\gamma}$, ${\theta}$, ${\delta}$, ${\eta}$) of these proteins in 86 patients of cholangiocarcinoma. ${\beta}$ and ${\sigma}$ isoform immunoreactivity was correlated with lymph node metastasis, tumor stage and patients' survival rate. In addition, ${\delta}$ isoform immunoreactivity showed trends with tumor location, tumor size, pathologic differentiation and tumor stage, while the ${\theta}$ isoform was correlated with pathologic differentiation. These results indicated that upregulated expression of some isoforms of 14-3-3 may be a common mechanism for evading apoptosis in cholangiocarcinoma, so that targeting 14-3-3 may be a novel promising strategy for the treatment of this tumor.

• Bulletin of the Korean Chemical Society
• /
• 제35권12호
• /
• pp.3495-3501
• /
• 2014

A novel crystal, the mono-protonated metformin acetate (1), was obtained and characterized by elemental analysis, IR spectroscopy and X-ray crystallography. It was found that one of the imino group in the metformin cation was protonated along with the proton transfer from the secondary amino group to the other imino group. Its crystal structure was then compared with the previously reported diprotonated metformin oxalate (2). The difference between them is that the mono-protonated metformin cations can be linked by hydrogen bonding to form dimers while the diprotonated metformin cations cannot. Both of them are stabilized by intermolecular hydrogen bonds to assemble a 3-D supermolecular structure. The four potential tautomer of the mono-protonated metformin cation (tautomers 1a, 1b, 1c and 1d) were optimized and their single point energies were calculated by Density Functional Theory (DFT) B3LYP method based on the Polarized Continuum Model (PCM) in water, which shows that the most likely existed tautomer in human cells is the same in the crystal structure. Based on the optimized structure, their Wiberg bond orders, Natural Population Analysis (NPA) atomic charges, molecular electrostatic potential (MEP) maps were calculated to analyze their electronic structures, which were then compared with the corresponding values of the diprotonated metformin cation (cation 2) and the neutral metformin (compound 3). Finally, the possible tautomeric mechanism of the mono-protonated metformin cation was discussed based on the observed phenomena.

• Tribology and Lubricants
• /
• 제34권2호
• /
• pp.55-59
• /
• 2018

This paper proposes a new type of electro-mechanical wedge brake for commercial vehicles. The brake operates on a novel mechanism for self-boosting braking friction forces using eccentric shafts, and involves wedges that are inserted between the rampbridge and traverse; this self-boosting mechanism is explained herein. A dynamic analysis using ADAMS was conducted, and the findings are reported. The constraint and contact conditions are explained to verify the precision of the dynamic analysis. The dynamic analysis shows that in the proposed mechanism, the self-boosting effect occurs as desired. However, it is also noted that the system has a limitation in terms of the production of unlimited braking forces that can jam the roller inside the wedges. After demonstrating the self-boosting effect, dynamic analyses are performed for several values of the wedge angles and friction coefficients between the brake pads and disks. Conventionally, a lower wedge angle has been suggested owing to its provision of a larger clamping force for given friction coefficients. However, it is noted that lower wedge angles can lead to a higher probability of occurrence of undesirable high braking forces, which can jam the roller into the wedge; thus, a larger wedge angle is preferable for avoiding the undesirable jamming phenomena. These analysis results are presented and discussed herein.