• Journal of Embryo Transfer
• /
• v.26 no.3
• /
• pp.165-169
• /
• 2011

The present study investigated the physiological evaluation of cloned mini-pigs in a transportable isolator. Transportable isolator was designed and manufactured by our research team for transporting gnotobiotic pig. Until now, no previous reports are available regarding the physiological activities and harmful effects when pigs were transported in this isolator. Five cloned mini-pigs of 1~2 year (s) old female with a body weight between 80~90 kg were used. The effects of transportable isolator on stress-related hormone, adrenocorticotrophic hormone (ACTH) and cortisol levels, and heart rate were evaluated. In addition, it was also examined the effects of transportable isolator on blood chemistry factors (alanine aminotransferase: ALT, aspartate aminotransferase: AST, blood urea nitrogen: BUN, glucose, and creatinine). Blood was sampled just before the beginning of transport (T0), at the end of transport (30min after the transport; T1), and 30 min after the end of transport (T2). At the same time, heart rate was also evaluated. As a result, heart rate had no significant (p>0.05) differences at the various-time points of study (T0, T1, T2). However, heart rate was slightly higher than normal range in T1 and T2. The ACTH level was higher than normal range. Whereas, the cortisol level was lower than normal range. There were no statistical significant differences both ACTH and cortisol level between different time groups. Also, there were no significant differences in blood chemistry factors. Therefore, our present study shows that transportable isolator has no harmful effect on stress and physiological condition in cloned mini-pigs.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 2002.10b
• /
• pp.83-84
• /
• 2002

For estimation of chain-matching phenomena between normal paraffin as a solvent and straight-chain fatty acid as an additive, the density measurement of n-dodecane, n-tetradecane and n-hexadecane were carried out at oil temperature 313K and pressure up to 1.3 GPa. Their solidification pressure were easily determined by the appearance of molecular crystal, abrupt volumetric contraction and generation of heat of solidification and showed minima under the matching condition. The bulk modulus K of molecular crystal was evaluated using phase diagram. The bulk modulus showed maxima under the each matching condition. The chain matching effect on the bulk modulus beyond the scope of the interfacial phenomena are confirmed.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
• /
• 2008.04a
• /
• pp.234-237
• /
• 2008

A direct numerical simulation (DNS) code suitable for the prediction of buoyant jet diffusion flames was developed in this study. The thermodynamic and transport properties were evaluated using CHEMKIN package to enhance the prediction performance of the developed DNS code. A two dimensional simulations were performed for the jet diffusion flames in normal and zero-gravity conditions where the Froude numbers are 5 and infinity, respectively. The simulated buoyant jet diffusion flame in normal gravity showed that the unsteady and dynamic motion although the reynolds number is low (400). It was identified that the flame in normal gravity flickered periodically. The periodic motion of the flame disappeared in zero-gravity condition. The dynamic motion of the buoyant jet diffusion flame could be well understood by comparing the flame structures obtained by the simulations of normal and zero-gravity conditions.

• Biomolecules & Therapeutics
• /
• v.24 no.1
• /
• pp.94-98
• /
• 2016

The objective of the present study was to elucidate the effect of bisphosphonates, anti-osteoporosis agents, on glucose uptake in retinal capillary endothelial cells under normal and high glucose conditions. The change of glucose uptake by pre-treatment of bisphosphonates at the inner blood-retinal barrier (iBRB) was determined by measuring cellular uptake of $[^3H]3$-O-methyl glucose (3-OMG) using a conditionally immortalized rat retinal capillary endothelial cell line (TR-iBRB cells) under normal and high glucose conditions. $[^3H]3$-OMG uptake was inhibited by simultaneous treatment of unlabeled D-glucose and 3-OMG as well as glucose transport inhibitor, cytochalasin B. On the other hand, simultaneous treatment of alendronate or pamidronate had no significant inhibitory effect on $[^3H]3$-OMG uptake by TR-iBRB cells. Under high glucose condition of TR-iBRB cells, $[^3H]3$-OMG uptake was increased at 48 h. However, $[^3H]3$-OMG uptake was decreased significantly by pre-treatment of alendronate or pamidronate compared with the values for normal and high glucose conditions. Moreover, geranylgeraniol (GGOH), a mevalonate pathway intermediate, increased the uptake of $[^3H]3$-OMG reduced by bisphosphonates pre-treatment. But, pre-treatment of histamine did not show significant inhibition of $[^3H]3$-OMG uptake. The glucose uptake may be down regulated by inhibiting the mevalonate pathway with pre-treatment of bisphosphonates in TR-iBRB cells at high glucose condition.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.17 no.2
• /
• pp.167-181
• /
• 2019

Currently, the development of evaluation technology for vibration and shock load characteristics and spent nuclear fuel structural integrity under normal conditions of transport is being conducted in the Republic of Korea. This is the first such research conducted in the Republic of Korea and, thus, previous international studies need to be investigated and will be referred to in the ongoing project. Before 2000, several studies related to measurement of vibration and shock loads on spent nuclear fuel were conducted in the US. US national research institutes conducted uniaxial fuel assembly shaker tests, concrete block tests, and multi-axis fuel assembly tests between 2009 and 2016. In 2017, multi-modal transportation tests including road, sea, and rail transport were also performed by research institutes from the US, Spain and the Republic of Korea. Therefore, test preparation procedures, acceleration and strain measurement results, and finite-element and multi-body dynamics analysis were investigated. Based on the measured strain data, the preliminary conclusion was obtained that the measured strain was too small to cause damage to spent nuclear fuel rods. However, this conclusion is a preliminary conclusion that only reviews part of the results; a detailed review is being conducted in the US. The investigation of international studies on spent nuclear fuel structural integrity tests considering vibration and shock loads under normal conditions of transport in the US will be useful data for the project being conducted in the Republic of Korea.

