• The Journal of Korean Society for School & Community Health Education
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• v.1 no.1
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• pp.45-59
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• 2000

This study was designed to figure out current situation of use of non prescription drugs and psychological factors of high school girl students on drug use, and conducted from Nov. 1 through Nov. 20. 1998. 536 girl students were randomly selected for this study. Symptom Check list-90-Revision questionnaires used for interview. The data obtained were analyzed by SAS program. The results are as follows: 1. 94.8% of students had experiences of using more than one kind of drug; lenitive(57.8%), digestant(74.1%), remedy for colds(84.9%), antibiotic(9.3%), stimulant(3.2%) remedy for constipation(22.4%). 2. Students had experiences of using non prescription drug, lenitive(88.1%), digestant(91.7%), remedy for colds(57.4%), antibiotic(58.0%), stimulant(88.2%) remedy for constipation(88.3%) 3. 19.4% of students had experiences using drugs more than one time a week and 23.5% of students experienced tolerance, prescription group(11.1%) and non prescription group(88.9%) and 21.4% of students were keeping some medicine who experienced tolerance. 4. The scores of Symptom Check list-90-Revision of students' were higher than Kim's standard group and the psychological states were worse than Kim's standard group. 5. There were significant differences among groups(no use of drug, use of less than three kinds of drugs, use of more than three kinds of drugs) in Symptom Dimension without Paranoid Ideation and Phobic Anxiety and between using group and non using group of drug in Psychological factors on Drug use by lenitive, antibiotic, and stimulant.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.19 no.2
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• pp.72-82
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• 2008

The aim of this paper is to evaluate the use of non-stimulants, including atomoxetine, bupropion and modafinil, as alternative approaches to the treatment of children with attention-deficit hyperactivity disorder. A comprehensive review of the empirically based literature regarding the efficacy and the safety of the non-stimulants was performed. There is a large and increasing body of data supporting the efficacy and the safety of non-stimulants. Although the treatment effect sizes for non-stimulants may be smaller than those for stimulants, non-stimulants alone have been shown to be effective in the treatment of attention-deficit hyperactivity disorder as well as several comorbidities. These results suggest that non-stimulants are effective in the treatment of attention-deficit hyperactivity disorder. Further studies are needed to improve our understanding of alternative pharmacological medications in the treatment of attention-deficit hyperactivity disorder.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2019.11a
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• pp.178-179
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• 2019

The cement industry is a large amount of carbon dioxide emission industry, and research and development on non-cement composition is underway at the time when the absolute reduction of cement use is urgently needed. In addition, limestone fine powder is a by-product and is required to be recycled in terms of resource circulation. The compressive strength of the lime cement powder added noncement composition showed that the compressive strength increased as the limestone powder was added. It is believed that limestone fine powder played a role of stimulant such as alkali activator in non-cement composition.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.23 no.2
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• pp.49-56
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• 2012

Methylphenidate is a widely used stimulant for treatment of attention-deficit hyperactivity disorder (ADHD). In addition to core symptoms of attention and behavioral symptoms, methylphenidate is even effective for executive functions. However, abuse and misuse of stimulants, including methylphenidate, for the purpose of cognitive enhancement is an issue of concern worldwide. Some prejudices and misunderstandings against methylphenidate are popular ; however, little attention has been given to the neuropsychiatric evidence of methylphenidate for enhancement of cognitive function among healthy populations. In this article, our aim was to conduct a review of previous studies investigating the effect of methylphenidate in healthy populations. Findings from several recent studies have demonstrated the effectiveness of methylphenidate for enhancement of cognitive function in healthy populations. The mechanisms of cognitive enhancement are thought to be associated with motivation and the reward circuit in the brain. However, when considering the risk to benefit, an official discussion of the use of methylphenidate among healthy members of the population would be premature. Instead, investigation of epidemiological studies of the prevalence of misuse of stimulants among healthy members of the population, particularly adolescents and college students, is needed. In addition, based on achievements reported in previous studies, investigation of the effect of an approach using non-pharmacological enhancing motivation, which will in turn result in increased cognitive function would be helpful.

• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.9
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• pp.1208-1214
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• 2011

Caffeine, a psychoactive stimulant, has been implicated in the modulation of learning and memory functions due to its action as a non-selective adenosine receptors antagonist. On the contrary, some side effects of caffeine have been reported, such as an increased energy loss and metabolic rate, decrease DNA synthesis in the spleen, and increased oxidative damage to exerted on LDL particles. Therefore, the aim of this study was to develop a safe stimulant from natural plants mixture (Aralia elata, Acori graminei Rhizoma, Chrysanthemum, Dandleion, Guarana, Shepherd's purse) that can be used as a substitute for caffeine. Thirty SD rats were divided into three groups; control group, caffeine group (15.0 mg/kg, i.p.), and natural plants mixture group (NP, 1 mL/kg, p.o.). The effect of NP extract on stimulant activity was evaluated with open-field test (OFT) and plus maze test for measurement of behavioral profiles. Plasma lipid profiles, lipid peroxidation in LDL (conjugated dienes), total antioxidant capacity (TRAP) and DNA damage in white blood, liver, and brain cells were measured. In the OFT, immobility time was increased significantly by acute (once) and chronic (3 weeks) supplementation of NP and showed a similar effect to caffeine treatment. Three weeks of caffeine treatment caused plasma lipid peroxidation and DNA damage in liver cells, whereas there were no changes in the NP group. NP group showed a higher plasma HDL cholesterol concentration compared to the caffeine group. The results indicate that the natural plants mixture had a stimulant effect without inducing oxidative stress.

• Journal of the Korean Society of School Health
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• v.4 no.1
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• pp.88-99
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• 1991

The purpose of this study was attempted to analyze the relationship between drug abuse and the other problem behavior Patterns among high school students in Cheju. In order to achieve these set-goals, questionaires were finally supplied to the total 379 case of 9 high school from October to December, 1990. The collected data were processed using the SPSS-X computer program and statistically analyzed by the Chi-square method and. percentage. Results of the study were as follows: Among the 370 adolescents, 32.4% of students experienced cigarette smoking in their life, adolescents who experienced alcohol drinking were 46.8%, 0.5% of the students ever used marihuana; cocaine 0.3%, stimulant 3.2%, hallucinogen and inhalants 0.5%, tranquilizer 1.4%, analgesics 31:6%, antitussives 6.5%, antihistamines 1.9%. And all students never experienced the amphetamines and narcotics. The rates of drug use except stimulant and antitussive were higher in the male than in the female students. For the analysis of personal identifying datum, the rates of experienced smokers increased among groups of buddhist and the rates of experienced alconoi drinking increased among groups of no religion. Drug abuser increased among the group lower socio-economic status student, the adolescents whose parents have traditional education point of view. And it was also higher in those who were living only one than in those who were living together. Most students tended to use drugs after 17 or 18 years old. Drug users were more inclined to commit other problem behaviors when compared non-drug users. In the conclusion of the above results, it will be necessary to investigate the drug problem of adolescent. Drug abuse of students must be seen in an environmental context including family, school, peer group and society and not solely as the characteristics of an individual adolescent. And their parents and teachers must be on the alert for the behavior changes of their children such as changes of school performance, neglecting homework, tardiness or truancy from school, runaway from home, and mingled with bad companions, etc. We must recognize that drug abuse is frequently symptomatic of problems in the adolescent's environment.

• Journal of the Korean Home Economics Association
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• v.12 no.34
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• pp.737-741
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• 1974

Coffee is a popular beverage with many people at home and in the tea-room, Caffeine is a major chemical compound of the coffee. A little caffeine is a stimulant to the movement and spiritual nerve, but much caffeine influences sleep, nervousness, non-concentration, headache and giddliness depending upon each person. The writhe expresses the result of the caffeine content in the coffee which is collected from the coffee-shapes of Seoul. The contents are as follows : 1) Caffeine content of the coffee of the tea-room was researched dividing into the contral Seoul city and the outskirts of Seoul. 2) Caffeine content of the coffee in the outskirts tea-rooms is 0.32-1.23 mg/ml and the average is 0.546 mg/ml (SD 0.19). 3) Caffeine content of the coffee of the central city is 0.34-0.73 mg/ml and the average is 0.513 mg/ml (SD 0.12). 4) There was no difference between the outskirts and the central city. 5) Caffeine content of the coffee of the tea-rooms according to each season is going to be researched.

