• The Korean Journal of Physiology and Pharmacology
• /
• v.9 no.1
• /
• pp.17-22
• /
• 2005

We examined whether the abnormal EEG state by NMDA receptor blocker MK-801 can be reversed by typical and atypical antipsychotics differentially by comparing their spectral profiles after drug treatment in rats. The spectral profiles produced by typical antipsychotics chlorpromazine (5 mg/kg, i.p.) and haloperidol (0.5 mg/kg, i.p.) were differ from that by atypical antipsychotic clozapine (5 mg/kg, i.p.) in the rats treated with or without MK-801 treatment (0.2 mg/kg, i.p.) which produce behavioral abnormalities like hyperlocomotion and stereotypy. The dissimilarity between the states produced by antipsychotics and the control state was examined with the distance of the location of the canonical variables calculated by stepwise discriminant analysis with the relative band powers as input variables. Although clozapine produced more different state from normal state than typical antipsychotics, clozapine could reverse the abnormal schizophrenic state induced by MK-801 to the state closer to the normal state than the typical antipsychotics. The results suggest that atypical anesthetic can reverse the abnormal schizophrenic state with negative symptom to the normal state better than typical antipsychotic. The results indicate that the multivariate discriminant analysis using the spectral parameters can help differentiate the antipsychotics with different actions.

• Korean Journal of Biological Psychiatry
• /
• v.14 no.2
• /
• pp.129-141
• /
• 2007

Objectives : Empathy has been conceptualized as the ability of emotional resonance and perspective-taking. Emotional awareness has been proposed as the basis of empathy. In this study we examined the relationship between empathy and mood awareness and their neural correlates in resting-state activity in normal controls and patients with schizophrenia. Methods : Empathy and mood awareness scale scores were compared between 29 patients with schizophrenia and 21 normal controls by voxel-based t-tests and voxel-based correlation analyses of resting-state $^{18}F$-FDG PET images. Results : Empathy and mood labeling scale scores were significantly decreased in schizophrenic patients. Mood monitoring was positively correlated with empathy score in normal controls, but not in schizophrenic patients. In normal controls, empathy was positively correlated with resting-state activities in the intraparietal sulcus and mood monitoring was positively correlated with the temporal pole, frontopolar cortex, inferior temporal gyrus, entorhinal cortex and the subgenual prefrontal cortex resting activities. The orbitofrontal cortex resting activity was positively correlated with mood monitoring-related subgenual prefrontal cortex activity in the normal controls. Patients with schizophrenia showed decreased orbitofrontal resting activity and loss of its correlations with mood monitoring-related regional activities. Conclusion : This study showed that alteration in the resting-state activity in schizophrenia may reflect dysfunctional empathy and distorted characteristic of emotional awareness. However, the resting-state activity may not reflect the relationship between emotional awareness and empathy.

• Journal of the Korean Mathematical Society
• /
• v.13 no.1
• /
• pp.87-97
• /
• 1976

• BMB Reports
• /
• v.44 no.2
• /
• pp.123-128
• /
• 2011

Leucine-rich repeat containing protein 10 (LRRC10) is characterized as a cardiac-specific gene, suggesting a role in heart development and disease. A severe cardiac morphogenic defect in zebrafish morphants was recently reported but a contradictory result was found in mice, suggesting a more complicated molecular mechanism exists during mouse embryonic development. To elucidate how LRRC10 is regulated, we analyzed the 5'enhancer region approximately 3 kilo bases (kb) upstream of the Lrrc10 start site using luciferase reporter gene assays. Our characterization of the Lrrc10 promoter indicates it possesses complicated cis-and trans-acting elements. We show that GATA4 and MEF2C could both increase transcriptional activity of Lrrc10 promoter individually but that they do not act synergistically, suggesting that there exists a more complex regulation pattern. Surprisingly, knockout of Gata4 and Mef2c binding sites in the 5’enhancer region (-2,894/-2,889) didn't change the transcriptional activity of the Lrrc10 promoter and the likely GATA4 binding site identified was located in a region only 100 base pair (bp) upstream of the promoter. Our data provides insight into the molecular regulation of Lrrc10 expression, which probably also contributes to its tissue-specific expression.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.57 no.10
• /
• pp.1713-1719
• /
• 2008

A high temperature superconducting power cable (HTS power cable) was applied large current capacity by no resistance in normal state. Fault state was risen out of over-current but, it was limited to resistance. This study was modeling equivalence, and unbalanced state analyzed operating characteristic of HTS power cable. The equivalence model was composed superconductor, shield, and former part. This model simulation was appeared conductor and shield current in normal state, but unbalanced state was appeared former current as rise current by resistance. So it need to sufficiently influenced the quench characteristic when the former design.

