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Utility Evaluation of Two-point Calibration Curve applied for TSH, FT4 Tests (TSH, FT4 검사의 Two-point Calibration Curve 적용의 유용성 평가)

  • Park, Hye-Mi;Yoo, Seon-Hee;Lee, Seon-Ho;Kim, Nyun-Ok
    • The Korean Journal of Nuclear Medicine Technology
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    • v.20 no.2
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    • pp.75-79
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    • 2016
  • Purpose The ASAN Medical Center, Nuclear Medicine performs TSH (Thyroid stimulating hormone) and FT4 (Free Thyroxine) tests 8 times per day. Accordingly, 70 ~ 80 kit tubes are consumed every day for the measurements and the time consumed for reagent dispensing averages over 170 seconds, where the TAT (turnaround time) may be effected when the number of test samples is larger than expected. Therefore, the following test was conducted with the purpose to reduce the number of kit tubes consumed, and reduce the time for reagent dispensing. Materials and Methods The test is based on applying the same reagent for tests where the number of samples is 30 or less. The test for TSH was conducted 9 times from July $1^{st}$ 2015 to July $10^{th}$ 2015. The test for FT4 was conducted 4 times from June $18^{th}$ 2015 to June $22^{nd}$, 2015. Standard Solution No.2 (0.153 uU/mL) and No.5 (4.96 uU/mL) was selected as the two-point standards for the TSH test, and Standard Solution No.3 (0.777 ng/dL) and No.4 (2.044 ng/dL) was selected as the two-point standards for the FT4 test. 38 test samples were subject to correlation analysis. Results For TSH, the result of the normal test shows ranges of 0.20 ~ 0.37 uU/mL for Control1, 0.53 ~ 0.71 uU/mL for Control2, and 6.77 ~ 7.94uU/mL for Control3, while the result of two-point calibration curve test shows ranges of 0.18 ~ 0.27 uU/mL for Control1, 0.53 ~ 0.71 uU/mL for Control2, and 7.30 ~ 8.52 uU/mL for Control3. For FT4, the result of the normal test shows ranges of 0.85 ~ 0.94 ng/dL for Control1 and 4.23 ~ 4.57 ng/dL for Control2, while the result of two-point calibration curve test shows ranges of 0.61 ~ 0.75 ng/dL for Control1 and 3.88 ~ 5.71 ng/dL for Control2. For TSH, the CV% of the normal test for Control1, Control2 and Control3 are 10.5, 3.3 and 3.6 respectively, while the CV% of the two-point calibration curve test for Control1 and Control1 are 12.4, 8.2 and 5.1 respectively. The result shows an outstanding correlation of TSH: y = 0.9985x - 0.0459 $R^2=0.9986$. For FT4, the CV% of the normal test for Control1 and Control2 are 0.70 and 0.71 respectively, while the CV% of the two-point calibration curve test for Control1 and Control1 are 8.7 and 16.2 respectively. The result shows an outstanding correlation of FT4: y = 1.2674x - 0.1133 $R^2=0.9824$. Conclusion The two-point calibration curve can be efficiently applied for TSH in cases where the number of test samples is not large, since the number of samples to be re-tested increases when the result is abnormal from the calibration curve. The two-point calibration curve test should not be applied for FT4 where the results do not consistently comply with the quality assessment range. Depending on how the two-point calibration curve is applied, up to 5 test tubes can be conserved per test, and the reduced time for reagent dispensing is anticipated to have a positive effect on the TAT (turnaround time).

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Histological Characteristics of Normal and Inferior Parts in Korean Red Ginseng (정상홍삼과 불량홍삼의 조직학적 특성)

  • 이종원;김천석;채순용;양재원;도재호
    • Journal of Ginseng Research
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    • v.25 no.2
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    • pp.82-88
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    • 2001
  • This study was carried out to investigate a point of difference between normal and inferior Korean red ginseng (Naeback red ginseng = red ginseng with white part of clear boundary in phloem and/or xylem of ginseng body, saengnaeback red ginseng red ginseng with white part of indistinct boundary). White part with clear or indistinct boundary in center of ginseng body was observed in inferior red ginseng (naeback and saengnaeback red ginseng), and the differences in the internal color intensity was also found with naked eye. In hunter color values of normal and inferior parts of red ginseng in accordance with particle size, L value was increased with a diminishment in particle size, while a and b value were decreased. Absorbance at visible spectrum did not differ from water and 70% ethanol extract from normal and inferior parts of red ginseng, but absorbance in UV spectrum of extract from naeback part showed higher than those of normal and saengnaeback part. In comparison of intrastructure by electron microscope, the horizontal and vertical section of cortex and pith layer from normal part showed the very dense state, but small holes were found in naeback part of red ginseng by naked eye and electron microscope. The specific surface area of normal, naeback and saengnaeback part appeared 3.02, 3.33 and 6.55 ㎡/g, respectively. From above results, we consider saengnaeback red ginseng is red ginseng in the intermediate process which normal red ginseng changes to naeback red ginseng.

