• Journal of Periodontal and Implant Science
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• v.28 no.1
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• pp.103-120
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• 1998

Prokaryotic and eukaryotic cells respond to heat stress and other environmental abuses by synthesizing a small set of stress proteins and by inhibiting post-transcription synthesis of normal proteins. The purpose of the present study was to document the stress response produced by inflamed gingival tissue in vivo, and cytokine inducted human periodontal ligament cells. Human PDL cells were exposed to TNF-$\alpha$(1ng/ml), INF-$\gamma$(200 U/ml), LPS(100ug/ml), combination of cytokine, and SDS-PAGE gels running and Western blotting analysis was done. In vivo studies, the healthy gingival tissusse of a control group and inflamed gingival tissue of adult periodontitis were studied by immunohistochemistry and histology. The results were as follows 1. HSP 47 was distributed on basal layer in healthy gingiva, but stronger stained in basal, suprabasal, and spinous layer of inflamed gingiva. 2. HSP 47 was rare on endothelial cells and mononuclear cells in healthy gingiva, but stronger expressed in inflamed gingiva. 3. HSP 70 expression was rare on epihelium and inflammatory cells hi both healthy & inflamed gingiva. 4. HSP 70 was actively expressed on endothelial cells and inflammatory cells of capillary lumen in moderately & mild inflamend gingiva. 5. PDL cells showed low level of HSP 47 protein expression which was significantly induced by cytokine stimulation (LSP only and combination). 6. Maximum HSP 70 protein induction was seen with stimulation by a combination of the cytokine, Combination of TNF-$\alpha$, INF-$\gamma$, LPS have been shown to synergistically effects of HSP 70 expression. On the above findings, HSP Is influenced by cytokine and chronic inflammation in vivo, and may be involved in protection of tissue during periodontal inflammatiom.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.91-91
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• 2011

The passage of the interplanetary discontinuity (i.e., sudden increases in the solar wind speed, density, and IMF strength) was detected by ACE near GSE (x, y, z) ~ (222, -36, 3) Re upstream of Earth around 22:48 UT on November 24, 2008. About 55 min later, this solar wind discontinuity was observed by Geotail near GSE (x, y, z) ~ (23, 18, -7) Re in front of Earth's bow shock. From the propagation time of the solar wind discontinuity between ACE and Geotail, it is expected that the discontinuity front is aligned with the Parker spiral and strikes the postnoon dayside magnetopause first. Using coordinated multi-point measurements (THEMIS and GOES) at or in geosynchronous orbit, we observed a tailward propagating sudden impulse (SI), excited by the interplanetary discontinuity, around 23:50 UT with its front retaining alignment similar to that of solar wind discontinuity. The SI event appears a negative-then-positive variation in the H component at high latitude Chokurdakh (CHD: MLAT ~ 64.7 deg) in the prenoon sector, which is opposite sense of normal SI event. During the positive deflection at CHD, the SuperDARN Hokkaido radar detected the downward motion of the ionosphere, implying westward electric field enhancement, at subauroral latitudes near CHD meridian. In our study we will discuss magnetospheric and ionospheric responses to the passage of the solar wind discontinuity using multi-point observations in space and on the ground.

• Korean Journal of Applied Biomechanics
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• v.16 no.2
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• pp.193-205
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• 2006

This study was to analysis the kinematic and kinetic differences between new walking shoe(NWS : RYN) and general walking shoe(GWS). The subjects for this study were 10 male adults who had the walking pattern of rearfoot shrike with normal foot. The movement of one lower leg was measured using plantar pressure and Vicon Motion Analysis Program(6 MX13 and 2 MX40 cameras : 100 f / s) while the subjects walked at the velocity(1.5m/s. on 2m).. The results of this study was as follows : 1. The NWS was better than the GWS that caused injuries such as adduction, abduction and pronation are reduced While walking on a perpendicular surface, the landing angle and the knees angles were extensive which makes walking more safe which reduces anxiety and uneasiness. 2. The bottom of the NWS were now made into a more circular arch which supports the weight of the body and reduces the irregular angles when wearing GWS. This arch made the supporting area more wide which made the upholding the trunk of the body more effective. The whole bottom of the foot that supports the weight is more flexible in addition, increases the safeness of walking patterns and the momentum of the body. 3. The moment the heel of the foot of the NWS touch the ground, the range of the pressure were partially notable and the range of the pressure on the upper part of the thigh were dispersed The injuries that occurred while walking. primary factors when a shock related injuries are reduced Judgements of the impacts of the knees and the spinal column dispersing could be made.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.4
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• pp.205-212
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• 2010

