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Alteration of the Metabolome Profile in Endothelial Cells by Overexpression of miR-143/145

  • Wang, Wenshuo;Yang, Ye;Wang, Yiqing;Pang, Liewen;Huang, Jiechun;Tao, Hongyue;Sun, Xiaotian;Liu, Chen
    • Journal of Microbiology and Biotechnology
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    • v.26 no.3
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    • pp.572-578
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    • 2016
  • Communication between endothelial cells (ECs) and smooth muscle cells (SMCs) via miR-143/145 clusters is vital to vascular stability. Previous research demonstrates that miR-143/145 released from ECs can regulate SMC proliferation and migration. In addition, a recent study has found that SMCs also have the capability of manipulating EC function via miR-143/145. In the present study, we artificially increased the expression of miR-143/145 in ECs, to mimic a similar change caused by miR-143/145 released by SMCs, and applied untargeted metabolomics analysis, aimed at investigating the consequential effect of miR-143/145 overexpression. Our results showed that miR-143/145 overexpression alters the levels of metabolites involved in energy production, DNA methylation, and oxidative stress. These changed metabolites indicate that metabolic pathways, such as the SAM cycle and TCA cycle, exhibit significant differences from the norm with miR-143/145 overexpression.

A Study on Library Users' Intention to Use in a Hybrid Environment of Academic Library (하이브리드 대학도서관 환경에서의 도서관 이용자의 이용 의도에 관한 연구)

  • Han, Jiyeon;Moon, Sung-Been
    • Journal of the Korean Society for information Management
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    • v.37 no.3
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    • pp.275-299
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    • 2020
  • This study investigates the factors affecting behavioral intention of professors and students at universities to use academic libraries in a hybrid library environment where a traditional physical library is combined with a digital library that is centered on online information use. The structural relationships among factors were also analyzed in this study by utilizing a combined behavioural model which was based on TPB and TAM. This study identified users' intention to use academic libraries according to changes in the use environment, and the findings of this study bring a valuable meaning to library administrators for setting up the strategic plan for the future of academic libraries. The results of this study imply that academic libraries should strategically setup an effective and efficient operating plan based on awareness, attention and cooperation, in order to survive as well as to accomplish balanced growth in rapidly changing environment.

Dynamic Power Management for Webpage Loading on Mobile Devices (모바일 웹 페이지 로딩에서 동적 관리 기법)

  • Park, Hyunjae;Choi, Youngjune
    • Journal of KIISE
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    • v.42 no.12
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    • pp.1623-1628
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    • 2015
  • As the performance of mobile devices has increased, high-end multicore CPUs have become the norm in smartphones. However, such high performance devices are exposed to the problem of battery depletion due to the energy consumption caused by software performance, and despite increases in battery capacity. The required resources are dynamic and varied, and further user interaction is highly random; thus, Linux-based power management such as DVFS is needed to fulfill requirements. In order to reduce power consumption, we propose a method to restrict the CPU frequency of data download while maintaining user reactivity. This can supplement the weakness of existing Linux-based power management techniques like DVFS in relation to webpage loading. Through the implementation of our method at the application level, we confirm that energy consumption from webpage loading is reduced.

The effect of social capital on firm performance within industrial clusters: Mediating role of organizational learning of clustering SMEs (산업클러스터 내 사회적 자본이 기업성과에 미치는 영향: 조직학습의 역할을 중심으로)

  • Kim, Shin-Woo;Seo, Ribin;Yoon, Heon-Deok
    • Knowledge Management Research
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    • v.17 no.3
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    • pp.65-91
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    • 2016
  • Although the success of industrial clusters largely depends on whether clustering firms can achieve economic performance, there has been less attention on investigating factors and conditions contributing to the performance enhancement for clustering small and medium-sized enterprises (SMEs). Along this vein, we adopt the theories of social capital and organizational learning as those success factors for clustering SMEs. This study thus aims at examining what effect social capital accrued in the relationships among actors within clusters has on firm performance of clustering SMEs and what role organizational learning plays in the linkage between social capital and firm performance. For the empirical analysis, we operationalized the variables and their measures to develop questionnaires through the theoretical reviews on literatures. As a sample of 227 clustering SMEs, our collected data was analyzed by hierarchical regression analysis. The results confirmed that a high level of social capital, represented by network, trust, and norm, has positive effect on firm performance of clustering SMEs. We also found that clustering firms presenting high organizational learning, represented by absorptive and transformative capability, achieve better performance than those placing less value on organizational learning. Furthermore the significant relationship between social capital and firm performance is mediated partially through organizational learning. These findings imply not only that the territorial agglomeration of industrial cluster does not guarantee the performance creation of clustering SMEs but that they need to develop social capital among various actors within clusters, facilitating their knowledge diffusion. In order to absorb and mobilize the shared knowledge and information into strategic resources, the firms should improve their capability associated with organizational learning. These expand our understanding on the importance of social capital and organizational learning for the performance enhancement of clustering firms. Differentiating from major studies addressing benefits and advantages of industrial cluster, this study based on the perspective of firm-internal business process contributes to the literature advancement. Strategic and policy implications of this study are discussed in detail.

