• Hip & pelvis
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• 제30권4호
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• pp.269-275
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• 2018

Purpose: The purpose of this study is to describe a method of inserting cement in the femoral head before fixation with dynamic hip screw to prevent screw cut out due to osteoporosis and to evaluate its clinical outcome in these patients. Materials and Methods: In this prospective study, 30 patients aged 60 years and older with intertrochanteric fracture were included. Bone mineral density was measured. After reaming of the femoral head and neck with a triple reamer and polymethyl methacrylate, bone cement was introduced into the femoral head using a customized nozzle and a barrel fitted on a cement gun. A Richard screw was inserted and the plate was fixed over the femoral shaft. Patients were mobilized and clinical outcomes were rated using the Salvati and Wilson's scoring system. Results: More patients included in this study were between 66 and 70 years old than any other age group. The most common fracture according to the Orthopaedic Trauma Association classification was type 31A2.2 (46.7%). The T-score was found to be $-2.506{\pm}0.22$ (mean${\pm}$standard deviation); all patients were within the range of -2.0 to -2.8. The duration of radiological union was $13.67{\pm}1.77$ weeks. Salvati and Wilson's scoring at 12 months of follow up was $30.96{\pm}4.97$. The majority of patients were able to perform their normal routine activities; none experienced implant failure or screw cut out. Conclusion: Bone cement augmentation may effectively prevent osteoporosis-related hardware complications like screw cut out in elderly patients experiencing intertrochanteric fractures.

• 한국치위생학회지
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• 제19권1호
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• pp.65-78
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• 2019

Objectives: This study was conducted to characterize the impact of cognitive function and oral health status on mastication in senior citizens, ${\geq}65$ years of age, using senior centers in the city of Wonju, South Korea. Methods: A cross-sectional study consisting of a simple oral examination and survey questionnaires was performed in 154 individuals. General characteristics, subjective masticatory function, objective masticatory function, cognitive function, and oral health status were collected as variables. Correlation and multiple linear regression analyses were conducted. A p-value of <0.05 was considered to be statistically significant. Results: The subjective masticatory function was scored using the 5-point Likert scale. When subjective masticatory function was analyzed in groups according to cognitive function, the mean subjective masticatory function scores were 4.31, 4.09, and 3.29 in the normal group (cognitive score of ${\geq}16$), suspected dementia group (cognitive score of 1215), and mild dementia group (cognitive score of ${\leq}11$), respectively. Thus, subjective masticatory function decreased along with decreasing cognitive function. When cognitive function, subjective masticatory function, and objective masticatory function were compared with indicators of oral health status (number of functional teeth, oral dryness), subjective masticatory function exhibited a significant positive correlation with objective masticatory function (r=0.635, p<0.01), cognitive function (r=0.292, p<0.01), and total number of functional teeth, including prosthetic appliances (dentures) (r=0.305, p<0.01). According to the regression analysis, age, sex, number of functional teeth, and cognitive function affected subjective masticatory function. Conclusions: The results of this study revealed that age, sex, number of functional teeth, and cognitive function affected subjective masticatory function, whereas oral dryness did not. Therefore, dental professionals must consider subjective masticatory function when providing oral care in senior patients with low cognitive function.

• Nutrition Research and Practice
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• 제15권2호
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• pp.173-186
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• 2021

BACKGROUD/OBJECTIVES: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Due to the increased incidence of dementia, there is a corresponding increase concerning the importance of AD. In this study, we investigated the protective effects conferred by Zizyphus jujuba (Zj) and Zizyphus jujuba fermented by yeast (Zj-Y), on cognitive impairment in an AD mouse model. MATERIALS/METHODS: AD was induced by injecting amyloid beta25-35 (Aβ25-35) in ICR mice, and subsequently 200 mg/kg Zj or Zj-Y was administered daily for 14 days. The cognitive ability of AD mice was observed through behavioral experiments in T-maze, novel object recognition, and Morris water maze tests. We subsequently measured the levels of malondialdehyde (MDA), nitric oxide (NO), aspartate aminotransferase, and alanine aminotransferase in either tissues or serum. RESULTS: In behavioral tests, deterioration was revealed in the short- and long-term learning and memory functions in the Aβ25-35-injected control group compared to the normal group, indicating that Aβ25-35 injection impairs cognitive functions. However, administration of Zj and Zj-Y improved cognitive function in mice, as compared to the Aβ25-35-injected control mice. In addition, the Aβ25-35 induced elevations of MDA and NO in the brain, kidney, and liver were suppressed after exposure to Zj and Zj-Y. Especially, Zj-Y showed stronger scavenging effect against MDA and NO, as compared to Zj. CONCLUSIONS: Results of the present study indicate that Zj-Y exerts a protective effect on cognitive impairment and memory dysfunction, which is exerted by attenuating the oxidative stress induced by Aβ25-35.

