• 대한전자공학회논문지SD
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• 제46권11호
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• pp.77-83
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• 2009

본 논문에서는 $0.18{\mu}m$ CMOS 공정을 이용하여 다양한 무선통신 시스템 표준을 포함하는 Selective 피드백 저잡음 증폭기(SF-LNA)를 설계하였다. 노치필터를 이용하여 불필요한 주파수 대역은 저지시키고 원하는 주파수 대역만 통과시키는 주파수 응답을 얻었고, 측정 결과 820~960MHz와 1.57~2.5GHz 주파수 대역에서 각각 13dB 및 11.5dB의 전력이득과 -10dB 이하의 입력 및 출력 임피던스 매칭을 얻었다. 제작한 칩은 1.8V의 단일 전원전압으로부터 15mW의 낮은 전력소모를 가지며, $1.17\times1.0mm^2$의 칩 사이즈를 갖는다.

• Molecules and Cells
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• 제24권1호
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• pp.139-147
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• 2007

Although transforming growth factors (TGFs) are implicated in the process of endochondral ossification, which is initiated by the differentiation of mesenchymal cells into chondrocytes, it is not clear how $TGF-{\beta}3$ regulates the chondrogenic differentiation of limb bud mesenchymal cells. Here, differential display polymerase chain reaction (DD-PCR) screening and RT-PCR analysis revealed that transcripts of A Disintegrin And Metalloprotease 10 (ADAM 10) decreased during the chondro-inhibitory action of $TGF-{\beta}3$ on cultured chick leg bud mesenchymal cells. Electroporation of ADAM 10 morpholino antisense oligonucleotides inhibited the ectodomain shedding of delta-1, and cell proliferation and subsequent precartilage condensation, in a manner similar to that caused by $TGF-{\beta}3$. The suppression of mesenchymal cell proliferation induced by $TGF-{\beta}3$ and ADAM 10 morpholino antisense oligonucleotides was reversed by activation of ADAM 10 with phorbol 12-myristate 13-acetate (PMA) or knockdown of Notch-1 with siRNA. Collectively, these data indicate that, in cultured chick leg bud mesenchyme cells, $TGF-{\beta}3$ downregulates ADAM 10 and inhibits cell proliferation and subsequent precartilage condensation by inhibiting the ectodomain shedding of delta-1, and that this results in the activation of Notch signaling.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3811-3816
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• 2015

Background: Hairy and enhancer of split 1 (Hes-1) protein is a downstream target of Notch signaling and is a basic helix-loop-helix transcriptional repressor. However, definitive evidence for a role in hepatocellular carcinoma (HCC) cells has not been reported. Here, Hes-1 was revealed to an important component of the Notch signaling cascade in HCC cell lines possessing different potential for lung metastasis. Materials and Methods: RNAi mediated by plasmid constructs was used to analyze the role of Hes-1 in MHCC-97L HCC cells by assessing proliferation, apoptosis, cell migration and matrigel invasion following transfection. Hes-1 protein expression analysis in HCC tissue was also conducted by immunohistochemistry. Results: Our studies revealed that Hes-1 was decreased in HCC cell lines with higher lung metastasis potential at both the mRNA and protein levels. Down-regulation of the Hes-1 gene in MHCC-97L cells resulted in increased cell proliferation, reduced apoptosis and increased migration and invasion. Conclusions: Hes-1 has potential prognostic value in post-surgical HCC patients and may be an independent prognostic indicator for overall survival and tumor recurrence. These findings have important implications for understanding the mechanisms by which Hes-1 participates in tumor proliferation and invasion.

• Archives of Plastic Surgery
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• 제42권2호
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• pp.226-231
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• 2015

The aim of this study is to consider breast imagery in art as depicted through western painting. Twenty western art paintings were collated. Most of the sample paintings were created from the mid-nineteenth century to the late twentieth century and some are from the Renaissance period. Ten anthropometric items were used to measure 15 distances between two landmarks and 3 angles between three points. The distance from the nipple to the sternal notch and to the midclavicular point was the same and they were 0.46 of the distance from the sternal notch to the umbilicus. The shape of the projection of the breast was almost an isosceles triangle and the altitude of the triangle was at a proportion of 0.45 of the bottom length and 0.16 of the distance from the sternal notch to the umbilicus. The distance between the lateral ends of the breasts was 2.14 times the facial width and the distance between nipples was 1.36 times the facial width. Proportions from works of art are more ideal and attractive than clinically measured proportions. The desirable ratios measured from historical paintings might be useful in planning breast surgeries.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.217-222
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• 2001

For the life evaluating of notched members, it is the best way that performing the real fatigue test of structure containing notch. But this method required generally much times and costs to evaluate fatigue life. So, generally we use the modified S-N curve or several methods to predict fatigue life. In this study, crack initiation life was evaluated by fatigue testing the SAE keyhole specimen and smooth specimen made of Al 7075-T6 alloys using the constant load then obtained S-N curve of smooth specimen and P-N curve of SAE keyhole specimen. And, fatigue lives of keyhole specimen are predicted using some life prediction methods (Nominal range I method, Nominal range II method, FEM analysis) for investigating experimented results, and that were compared with experimental data. Predicted fatigue lives by FEM analysis were corresponded with experimental data between 1/3times and 3times on the whole, and predicted fatigue lives using modified S-N curve (Nominal range I method, Nominal range II method) were nonconservative compared with that of FEM analysis.

