• Clinical and Experimental Reproductive Medicine
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• 제39권4호
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• pp.176-181
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• 2012

Objective: In 2009 anti-M$\ddot{u}$llerian hormone (AMH) assay was approved for clinical use in Korea. This study was performed to determine the reference values of AMH for predicting ovarian response to controlled ovarian hyperstimulation (COH) using the clinical assay data. Methods: One hundred sixty-two women who underwent COH cycles were included in this study. We collected data on age, basal AMH and FSH levels, total dose of gonadotropins, stimulation duration, and numbers of oocytes retrieved and fertilized. Blood samples were obtained on cycle day 3 before gonadotropin administration started. Serum AMH levels were measured at a centralized clinical laboratory center. The correlation between the AMH level and COH outcomes and cut-off values for poor and high response after COH was analyzed. Results: Concentration of AMH was significantly correlated with the number of oocytes retrieved (OPU; r=0.700, p<0.001). The mean${\pm}$SE serum AMH levels for poor ($OPU{\leq}3$), normal ($4{\leq}OPU{\leq}19$), and high ($OPU{\geq}20$) response were $0.94{\pm}0.15$ ng/mL, $2.79{\pm}0.21$ ng/mL, and $6.94{\pm}0.90$ ng/mL, respectively. The cut-off level, sensitivity and specificity for poor and high response were 1.08 ng/mL, 85.8%, and 78.6%; and 3.57 ng/mL, 94.4%, and 83.3%, respectively. Conclusion: Our data present clinical reference values of the serum AMH level for ovarian response in Korean women. The serum AMH level could be a clinically useful predictor of ovarian response to COH.

• 대한미생물학회지
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• 제10권1호
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• pp.1-8
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• 1975

Despite a number of recent studies on appendix its function appears to remain unknown. The present studies were undertaken in order to extend and confirm the previous studies concerning the role of appendix in immune response. An early hemagglutinin response of mercaptoethanol sensitive antibody(IgM antibody) in rabbit injected intravenously(i.v.) with 200mcg of bovine gamma globulin(BGG) was abolished by lethal whole body irradiation(900 r), but preserved in animals whose appendix and bone marrow were shielded during irradiation. Late formation of mercaptoethanol resistant antibody(IgG antibody) and the development of memory in bone marrow shielded animals were not affected by irradiation of the appendix. Formation of either IgM or IgG antibody to sheep red blood cells(SRBC) injected i.v. as determined by direct plaque forming cell(DPFC) technique in spleen were effectively abolished by appendectomy, thymectomy, or both followed by irradiation. When bone marrow was shielded in combination with autologous appendix reconstitution, DPFC response was about 5 times greater than the sum of two. Lysed appendix cells failed to restore the response. Lethally irradiated rabbits restored with combination of autologous appendix and thymus cells showed DPFC responses which were essentially normal. Three pools of appendix were obtained by manual separation technique and were stimulated with soluble concanavalin A(Con A), phytohemagglutinin-P(PHA) and pokeweed mitogen(PWM). Rabbit appendix cells responded to Con A, PHA and PWM. Cells of thymus dependent area(TDA) of the appendix were relatively enriched in their response to T cell mitogens compared to dome and follicle cells. The PHA/Con A responsive ratio of appenix TDA subpopulation was high, indicating that Con A responsive cells have a wider distribution among appendix. This finding showed that interfollicular area of the appendix is thymus-dependent. The present studies confirmed other evidence that the rabbit appendix cells itself are unable to form antibody and T lymphocytes in appendix TDA may be heterogenous, and that the appendix cells are synergistic with either bone marrow or thymus cells in the early hemagglutinin on splenic antibody response to BGG or SRBC.

• 한국생활과학회지
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• 제6권1호
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• pp.1-14
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• 1997

The purpose of this study was to comprehend the age-related differences in the relationship and developmental tendency between Orphanage and Normal Children's affective and cognitive perspective-taking ability. The subjects were 5-year-old (N=64) and 7-year-old (N=64) children. In each group, there were equal number of boys and girls, 128 Children were composed of(male: 32, female: 32) and orphanage Children(male: 32, female: 32). Feshbach & Roe's child perspective-taking ability test was modified for this study and the test included four facial expression cards and six different stories including three types of affection. In the procedure of study, after a set of story cards containing one of three affective types, the subject was asked to retell the story shown in each cards to study cognitive perspective-taking ability, and for the affective perspective-taking ability. Then the subject was asked to tell the feeling of the hero in the story and to select one of the four facial expression which is consistent with the feeling. The cognitive perspective-taking ability and affective perspective-taking ability response were coded three kinds of scoring respectively. Scored data were analyzed with MANOVA. t-test, Pearson Correlations and Fisher-z test. The results were shown as follow : First, both Orpanage and Normal Children's the cognitive and affective perspective-taking ability increased with age. Secondly, both Orpanage and Normal Children's perspective-taking ability was lower than Normal Children's perspective-taking ability. Thirdly, both Orpanage and Normal Children's correlation between cognitive and affective perspective-taking ability increased with age.

