• 생명과학회지
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• 제26권8호
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• pp.921-927
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• 2016

식후 고혈당은 제2형 당뇨병 초기 진단과 항당뇨병의 중요한 바이오마커 중 하나이다. α-글루코시다아제 억제제는 소장에서 탄수화물 소화의 속도를 방해함으로써 식후 고혈당을 조절한다. 본 연구에서는 오디열매추출물이 α-글루코시다아제와 α-아밀라아제에 미치는 억제효과 및 스트렙토조토신(STZ)이 유발하는 당뇨병 생쥐의 식후고혈당에 미치는 완화 효과를 조사하였다. α-글루코시다아제와 α-아밀라아제에 대한 오디열매추출물(MFE)의 IC₅₀ 값은 각각 0.16과 0.14 mg/ml의 결과값을 나타내어, 양성대조군인 acarbose보다 더 효과적이었다. STZ으로 유발된 당뇨병 흰쥐의 식후 혈당 수치는 정상 대조군에 비해 오디열매추출물에서 유의적으로 더 낮았다. 더욱이, 오디열매추출물 투여는 당뇨병 흰쥐에서 포도당 반응에 대한 곡선하면적 감소와 관련이 있었다. 결론적으로, 오디열매추출물은 α-글루코시다아제와 α-아밀라아제 활성의 강력한 억제제이며 식후 고혈당을 완화할 수 있다는 내용이다. 따라서 오디열매추출물은 당뇨병 치료제 및 기능성식품의 소재로 가치가 높다고 사료된다.

• 재활치료과학
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• 제8권4호
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• pp.65-76
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• 2019

목적 : 본 연구는 문화적 차이를 보이는 Upper extremity performance test for elderly (TEMPA)를 한국판으로 수정 및 번역하고 그 타당도 및 신뢰도를 검증하는 것이다. 연구방법 : 연구대상자는 40세이상의 손 기능에 장애가 없는 성인 171명과 손 기능에 장애가 있는 성인 41명 이었다. 내용 타당도와 분별 타당도를 검증하였고, 검사-재검사 신뢰도와 검사자 간 신뢰도를 검증하였다. 결과 : 내용 타당도를 통해 문화적 차이를 보이는 2개의 항목 ('자물쇠 열고 약통 열기', '편지 봉투 작성하고 우표 붙이기')을 수정하였다. 분별 타당도를 통해 TEMPA는 손 기능에 장애가 있는 성인과 없는 성인을 구별할 수 있는 평가 도구임을 확인 하였다 (p<.001). 신뢰도 검증 결과 수행 속도는 급간 내 상관계수(ICC)= .71-.92, 기능 정도는 카파계수 (kappa) = 1.0, 수행 분석은 ICC = 1.0로 중간수준에서 높은 수준의검사-재검사 신뢰도를 보였다. 검사자 간 신뢰도는 실행 속도 ICC = 1.0, 기능 정도 kappa = .79-1.0, 수행 분석 ICC = .94-1.0으로 상당한 수준에서 높은 수준의 신뢰도를 보였다. 결론 : TEMPA는 손 기능의 장애가 있는 성인을 구별해 낼 수 있고, 높은 수준의 신뢰도를 보이는 평가 도구로 임상적 평가 및 근거 기반의 연구에 있어 많이 사용되기를 기대한다.

• 한국환경보건학회지
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• 제46권3호
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• pp.267-275
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• 2020

Objectives: The causes of dementia have been reported in various ways, but there has been little research on the interrelationship between heavy metals and dementia, and the results also show little consistency. Therefore, it is imperative to compare the levels of heavy metal exposure between the dementia-suffering group and a control group to confirm the correlation between the level of heavy metal exposure and the likelihood of dementia. Methods: In order to assess the dementia level of the elderly, the Global Deterioration Scale (GDS) and Mini Mental State Examination (MMSE) were applied. To analyze the concentration of heavy metals in the blood, blood was collected from the veins of study subjects and measured using Inductively Coupled Plasma-mass spectrometry (ICP-MS). Results: There was a statistically significant correlation between lead and manganese concentrations in the blood and the MMSE and GDS. It was found that there was a statistically significant correlation between cadmium concentration in the blood and the GDS, but the MMSE was less relevant. It was found that the blood mercury concentration and the MMSE and GDS were less relevant. The lead concentration in the blood was 0.95±0.74 ㎍/dL in the dementia patient group and 0.33±0.22 ㎍/dL in the normal group, while cadmium was 0.69±0.37 ㎍/L in the dementia group and 0.18±0.10 ㎍/L in the normal group. Mercury was 0.81±0.31 ㎍/L in the dementia group and 1.16±0.80 ㎍/L in the normal group. Manganese was 6.83±2.01 ㎍/L in the dementia group and 4.78±1.59 ㎍/L in the normal group. All of these show statistically significant differences. Conclusions: As the concentration of lead, cadmium and manganese in the blood increases, the MMSE scores and GDS scores were found to worsen, and it was confirmed that there is a correlation between heavy metal exposure and cognitive degradation.

