• 제목/요약/키워드: Northeast Pacific

검색결과 195건 처리시간 0.025초

Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions

  • Rasul, Azhar;Zhao, Bin-Ji;Liu, Jun;Liu, Bao;Sun, Jia-Xin;Li, Jiang;Li, Xiao-Meng
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권21호
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    • pp.9049-9058
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    • 2014
  • Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone) is an active compound isolated from roots, stems, leaves, fruits and seeds of a variety of plants. It is well known for its pharmacological properties and has been utilized as an anti-hyperprolactinemia, anti-tumor, anti-inflammatory, neuroprotetective, analgesic and immunomodulatory agent. Recently, the anticancer activity of casticin has been extensively investigated. The resulkts showed that it exerts protective potential by targeting apoptosis, considered important for cancer therapies. In this article, our aim was to review the pharmacological and therapeutic applications of casticin with specific emphasis on its anticancer functions and related molecular mechanisms. Chemotherapeutic effects are dependent on multiple molecular pathways, which may provide a new perspective of casticin as a candidate anti-neoplastic drug. This review suggests that additional studies and preclinical trials are required to determine specific intracellular sites of action and derivative targets in order to fully understand the mechanisms of its antitumor activity and validate this compound as a medicinal agent for the prevention and treatment of various cancers.

Risk Factors for Cholangiocarcinoma in the Lower Part of Northeast Thailand: a Hospital-based Case-control Study

  • Manwong, Mereerat;Songserm, Nopparat;Promthet, Supannee;Matsuo4, Keitaro
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권10호
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    • pp.5953-5956
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    • 2013
  • Background: Cholangiocarcinoma (CCA) is the most common cancer in Northeast Thailand. It is also a crucial health problem for Thai people. Various risk factors for CCA have been identified in the upper part of Northeast Thailand, but no similar studies of risk factors have been conducted in the lower parts of the region. This study aimed to investigate factors associated with CCA in the resident population. Materials and Methods: A hospital-based case-control study was conducted during 2009-2012 with the recruitment of 123 CCA cases and 123 non-CCA patient controls, matched for sex, age and residential area. Information was collected by interview with a structured questionnaire. Blood samples were collected for assays of anti-OV antibodies. Associations between various personal factors, dietary habits, family history, the presence of anti-OV antibodies and CCA were analyzed using multiple conditional logistic regression. Results: Patients who consumed raw meat (beef, pork) and alcoholic beverages ${\geq}3$ times per week had a higher risk of CCA than non-consumers ($OR_{adj}$=4.33; 95%CI=1.14-16.35 and $OR_{adj}$=2.13; 95%CI=1.00-4.55, respectively). Patients who had a family history of cancer had a higher risk than those who did not ($OR_{adj}$=4.34; 95%CI=1.80-10.43). Also, patients who had anti-OV antibodies (AU>23.337) had a higher risk than those whose anti-OV antibodies were below the cut-off ($AU{\leq}23.34$) ($OR_{adj}$=3.09; 95%CI=1.04-9.16). Conclusions: As is the case in the upper part of Northeast Thailand, OV infection is a crucial risk factor for CCA in people who live in lower part of the region. Similarly, a family history of cancer and the consumption of alcohol are risk factors for CCA.

Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand

  • Saengsawang, Phubet;Promthet, Supannee;Bradshaw, Peter
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권5호
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    • pp.2963-2966
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    • 2013
  • Infection with Opisthorchis viverrini (OV) due to eating certain traditional freshwater fish dishes is the principal risk factor for cholangiocarcinoma in Northeast Thailand where the infection is endemic and the incidence of this form of primary liver cancer has been the highest in the world. This paper is the second report of a prospective research project to monitor the impacts of a national liver fluke control programme in a rural community of Northeast Thailand. A sample of 684 villagers aged 20-65 years completed an interview questionnaire and were tested for infection using the Kato thick smear technique. The questionnaire was designed for the exploration of associations between OV infection, previous treatment with praziquantel, and knowledge and beliefs about the drug. The data were analysed using descriptive statistics and multiple logistic regression. The overall prevalence of OV infection was 37.2% and was highest in the 20-35 year age group, in those with a university degree and in those employed in the government sector. As many as 91.8% reported eating fish dishes known to place them at risk of infection. In the multiple regression analysis, previous use of praziquantel and lack of knowledge about whether or not the drug has a protective effect against re-infection were the only factors related to OV infection ($OR_{adj}$= 2.31, 95%CI =1.40-3.79 and $OR_{adj}$= 1.95, 95%CI= 1.24-3.05). The findings were discussed in terms of the possibly unwise dependency on praziquantel as a primary element in a control programme.