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Chemical Characteristics of Normal and Inferior Parts in Korean Red Ginseng (정상홍삼과 불량홍삼의 화학적 특성)

  • 김천석;이종원;도재호
    • Journal of Ginseng Research
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    • v.25 no.2
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    • pp.89-93
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    • 2001
  • This study was carried out to investigate a point of difference in chemical characteristics between normal and inferior Korean red ginseng (Naeback red ginseng=red ginseng with white part of clear boundary in phloem and/or xylem of ginseng body, saengnaeback red ginseng=red ginseng with white part of indistinct boundary). content of total sugar as chemical components of naeback and saengnaeback part from Korean red ginseng were less than that of normal part, and content of reducing sugar in normal and saengnaebakc part showed higher than that of naeback part. But differences in content of total phenolic compounds was not found. The content of crude saponin in normal part was highest, amounts of ginsneoside were about same. The content of constituent amino acid in normal part was about 2 times as compared with those in naeback and saengnaeback part in red ginseng. Among the various amino acids, the contents of arginine, glutamic acid, aspartic acid, leucine and alanine of normal and naeback part were higher than others, but in saengnaeback proline, glutamic acid, aspartic acid, threonin and glycine etc. were higher. In the total amount of free amino acids, those in normal, naeback and saengnaeback part were about the same one another, and arginine, glutamic acid and aspartic acid were major free amino acids.

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Analysis of abnormal traffic controller based on prediction to improve network service survivability (네트워크 서비스의 생존성을 높이기 위한 예측기반 이상 트래픽 제어 방식 분석)

  • Kim Kwang sik
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.30 no.4C
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    • pp.296-304
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    • 2005
  • ATCoP(Abnormal traffic controller based on prediction) is presented to securely support reliable Internet service and to guarantee network survivability, which is deployed in Internet access point. ATCoP is a method to control abnormal traffic that is entering into the network When unknown attack generates excessive traffic, service survivability is guaranteed by giving the priority to normal traffic than abnormal traffic, that is reserving some channels for normal traffic. If the reserved channel number increases, abnormal traffic has lower quality service by ATCoP system and then its service survivability becomes worse. As an analytic result, the proposed scheme maintains the blocking probability of normal traffic on the predefined level in the specific interval of input traffic.

Physical Characteristics of Disabled Women by the Cause of Disability (장애원인에 따른 여성 장애인의 신체 특성)

  • Park, Kwang-Ae
    • Fashion & Textile Research Journal
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    • v.7 no.4
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    • pp.419-425
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    • 2005
  • The purpose of this study is to analyze the physical characteristic by directly measuring the wheelchair using disabled women. The subjects were 103 disabled women of wheelchair used women and between 20 - 55 years of age. The result of this study is as follow. There was a remarkable difference in the physical characteristic of wheelchair using disabled women due to their cause of disability. The cause of disability was classified into the 4 groups; poliomyelitis, spiral cord injury, muscular dystrophy, cerebral palsy. Poliomyelitis disability generally had a large horizontal area due to their strong upper body. People with spiral cord injury disability was shown to have the largest height, cervical height, waist back length, crotch length, knee length, The group of muscular dystrophy disabled people have the shortest length of body and also lean. The cebral palsy group of disabled people has an average length and height size body. A comparison of anthropometric measurements of wheelchair using disabled women with National Anthropometric Survey Korea(1997) was significant difference. People with poliomyelitis disability was shown to have a larger waist back length, neck point to breast point compared to normal women, but stature, crotch length was shorter compared to normal women. People with spiral cord injury disability had a similar in the vertical area. The group of muscular dystrophy and cebral palsy disabled people was short and smaller in general compared to a normal woman.

A RADIOGRAPHIC STUDY ON CRANIOFACIAL ASYMMETRY BY POSTERO-ANTERIOR CEPHALOMETRY (Postero-Anterior Cephalometry를 이용한 안모의 비대칭에 관한 연구)

  • Ko Jae Kyeung;Kim Jae Duk
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.17 no.1
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    • pp.249-258
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    • 1987
  • The purpose of this article was to determine the amount of cranio-facial asymmetry in normal subject before the analysis of the cranio-facial asymmetry as the result of internal derangement in T.M.J. dysfunction. The author has conducted analysis using Cephalometric P-A reviews of 54 males and 51 females. Following the Grayson's method of measurement, the standard value of cranio-facial asymmetry in normal subject was obtained. The following results were obtained: 1. Compared with right and left width, asymmetry could be identified in normal subject, although the degree of the difference appears to be small. 2. In male, asymmetric value of contact point of the upper central incisors is 0.76±0.84㎜ that of the lower central incisors is 0.86±0.86㎜, and that of center of genial tubercle is 0.87±1.06㎜. In female, asymmetric value of contact point of the upper central incisors is 1.03±1.29㎜, that of lower incisors is 1.11 ±1.18㎜, and that of center of genial tubercle is 1.45±2.15㎜. 3. Cranio-facial saymmetry in female is somewhat greater than that of male.

