• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.3
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• pp.639-647
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• 2011

In this paper, we introduce a design methodology of data-centroid Radial Basis Function neural networks with extended polynomial function. The two underlying design mechanisms of such networks involve K-means clustering method and Particle Swarm Optimization(PSO). The proposed algorithm is based on K-means clustering method for efficient processing of data and the optimization of model was carried out using PSO. In this paper, as the connection weight of RBF neural networks, we are able to use four types of polynomials such as simplified, linear, quadratic, and modified quadratic. Using K-means clustering, the center values of Gaussian function as activation function are selected. And the PSO-based RBF neural networks results in a structurally optimized structure and comes with a higher level of flexibility than the one encountered in the conventional RBF neural networks. The PSO-based design procedure being applied at each node of RBF neural networks leads to the selection of preferred parameters with specific local characteristics (such as the number of input variables, a specific set of input variables, and the distribution constant value in activation function) available within the RBF neural networks. To evaluate the performance of the proposed data-centroid RBF neural network with extended polynomial function, the model is experimented with using the nonlinear process data(2-Dimensional synthetic data and Mackey-Glass time series process data) and the Machine Learning dataset(NOx emission process data in gas turbine plant, Automobile Miles per Gallon(MPG) data, and Boston housing data). For the characteristic analysis of the given entire dataset with non-linearity as well as the efficient construction and evaluation of the dynamic network model, the partition of the given entire dataset distinguishes between two cases of Division I(training dataset and testing dataset) and Division II(training dataset, validation dataset, and testing dataset). A comparative analysis shows that the proposed RBF neural networks produces model with higher accuracy as well as more superb predictive capability than other intelligent models presented previously.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.3
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• pp.184-196
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• 2020

In this paper, a single-bit 2nd-order delta-sigma modulator with the architecture of cascaded-of-integrator feedforward (CIFF) is proposed for precision measurement of current flowing through a secondary cell battery in a battery management system (BMS). The proposed modulator implements two switched capacitor integrators and a single-bit comparator with peripheral circuits such as a non-overlapping clock generator and a bias circuit. The proposed structure is designed to be applied to low-side current sensing method with low common mode input voltage. Using the low-side current measurement method has the advantage of reducing the burden on the circuit design. In addition, the ±30mV input voltage is resolved by the ADC with 15-bit resolution, eliminating the need for an additional programmable gain amplifier (PGA). The proposed a single-bit 2nd-order delta-sigma modulator has been implemented in a 350-nm CMOS process. It achieves 95.46-dB signal-to-noise-and-distortion ratio (SNDR), 96.01-dB spurious-free dynamic range (SFDR), and 15.56-bit effective-number-of-bits (ENOB) with an oversampling ratio (OSR) of 400 for 5-kHz bandwidth. The area and power consumption of the delta-sigma modulator are 670×490 ㎛2 and 414 ㎼, respectively.

• The Transactions of the Korea Information Processing Society
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• v.7 no.3
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• pp.879-890
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• 2000

Designing a multilevel database application is a complex process, and the entities and their associated security levels must be represented using an appropriate model unambiguously. It is also important to capture the semantics of a multilevel databse application as accurate and complete as possible. Owing to the focus of the IDEA Methodology for designing the non-secure database applications on the data-intensive systems, the Object Model describes the static structure of the objects in an application and their relationships. That is, the Object Model in the IDEA Methodology is an extended Entity-Relationship model giving a static description of objects. The IDEA Methodology has not been developed the multilevel secure database applications, but by using an existing methodology we could take advantage of the various techniques that have already been developed for that methodology. That is, this way is easier to design the multilevel secure schema than to develop a new model from scratch. This paper adds the security features 새？ Object Model in the IDEA Methodology, and presents the transformation from this model to a multilevel secure object oriented schema. This schema will be the preliminary work which can be the general scheme for the automatic mapping to the various commercial multilevel secure database management system such as Informix-Online/Secure, Trusted ORACLE, and Sybase Secure SQL Server.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.6
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• pp.148-156
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• 2018

The integrity assessment of the bridge behavior is generalized by field data of a static load-deformation curve and dynamic properties such as impact factors and natural frequencies. Evaluating it with numerical analysis is a reasonable method. The results of the mockup test and the numerical analysis are corresponded with each other since the behavior of service load proceeds in elastic region. In case of the dynamic behavior of structure, especially for the analysis of vibration, the result of the mockup test differs from the result of numerical analysis a little due to the geometric shape and non-homogeneous materials. In order to converge on these tolerances, this study suggested several numerical models, analyzed the sensitivity and finally offered a practical modeling method for the estimation of bridge on the basis of the result of mockup test. Based on the model substituted concrete section for strands section, the natural frequency of the model composed with axial stiffness of strands or the model applied the modified modulus of elasticity was closest with the result of the mockup test.