Interaction of Tobacco Smoking and Chewing with Angiotensin Converting Enzyme (Insertion/Deletion) Gene Polymorphisms and Risk of Lung Cancer in a High Risk Area from Northeast India

  • Phukan, Rup Kumar;Borah, Prasanta Kumar;Saikia, Bhaskar Jyoti;Das, Mandakini;Sekhon, Gaganpreet Singh;Mahanta, Jagadish
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권24호
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    • pp.10691-10695
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    • 2015
  • Background: Association of angiotensin converting enzyme (ACE) gene polymorphisms with lung cancer susceptibility remains uncertain and varies with ethnicity. Northeast India represents a geographically, culturally, and ethnically isolated population. The area reports an especially high rate of tobacco usage in a variety of ways of consumption, compared with the rest of the Indian population. Materials and Methods: We conducted a population based case control study in two major high risk region for lung cancer from Northeast India. A total of 151 consecutive lung cancer cases diagnosed histopathologically and equal numbers of controls were recruited with record of relevant sociodemographic information. Blood samples were collected and processed to identify ACE gene polymorphism. Results: Significantly higher (40.4 % vs 29.1%, OR=1.97, CI=1.04-3.72; p=0.037) prevalence of the ACE II genotype was observed among lung cancer cases. Smoking was significantly associated with increased risk of lung cancer (OR=1.70, CI=1.02-2.81; p=0.041). An enhanced risk was also observed for interaction of ACE II genotype with tobacco smoking (OR=4.09, CI=1.51-11.05; p=0.005) and chewing (OR=3.68, CI=1.22-11.13; p=0.021). Conclusions: The present study indicates significant association s of the ACE II genotype with lung cancer in high risk Northeast India.

장보고의 해양네트워크 경영의 재조명을 통한 동북아 허브항만 구축에 관한 연구 (A Study on Establishing a Hub Port in Northeast Asia through the Reconsideration of the Maritime Network Management of Jang BoGo)

  • 박명섭
    • 무역상무연구
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    • 제27권
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    • pp.69-95
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    • 2005
  • East Asia has played an important role in the economic and social development in the Asian pacific region and in the global arena. In the region the impact of companies centralizing their logistics activities around a few distribution centers has already led some leading ports such as Singapore, Hong Kong to transform and expand their functions and business activities to provide port users with value added logistics services. Other ports in the region also have an important part to play in the total logistics Chain. In these environments, the maritime activities of Jang BoGo, who was the maritime king of the commercial maritime empire in East Asia in the 9th century, give many implications to the international logistics network strategy that Korea has to take in order to become a power of International Logistics. Though the trading and economic environments at that time may be quite different from today, the super-national maritime management pattern that Jang Bo-go, founder of the Northeast Asian maritime trading kingdom devised, gives us many implications in the global trading and economic environments, in the respects of overseas direct investment and international logistics. Accordingly, the paper aims to examine the establishment of hub port in Northeast Asia, modelled after the maritime network management strategy of Jang BoGo.

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신해양질서 10년후 세계어업자원 이용동향 (The Exploitation of World Fishery Resources for 10 Years under the New Regime in the Sea)