Factors influencing fast food consumption behaviors of middle-school students in Seoul: an application of theory of planned behaviors

  • Seo, Hyun-Sun;Lee, Soo-Kyung;Nam, So-Young
    • Nutrition Research and Practice
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    • v.5 no.2
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    • pp.169-178
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    • 2011
  • Fast food is popular among children and adolescents; however, its consumption has often been associated with negative impacts on nutrition and health. This study examined current fast food consumption status among middle school students and explored factors influencing fast food consumption by applying Theory of Planned Behavior. A total of 354 (52.5% boys) students were recruited from a middle school. The subjects completed a pre-tested questionnaire. The average monthly frequency of fast food consumption was 4.05 (4.25 for boys, 3.83 for girls). As expected, fast food consumption was considered to be a special event rather than part of an everyday diet, closely associated with meeting friends or celebrating, most likely with friends, special days. The Theory of Planned Behavior effectively explained fast food consumption behaviors with relatively high $R^2$ around 0.6. Multiple regression analyses showed that fast food consumption behavior was significantly related to behavioral intention (b = 0.61, P < 0.001) and perceived behavioral control (b = 0.19, P < 0.001). Further analysis showed that behavioral intention was significantly related to subjective norm (b = 0.15, P < 0.01) and perceived behavioral control (b = 0.56, P < 0.001). Attitude toward fast food consumption was not significantly associated with behavioral intention. Therefore, effective nutrition education programs on fast food consumption should include components to change the subjective norms of fast food consumption, especially among peers, and perceived behavioral control. Further studies should examine effective ways of changing subjective norms and possible alternatives to fast food consumption for students to alter perceived behavioral control.

Constructive music creation: the process and effectiveness of sampling in computer-based electronic music production (구성적 음악 창작: 컴퓨터 기반 전자적 음악 프로덕션 상에서 샘플링의 과정과 효과)

  • Han, Jinseung
    • Proceedings of the Korea Contents Association Conference
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    • 2009.05a
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    • pp.127-134
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    • 2009
  • In spite of controversial debates on aesthetic issues of computer-generated electronic music, rapid advancement of music technologies in the past decade have resulted proliferation of using virtual software synthesizers and samplers in music composition. Computer-based music production platform has become not only a norm among some of contemporary music composers but also vital apparatus for their compositional process. There are two imperative parts of this compositional process involving sampling in computer-based music production, which are commercially available sample libraries that include pre-recorded audio samples, and music production software that processes them. The purpose of this study is to investigate the process and effectiveness of reconstructive compositional process utilizing distinctive features of sampling on computer music production software. This study addresses issues such as: the definition of audio sampling, how sampling is incorporated in compositional process, and what features of music production software are particularly effective in various musical expressions. The result of this study will hopefully accommodate and fulfill the needs of electronic and acoustic musicians' creativeness.

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Intention to Participate in Collaborative Consumption as Providers and Users (제공자 및 사용자로서의 협력적 소비 참여의도에 관한 연구)

  • Hwang, Hyesun;Kim, Jee Hye;Kim, Kee-Ok
    • The Journal of the Korea Contents Association
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    • v.18 no.3
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    • pp.19-33
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    • 2018
  • Collaborative consumption was suggested as a new paradigm of consumption and business model that focuses on sharing and using resources to reduce the risks of resource depletion and environmental impact. Individual consumers carry out a role not only as users but also as providers for collaborative consumption. In the present study, the authors investigated consumers' intention to participate in collaborative consumption both as providers and users. The effects of perceived benefit of collaborative consumption, subjective norms and ease of participation on the intention to participate in collaborative consumption were analyzed. The perceptions on benefits and subjective norms were relatively high, while the perception on ease of participation was relatively low. The effects of subjective norms and ease of participation on the intention to participate in collaborative consumption were significant. The result shows that support from one's reference group and the perception on ease of participation have significant positive effects on the intent to participate in collaborative consumption. Therefore, communication strategies for developing a positive consumer attitude and a social consensus about the necessity of collaborative consumption are needed.