• Proceedings of the KIEE Conference
• /
• 2003.07a
• /
• pp.555-557
• /
• 2003

As electric power transmission systems grow to supply the increasing electric power demand, transmission capacity is larger. but that's really difficult to secure the location for power transmission and distribution to user. The high temperature superconducting(HTS) cable is a method to solve this problem. But for applying to real systems, it needs to investigate the effect of HTS cable. The most important things is the investigation of fault condition. the fault on HTS cable include the quench state. When a fault occur in a circuit, three critical parameters(temperature, current density, magnetic field) exist. when one of these parameters exceeds the critical value, the superconducting becomes normal-conducting. f the cooling power is insufficient to recover the superconducting state, the normal-conducting zone expands. In order to solve these problem, this paper present simulate the quench state considering the over-current and over-voltage in the informal circuit and analyze the quench state.

• Bulletin of the Korean Chemical Society
• /
• v.19 no.9
• /
• pp.980-985
• /
• 1998

The excited-state intramolecular proton transfer (ESIPT) emission has been observed for 0.01 mM p-aminosalicylic acid (AS) in nonpolar aprotic solvents as demonstrated by the large Stokes' shifted fluorescence emission around 440 nm in addition to the normal emission at 330 nm. However in aprotic polar solvent such as acetonitrile, the large Stokes' shifted emission band becomes broadened, indicating existence of another emission band originated from intramolecular charge transfer (ICT). It is noteworthy that in protic solvents such as methanol and ethanol the normal and ICT emissions are quenched as the AS concentration decreases, followed by the appearance of new emission at 380 nm. These results are interpreted in terms of ESIPT coupled charge transfer in AS. Being consistent with these steady-state spectroscopic results, the picosecond time-resolved fluorescence study unravelled the decay dynamics of the ESIPT and ICT state ca. 300 ps and ca. 150 ps, respectively with ca. 40 ps for the relaxation time to form the ICT state.

• Journal of Korean Academy of Nursing
• /
• v.10 no.1
• /
• pp.11-19
• /
• 1980

The purpose of study carried out to determine the effects of antenatal education about the normal course of la-bor in last trimester (pregnancy 36 wks longer ) influencing the State- Anxiety of primigravida. And the relation-ship between primigravia’s general characteristics and State-Anxiety. This study was carried out between May 1. to October 20. 1979. The study sample consisted of 150 primigravidas who visited the out- patient of Department of obstetrics of Ewha Womans University Hospital. The method used for the collection of data were Antenatal Education Curriculum made by researcher and State-Anxiety Inventory. The questionnaire of State Anxiety Inventory is made up 20 items. The data was analysed by computer program. The followings are results. 1. There was shown State-Anxiety to to be alleviated by experimental group than control group. There was significant relation between experimental group and control group. (p< 0.01) 2. Within the experimental group, there was no significant relation to State-Anxiety by age and education level. (p ＞ 0.05) 3. In the investigation sample, according to the primigravida's gestation, there was shown State-Anxiety to be increased by closing to the delivery ( p <0.01). There was no relation of State-Anxiety response by age, education level, religion and acceptance of pregnancy. (p >0.05).

• BMB Reports
• /
• v.43 no.6
• /
• pp.400-406
• /
• 2010

Cancer/testis (CT) antigens exhibit highly tissue-restricted expression and are considered promising targets for cancer vaccines. Here we identified a novel CT gene ZNF645 which restrictively expresses in normal human testes and lung cancer patients (68.3%). To investigate the promoter methylation status of ZNF645, we carried out bisulfite genomic sequencing and found that the CpG island in its promoter was heavily methylated in normal lung tissues without the expression of ZNF645, whereas there was high demethylation in normal human testes and lung carcinoma tissues with its expression. Also ZNF645 could be remarkably activated in A549 and HEK293T cells treated by DNA demethylation agent 5'-aza-2'-deoxycytidine. And the dual luciferase assay revealed that the promoter activity of the ZNF645 was inhibited by methylation of the CpG island region. Therefore, we proposed that ZNF645 is a CT gene and activated in human testis and lung cancers by demethylation of its promoter region.

• Proceedings of the Korean Institute of Industrial Safety Conference
• /
• 1997.11a
• /
• pp.117-122
• /
• 1997

This paper presents a study on the fuzzy based approach for the safety assessment of human body under ELF electric and magnetic(EM) field considering power system states. The analysis of ELF EM field based on quasi-static method is introduced. UP to the present, the analysis of ELF EM field has been conducted with the consideration of one transmission line, or a power line model only In this paper, however, the power system is included to model the expected and/or unexpected uncertainty caused by the load fluctuation and parameter changes and the states are classified into two types, normal state resulting from normal operation and emergency state from outages. In order to analyze the uncertainty in the normal state, the Monte Carlo Simulation, a statistic approach was introduced and line current and bus voltage distribution are calculated by a contingency analysis method, in the emergency state. To access the safety of human body, the approach based on fuzzy linguistic variable is adopted to overcome the shortcomings of the assessment by a crisp set concept. In order to validate the usefulness of the approach suggested herein, the case study using a sample system with 765(kV) was done. The results are presented and discussed.