• Journal of Pharmacopuncture
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• v.18 no.2
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• pp.7-18
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• 2015

Objectives: Lawsone (1,4 naphthoquinone) is a non redox cycling compound that can be catalyzed by DT diaphorase (DTD) into 1,2,4-trihydroxynaphthalene (THN), which can generate reactive oxygen species by auto oxidation. The purpose of this study was to evaluate the toxicity of the phytomarker 1,4 naphthoquinone and its metabolite THN by using the molecular docking program AutoDock 4. Methods: The 3D structure of ligands such as hydrogen peroxide ($H_2O_2$), nitric oxide synthase (NOS), catalase (CAT), glutathione (GSH), glutathione reductase (GR), glucose 6-phosphate dehydrogenase (G6PDH) and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) were drawn using hyperchem drawing tools and minimizing the energy of all pdb files with the help of hyperchem by $MM^+$ followed by a semi-empirical (PM3) method. The docking process was studied with ligand molecules to identify suitable dockings at protein binding sites through annealing and genetic simulation algorithms. The program auto dock tools (ADT) was released as an extension suite to the python molecular viewer used to prepare proteins and ligands. Grids centered on active sites were obtained with spacings of $54{\times}55{\times}56$, and a grid spacing of 0.503 was calculated. Comparisons of Global and Local Search Methods in Drug Docking were adopted to determine parameters; a maximum number of 250,000 energy evaluations, a maximum number of generations of 27,000, and mutation and crossover rates of 0.02 and 0.8 were used. The number of docking runs was set to 10. Results: Lawsone and THN can be considered to efficiently bind with NOS, CAT, GSH, GR, G6PDH and NADPH, which has been confirmed through hydrogen bond affinity with the respective amino acids. Conclusion: Naphthoquinone derivatives of lawsone, which can be metabolized into THN by a catalyst DTD, were examined. Lawsone and THN were found to be identically potent molecules for their affinities for selected proteins.

• Applied Microscopy
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• v.39 no.3
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• pp.227-236
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• 2009

The ultrastructure of spermatogenesis and sperm in Coreoleuciscus splendidus, belonging to Gobioninae, Cyprinidae was investigated by light and electron microscopes. The testis was located between intestine and air bladder. The size of testis was major axis 1.8 cm, minor axis 3 mm. The testis of C. splendidus contained numerous testicular cysts, and spermatogenesis was non-synchronized in these testicular cysts. In May, the upper area of testis contained with other germ cells and sperm but the lower area of testis contained with matured sperm only. In case of spermatogonia, the nucleus was comparatively large spherical, and mitochondria showed a marked development. The size of primary spermatocyte was smaller than that of spermatogonia, and that of secondary spermatocyte was smaller than that of primary spermatocyte. The chromatin of spermatocyte was highly condensed according to their development. The nucleus with electron-dense was round shape. In spermiogenesis, flagella started to be formed and chromatin was more condensed. The mitochondria were rearranged in a middle piece. The head of matured sperm was a spherical shape and had not acrosome. The microtubules of flagella were arranged 9+2 structure. Also, the tail of sperm had not lateral fins and 7 outer coarse fibers.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.17 no.1
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• pp.81-90
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• 2014