  • 이장욱;허영희
    • 수산경영론집
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    • 제23권1호
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    • pp.43-87
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    • 1992
  • In this paper, state of exploitation of world fishery resources after 10 years under the new regime in the sea, called the era of exclusive economic zone (EEZ) expending up to a 200 nautical miles from coastal line, was reviewed to determine effect from establishing EEZ in the world fishery production and its export/import volume based on the fishery statistics annually published by the Food and Agriculture Organization (FAO) of United Nation. The world total production from marine living resources had a trend showing a waned increase during 1970's when most of coastal states were translated into the reality of EEZ. From mid-1980's onwards, it increased rapidly, reaching about 85 million tons . Such increase in production was basically from the Pacific Ocean, accounting for more than 60% of the world total production. Fishing areas where showed increase in the production after the new regime in the sea were the southwestern Atlantic (FAO area 41) , the eastern Indian (FAO area 57) and the whole fishing areas in the Pacific except the eastern central Pacific (FAO area 77). Increase in the production from distant-water fishing countries came from the regions of the southwest Atlantic (FAO area 41) and the southwest Pacific (FAO area 81) . The production from coastal states was up from the regions of the eastern Indian (FAO area 57) , the northwest and northeast Pacific (FAO areas 61 and 67) and the southeast Pacific (FAO area 87) . It was likely that the exploitation of the fishable stocks was well monitored in the areas of the northwest Atlantic (FAO area 21) , the eastern central Atlantic (FAO area 34) and the northeast Pacific (FAO area 67) through appropriate management measures such as annual harvest level, establishment of total allowable catch etc. The marine fisheries resources that have made contribution to the world production, despite expansion of 200 EEZ by coastal states, were sardinellas, Atlantic cod, blue whiting and squids in the Atlantic Ocean : tunas which mainly include skipjack, yellowfin and bigeye tuna, croakers and pony fishes in the Indian Ocean : and sardine, Chilean pilchard, Alaska pollock, tunas (skipjack and yellowfin tuna) , blue grenadier and blue whiting including anchoveta in the Pacific Ocean. It was identified that both fishery production and its export since introduction of the new regime in the sea were dominated by such coastal states as USA, Canada, Indonesia, Thailand, Mexico, South Africa and Newzealand. But difficulties have been experienced in the European countries including Norway, Spain, Japan and Rep. of Korea. Therefore, majority of coastal states are unlikely to have yet undertaken proper utilization as well as rational management of marine living resources in their jurisdiction during the last two decades. The main target species groups which led the world fishery production to go up were Alaska pollock, cods, tunas, sardinellas, chub and jack mackerel and anchoveta. These stocks are largely expected to continue to contribute to the production. The fisheries resources which are unexploited, underexploited and/or lightly exploited at present and which will be contributed to the world production in future are identified with cephalopods, Pacific jack mackerel and Atlantic mackerel, silver hake including anchovies. These resources mainly distribute in the Pacific regions, especially FAO statistical fishing areas 67, 77 and 87. It was likely to premature to conclude that the new regime in the sea was only in favour of coastal states in fishey production.

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동북아시아 해양환경보전을 위한 국제협력활동의 현황과 발전방향: 북서태평양보전실천계획(NOWPAP)을 중심으로 (Review on the Regional Cooperative Activities for Marine Environmental Conservation in Northeast Asia: with Special Reference to the Northwest Pacific Action Plan (NOWPAP))

  • 강창구;강성길
    • 한국해양환경ㆍ에너지학회지
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    • 제6권1호
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    • pp.30-43
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    • 2003
  • 반폐쇄성인 북서태평양 해역은 지형, 해류순환, 생태학적 관점에서 하나의 큰 시스템으로 간주되어 관리되어야 한다 현재 북서태평양권에서 진행되고 있는 해양환경 관련 다자간 협력 활동은 WESTPAC, PEMSEA, PICES, NOWPAP 등 다양하다. 본 논문에서는 특히 유엔환경계획의 주관하에 한ㆍ중ㆍ일ㆍ러가 지난 1994년부터 채택하여 수행중인 북서태평양보전실천계획(NOWPAP)사업을 중심으로 하여 북서태평양에서 진행되고 있는 지역협력 활동의 제반현황과 문제점을 살펴보고 이의 가능한 해결책을 제시하고자 하였다. 주요 제안으로는 (1) 북서태평양 인접국들은 해양환경 관련 국제협력 활동에 있어서 법적 구속력 있는 지역 차원의 협약의 중요성을 인식하고 실질적인 지역 협력활동을 수행함에 있어 큰 우산으로 작용할 수 있는 해양환경 관련 협약을 개발하여야 하며, 이에 (2) 현재의 제반 상황을 고려하여 현 단계에서는 국가의 영해나 관할권 등의 이슈를 침해하지 않는 느슨한 형태의 협약 개발을 시도할 필요가 있다. 아울러 (3) 지역내 다양한 정치 사회적 문제로 인해 환경분야의 협력사업이 종종 중단되거나 간섭받지 않도록 하기 위하여 유엔환경계획이나 다른 국제기구로부터의 지도력이 계속 발휘되어야 한다 (4) 재정적 및 제도적 기반을 계속 강화시켜야 하며, (5) 또한 북서태평양에서 연안 및 해양환경에의 위해 요소에 대응하기 위한 지역내 다자간 협력활동을 지속적으로 수행하여야 한다