• 한국엔터테인먼트산업학회논문지
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• 제14권8호
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• pp.391-396
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• 2020

본 연구는 하지 사슬운동 유형이 라이프케어먼트를 위한 운동 수행능력에 미치는 영향을 알아보고자 하였다. 이를 위해 전라북도 소재 J대학의 정상 성인 여성 20명이 참여하여 두 가지 유형의 사슬운동을 적용하여 배곧은근의 활성도와 균형 능력에 대한 운동 효과 차이를 검사하였다. 참여자들은 각 유형의 운동에 대해 4주 동안 운동을 시행하도록 하였고 그룹 내 및 그룹 간 차이를 비교하기 위해 대응표본 t-검정과 독립 표본 t- 검정을 이용해 분석하였다. 연구 결과, 근육활성도와 균형 기능에서 닫힌사슬 운동이 열린사슬 운동보다 더 효과적이라는 것을 알 수 있었다. 따라서 임상 치료 환경에서 환자에게 하지 운동기능 향상을 위해 사슬운동을 적용할 경우에 닫힌사슬 운동 적용이 보다 효과적일 수 있음을 제시한다.

• 대한본초학회지
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• 제28권3호
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• pp.95-106
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• 2013

Objectives : The researcher investigated the anti-obesity effect of Alismatis Orientale Rhizoma(AP) water extract in mice fed a high fat diet and focused on the analysis of local area adipose tissue. Methods : Male ICR mice were divided into three groups, which were fed either a normal AIN diet, a 45% high fat diet (CT group), or a high fat diet and orally administration with a concentrations of 100 mg/kg (AP100 group) and 300 mg/kg body weight (AP300 group) for eight weeks. Results : As compared with CT group, AP100 group showed significant reductions in absolute weight of liver. As compared with CT group, AP100 group and AP300 group showed significant reductions in weight gain and relative weight of total fat. AST, triglyceride, total-cholesterol levels from the AP 100 group and 300 group were significantly lower than those of the CT, and ALT, LDL-cholesterol levels from the AP 100 group was significantly lower than those of the CT. But serum HDL-cholesterol levels from the AP 100 group and 300 group were significantly higher than those of the CT. And serum adiponectin levels from the AP 100 group was significantly higher than those of the CT. In result of real time PCR, all mRNA expression(PEPCK, G6Pase, PGC-$1{\alpha}$ and $ERR{\gamma}$) of two experimental groups were significantly decreased compared to those of CT group. The treatment with AP on local abdominal area made a fat cell size lessen on the fat tissue in the abdominal cavity and subcutaneous area. Conclusions : These results suggest that AP has an anti-obesity effect and the effect is mediated by inhibition of fat gain.

• 한국재난정보학회 논문집
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• 제18권3호
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• pp.433-443
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• 2022

연구목적: 본 논문에서는 스마트 디바이스의 높은 보급률을 활용하여 근감소증을 추정 및 예측하는 딥러닝 알고리즘을 제안과 연구를 수행한다. 연구방법: 딥러닝 학습을 위해 스마트 디바이스에 내장된 관성센서를 활용하여 실험 데이터를 수집하였다. 데이터를 수집하는 테스트용 어플리케이션 구현하여 '정상'과 '비정상'걸음과 '달리기', '낙상', '스쿼트' 자세의 5 가지 상태를 구분하여 데이터를 수집하였다. 연구결과: LSTM, CNN, RNN model 사용 시 예측 정확도를 분석했고 CNN-LSTM 융합형 모델을 활용하여 이진분류 정확도 99.87%, 다중 분류 92.30%의 정확도를 보였다. 결론: 근감소증이 있는 사람의 경우 걸음걸이의 이상이 생긴다는 점에 착안하여 스마트 디바이스를 활용한 연구를 진행하였다. 본 연구를 활용하여 근감소증으로 인해 생기는 재난안전을 강화 할 수 있을 것이다.

• 한국융합학회논문지
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• 제13권5호
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• pp.357-363
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• 2022