A Fairy Pitta is a bird known to breed only in mainland China, Taiwan, Japan and Korea and is listed as Vulnerable in the IUCN Red List. We carried out a DNA analysis to contribute to conserve the genetic diversity of Fairy Pitta. 32 samples were collected at Jeju Island, the Korean Peninsula and Taiwan from 2004 to 2013 and DNA was extracted from them and several sequences were amplified-it through PCR. And then we performed the population genetic analysis. We found there was a transversion between nucleotide sequences at CO1 gene, while there was no changes at Cyt-b gene. And we confirmed the polymorphism from two genes was caused from genetic drift not from selection. Through this analysis, the group within the Peninsula was found bigger than other two groups based on the analysis of CO1 gene, and the group from Taiwan was found bigger than other two groups through the analysis of Cyt-b gene. The population genetic structure of mitochondria gene of three group was showing CO1 gene had 5 haplotypes and Cyt-b gene had 6 haplotypes. Haplotype 2 in CO1 gene was found in three group and many individuals of samples had this haplotype. Like CO1 gene, haplotype 2 in Cyt-b gene was found in three group and was included in plenty of individuals. Other haplotypes were not overlaped and broke off among the three groups. To prevent from the extinction of Fairy Pitta and to obtain the genetic diversity, we need to compare with other regional group such as Japan, China and perform additional research in the non-breeding area.

• Journal of Microbiology and Biotechnology
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• v.25 no.8
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• pp.1339-1348
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• 2015

Until now, considerable effort has been made to engineer novel nitrogen-fixing organisms through the transfer of nif genes from various diazotrophs to non-nitrogen fixers; however, regulatory coupling of the heterologous nif genes with the regulatory system of the new host is still not well understood. In this work, a 49 kb nitrogen fixation island from P. stutzeri A1501 was transferred into E. coli using a novel and efficient transformation strategy, and a series of recombinant nitrogen-fixing E. coli strains were obtained. We found that the nitrogenase activity of the recombinant E. coli strain EN-01, similar to the parent strain P. stutzeri A1501, was dependent on external ammonia concentration, oxygen tension, and temperature. We further found that there existed a regulatory coupling between the E. coli general nitrogen regulatory system and the heterologous P. stutzeri nif island in the recombinant E. coli strain. We also provided evidence that the E. coli general nitrogen regulator GlnG protein was involved in the activation of the nif-specific regulator NifA via a direct interaction with the NifA promoter. To the best of our knowledge, this work plays a groundbreaking role in increasing understanding of the regulatory coupling of the heterologous nitrogen fixation system with the regulatory system of the recipient host. Furthermore, it will shed light on the structure and functional integrity of the nif island and will be useful for the construction of novel and more robust nitrogen-fixing organisms through biosynthetic engineering.

• Journal of Korean Society of Environmental Engineers
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• v.33 no.11
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• pp.847-854
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• 2011

To deal with issues from global climate changes, renewable bioenergy has become important. Algae have been regarded as a good resource for biorefinery and bioenergy, and also have potential capability to remove nutrient and non-decompositional pollutants for wastewater advanced treatment. Although algal-bacterial ecological interaction would be a crucially important factor in using algae for wastewater advanced treatment and resource recovery from wastewater, very little is known about ecological interaction between algae and bacteria in a real wastewater environment. In this study, under a real municipal wastewater condition, we characterized wastewater pollutant treatability and bacterial communities in response to growth of Ankistrodesmus gracilis SAG278-2, which can grow in wastewater and has a high lipid contents. The growth of algal population using the wastewater was inhibited by increase in wastewater bacteria while bacterial survival and cellular decay rate were not influenced by the algal growth. Removals of recalcitrant organic matters and total nitrogen were improved in the presence of algal growth. According to T-RFLP and statistical analysis, algal growth affected time-course changes in bacterial community structures. The following 16S rRNA gene amplicon, cloning results showed that the algal growth changes in bacterial community structure, and that bacterial populations belonging to Sediminibacterium, Sphingobacterium, Mucilaginibacter genera were identified as cooperative with the algal growth in the wastewater.

• Journal of Broadcast Engineering
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• v.17 no.1
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• pp.152-164
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• 2012

DMB provides various kinds of data services such as BWS and TPEG service in addition to audio and video services. But recently the necessity of new business models creating profit has been on the rise due to the saturation of DMB receiver market and break-down of market barrier between mobile IPTV and DMB services. This paper introduces DMB filecasting service technology, which can be expected a new profit-creative business model. The purpose of DMB filecasting service is to transmit non-real time multimedia contents based on DMB AF format to the users through DMB channels. It makes possible to consume DMB contents with any DMB-installed device anytime, anywhere and share them with others. Also DMB filecasting service makes consumption and request of DMB contents possible to be extented to a variety of networks as well as DMB channels. The paper explains the standardization status of DMB filecasting service and various DMB filecasting service scenarios. And also it proposes a signalling methode, a transmission and reception protocol and a receiver structure using DMB broadcasting program guide information.