• 음성과학
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• 제9권3호
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• pp.87-97
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• 2002

The purpose of this study is to analyze the speech duration in Korean-speaking aphasics. Five patients with nonfluent aphasia (2 with traumatic brain injury and 3 with strokes) and five normal adults participated in this experiment. The mean age in patients with nonfluent aphasia was $45.8\pm2.3$ years and $47.4\pm2.3$ years for the normal adults. The Computerized Speech Lab was used to evaluate the acoustic characteristics of the subjects. Voice onset time, vowel duration, total duration, hold and consonant duration were evaluated for the monosyllabic and the polysyllabic words. The patients with nonfluent aphasia did not show the voicing bar on hold area, however, it was seen in the normal persons in the intervocalic position. Explosion duration of glottalized stops in the intervocalic position was significantly prolonged in nonfluent aphasics in comparison with the normal persons. This suggestes that the laryngeal adjustment is disturbed in these patients. Consonant duration, vowel duration, and total duration of the polysyllabic words were significantly longer in the patients with nonfluent aphasia than those of the normal persons. These results demonstrate the disturbances in controlling articulatory muscles during sound production in patients with nonfluent aphasia. The objective and quantitative analysis based on the acoustic characteristics of nonfluent aphasics, will be very useful in therapeutic planning and on the the effects of speech therapy.

• 대한치매학회지
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• 제17권3호
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• pp.110-119
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• 2018

Background and Purpose: To analyze $^{18}F-THK5351$ positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA). Methods: Thirty-one participants, including those with Alzheimer's disease (AD, n=13), navPPA (n=3), and those with normal control (NC, n=15) who completed 3 Tesla magnetic resonance imaging, $^{18}F-THK5351$ PET scans, and detailed neuropsychological tests, were included. Voxel-based and region of interest (ROI)-based analyses were performed to evaluate retention of $^{18}F-THK5351$ in navPPA patients. Results: In ROI-based analysis, patients with navPPA had higher levels of THK retention in the Broca's area, bilateral inferior frontal lobes, bilateral precentral gyri, and bilateral basal ganglia. Patients with navPPA showed higher levels of THK retention in bilateral frontal lobes (mainly left side) compared than NC in voxel-wise analysis. Conclusions: In our study, THK retention in navPPA patients was mainly distributed at the frontal region which was well correlated with functional-radiological distribution of navPPA. Our results suggest that tau PET imaging could be a supportive tool for diagnosis of navPPA in combination with a clinical history.

• 생물정신의학
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• 제23권3호
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• pp.69-79
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• 2016

Frontotemporal dementia (FTD) is a degenerative disease characterized by the selective frontal and temporal lobe atrophy, and progressive deficits in behavior, executive function, or language. The prevalence and incidence of FTD are 15-22/100000 and 2.7-4.1/100000, respectively, in midlife. Hereditary is an important risk factor for FTD. Although there is some controversy regarding the further syndromatic subdivision of the different types of FTD, FTD is clinically classified into behavioral variant of frontotemporal dementia, semantic dementia and progressive nonfluent aphasia. FTD can be misdiagnosed as many psychiatric disorders because of similarity of the prominent behavioral features. Advances in clinical, imaging, and molecular characterization have increased the accuracy of FTD diagnosis, thus developing for the accurate differentiation of these syndromes from psychiatric disorders. We also discuss about therapeutic strategies for symptom management of FTD. Medications such as serotonin reuptake inhibitors, antipsychotics, and other novel treatments have been used in FTD with various rates of success. Further advanced research should be directed at understanding and developing new diagnostic and therapeutic modalities to improve the FTD patients' prognosis and quality of life.

• 재활복지
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• 제20권1호
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• pp.171-188
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• 2016

이 연구는 비유창성 실어증 환자 집단과 정상 성인 집단을 대상으로 단어빈도, 단어길이, 생물성의 세 가지 어휘조건에 따른 이름대기 수행에 차이가 있는지 알아보는 것을 목적으로 하였다. 연구 대상은 비유창성 실어증 환자 15명과 정상 성인 15명이었다. 이름대기 과제의 목표 단어는 그림으로 표현 가능한 구체명사만 사용하였으며, 이름대기 평가는 그림을 이용한 대면이름대기방법을 사용하였다. 목표 단어는 단어빈도(저빈도어/고빈도어), 단어길이(1음절/3음절), 생물성(생물/무생물)의 어휘조건을 적용하여 총 40개의 문항으로 구성하였다. 연구 결과를 살펴보면 다음과 같다. 첫째, 두 집단 모두 고빈도 단어의 이름대기 수행이 저빈도 단어보다 높게 나타났다. 둘째, 두 집단 모두 1음절 단어의 이름대기 수행이 3음절 단어보다 높게 나타났다. 셋째, 두 집단 모두 생물성에 따른 이름대기 수행에는 유의한 차이가 없었다. 넷째, 집단과 어휘조건의 상호작용 효과는 단어빈도에서만 나타났다. 이러한 결과는 비유창성 실어증 환자들의 어휘조건에 따른 이름대기 능력의 저하는 단어길이나 생물성에 비해 단어빈도의 효과가 크다는 것을 시사한다. 이러한 연구결과는 비유창성 실어증 환자의 이름대기 평가와 중재의 기초 자료로 활용될 수 있다.

• 음성과학
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• 제4권2호
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• pp.91-102
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• 1998

The present study attempted to modify the conventional Melodic Intonation Therapy (MIT) in three aspects: number of syllables of adjacent target utterances (ATU), melody patterns of ATU, and initial listening of melody and intoned speech with the eyes closed. The modified Melodic Intonation Therapy (MMIT) was applied to two severe Korean aphasics. The patients exhibited a severely nonfluent aphasia resulting from a left CVA(Cerebrovascular Accident). The purpose of the modification was to avoid perseveration and improve reflective listening skills. First, the treatment program avoided ATU with the same number of syllables. Second, four different patterns of melody were developed: rising type, falling type, V-type, and inverted V-type. One type of prosodic pattern was preceded and followed by another type of melody. These two variations were to decrease perseverative behaviors. Finally, the patients kept their eyes closed when the clinician played and hummed a target melody at the initial stage of the program in order to improve reflective listening skills. A single-subject alternating treatment design was used. The effects of MMIT were compared to the conventional MIT. Differing the number of syllables and the type of melodic patterns decreased perseverative behaviors and produced more correct names. The initial listening of the target melody with the patients' eyes closed seemed to increase their attentiveness and result in a more fluent production of target utterances. Probable reasons for the effectiveness of MMIT were discussed.