• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.181-186
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• 2006

In this paper, generation mechanisms of ocean freak waves are briefly introduced in the context of wave-current interaction phenomena. The present model of the fluid motion is based on the Navier-Stokes equations incorporating velocity-pressure formulation because of need to model the nonlinear wave interaction with spatially non-uniform current field. In order to deal with the free surface motion, an Arbitrary Lagrangian-Eulerian (ALE) description is adopted. As an accurate and efficient numerical tool, the spectral element method is presented with general features and specific treatment for the wave-current interaction problem. As an intermediate stage of development, solution procedure and characteristics aspects of the present modeling and numerical method are addressed in detail, and preliminary numerical results prove its accuracy and convergence.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.12
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• pp.100-108
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• 2004

In reverse engineering, data acquisition methodology can generally be categorized into contacting and non-contacting types. Recently, researches on hybrid or sensor fusion of the two types have been increasing. In addition, efficient construction of a geometric model from the measurement data is required, where considerable amount of user interaction to classify and localize regions of interest is inevitable. Our research focuses on the classification of each bounded region into a pre-defined feature shape fer a hybrid measuring scheme, where the overall procedures are described as fellows. Firstly, the physical model is digitized by a non-contacting laser scanner which rapidly provides cloud-of-points data. Secondly, the overall digitized data are approximated to a z-map model. Each bounding curve of a region of interest (featured area) can be 1.aced out based on our previous research. Then each confined area is systematically classified into one of the pre-defined feature types such as floor, wall, strip or volume, followed by a more accurate measuring step via a contacting probe. Assigned to each feature is a specific digitizing path topology which may reflect its own geometric character. The research can play an important role in minimizing user interaction at the stage of digitizing path planning.

• Computers and Concrete
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• v.14 no.4
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• pp.463-477
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• 2014

The modelling approach in the case of connections in precast buildings is specific. The assembly of the constitutive parts of the connection requires the inclusion of contact definitions in the model. In addition, the material non-linearity including the influence of the spatial stress distribution should be taken into account where appropriate. Here a complex model of a beam-to-column dowel connection is presented. Experiments on the analysed connection were performed within the framework of the European project SAFECAST (Performance of Innovative Mechanical Connections in Precast Building Structures under Seismic Conditions). Several material and interaction parameters were investigated and the influence of each of them was evaluated. The set of parameters which gave the best match with the experiments was chosen.

• Bulletin of the Korean Chemical Society
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• v.15 no.3
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• pp.214-221
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• 1994

We present some results obtained from theoretical study on a non-symmetrical A/BC polymeric system including solvent which consists of two phases, a polymeric phase A on one side and a mixture of polymers B (as a compatibilizer) and C on the other in the presence of a solvent. By employing the functional integral techniques we derive the mean-field equations and solve them numerically to deduce the physical properties of the interface involving the polymers and solvent concentration profiles in the limit that molecular weights of all the polymers involved tend to infinity. The calculations are performed for typical values of the Flory interaction parameters and for the volume fraction of polymer B in the asymptotic phase and of solvent. In the polymers/solvent blend under consideration the interfacial adsorption of polymer B, the solvent concentration, and degrees of the specific interaction between the polymers are found to play important roles in modification of the interfacial properties.

• Science of Emotion and Sensibility
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• v.23 no.1
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• pp.41-56
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• 2020

This study suggests multisensory interaction techniques to help visually impaired people appreciate and understand artworks through non-visual senses such as tactile, auditory, and olfactory senses. A user study was conducted on the basis of a qualitative interview about the experience of appreciating artwork through the multisensory interaction system to visually impaired people so as to verify the development of the interaction techniques. The user test shows that the multisensory interactions in artwork generally not only help them appreciate and understand it but also give them satisfaction through artwork appreciation. However, it also indicates that some multisensory interactions caused the visually impaired people confusion and could not be perceived during the appreciation. On the basis of these outcomes, implications in this study are as follows. This study has contributed to providing specific development guidelines and indicators of non-visual multisensory interactions as a technical alternative to improve accessibility to cultural and artistic activities for the visually impaired. Furthermore, this study is expected to contribute to building a technical background, which can provide comprehensive sensory experiences with not only blind people but also non-blind people such as children and the elderly through universal interaction techniques beyond existing visual-oriented fragmentary experience.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.29 no.3
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• pp.43-53
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• 2023

