• BMB Reports
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• 제51권2호
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• pp.59-64
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• 2018

The airway epithelium is the first place, where a defense mechanism is initiated against environmental stimuli. Mucociliary transport (MCT), which is the defense mechanism of the airway and the role of airway epithelium as mechanical barriers are essential in innate immunity. To maintain normal physiologic function, normal oxygenation is critical for the production of energy for optimal cellular functions. Several pathologic conditions are associated with a decrease in oxygen tension in airway epithelium and chronic sinusitis is one of the airway diseases, which is associated with the hypoxic condition, a potent inflammatory stimulant. We have observed the overexpression of the hypoxia-inducible factor 1 (HIF-1), an essential factor for oxygen homeostasis, in the epithelium of sinus mucosa in sinusitis patients. In a series of previous reports, we have found hypoxia-induced mucus hyperproduction, especially by MUC5AC hyperproduction, disruption of epithelial barrier function by the production of VEGF, and down-regulation of junctional proteins such as ZO-1 and E-cadherin. Furthermore, hypoxia-induced inflammation by HMGB1 translocation into the cytoplasm results in the release of IL-8 through a ROS-dependent mechanism in upper airway epithelium. In this mini-review, we briefly introduce and summarize current progress in the pathogenesis of sinusitis related to hypoxia. The investigation of hypoxia-related pathophysiology in airway epithelium will suggest new insights on airway inflammatory diseases, such as rhinosinusitis for clinical application and drug development.

• 약학회지
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• 제13권4호
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• pp.101-110
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• 1969

The isozyme alteration of lactic dehydrogenase in the tissues of albino rat inhaled SO$_{2}$ were studied in vivo and in vitro, with the following results: (1) The H-type of LDH activity relatively dominated in the normal brain, heart and kidney tissues of rat, M-type in the normal lung, liver, and muscle tissues of the animal. (2) When rats inhale SO$_{2}$ in the concentration of 250 ppm, it appears that the M-type tends to predominate in the anaerobic tissues such as liver, kidney and muscle tissues and the H-type in the aerobic tissues such as brain and heart tissues. (3) When 5% SO$_{2}$ is introduced into tissue homogenates, LDH activities in the heart, lung, liver and muscle tissues are increased more than that of introducing room-air only. With sam treatment, LDH activity is decreased in the kidney tissue and no alteration is observed in the brain tissue. (4) Although, after the aeration of SO$_{2}$, the oxygen tension seems to bring decreases in the level of LDH activity in the anerobic tissues such as liver and muscle tissues, while, on the other hand, increases in the level of the activity in the aerobic tissues, such as the brain, heart and lung tissues. (5) Accordinglly, SO$_{2}$ affects LDH activities, its isozyme pattern of each organs, and their metabolic pathway by its absorption of the gas.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 전기설비
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• pp.25-26
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• 2006

An electrical fault is defined as any abnormal condition caused by reduction in the insulation strength between energized conduction parts and ground or any grounded part of an electrical system. Failure of solid insulation can be caused by excessive mechanical tension being applied on the insulation, harsh service environment, aging, and also by corona phenomena. The number of empty houses during normal working hours is rising. As a result, the number of uninspected electric installation for general use is increasing. To define the potential risk of the electric installation, measurement of leakage current has been getting considered, but because the measured leakage current value also contained leakage current by capacitance, the measured value can not be adapted to absolute reference to the installation. Therefore, in this paper, the correlation between the condition of electric installation and leakage current were analyzed.

• 대한안과학회지
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• 제58권8호
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• pp.960-967
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• 2017

목적: 갑상샘눈병증과 정상안, 정상안압녹내장 환자의 황반하 맥락막 두께를 비교해 보고자 한다. 대상과 방법: 정상군 70안, 갑상샘눈병증군 74안, 정상안압녹내장군 60안을 대상으로 하였다. 모든 환자는 스펙트럼영역 빛간섭단층촬영의 Enhanced Depth Imaging 방법으로 중심와 맥락막두께를 측정하였다. 평균 중심와 맥락막 두께는 중심와아래, 중심와 아래에서 각각 1.5 mm 비측 및 이측의 세 지점의 평균으로 정의하였다. 일반화 추정 방정식을 통하여 맥락막 두께에 미치는 변수를 알아보았다. 결과: 평균 중심와 맥락막 두께는 정상 $252.07{\pm}55.05{\mu}m$, 갑상샘눈병증 $281.01{\pm}60.06{\mu}m$, 정상안압녹내장 $241.66{\pm}55.00{\mu}m$로 유의한 차이를 보였다(p=0.013). 중심와아래, 비측, 이측 중심와 맥락막 모두 정상안압녹내장에서 갑상샘눈병증에 비해 얇았다(p=0.014, 0.012, and 0.034). 갑상샘눈병증에서 나이, 성별, 굴절률, 안압을 보정한 후에도 정상안압녹내장군에 비해 맥락막 두께가 유의하게 두꺼웠다(${\beta}=32.61$, p=0.017). 결론: 갑상샘눈병증군에서 정상안압녹내장군과 정상군보다 유의하게 두꺼운 맥락막을 보였고 평균 망막신경섬유층 두께는 정상안압녹내장군이 갑상샘눈병증군보다 유의하게 얇았다. 갑상샘눈병증 환자에서의 두꺼운 맥락막이 녹내장 진행에 있어 어떠한 효과를 가지는지 향후 추가적인 연구가 필요할 것으로 보인다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2003년도 봄 학술발표회 논문집
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• pp.805-812
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• 2003