• 화약ㆍ발파
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• 제26권1호
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• pp.57-66
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• 2008

발파에서 특정한 방향으로 균열 성장을 제어하는데 장약공 노치가 유효하다는 연구결과가 발표되어오고 있다. 본 연구에서는 장약공의 노치가 파단면 형성에 미치는 영향을 살펴보기 위하여 일반 장약공과 노치 장약공에 의한 파단면의 표면을 비교하였다. 암석시편에 노치를 형성하기 위하여 노치비트시스템이 적용되었다. 파단면의 표면은 디지털 영상 계측법을 적용하여 DEM 모델로 재구성하고, 표면 거칠기 지수를 사용하여 파단면의 거칠기를 평가하였다.

• 전력전자학회논문지
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• 제19권3호
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• pp.276-282
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• 2014

In a single-phase grid-connected power system consisting of a dc-dc converter and a dc-ac converter, the current drawn from renewable energy sources has a tendency to be pulsated and contains double-fundamental frequency ripple components, which results in several drawback such as a power harvesting loss and a shortening of the energy source's life. This paper presents a new double-fundamental current reduction-scheme with a fast dc-link voltage loop for two-stage dc-dc-ac grid connected systems. In the frequency domain, an adequate control design is performed based on the small-signal transfer function of a two-stage dc-dc-ac converter. To verify the effectiveness of proposed control algorithm, a 1 kW hardware prototype has been built and experimental results are presented.

• 대한기계학회논문집A
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• 제20권7호
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• pp.2097-2107
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• 1996

The dynamic photoelastic technique had been utilized to investigate the possibillity of relieving the large local singular stresses induced at the corner of a right- angle- indenter. The indenter compressed a semi-infinite body dynamically with an impact load applied on the top of the indenter. The effects of the geometric changes of the indenter in terms of the diameter (d) and the location (1) of the stress relieving notch on the behavior of the dynamic contact stresses were investigated. The influence of stress relieving notches positioned along the edge of the semi-infinite body on the dynamic contact stresses were also studied by changing the diameter (D) and the location (L) of the notch. A multi-speak-high speed camera with twelve sparks were used to take photographs of full field dynamic isochromatic fringe patterns. The contact singular stresses were found to be released significantly by the stress relief notches both along the indenter and the edge of the semi-infinite body. The optimal position and geometry of the stress relieving notches were obtained with the aid of limited experimental results.

• 센서학회지
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• 제22권2호
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• pp.136-143
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• 2013

In the study, novel blood pressure estimation method was proposed to improve the accuracy of oscillometric method. The proposed algorithm estimated the blood pressure by comparing and analyzing the point variation aspect of dicrotic notch on pulsating waveform during each cardiac cycle. The waveforms of each cardiac cycle were extracted by maximum points. The extracted pulsating waveforms were applied by re-sampling, end-matching, and normalization. The systolic and diastolic blood pressures were estimated by point variation aspect of dicrotic notch. The blood pressures, which were estimated from proposed algorithm, were compared and analyzed by blood pressures from oscillometric methods and auscultation. The systolic blood pressure from oscillometric methods were +0.88 mmHg more than proposed algorithm, and 1.875 less than the diastolic blood pressures from proposed algorithm. The systolic and diastolic blood pressures from auscultation were 2.89 mmHg and 3.44 mmHg less than the blood pressures from proposed algorithm. As the errors between blood pressures from proposed algorithm, oscillometric method and auscultation were less than 5 mmHg, the proposed algorithm was effective.

• Journal of Medicine and Life Science
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• 제17권3호
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• pp.65-73
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• 2020

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a single-gene disease of the cerebral small blood vessels caused by mutations in the NOTCH3 gene on chromosome 19. Although CADASIL was known as a rare disease, recent research has suggested that the NOTCH variants could be found frequently even in the general population. The main clinical features included recurrent stroke, migraine, psychiatric symptoms, and progressive cognitive decline. On brain magnetic resonance imaging, patients with CADASIL showed multifocal white matter hyperintensity lesions, lacunar infarcts, microbleeds, and brain atrophy. Among them, lacunar infarcts and brain atrophy are important in predicting the clinical outcomes of patients with CADASIL. In the Jeju National University Hospital, we have diagnosed 213 CADASIL patients from 2004 to 2020. Most NOTCH3 mutations were located in exon 11 (94.4%), and p.Arg544Cys was the most common mutation. The mean age at diagnosis was 61.0±12.8 years. The most common presenting symptoms were ischemic stroke (24.4%), followed by cognitive impairment(15.0%), headache (8.9%), and dizziness(8.0%). Although the exact prevalence of CADASIL in Jeju is still unknown, the disease prevalence could be as high as 1% of the population considering the prevalence reported in Taiwan. Therefore, it is necessary to discover efficient biomarkers and genetic tests that can accurately screen and diagnose patients suspected of having CADASIL in this region. Ultimately, it is urgent to explore the exact pathogenesis of the disease to identify leading substances of treatment potential, and for this, multi-disciplinary research through active support from the Jeju provincial government as well as the national government is essential.