• 한국식생활문화학회지
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• 제26권6호
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• pp.727-733
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• 2011

This study was performed to examine the relationship between the body mass index (BMI), the body fat, and the serum lipids of post-menopausal women in rural areas. The subjects were 510 women aged 50 and over. As a result of this study, we found a trend of decreasing BMI as age increased, but body fat increased. In addition, there was a significant decreasing of the lean body mass than an increasing of the body mass index according to increasing age. Therefore, this study confirmed that a main cause of rural women being classified as obese is a decrease in lean body mass, rather than an increase in of body fat. Of all subjects, 36.3% ($18.5{\leq}BMI$ < 23) of all subjects were classified as having normal BMI, whereas only 21.4% were classified as having normal body fat. Out of 190 subjects who were body fat 30% and over, 38 subjects were classified as obese ($BMI{\geq}25$) and 113 subjects were classified as overweight ($23{\leq}BMI$ < 25). The percentile of those with a BMI of $25kg/m^2$ was 70, and they had 30.82% body fat. HDL cholesterol showed a negative correlation with anthropometric factors (height, weight, body mass index, waist circumference, waist hip ratio, body fat), and total cholesterol, LDL cholesterol, and triglycerides showed a positive correlation. Especially, total cholesterol, LDL cholesterol, and hip circumference showed significant correlations. Because of differences in the body fat and lean body mass by age group, it seems difficult to assess obesity via BMI only. The elderly especially should have a higher significance placed on body fat or abdominal fat than only BMI.

• The Journal of Korean Physical Therapy
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• 제18권2호
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• pp.17-24
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• 2006

Purpose: This study was aimed for service to clinical data of physical therapy necessity of bone complication through analysis method of BMD (bone mineral density) used DEXA (dual energy X-ray absorptiometry) to their skeletal system for physical therapy assesement and intervention program in type II diabetic patients. Methods: Experimental group of 75 subjects and comparison group of 62 subjects were participated in type II diabetic patients(40-80 ages). BMD was measured by DEXA. BMD change of BMI score and BMD comparison of age and sex would be known. Results: This study was found that decreased BMD and increased osteopenea in type II diabetes. In particular, women were lower BMD and higher incidence of osteopenea than men. Men showed significant difference in normal group. Influence of type II diabetes was great on change of BMD in men. however, it showed no significant difference from normal group. Conclusion: it was found that skeletal system complication by type II diabetes had some relations. Because reduction of BMD had a great danger to induce trauma by fall or degenerative disease of system, evaluation of proper physical therapy for its prevention and improvement and intervention program are needed. In addition, it would be important to divide type II diabetic patients into osteopenea and osteoporosis changes of skeletal system at comprehensive aspect of physical therapy.

• The Journal of Korean Physical Therapy
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• 제24권6호
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• pp.419-422
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• 2012

Purpose: Malalignment of the lower limbs may increases the difficulty of maintaining equilibrium. The purpose of this study was to study the effects of genu varum and poor posture in the sagittal plane on postural stability. Methods: We had 27 subjects with varus and 27 normal subjects participate in this study. Subjects for whom the distance between the medial epicondyles in the knee joint was more than 3 cm were classified as varus group, and subjects for whom the distance was less than 3 cm were classified as normal group. The measurements of static and dynamic stability were used overall stability index (OSI), anterioposterior stability index (APSI), and mediolateral stability index (MLSI) using a Biodex balance system. Results: When measuring the static stability index, there were significant differences in the mediolateral stability index between the varus and control groups. When measuring the dynamic stability index, there were significant differences in the overall, anteriorposterior, and mediolateral stability index between the varus and control groups. These results demonstrated that genu varum affects mediolateral movement in static stability, and overall, anterioposterior and mediolateral movements in dynamic stability. Conclusion: As genu varum affects static and dynamic stability in young adults, it increases the risk of injuries or falls. Exercise and surgery are required for realigning the genu varum. Future studies about postural stability in young children and elderly people who have a risk of falls due to lower postural control ability, are needed, as well as in young adults.