• 대한한방소아과학회지
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• 제21권2호
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• pp.1-12
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• 2007

Objectives : Allergic children have known to have multiple behavior problems. Among them, attentional ability disorder is one of the most common problems. This study is to examine relationship between learning ability and allergic rhinitis by analyzing EEG status of children. Methods : We analyzed cognitive functions of two different children groups; 21 children with allergic rhinitis and 19 normal children with CANS 3000(Central & Autonomic Nervous System, LAXTHA Inc., Korea), cognitive functions assessment program by EEG. Results : 1. According to mean active EEG rhythm of Theta, Alpha, SMR, M-beta, there were no significant difference between allergic rhinitis and the normal group. 2. According to mean active EEG rhythm of right H-beta, Gamma wave allergic rhinitis group's value was significantly higher than that of the normal group. 3. According to mean cognitive strength, response, concentration, left / right brain activity and learning ability score, there were no significant difference between allergic rhinitis and the normal group. 4. According to mean workload score, allergic rhinitis group's value was significantly higher than that of the normal group. Conclusions : It is likely that allergic rhinitis group, which showed relatively high frequency EEG rhythm, is more fragile to stress and less active on mental processing. Along side with physical examination, psychological assessment should also be conjugated on treating children with allergic rhinitis.

• 대한의생명과학회지
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• 제20권3호
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• pp.111-116
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• 2014

Human neutrophils play an essential role in the innate immune response and are involved in the pathogenesis of the severe and corticosteroid-resistant asthma. Asthma is characterized by an infiltration of inflammatory cells into the lung and by a cytokine release. The aim of this study is to investigate the effects of a bronchoalveolar lavage fluid (BALF) on the chemotaxis and apoptosis of neutrophils which were isolated from healthy subjects. The BALF of subjects with asthma induces the blood neutrophil chemotaxis in the opposite of that in normal subjects. The IL-8, IL-6, and monocyte chemoattractant protein-1 (MCP-1) levels in BALF were higher in subjects with asthma than in normal subjects. The BALF of normal and asthmatic subjects has no effect on neutrophil apoptosis of BALF. MCP-1 delays the constitutive apoptosis of normal blood neutrophils, but has no effect in normal BALF neutrophils. These results may indicate that inflammatory factors secreted by the lung tissue of patients with asthma trigger the neutrophil chemotaxis and also induce the neutrophil dysregulation.

• 대한한방종양학회지
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• 제4권1호
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• pp.111-129
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• 1998

In order to research the effect of Sipjundaebotang on the immune respons of CD4+ T cell and CD8+ T cell in rats, author have performed this experimental study. Experimental groups are divided into 5 groups(intact, control, sample I, sample II, sample III). Normal group was intact, control group was administrated normal saline 2cc for 5 days, sample I was administrated low concentration of Sipjundaebotang(100/3100pack/ml) 2cc for 5 days, sample II was administrated middle concentration of Sipjundaebotang(500/3100pack/ml) 2cc for 5 days, sample III was administrated high concentration of Sipjundaebotang(2500/3100pack/ml) 2cc for 5 days. WBC, Lymphocyte, CD4+ T cell in the blood, spleen, axillary node and CD8+ T cell in the blood, spleen and axillary node were determined. The results was as follows: 1. WBC count in blood was significantly decrcased in the control, sample I, II, III groups as compared with the normal group. 2. Lymhocyte count in the blood was significantly decreased in the control, sample I, II groups as compared with the normal group. 3. CD4+ T cell count in the blood was significantly increased dose-dependently in the sample I, II, III groups as compared with the normal group. 4. CD4+ T cell count in the spleen was significantly increased in the sample I, II, III groups as compared with the normal group. 5. CD4+ T cell count in the axillary node was significantly increased in the sample III group as compared with the normal group, however significantly decreased in the sample I, II groups as compared with the normal group. 6. CD8+ T cell count in the blood was significantly increased in the sample III groups as compared with the normal group. 7. CD8+ T cell count in the spleen was significantly increased in the sample I, II, III groups as compared with the normal group. but there was no differences in the sample groups. 8. CD8+ T cell count in the axillary node was decreased in the sample I, II groups as compared with the normal group.