Endometritis is one of the primary reasons for reproductive failure. In order to investigate endometritis-associated marker proteins, proteomic analysis was performed on bovine endometrium with endometritis. In bovine endometritis, desmin, $\alpha$-actin-2, heat-shock protein (HSP) 27, peroxiredoxin-6, luteinizing hormone receptor isoform 1, collectin-43 precursor, deoxyribonuclease-I (DNase-I), and MHC class I heavy chain (MHC-Ih) were up-regulated. In contrast, transferrin, interleukin-2 precursor, hemoglobin $\beta$ subunit, and potassium channel tetramerisation domaincontaining 11 (KCTD11) were down-regulated in comparison to normal endometrium. The proteomic results were validated by semiquantitative-PCR and immunoblot analysis. The mRNA levels of desmin, transferrin, $\alpha$-actin-2, HSP27, KCTD11, and MHC-Ih were up-regulated by over 1.5-fold, and showed a pattern similar to their proteomic profiles. Desmin and $\alpha$-actin-2 protein showed positive correlations between proteomic analysis and immunoblot analysis. These results suggest that desmin and $\alpha$-actin-2 may play important roles in endometritis-related function, and could be useful markers for the diagnosis of bovine endometritis.

• Journal of the Society of Disaster Information
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• v.18 no.3
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• pp.495-506
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• 2022

Purpose: When a serious disaster occurred in East Japan on March 11, 2011, some evacuees in shock failed to avoid danger to the best of their ability. Why did they hesitate and waste their time? And why didn't they choose correct escaping routes? This study attempts to classify human behavior through psychological point of view and cognitive science and to interpret behavioral patterns based on animal behaviors from the field of biology. Method: This study first conceptually categorized walking behavior into intellectualization, automaticity and instinct based on the existing literature and matched these with empirical data. Result: The actual walking patterns observed failed to be compatible with these categories and consequently, this study suggests the following five categories: normal, busy, fast & straight, freezing and tizzy. This new classification of walking behavior is based on speed, variation of speed and change of direction. Conclusion: The method used in this study and the results can be applied to simulations of walking behavior and analysis of behavior in emergency situations.

• Journal of the Korean Society of Radiology
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• v.17 no.1
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• pp.71-77
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• 2023

The issue of North Korea's denuclearization is an global issue that transcends the North and South. It is necessary to prepare for the denuclearization process in preparation for the situation in which North Korea reveals its intention to denuclearize. In the process of North Korea's denuclearization, it is required to guarantee the normal operation of the denuclearization verification equipment. If a performance test criteria that takes into account the North Korean environment is established, it is highly likely that it will be used in the future denuclearization process. For this purpose, basic materials related to performance test standards were established through analysis of test standards such as international standards. After that, we established a performance test criteria. This includes high temperature, low temperature, humidity, vibration and shock tests. Through follow-up studies, validity of test criteria will be established through actual device testing.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2002.11a
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• pp.112-112
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• 2002

Under normal conditions, women produce a single dominant follicle that participates in a single ovuation each menstrual cycle. But Polycystic ovary syndrome(PCOS) conditions, folliculogenesis does not proceed normally. This condition leads to the accumlation of large numbers of small graffian follicles in which the theca interstitial cells (TIC) produce abnormally large amounts of androgen. PCOS is probably the most common endocrine disorder, affecting women of reprodutive age with 5-10% prevalence estimate. Chronic anovulation, hyperandrogenism, hirsutism, obesity, infertility and polycystic ovaries are clinical hallmarks of women with PCOS. Its etiology remains unknown. To investigate the gene expression pattern of ovary in PCO-induced rat, we used cDNA expression analysis. Total RNA was extracted from the ovary of PCO-induced rat and reverse-transcribed in the presence of［$\alpha$$^{32}$P］-dATP Which were hybridized to Atlas$^{TM}$ Rat Toxicology 1.2 array (Clontech) representing approximately 1176 rat genes. We compared gene expression between ovary of pco-induced immature female rats and control. Differential gene expression profiles were revealed (LIFR-alpha, ADRA1A, Heat shock 90-kDa protein A, PDGFRA). Reverse transcription-polymerase chain reaction(RT-PCR) was used to validate the relative expression pattern obtained by the cDNA array. The precise relationship between the altered expression of genes and PCO is a matter of further investigation. This study was supported by Korea Science and Engineering Foundation(KOSEF)