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Design of an Intelligent Speed Control System for Marine Diesel Engines (선박용 디젤엔진을 위한 지능적인 속도제어시스템의 설계)

  • J.S.Ha;S.J.Oh
    • Journal of Advanced Marine Engineering and Technology
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    • v.21 no.4
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    • pp.414-420
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    • 1997
  • An intelligent speed control system for marine diesel engines is presented. The approach adopt¬ed is to use a conventional PID controller for normal operation and a feedforward controller for adaptive control. The feedforward controller is a neural network. The neural network is the inverse dynamics model of the plant, which is being trained on line. The parametric model of the diesel engine is represented in a linear second-order system, with a first-order combustion part and a revolution part each at a normal operating point. The time delay in the control of the com¬bustion part is approximated to the first-order system. The tuned PID parameters are set based on the model for normal operating point. To obtain the inverse dynamics of the diesel engine system, two neural networks are used, one for inverse, the other for forward dynamics. The former is posi¬tioned across the plant to learn its inverse dynamics during operation, and the latter is placed in series with the controlled plant. Simulation results are presented to illustrate the applicability of the proposed scheme to intelligent adaptive control of diesel engines.

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Development of Facial Nerve Palsy Grading System with Image Processing (영상처리를 이용한 안면신경마비 평가시스템 개발)

  • Jang, Min;Shin, Sang-Hoon
    • The Journal of the Society of Korean Medicine Diagnostics
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    • v.17 no.3
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    • pp.233-240
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    • 2013
  • Objectives The objective and universal grading system for the facial nerve palsy is needed to the objectification of treatment in Oriental medicine. In this study, the facial nerve palsy grading was developed with combination of image processing technique and Nottingham scale. Methods The developed system is composed of measurement part, image processing part, facial nerve palsy evaluation part, and display part. With the video data recorded by webcam at measurement part, the positions of marker were measured at image processing part. In evaluation part, Nottingham scales were calculated in four different facial expressions with measured marker position. The video of facial movement, time history of marker position, and Nottingham scale were displayed in display part. Results & Conclusion The developed system was applied to a normal subject and a abnormal subject with facial nerve palsy. The left-right difference of Nottingham scores was large in the abnormal compared with the normal. In normal case, the change of the length between supraorbital point and infraorbital point was larger than that of the length between lateral canthus and angle of mouth. The abnormal case showed an opposite result. The developed system showed the possibilities of the objective and universal grading system for the facial nerve palsy.

Behaviors of novel sandwich composite beams with normal weight concrete

  • Yan, Jia-Bao;Dong, Xin;Wang, Tao
    • Steel and Composite Structures
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    • v.38 no.5
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    • pp.599-615
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    • 2021
  • The ultimate strength behaviour of sandwich composite beams with J-hooks and normal weight concrete (SCSSBJNs) are studied through two-point loading tests on ten full-scale SCSSBJNs. The test results show that the SCSSBJN with different parameters under two-point loads exhibits three types of failure modes, i.e., flexure, shear, and combined shear and flexure mode. SCSSBJN failed in different failure modes exhibits different load-deflection behaviours, and the main difference of these three types of behaviours exist in their last working stages. The influences of thickness of steel faceplate, shear span ratio, concrete core strength, and spacing of J-hooks on structural behaviours of SCSSBJN are discussed and analysed. These test results show that the failure mode of SCSSBJN was sensitive to the thickness of steel faceplate, shear span ratio, and concrete core strength. Theoretical models are developed to estimate the cracking, yielding, and ultimate bending resistance of SCSSBJN as well as its transverse cross-sectional shear resistance. The validations of predictions by these theoretical models proved that they are capable of estimating strengths of novel SCSSBJNs.

Understanding Automobile Roll Dynamics and Lateral Load Transfer Through Bond Graphs

  • ;Deam Karnopp
    • Transactions of the Korean Society of Automotive Engineers
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    • v.6 no.3
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    • pp.34-44
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    • 1998
  • It is clear that when an automobile negotiates a curve the lateral acceleration causes an increase in tire normal load for the wheels on the outside of the curve and a decrease in load for the inside wheels. However, just how the details of the suspension linkages and the parameters of the springs and shock absorbers affect the dynamics of the load transfer os not easily understood. One even encounters the false idea that since it is the compression and extension of the main suspension springs spring body role which largely determines the changes in normal load, of roll could be reduced, the load transfer would also be reduced. Using free body diagrams, one can explain quite clearly how the load is transferred for steady state cornering, and, using complex multibody models of particular vehicles one can simulate in good fidelity how load transfer occurs dynamically. Here we adopt a middle ground by using the concept of roll center and using a series of half-car bond graph models to point out main effects. Since bond graph junction structures automatically and consistently constrain geometric and force variables simultaneously, they can be used to point out hidden assumptions of other simplified vehicle models.

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