• 대한가정학회지
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• 제28권3호
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• pp.171-186
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• 1990

The purpose of this study is to analyze the desirable life emotion and life interchange between lod parents and married children. The focus was particulary laid on the investigation of the life emotion and life interchange between the aged living with their married sons and those living with their married daughters. The major findings of this study can be summarized as follows: 1. More old parents live with their married sons than with their married daughters. Also was found that they live with their eldest married sons or daughters and that they keep a normal relation with their married sons, and an emotional relation with their married daughters. This shows that more old people will live with their married daughters than with their married sons in the future. 2. The facts which affect the realtion between old parents2 2and their marreid children are age, sex, religion, marital status, educational background, health condition. These facts prove that they may improve the life interchange with their married children through such deliberate effects as the life-long marriage life with their spouse, the maintenance of health, and the religious life. 3. The affection relation between old parents and the married children was found to be high and the conflict between them was found to be low. Those who live with their married daughters especially showed a higher rate of love relation, and a lower rate of conflict than those who live with their married sons. The former were of more service interchange to their married children than the latter. Furthermore, the aged people were more satisfied with emotional and kindly daughters than with normal sons. 4. Affection was found to be the most importnat variable in promoting the emotional life interchange, and dependency was found to be a negative variable. Therefore, both the aged and the marreid children should try to show high affection to each other and try not to impose and dependency on the other.

• 성인간호학회지
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• 제16권2호
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• pp.245-255
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• 2004

Purpose: this study was to evaluate Cognitive Function Test for the Korean population. Digit Forward (DF), Digit Backward (DB) and Trail Making Test-A(TMT-A) and the translated version of the Trail Making Test-B (TMT-B) were used. The study examined the performance of Korean normal adult population whose age ranged from 20 to over 80. It was predicted that performances of the Korean population would be different from that of the United States population due primarily to their differences in language, and education. Method: Normal Korean adults at the Daejeon Metropolitan City and Chungchung Province (N=298) participated in this study. Seven age scores were evaluated; 20~29, 30~39, 40~49, 50~59, 60~69, 70~79, & >80s. The effects of age, gender, and years of education was examined, which yielded significant age and education effects. The scores were further specified accordingly in terms of years of education (0, 1~6, 7~12, 13~16, & >17), and gender. Result: As the age increased cognitive function score decreased. As the years of education increased, cognitive function scores increased. There was no difference in cognitive function scores according to gender. Age and year of education had significant effects on cognitive function and explained 52-58% of variants of each test. Conclusion: The data of the cognitive function tests are expected to be utilized for research purposes such as basic and clinical studies, as well as practical purpose such as cognitive assessment for traumatic brain injury, stroke, and elderly and nursing education for assessment tools.

• 대한간호학회지
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• 제50권2호
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• pp.191-199
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• 2020

Purpose: The purpose of this study was to compare sociodemographic characteristics of a normal cognitive group and mild cognitive impairment group, and establish prediction models of Mild Cognitive Impairment (MCI). Methods: This study was a secondary data analysis research using data from "the 4th Korea Longitudinal Study of Ageing" of the Korea Employment Information Service. A total of 6,405 individuals, including 1,329 individuals with MCI and 5,076 individuals with normal cognitive abilities, were part of the study. Based on the panel survey items, the research used 28 variables. The methods of analysis included a χ²-test, logistic regression analysis, decision tree analysis, predicted error rate, and an ROC curve calculated using SPSS 23.0 and SAS 13.2. Results: In the MCI group, the mean age was 71.4 and 65.8% of the participants was women. There were statistically significant differences in gender, age, and education in both groups. Predictors of MCI determined by using a logistic regression analysis were gender, age, education, instrumental activity of daily living (IADL), perceived health status, participation group, cultural activities, and life satisfaction. Decision tree analysis of predictors of MCI identified education, age, life satisfaction, and IADL as predictors. Conclusion: The accuracy of logistic regression model for MCI is slightly higher than that of decision tree model. The implementation of the prediction model for MCI established in this study may be utilized to identify middle-aged and elderly people with risks of MCI. Therefore, this study may contribute to the prevention and reduction of dementia.

• 대한의용생체공학회:의공학회지
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• 제18권2호
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• pp.157-166
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• 1997

Postural balancing in human is known to be maintained by the complex mechanism coupled with cerebellum, equilibrium organ of ear, proprioception and other various organs. We developed a Computerized Balance Evaluation and Training system(COBET system) to evaluate postural control and to rehabilitate geriatrics and disabled patient. In addition, 55 normal adult were tested to investigate the influencing factors on balancing posture. For the analysis of static postural sway, areas of the moving center of pressure were calculated under 8 different positions of subjects. And subjects were also asked to follow the visual targets on monitor for the evaluation of the dynamic postural sway. In comparison of the first and the second sets of tests, there was test-retest reliability($\textit{p}$< 0.05). The controllability of the static pmtwn sway was decreased as the ages of subjects increase. When the ages of subject are over 60, the controllability was significantly decrease4 The dynamic postural sway was significantly greater in the age groups of 7th and 8th decade than the younger groups. It is concluded that COBET system is a reliable system in the evaluation of postural sway. The COBET system is considered to be a valuable training modality for the disabled patients as well as the elderly.