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.36.1-36.1
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• 2020

The progenitor of Type Ia supernovae (SNe Ia) is mainly believed to be a carbon/oxygen white dwarf (WD) with non-degenerate (single degenerate) or another WD companion (double degenerate). However, there is little observational evidence of their progenitor system. Recent studies suggest that shock-breakout cooling emission after the explosion can constrain the size of the progenitor system. To do so, we obtained a optical/Near-IR light curve of SN 2019ein, a normal but slightly sub-luminous type Ia supernova, from the very early phase using our high-cadence observation of Intensive Monitoring Survey of Nearby Galaxies (IMSNG). Assuming the expanding fireball model, the simple power-law fitting of the early part of the light curve gives power indices of 1.91 (B) and 2.09 (R) implying radioactive decay of 56Ni is the dominant energy source. By comparison with the expected light curve of the cooling emission, the early observation provides us an upper limit of the companion size of R∗≤1R⊙. This result suggests that we can exclude a large companion such as red giants, which is consistent with the previous study.

• The Journal of Internal Korean Medicine
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• v.44 no.5
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• pp.1050-1061
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• 2023

This study reported the case of a patient with quadriparesis due to cerebral aneurysm rupture, subarachnoid hemorrhage, and intraventricular hemorrhage (IVH) treated with Korean medicine. The patient was treated with acupuncture, herbal medicine (mainly Tonggyuhwalhyeol-tang-gagam), Western medicine, moxibustion, cupping, and rehabilitative therapy for 75 days, and improved after administration. After treatment, the Manual Muscle Test grade improved from 4/4-/3+/3 to 4+/4+/4+/4+, the Korean version of the modified Barthel Index score improved from 9 to 100, the National Institute of Health's Stroke Scale score improved from 2 to 0, the Global Deterioration Scale score improved from 3 to 2, and the Korean version of the Mini-Mental State Examination score improved from 22 to 30. During administration, the patient did not show seizures, shock, or loss of consciousness, and the vital signs were stable in the normal range. We followed up the brain computed tomography findings for 2 times and found that there was no definite evidence of intracranial hemorrhage or IVH or re-rupture or rebleeding after Korean medicine treatment. This study suggests that Korean medicine treatment with blood-invigorating and stasis-removing herbs could be a safe and effective intervention option for improving quadriparesis due to cerebral aneurysm rupture and subarachnoid hemorrhage.

• Asia-Pacific Journal of Business
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• v.15 no.2
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• pp.257-270
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• 2024

Purpose - The purpose of this study is to analyze the changes in the business environment, business conditions, and detailed indicators related to management of Korea's port industry companies as global supply chains have been reorganized since the shock of COVID-19 in 2020 and uncertainties in the global economy have expanded. Design/methodology/approach - This study use the business survey index of the port industry to analyze. It is a weighted BSI with the weight of workers applied. Findings - Since 2020 the BSI in the port industry including business conditions, sales unit price, profitability, and financial conditions fluctuated, but it has been generally above normal level(100). During the analysis period, the BSI for export sales was found to be better than that of domestic sales. Employment BSI was generally stable, and in the case of facility BSI, the port industry was shown to be very active in facility investment. Research implications or Originality - First, it is necessary to make manpower training systems to cultivate experts in the port industry to cope with uncertainties caused by the rapidly changing global economy and the global supply chain environment. Second, it is necessary to support for investment in technology and facilities for automation and smartization. Finally, it is necessary to establish a continuous monitoring system for the business conditions.