• 대한족부족관절학회:학술대회논문집
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• 2008.11a
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• pp.47-47
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• 2008

• The Journal of the Korean bone and joint tumor society
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• v.5 no.3
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• pp.178-182
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• 1999

We report a case of bizarre parosteal osteochondromatous proliferation of the right femur in an 18-year-old man. Roentgenograms showed a calcific mass attached to the underlying cortex with a broad base. Histologically, the lesion showed hypercellular cartilaginous tissue with maturation into trabecular bone, which contained spindle cells and lymphocytes in the intertrabecular spaces. Bizarre parosteal osteochondromatous proliferations are a form of heterotopic ossification and should not be mistaken for osteosarcoma or chondrosarcoma.

• Journal of Korean Foot and Ankle Society
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• v.2 no.1
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• pp.48-51
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• 1998

Bizarre parosteal osteochondromatous proliferation of bone (BPOP) was first described in 1983 by Nora et. al., who reported 35 cases of a bizarre proliferative lesion involving the small bones of the hands and less often the feet. These lesions simulate osteochondromas and conlain cartilage cap exhibiting atypical chondrocytes often undergoing ossification. Radiologically, they differ from osteochondromas. The lesion recurs in a significant number of cases after local excision, and the disturbing cytologic features may lead to a mistaken diagnosis of malignancy. The purpose of this report is to describe a case of bizarre parosleal osteochondromatous proliferation of the foot in a patient without traumatic history.

• The Journal of the Korean bone and joint tumor society
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• v.20 no.2
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• pp.104-108
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• 2014

Bizarre parosteal osteochondromatous proliferation (Nora's lesion) is a rare benign tumor and known to be primarily occur in the small tubular bone of the hands and feet. However, it is very unusual to be reported that it occurs in metatarsal bone in Korea. Thus, we report this tumor of metatarsal bone including the literature review because we have experienced this example.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.675-677
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• 2023

본 연구는 병리학 이미지 분석에서 자주 발생하는 문제 중 하나인 레이블링 불일치 문제를 해결하고자 준지도학습(semi-supervised learning) 기법을 적용하였다. 기존의 병리 진단 과정은 정확한 판정 및 치료를 위해 전문가의 판단을 필요로 한다. 이로 인해, 시간이 매우 많이 소모되며 전문가의 피로도가 증가한다. 최근 이를 해결하고자 지도학습(supervised learning) 기법을 사용하여 업무의 피로도를 감소시키고자 하는 연구가 진행되고 있다. 하지만 병리 이미지 데이터에 대한 접근이 어렵고, 병변의 위치를 레이블링 하는 부분에서 많은 비용이 발생한다. 또한 암 병변의 스펙트럼적 특성으로 인해 레이블링 과정 속에서 레이블링 불일치 문제가 발생할 가능성이 높다. 이러한 문제를 극복하기 위해, 우리는 제한된 레이블 된 데이터와 많은 양의 레이블 되지 않은 데이터를 활용하는 준지도학습 방법론을 제안한다. 이 제안하는 방법은 필요한 수동 레이블링 작업량을 줄여, 병리학자들에게 보다 효과적인 진단 도구를 제공할 것으로 예상된다.

• The Journal of the Korean bone and joint tumor society
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• v.10 no.2
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• pp.142-146
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• 2004

Bizzare parosteal osteochondromatous proliferation is a rare lesion, tends to frequently recur. It was first described in 1983, when Nora and his colleagues reported 35 examples of a proliferative lesion involving small bones of the hand and the feet. It was regarded as occurring only in the small bones of the hand and the feet initially, but from then on, other authors have been reported cases including those involving long bones, skull and maxilla. We experienced a case of bizzare parosteal osteochondromatous proliferation which affects the humeral shaft in a 14-year-old male patient. Radiographs showed calcified mass measuring $4{\times}3$ cm in size and attached to the underlying cortex, which had a broad stalk base. Histologically, it showed hypercellular cartilage maturation to the trabecular bone and plump amount of fibrous stroma in the spaces around the bony trabeculae. Bizzare parosteal osteochondromatous proliferation is a relatively rare lesion, but has a recurrent behavior and histologically tends to be mistaken for malignancy. It can be treated by excision.

• Journal of Biomedical Engineering Research
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• v.23 no.3
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• pp.189-196
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• 2002

Transdermal drug delivery offers an alternative method to the conventional oral and injection delivery method. Its advantages include its ability to deliver drugs directly into systemic circulation. However, there have been restrictions in its application to deliver drugs because of the skin's barrier function. In this study, we try to combine a Sonophoresis and oxygen Pressure method in order to increase the Permeability of the skin. we used water as the compound and by utilizing the skin impedance method. we measured the hydration Permeability of skin Ultrasound was applied using a sonicator(Solcare-U1000. Solco, Korea) operating at a frequency of 1MHz. oxygen Pressure was applied using a compressor(Oxyjet-Pointer, Nora Bode. Germany) operating at a pressure of 2Bar/cm2. Experiment was performed in vivo for 42 People. We divided the subjects into four smaller groups. A different transdermal drug delivery method was applied for each group on the back of their hand. We measured the skin impedance variations on the hand. during a 20-minute time Period. The control group did not show any significant increase or variation of skin impedance to water. In comparison to the control group(Passive diffusion) the hydration Permeability of the ultrasound group and the oxygen Pressure group was approximately 25 and 30 times higher consecutively. Futhermore, the hydration permeability of the combination of ultrasound and oxygen Pressure group was about 70-fold higher in comparison to the control group(passive diffusion) . The results reveal that a combination of ultrasound and oxygen Pressure will significantly enhance transdermal water transport compared when only one of them is used.