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지자기 방향변화 및 베릴륨 동위원소비를 이용한 북동 적도 태평양 주상시료의 층서확립 (Stratigraphy of a Sediment Core Collected from the NE Equatorial Pacific Using Reversal Patterns of Geomagnetic Field and Be Isotope Ratio)

  • 김원년;형기성;공기수
    • Ocean and Polar Research
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    • 제36권4호
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    • pp.395-405
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    • 2014
  • A 570 cm-long sediment core was retrieved at $9^{\circ}57^{\prime}N$ and $131^{\circ}42^{\prime}W$ in 5,080 m water depth from the northeast equatorial Pacific and its stratigraphy was established with $^{10}Be/^9Be$ and paleomagnetic measurements. Successive AF demagnetization reveals eight geomagnetic field reversals. In the reference geologic time scale, the eight reversal events correspond to an age of about 4.5 Ma. However, $^{10}Be/^9Be$-based age yields 9.5 Ma at a depth of 372 cm. Such a large discrepancy in determined ages is attributed to an extremely low sedimentation rate, 0.4 mm/kyr on average, of the study core and resultant loss or smoothing of geomagnetic fields. The composite age model reveals a wide range in the sedimentation rate - varying from 0.1 to 2.4 mm/kyr. However, the sedimentation rate shows systematic variation depending on sedimentary facies (Unit II and III), which suggests that each lithologic unit has a unique provenance and transport mechanism. At depths of 110-80 cm with a sedimentation rate of about 0.1 mm/kyr, ancient geomagnetic field reversal events of at least a 1.8 Myr time span have not been recorded, which indicates the probable existence of a hiatus in the interval. Such a sedimentary hiatus is observed widely in the deep-sea sediments of the NE equatorial Pacific.

Molecular diversity and morphology of the genus Actinotrichia (Galaxauraceae, Rhodophyta) from the western Pacific, with a new record of A. robusta in the Andaman Sea

  • Wiriyadamrikul, Jutarat;Lewmanomont, Khanjanapaj;Boo, Sung Min
    • ALGAE
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    • 제28권1호
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    • pp.53-62
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    • 2013
  • Actinotrichia is a calcified galaxauracean red algal genus with temperate and tropical distributions in the Indian and Pacific Oceans. Morphological characteristics, along with rbcL and cox1 sequences, were analyzed from specimens collected in the western Pacific and the Indian Oceans. Both rbcL and cox1 data confirmed the occurrence of A. fragilis, A. robusta, and Actinotrichia sp. in this region. The presence of A. fragilis was verified in tropical Indo-Pacific and temperate northeast Asian waters and was characterized by high genetic diversity. Although A. robusta commonly occurs in the East China Sea, we confirmed its presence on rocks and crustose algae in the subtidal zone of three islands in the Andaman Sea. Actinotrichia sp. was similar to A. calcea in morphology and distribution, but with sufficiently different sequences, thus, additional sampling over the range will enable a more realistic evaluation of its taxonomic status.

한국의 환태평양연합훈련 참여와 발전방향 (Korea's Participation in the Rim of the Pacific and It's Future Development)

  • 김현기
    • 한국국방경영분석학회지
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    • 제17권1호
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    • pp.25-42
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    • 1991
  • Participation of ROK navy in the Rim of the Pacific(RIMPAC) in likely to stimulate rethinking of Korea's defense role in Northeast Asia. Although the RIMPAC exercise was originally maneuvers to improve combat techniques in ASW, anti-aircraft combat. ocean supply support. surface combat. and electronics warfare. it will be finally be directed to ward securing the SLOC connecting the US, Canada. Australia and the Far East. Based on this concept, my conclusion is that two future arrangements are possible for the security of the Korean peninsula and protecting the SLOC in the combined defense of the Pacific. One is the naval cooperation between ROK and Japan. the other is the Standing Naval Force Pacific(STANAVFORPAC) The concepts of the Naval Cooperation between ROK and Japan and the STANAVFORPAC is whose time has come. The leaders, policymakers, and planners of the countries concerned need to consider such a move seriously.

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