• Journal of the Korean Society of Food Science and Nutrition
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• v.4 no.1
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• pp.45-48
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• 1975

Coffee is a popular beverage with many people at home and in the tea-room. Caffeine is a major chemical compound of coffee. A little caffeine is a stimulant to the movement and spiritual nerve, but much caffeine influences sleep, nervousness, non-concentration, headache and giddiness depending upon each person. The writer expresses the result of the caffeine content in the coffee which is collected from the coffee- shops of Seoul. The contents are as follows : 1) Caffeine content of the coffee of the tea-room was researched dividing into the central Seoul city and the outskirts of Seoul. 2) Caffeine content of the coffee in the outskirts tea-rooms is $0.32{\sim}1.23mg/ml$ and the average is 0.546mg/ml (SD 0.19). 3) Caffeine content of the coffee of the central city is $0.34{\sim}0.73mg/ml$ and the average is 0.513mg/ml(SD 0.12). 4) There was no difference between the outskirts and the central city. 5) Caffeine content of the coffee of the tea-rooms according to each season is going to be researched.

• The Plant Pathology Journal
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• v.34 no.6
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• pp.459-469
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• 2018

Plants and microorganisms (microbes) use information from chemicals such as volatile compounds to understand their environments. Proficiency in sensing and responding to these infochemicals increases an organism's ecological competence and ability to survive in competitive environments, particularly with regard to plant-pathogen interactions. Plants and microbes acquired the ability to sense and respond to biogenic volatiles during their evolutionary history. However, these signals can only be interpreted by humans through the use of state-of the-art technologies. Newly-developed tools allow microbe-induced plant volatiles to be detected in a rapid, precise, and non-invasive manner to diagnose plant diseases. Beside disease diagnosis, volatile compounds may also be valuable in improving crop productivity in sustainable agriculture. Bacterial volatile compounds (BVCs) have potential for use as a novel plant growth stimulant or as improver of fertilizer efficiency. BVCs can also elicit plant innate immunity against insect pests and microbial pathogens. Research is needed to expand our knowledge of BVCs and to produce BVC-based formulations that can be used practically in the field. Formulation possibilities include encapsulation and sol-gel matrices, which can be used in attract and kill formulations, chemigation, and seed priming. Exploitation of biogenic volatiles will facilitate the development of smart integrated plant management systems for disease control and productivity improvement.

• Journal of Pharmaceutical Investigation
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• v.33 no.1
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• pp.29-36
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• 2003

Clenbuterol, a selective ${\beta}_2-adrenergic$ receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease, chronic bronchitis and pulmonary emphysema. The percutaneous permeation of clenbuterol was investigated in hairless mouse skin after application of 50/50 buffer(pH 10)/propylene glycol solvent mixture. The enhancing effects of various penetration enhancers such as terpenes, non-ionic surfactants, pyrrolidones, fatty acids and some other enhancers on the permeation of clenbuterol were evaluated using Franz diffusion cell. Among terpenes studied, 1,8-cineole was the most effective enhancer, which increased the permeability of clenbuterol approximately 39.33-fold compared with the control without penetration enhancer, followed by menthone with enhancement ratio of 23.57. Nonionic surfactants did not have significant enhancing effects. N-Lauryl-2-pyrrolidone increased the permeability of clenbuterol approximately 4.51-fold compared with the control. Lauric acid increased the permeability of clenbuterol approximately 35.57-fold with decreasing the lag time from 2.64 to 0.52 hr. Oleic acid, linoleic acid, linolenic acid and capric acid showed enhancement ratio of 22.62, 19.60, 17.45 and 16.51, respectively. $Labrafil^{\circledR}$ enhanced the permeability of clenbuterol 9.24-fold compared with that without enhancer.