한국은 저출생 현상과 급속한 고령화로 인하여 노인돌봄 위기에 처해 있다. 2008년 노인장기요양보험이 본격적으로 실시되면서 노인돌봄의 사회화가 이루어지게 되었으나 다양하지 못한 서비스 선택권, 맞춤형 돌봄의 부족, 커뮤니티 케어의 불안정함 등으로 돌봄의 공백은 아직 사회문제로 남아있다. 또한 고령화의 진전에 따라 치매유병율의 증가는 새로운 사회위기이다. 이러한 상황에서 복지기술은 부족한 자원과 증가하는 수요의 공백을 메꾸어줄 미래의 중요한 대안이다. 본 논문에서는 지역에서 다양하게 제공되고 있는 치매서비스를 경험한 바 있는 경증치매노인 집단그룹면접, 치매고위험군 집단그룹면접을 통해 복지기술에 대한 친밀성, 접근성, 치매예방방안 등을 파악하였다. 치매 정도에 따른 차이는 있으나 두 그룹 모두 복지기술을 활용한 치매서비스에 관심이 높았다. 특히, 일상생활에서 자립적 훈련은 친밀한 도구인 TV나 전화를 활용하는 방안이 제시되었고 경증치매노인군의 경우 데이케어센터에서 기술활용을 위한 도움서비스와 가정 내 연계방안의 필요성이 제시되었다.

• Journal of Preventive Medicine and Public Health
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• 제56권1호
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• pp.31-40
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• 2023

Objectives: This study investigated the effect of cognitive impairment on the association between social network properties and mortality among older Korean adults. Methods: This study used data from the Korean Social Life, Health, and Aging Project. It obtained 814 older adults' complete network maps across an entire village in 2011-2012. Participants' deaths until December 31, 2020 were confirmed by cause-of-death statistics. A Cox proportional hazards model was used to assess the risks of poor social network properties (low degree centrality, perceived loneliness, social non-participation, group-level segregation, and lack of support) on mortality according to cognitive impairment. Results: In total, 675 participants (5510.4 person-years) were analyzed, excluding those with missing data and those whose deaths could not be verified. Along with cognitive impairment, all social network properties except loneliness were independently associated with mortality. When stratified by cognitive function, some variables indicating poor social relations had higher risks among older adults with cognitive impairment, with adjusted hazard ratios (HRs) of 2.12 (95% confidence interval [CI], 1.34 to 3.35) for social nonparticipation, 1.58 (95% CI, 0.94 to 2.65) for group-level segregation, and 3.44 (95% CI, 1.55 to 7.60) for lack of support. On the contrary, these effects were not observed among those with normal cognition, with adjusted HRs of 0.73 (95% CI, 0.31 to 1.71), 0.96 (95% CI, 0.42 to 2.21), and 0.95 (95% CI, 0.23 to 3.96), respectively. Conclusions: The effect of social network properties was more critical among the elderly with cognitive impairment. Older adults with poor cognitive function are particularly encouraged to participate in social activities to reduce the risk of mortality.

• 노인정신의학
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• 제16권1호
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• pp.17-23
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• 2012

The diagnosis of Alzheimer's disease (AD) is still obscure even to specialists. To improve the diagnostic accuracy, to find at-risk people as early as possible, to predict the efficacy or adverse reactions of pharmacotherapy on an individual basis, to attain more reliable results of clinical trials by recruiting better defined participants, to prove the disease-modifying ability of new candidate drugs, to establish prognosis-based therapeutic plans, and to do more, is now increasing the need for biomarkers for AD. Among AD-related biochemical markers, cerebrospinal beta-amyloid and tau have been paid the most attention since they are materials directly interfacing the brain interstitium and can be obtained through the lumbar puncture. Level of beta-amyloid is reduced whereas tau is increased in cerebrospinal fluid of AD patients relative to cognitively normal elderly people. Remarkably, such information has been found to help predict AD conversion of mild cognitive impairment. Despite inconsistent findings from previous studies, plasma beta-amyloid is thought to be increased before the disease onset, but show decreasing change as the disease progress. Regarding other peripheral biochemical markers, omics tools are being widely used not only to find useful biomarkers but also to generate novel hypotheses for AD pathogenesis and to lead new personalized future medicine.

• 대한정형도수물리치료학회지
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• 제29권3호
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• pp.1-11
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• 2023

Background: The aim of this study was to compare the effects of squat training on an unstable support surface with different knee flexion angles on the balance ability of normal adults balance ability. Methods: 41 university students in their 20s attending N University in Cheonan, Chungcheongnam-do were divided into a 45-degree knee-bending squat training group and a 90-degree knee-bending squat training group. The groups trained on an unstable support surface 20 minutes per day, 3 times a week, for a total of 4 weeks. Results: Changes in static balance ability were not significant within and between the groups for both the sway distance and sway area in the eyes open and eyes closed states (p<.05). The changes in dynamic balance ability were significant in the forward, leftward, and rightward angles in both groups at the limit of stability (p<.05), but not significant in the backward angle (p>.05), and the comparison between groups was not significant (p>.05). Conclusion: No significant difference between static balance-related variables within and between the groups was found. Significant changes in dynamic balance-related variables within the groups were found but not between the groups. Therefore, in future studies, it is considered necessary to study various ages and differentiated intervention periods, such as young adults and the population of elderly people, with sufficient intervention periods to affect balance ability.