• 감성과학
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• 제20권3호
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• pp.13-22
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• 2017

감성은 의사 결정, 지각 등에 직접적으로 영향을 미치며 인간의 삶에서 중요한 역할을 한다. 본 논문에서는 고각성 부정 감성의 편리하고 정확한 인식에 있어서, 생체신호를 이용한 분석 알고리즘을 설계하고자 한다. 이를 위해 본 연구에서는 보통 / 공포 감성 유발 영상을 이용하여 두 감성을 유도한 후, 생체신호 중 간단한 피부전도도 신호를 측정하였다. 측정된 피부전도도에 대해 Tonic 성분과 Phasic 성분으로 분해하고 감성 자극과 관련된 Phasic 성분을 더 상세하게 SCVSR, SCSR로 분해하여 각 성분의 주요한 특징들을 추출함으로써, 정확한 분석을 하기 위해 기존의 사용된 방법이 아닌 우수한 시간-주파수 지역화 특성을 가진 이산 웨이브렛 변환을 사용하였다. 추출된 특징들은 Phasic 성분의 최댓값, Phasic 성분의 진폭, SCVSR의 영교차율, SCSR의 영교차율이다. 분석 결과, 4가지 특징들 모두 고각성 부정 감성의 경우가 저각성 보통 감성의 경우보다 더 높은 값을 나타내고, 기존의 분석 방법보다 통계적으로 두 감정 사이의 더 유의미한 차이를 확인할 수 있었다. 이에 따라 본 연구의 결과는 피부전도도가 고각성 부정 감성 측정에 대해 유용한 지표라는 것을 확인하였으며, 향후 피부전도도를 이용한 실시간 부정 감성 평가 시스템 개발에 기여할 수 있을 것을 나타낸다.

• 한국전산구조공학회논문집
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• 제20권5호
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• pp.623-628
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• 2007

마찰형 감쇠를 갖는 구조물은 구조물의 고유주기, 하중의 특성, 그리고 외부하중에 대한 마찰력의 상대적인 크기에 따라 강한 비선형성을 나타내므로, 구조물의 최대응답을 예측하기 매우 어렵다. 기존의 연구에서는 비선형 시스템을 등가의 선형 시스템으로 치환하거나, 구조물의 비선형 시간이력해석을 통한 응답스펙트럼 분석에 의한 간단한 확률해석에 의해 수행되었다. 지진 하중은 불확실성과 불규칙성을 갖고 있기 때문에 확률적으로 정의된다면, 지진하중을 받는 마찰형 감쇠를 갖는 구조물의 응답 역시 확률분포를 나타낼 것이다. 본 논문에서는 Kanai-Tajimi 필터를 이용해 생성된 인공지진하중에 대해 마찰형 감쇠를 갖는 구조물의 비선형 시간이력 해석이 수행되었다. 그리고 정규분포 확률밀도 함수에 선형 회귀분석을 통해 얻어진 구조물의 주기와 마찰력의 크기에 의한 변수를 업데이트 시킨 마찰형 감쇠를 갖는 구조물의 변위 응답 확률밀도함수식이 제시된다.

• 한국공간구조학회논문집
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• 제8권6호
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• pp.49-57
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• 2008

지진에 의한 구조물의 응답을 저감시키기 위하여 다양한 면진장치가 사용되고 있으며 면진장치가 설치된 구조물은 고유주기가 길어져서 지진파의 탁월 주기를 벗어나게 된다. 대공간 구조물의 상부(지붕)구조인 트러스 아치는 하부구조인 기둥에 의하여 지지되는 경우가 있을 수 있다. 본 연구에서는 하부 기둥에 따른 면진 트러스 아치구조물의 거동을 분석하고자 한다. 면진장치를 대공간 구조물에 적용할 경우에 수평지진하중에 의하여 수평방향 지진응답이 저감되는 것은 물론 면진장치의 수직강성으로 인하여 수직응답도 현저하게 저감되는 것을 알 수 있었다. 하부의 기둥 강성이 큰 경우에 트러스 아치의 거동은 기둥 없이 트러스 아치가 지반에 직접 지지되는 트러스 아치의 거동과 유사하게 나타나고 있다. 또한 하부구조의 강성이 비교적 작은 대공간구조물에 면진장치를 적용할 경우에는 지진응답에 대한 우수한 제어 성능을 얻을 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5747-5751
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• 2013

Golgi phosphoprotein 2 (GOLPH2) is a very important biomarker in a variety of diseases. Its biological function is not clear, particularly in gastric cancer. To investigate the role of GOLPH2 in human gastric cancer, and determine its effect on the Th1 lymphocyte response, its expression and that of IL-12A were measured by real-time PCR and immunohistochemistry. The relationship between GOLPH2 and IL-12A was analysed statistically. The effect of GOLPH2 on the Th1 lymphocyte response was investigated with an in vitro co-culture system. The results showed that in human gastric cancer, the expression of GOLPH2 was significantly higher and the expression of IL-12A was lower than in normal gastric mucosal tissues, and the expression levels of GOLPH2 and IL-12A were negatively correlated. In addition, obvious down-regulation of the Th1 response was observed when lymphocytes were co-cultured with gastric cancer SGC7901 cells over-expressing GOLPH2. GOLPH2 down-regulated the expression of IL-12A, and inhibited the expression of TNF-${\alpha}$ and IFN-${\gamma}$. The results indicated that GOLPH2 down-regulates the Th1 response via suppression of IL-12A in human gastric cancer, and this might provide a target for the prevention and treatment.