• Nuclear Engineering and Technology
• /
• v.25 no.2
• /
• pp.248-254
• /
• 1993

The purpose of this study is to evaluate the thermal safety for dry transport of a shipping cask. Analysis condition was based on an ambient temperature of 38$^{\circ}C$ for normal heat condition. The cask was designed to carry 4PWR spent fuel assemblies with a burnup of 38,000 MWD/MTU and 3 years of cooling time. Thermal analysis was carried out by using the COBRA-SFS code. The fuel cavity was considered to be filled with air, nitrogen or helium gas for dry transport. The results of analysis showed that the maximum temperatures of fuel rod cladding in air and helium cavity would be 277$^{\circ}C$ and 226$^{\circ}C$, respectively, for 3 years of cooling time. These values were less than the specified temperature to maintain the thermal integrity of fuel assembly for dry transport.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.5 no.3
• /
• pp.199-212
• /
• 2007

If a type IP-2 transport package were to be subjected to a free drop test and a penetration test under the normal conditions of transport, it should prevent a loss or dispersal of the radioactive contents and a more than 20% increase in the maximum radiation level at any external surface of the package. In this paper, we suggested the analytic method to evaluate the structural safety of a type IP-2 transport package using a thick steel plate for a structure part and a bolt for tying a bolt. Using an analysis a loss or dispersal of the radioactive contents and a loss of shielding integrity were confirmed for two kinds of type IP-2 transport packages to transport radioactive waste drums from a waste facility to a temporary storage site in a nuclear power plant. Under the free drop condition the maximum average stress at the bolts and the maximum opening displacement of a lid were compared with the tensile stress of a bolt and the steps in a lid, which were made to avoid a streaming radiation in the shielding path, to evaluate a loss or dispersal of radioactive waste contents. Also a loss of shielding integrity was evaluated using the maximum decrease in a shielding thickness. To verify the impact dynamic analysis for free drop test condition and evaluate experimentally the safety of two kinds of type IP-2 transport packages, free drop tests were conducted with various drop directions. For the tests we examined the failure of bolts and the deformation of flange to evaluate a loss or dispersal of radioactive material and measured the shielding thickness using a ultrasonic thickness gauge to assess a loss of shielding integrity. The strains and accelerations acquired from tests were compared with those by analyses to verify the impact dynamic analysis. The analytic results were larger than the those of test so that the analysis showed the conservative results. Finally, we evaluated the safety of the type IP-2 transport package under the stacking test condition using a finite element analysis. Under the stacking test condition, the maximum Tresca stress of the shielding material was 1/3 of the yielding stress. Two kinds of a type IP-2 transport package were safe for the free drop test condition and the stacking test condition.

• Nuclear Engineering and Technology
• /
• v.30 no.5
• /
• pp.462-469
• /
• 1998

A package to transport high-level radioactive materials is required to withstand normal transport and hypothetical accident conditions pursuant to the IAEA and domestic regulations. The package should maintain the structural safety not to release radioactive material in any condition. The structural safety of the package has been evaluated by tests using proto-type or scaled-down models, however, the method by analysis is gradually utilized due to recent advancement of computers and computer codes. In this paper, to evaluate the structural safety of a radioisotope package of the KAERI, the three dimensional impact analyses under 9m free drop and 1m puncture were performed with an explicit finite-element code, the LS-DYNA3D code. The maximum stress intensity on each part was calculated and the structural safety of the package was evaluated in accordance with the regulations.

• Journal of Environmental Science International
• /
• v.2 no.3
• /
• pp.161-177
• /
• 1993

The Yellow Sand Events observed over the Korean peninsula during 22-24 April, 1993 were examined using the synoptic data and GMS visible image to identify the transport path of the Yellow Sand and the main factor governing the duration of the Yellow Sand phenomenon. The 850 hPa convergence chart and the 700 hPa trajectory analyses of the air mass laden with Yellow Sand particles suggested that the Yellow Sand particles observed over Korea were probably transported from the Gobi Desert and the Loess Plateau. The duration of the Yellow Sand Events was about 35-40 hours rather shorter than normal as the high pressure system centered near the Mongolia region moved rapidly toward the Yellow Sea, which drove away the Yellow Sand particles over the Korean peninsula toward the Japan Islands, furthermore the low-level stratification of the air mass over the Korean penishula showed the unstable atmospheric condition leading to atmospheric diffusion of the particles. The trajectory analyses and the GMS visible image indicated that the long-range transport of the air mass laden with the Yellow Sand particles of this case was more dependent on the 700 hPa air flow than on the 850 hPa air flow.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.14 no.6
• /
• pp.35-40
• /
• 2015

An IP-2 type container is used for the transport of low-level radioactive materials. An IP-2 type metal container was modeled and analyzed for the dropping conditions in normal transport conditions required by NSSC Notice 2014-50, "Regulations on the packaging and transport of radioactive materials." Structural analyses were performed by finite element method, and the acceptability was reviewed by comparing the results with technical standards and maximum allowable stresses of each material. Structural members of the container were modeled as 3D solid elements, and the possible dropping directions were considered in these analyses. Results show that maximum stresses, maximum deformed gaps in the cover, and maximum estimated thickness reduction in structural members were well below the allowable limits; thus, the structural integrity of the container was confirmed.