The purpose of this study is to evaluate the behavior of a reinforced earth wall by modeling the properties of the interface between soil and reinforced elements as well as the non-linear stress-strain characteristics of soil. The effect of lateral earth pressures induced during construction is also included in the analyses. The interface element used to evaluate the relative movement of the interface between soil/reinforcement and soil/wall- facing has a zero thickness and essentially consists of normal and shear springs. The behavior of soil element is calculated based on the hyperbolic model. The computer program SSCOMPPC which includes the interface element, hyperbolic model and bi-linear model is applied in this study. From the analyses, it is showed that the locus of maximum tension were closed to the hi-linear failure line of theoretical analyses. The lateral displacement of SSCOMPPC is larger than that of the FLAC which adopts the elastic model. This means the analysis which is adopted the hyperbolic model and interface element induced more larger displacement.

• Computers and Concrete
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• 제20권2호
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• pp.129-143
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• 2017

Seismic design of reinforced concrete (RC) structures requires a certain minimum level of flexural ductility. For example, Eurocode EN1998-1 directly specifies a minimum flexural ductility for RC beams, while Chinese code GB50011 limits the equivalent rectangular stress block depth ratio at peak resisting moment to achieve a certain nominal minimum flexural ductility indirectly. Although confinement is effective in improving the ductility of RC beams, most design codes do not provide any guidelines due to the lack of a suitable theory. In this study, the confinement for desirable flexural ductility performance of both normal- and high-strength concrete beams is evaluated based on a rigorous full-range moment-curvature analysis. An effective strategy is proposed for flexural ductility design of RC beams taking into account confinement. The key parameters considered include the maximum difference of tension and compression reinforcement ratios, and maximum neutral axis depth ratio at peak resisting moment. Empirical formulae and tables are then developed to provide guidelines accordingly.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.384.2-384.2
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• 2016

Recent publications reported the self-propelled jumping of coalescing dew droplets on superhydrophobic surfaces [1-2]. We further investigated the initial growth, coalescence, and removal by self-propelled ejection of nano and microscopic water droplets on the superhydrophobic surface of lotus leaves under condensing conditions. By using a high-speed digital camera mounted on an optical microscope, we have found: (1) sub-micrometer droplets form and grow on nanoscale waxy hairs; (2) growing droplets coalesce rapidly upon contact, but never jump off the surface unless the diameter of merged droplets exceeds ${\sim}15{\mu}m$; (3) the diameter and direction of jumping droplets are very narrowly distributed, centered at $20-30{\mu}m$ and ${\sim}20$ degrees from the surface normal, respectively. We present a rationale for these observations on the basis of: (a) the hierarchically rough surface structure on nano- and micro-scales; (b) its chemical composition; and (c) the balance among competing forces of cohesion (surface tension), adhesion and gravity.

• Ocean Systems Engineering
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• 제10권2호
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• pp.227-241
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• 2020

This paper deals with the problem of the global stabilization for a class of tension leg platform (TLP) nonlinear control systems. Problem and objective: Based on the relaxed method, the chaotic system can be stabilized by regulating appropriately the parameters of dither. Scope and method: If the frequency of dither is high enough, the trajectory of the closed-loop dithered chaotic system and that of its corresponding model-the closed-loop fuzzy relaxed system can be made as close as desired. Results and conclusion: The behavior of the closed-loop dithered chaotic system can be rigorously predicted by establishing that of the closed-loop fuzzy relaxed system.

• The Journal of Korean Physical Therapy
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• 제13권2호
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• pp.421-431
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• 2001

It is important to maintain good habitual posture in daily life. Abnormal body aligament is provoked by excessive tension of bad posture. And these symptom is connected with other disorder of the body like back pain, cervical pain and shoulder pain through inaccurate body mechanism in daily life. This study was searched to figure out effects of factor that how to balance good posture and normal posture. And the other purpose of this study was to make new calculate device for analysis of effective posture in clinic.

• The Korean Journal of Pain
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• 제10권1호
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• pp.121-123
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• 1997

Stellate ganglion block(SGB) is frequently performed to relieve a patient from headache of various. We experienced a rare case of subarachnoid hemorrhage by aneurysmal rupture after SGB. A 46-year-old female patient diagnosed with tension headache, and normal MRI finding consulted our pain clinic. We performed right SGB in combination with greater occipital nerve block. The next day, we performed left SGB with 6 ml of 0.25% bupivacaine. She had no evidence of subarachnoid block or intravascular injection. 15 minutes after injection, she abruptly developed convulsion and loss of consciousness. She was given artificial respiration with oxygen. The diagnosis of ruptured left posterior communicating aneurysm was confirmed by 4-vessels angiography.