• Journal of Pharmaceutical Investigation
• /
• 제18권2호
• /
• pp.49-53
• /
• 1988

Pivaloyloxymethyl ester of piperacillin was synthesized by reacting sodium piperacillin with chloromethyl pivalate, and its chemical structure was determined by infrared and $^1H$ nuclear magnetic resonance spectroscopic methods. The pharmaceutical properties of the ester were investigated to assess its potential as a novel prodrug of piperacillin. The interface transfer of piperacillin and the ester was studied in a two-phase in vitro system composed of aqueous pH buffers and n-octanol. The ester was more lipophilic, and less water soluble above pH 4.0 than piperacillin. Significant antibacterial activity was not observed in the ester in vitro, but the ester was hydrolyzed into the parent drug in the rat liver homogenate. The serum levels of orally administered ester suspension containing 0.1% Tween 80 were measured in rabbits. It was found that the ester showed higher blood level, comparing with no observation of piperacillin in serum, but the time reaching the maximum serum concentration was 5 hr.

• Fibers and Polymers
• /
• 제5권1호
• /
• pp.44-51
• /
• 2004

Three bi-functional reactive dyes such as Bis(vinylsulphone) type, Bis(monochlorotriazine) type and Bis(mononicotinotriazine) type were applied to regular viscose rayon and new regenerated cellulosic fiber ($enVix^ⓡ$) which was prepared from cellulose acetate fiber by the hydrolysis of acetyl groups, and their dyeing properties and fastness properties were compared. enVix exhibited better dyeability and fastness than regular viscose rayon and these results were also explained by the differences in the supramolecular structure of these two fibers.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2008년도 추계학술대회A
• /
• pp.1821-1824
• /
• 2008

A novel in-mold packaging process has been developed to manufacture devices with closed channels. In this unified process, fabrication of open channels and forming the rigid cover on top of them are sequentially integrated in the same mold. The entire process is comprised of two phases. In the first phase, the open channels are fabricated under an exquisitely controlled temperature and pressure using the conventional micro injection molding technology. In the second phase, the closed channels are fabricated by conducting the injection molding process using the molded structure with the open channels as a mold insert. As a result, the in-mold technology can eliminate the bonding processes such as heating, ultrasonic or chemical processes for cohesion between the channel and the cover, which have been required in conventional methods.

• 한국정보디스플레이학회:학술대회논문집
• /
• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
• /
• pp.1020-1023
• /
• 2002

We successfully developed a-Si TFT controlled active matrix cathode (AMC) with gated Mo emitters. Also, we could remove emitter failures of the AMC through a novel surface treatment of Mo-tips, which indicates reduction of $MoO_3$ or chemical wet etching of $MoO_3$ by surface treatment. Transient behaviors of the AMC are strongly dependent on not only DC characteristics of device but also the device structure. Brightness and gray scale were well realized by low-voltage scan and data signals addressed to a-Si TFTs.

• Journal of Microbiology and Biotechnology
• /
• 제30권5호
• /
• pp.749-752
• /
• 2020

In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.

• 한국수자원학회:학술대회논문집
• /
• 한국수자원학회 2007년도 학술발표회 논문집
• /
• pp.1081-1083
• /
• 2007

The study in river basin has been performed for the identify water quality impaired stream segments, to create a priority ranking of those segments, and to calculate the heavy metal ion distribution for each impaired segment based on chemical and physical water quality standards. Two methods for modeling the potential area-specific heavy metal distribution are pursued in this study. First, a novel approach focuses on distance. Heavy metal distribution can be associated with a particular small geographic area. Based on the derived estimates an distribution map can be generated. Second, the approach is used the near watershed by means of kriging interpolation algorithm. These approaches provide an alternative distribution mapping of the area. The exposure estimates from both of these modeling methods are then compared with other environmental monitoring data. A GIS-based model will be used to mimic the hierarchical stream structure and processes found in natural watershed. Specifically, the relationship between landscape variables and reach scale habitat conditions most influential found in the Abandoned mine will be explored.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
• /
• pp.244-244
• /
• 2012

Polymer memory devices have attracted considerable attention because of their advantages such as low cost potential, good scalability, flexibility, simplicity in structure, and large capacity for data storage. Metal/poly (4,4'-aminotriphenylene hexafluoroisopropylidenediphthalimide) (6F-TPA PI)/metal system has been found to show an electrical bi-stable behavior. Here, we show a novel set-up of 6F-TPA PI/Al sample in which holes are injected by photoelectron emission process instead of direct charge carrier injection via metal electrode. In this process, an irreversible electrical phase transition of 6F-TPA PI is found, leading to a write-once-read-many (WORM) behavior. The photoelectron spectroscopy results measured before and after the switching process revealed that the irreversible electrical phase transition of 6F-TPA PI is attributed to the chemical modification of the carbonyl group in phthalimide moiety.

• 한국전기전자재료학회논문지
• /
• 제16권12S호
• /
• pp.1237-1241
• /
• 2003

In this paper, we report a novel RF-MEMS packaging technology with lightweight, small size, and short electric path length. To achieve this goal, we used the ultra thin silicon substrate as a packaging substrate. The via holes lot vortical feed-through were fabricated on the thin silicon wafer by wet chemical processing. Then, via holes were filled and micro-bumps were fabricated by electroplating. The packaged RF device has a reflection loss under 22 〔㏈〕 and a insertion loss of -0.04∼-0.08 〔㏈〕. These measurements show that we could package the RF device without loss and interference by using the vertical feed-through. Specially, with the ultra thin silicon wafer we can realize of a device package that has low-cost, lightweight and small size. Also, we can extend a 3-D packaging structure by stacking assembled thin packages.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2002년도 추계학술대회 논문집 Vol.15
• /
• pp.592-595
• /
• 2002

New polymeric hydrogels based on vinyl ethers have been synthesized by the ${\gamma}$-initiated polymerization method. Their physical chemistry and physical mechanical properities have been studied. It has been shown that structure and swelling behavior of the hydrogels can be regulated by the changing of synthesis conditions nature of monomers. Novel stimuli-sensitive polymers have been synthesized by the varying of macrochains hydrophilic-hydrophobic balance. The some biomedical aspects of application of hydrogels in capacity of drain aging polymeric materials in ophthalmology surgery, implants in plastic surgery as well as drug delivery systems have been investigated.

• Macromolecular Research
• /
• 제13권6호
• /
• pp.529-532
• /
• 2005

A novel amphiphilic, symmetric rod-coil, triblock copolymer (denoted as PHEMA-b-PF-b-PHEMA) of poly(9,9-didodecylfluorene-2,7-diyl) (PF) and poly(hydroxyl ethyl methacrylate) (PHEMA) was synthesized. A $\pi$-conjugated poly(9,9-didodecylfluorene-2,7-diyl) (PF) was used as a rodlike midblock segment and connected with hydrophilic end blocks of poly(hydroxyl ethyl methacrylate) (PHEMA) by using an ATRP technique. The chemical structure of PHEMA-b-PF-b-PHEMA was confirmed by $^{1}H$-NMR and GPC, and its PL properties were investigated in selected solvents. Due to the dissimilarities in molecular conformation and solubility between PHEMA and PF blocks, both block segments were segregated to display a phase-separated morphology on a Si wafer.