A ECG Analysis with Activity Monitrong for Healthcare of Elderly Person (노인 헬스케어를 위한 ECG분석 및 활동량 모니터링 구현)

  • Bhardwaj, Sachin;Purwar, Amit;Lee, Dae-Seok;Chung, Wan-Young
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2007.06a
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    • pp.347-350
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    • 2007
  • An ECG analysis with activity monitoring for the home care of elderly persons or patients, using wireless sensors technology was design and implemented. The changes in heart rate occur before, during, or following behavior such as posture changes, walking and running. Therefore, it is often very important to record heart rate along with posture and behavior, for continuously monitoring a patient's cardiovascular regulatory system during their daily life activity. The ECG and accelerometer data are continuously recorded with a built-in automatic alarm detection system, for giving early alarm signals even if the patient is unconscious or unaware of cardiac arrhythmias. The hardware allows data to be transmitted wirelessly from on-body sensors to a base station attached to server PC using IEEE802.15.4. If any abnormality un at server then the alarm condition sends to the doctor' PDA (Personal Digital Assistant).

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Analysis about relation of Won/Dollar Foreign Exchange Rate and Interest Rate of Korea (한국 원/달러환율과 금리의 관계분석)

  • 김종권
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.21 no.48
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    • pp.133-144
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    • 1998
  • International capital movement has made progress at global liberalization of finance and foreign exchange, international monetary norm changing into floating exchange rate system, easiness of collection of information and trade at improvement of information communication technology from early of 1970's. Results of empirical test for relation between foreign exchange rate or various determination factors of foreign exchange rate and interest rate are followed by next sentences. First, according to relation between foreign exchange rate and interest rate, correlation for each of variables after OECD entrance is increased. But, long-term & short-term interest rate is affected by Hanbo & Kia's bankruptcy, continuous large scale corporates bankruptcy and crisis of foreign exchange. Therefore, financial instability is occured. If portfolio investment fund has been inflow as it is mollified by continuous shortage of foreign exchange and fall of country's credit rating, it is expected to have positive effect for long-term & short-term interest rate from appreciation of won against dollar. Second, results from relation between determination factor of foreign exchange rate and interest rate are followed by next sentences. If surplus of current account and goods account is continued, yield of corporate bond is to be stable. But, margin of surplus is expected to diminish after second quarter 98, and difference between external and domestic interest (after adjusting foreign exchange rate) is to be diminished. And if net inflows of foreign investor's fund (stock and bond) is diminished, it is to have negative effect for yield of corporate bond. According to foreign investor's investment movement of previous years, hedge fund were stayed at least during two years in Mexico. It means that sudden capital outflow is not to be happened at Korea. But if external factors from depreciation of yen and China's renminbi are instable, interest rate is expected to increase from capital's outflows. Third, if it is to decrease instability of foreign exchange rate from increase in surplus of future current account, credit rating's upwardness, stability of yen and renminbi, foreign exchange rate is expected to be stable. It is expected to have continuous stability from short-term interest rate to long-term interest rate in this empirical test.

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Development of the Aggressive Regulation Behavior Scale for Middle School Student: Based on Ajzen's Theory of Planned Behavior (중학생의 공격조절행위 측정 도구 개발: Ajzen의 계획된 행위 이론을 기반으로)

  • Jang, Sook;Ahn, Hye Young
    • The Journal of Korean Society for School & Community Health Education
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    • v.21 no.2
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    • pp.39-57
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    • 2020
  • Objectives: This study was to develop a measurement scale that explains aggressive regulation behavior of middle school student, based on Ajzen's Theory of Planned Behavior (TPB) and verify its validity and reliability. Methods: The basic items were modified by selecting 41 items of middle school student aggressive behavior measurement scale. Through the content validity test, 63 first preliminary question items and 42 second preliminary question items were developed. The participants were 286 middle school students. The collected data were analyzed using content validity, correlation coefficient, exploratory factor analysis, confirmatory factor analysis, reliability and Cronbach α. Results: In this study, it was proved that the most important variable showing aggressive regulation behavior was aggressive regulation intention. This study was composed of 4 factors for direct measurement(attitude toward the behavior, subjective norm, perceived behavioral control, behavior intention) and 5 factors for indirect measurement(behavioral beliefs, outcome evaluation, normative beliefs, motivation to comply, control beliefs). The total variance was 65.4% and 67.6%, respectively, and the reliability was .90, .82. Finally, 42 questions were developed. Conclusion: We found the questionnaire used in this study was valid and reliable as a measure scale to explain the aggressive regulation behavior of middle school student based on TPB. Therefore, it is concluded that the aggressive regulation behavior scale could be a useful scale for the measurement of the aggressive regulation behavior of middle school student.