Background: Patients with neck pain develop instability due to muscle imbalance, decreased proprioception, and balance disorders. Studies have examined various exercise methods as treatment methods, but few studies have compared the effects of cervical stabilization exercise and dynamic balance exercise. The purpose of this study was to investigate the effects of dynamic balance exercise on pain, functional level, and psychosocial level in patients with non-specific chronic neck pain. Methods: Thirty-four non-specific chronic neck pain patients were randomly assigned to the experimental group (EG, n=17) and control group (CG, n=17); the cervical stabilization exercise and dynamic balance exercise program were applied to the EG; and only the cervical stabilization exercise program was applied to the CG. The intervention was conducted twice a week, for six weeks. Assessment items evaluated pain, dysfunction (Korean version neck disability index), range of motion, craniocervical flexion test, cervical deep flexor endurance test, and psychosocial level. Data analysis was performed using intention-to-treat analysis as assigned. To analyze differences in the items assessed in the two groups, we used a repeated measures analysis of variance with an interaction between group (EG, CG) and time point (baseline, 6 weeks, 12 weeks). Results: The endurance of the cervical flexor muscles between the group and the measurement point after intervention (p<.05). Both groups showed significantly improved endurance between time points after the intervention (p<.05), with the EG showing a greater change than the CG. None of the other measurement items differed in the pattern of change between measurement points. Conclusion: In conclusion, the EG applying a cervical stabilization exercise and a dynamic balance exercise experienced a significant difference in muscle endurance improvement compared to the CG. We propose an exercise intervention program that includes stabilization exercises and dynamic balance exercises for patients with chronic cervical pain who lack muscle endurance.

• Journal of Nutrition and Health
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• v.28 no.10
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• pp.1022-1030
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• 1995

Saponins are glycosidic compounds present in many plant foods. They are characterized by their ability to lyse cell membranes due to their surface-active properties. Saponins are believed to interact primarily with cholesterol in the cell membrane. In this study, the interaction of soybean(SS) with cell membrane was investigated using erythrocytes as a model. Mechanisms of interaction was also investigated by measuring their binding capacity with different membrane lipid fractions. Throughout the study, gypsophilla saponin(GS) and quillaja saponin(QS) were used to evaluate the membranolytic activity of soybean saponins. All saponins released hemoglobin in a concentration-dependent manner. SS induced 40% hemolysis at the concentration of 400 ppm, however there was no increase in hemoglobin release above 400ppm concentration. 5ppm of GS and 8 ppm of QS hemolyzed 100% of erythrocytes. Isolation of SS fractions by thin layer chromatography revealed that only one non-polar saponin possesses strong hemolytic activity. When saponins were incubated decreased the release of cholesterol. When the hemolytic activity of saponins was measured in the presence of other major membrane lipid components, sphingomyelin significantly reduced the hemolytic activity of SS, while cholesterol reduced the activity of QS. GS showed high affinity to other component(s) in the incubation media as well as lipids. These results suggest that the membranolytic activity of saponins are related to their specific chemical structure, which determines the interaction behavior between saponins and different membrane components, and thereby influence the biological activity.

• Bulletin of the Korean Chemical Society
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• v.25 no.10
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• pp.1559-1563
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• 2004

The topoisomerase II poisoning effect of certain protoberberine alkaloids is associated with anti-cancer activity. Structure-activity relationships of protoberberine analogues substituted on the ring protons reveal that substitution at the C19 position is an important determinant of biological activity. In this study, the effects of substituent modification at the C19 position on the interaction of protoberberines with DNA are determined using UV and NMR spectroscopy. The line broadening effect on aliphatic resonances, chemical shift changes of the imino protons of HP14 upon berberine and berberrubine binding to HP14, and the rate of the exchange process between protoberberine analogs bound indicate that berberrubine binds HP14 more specifically than berberine. In addition, the free HP14 is altered by the substituent at the 19-position. UV spectra of berberrubine have shown a hypochromic effect together with a slight red shift, which are usually regarded as characteristics of DNA intercalation. These results are consistent with our previous report that the berberrubine is partially intercalated with HP14 with molar ratio 1 : 1, whereas a non-specific interaction is predominant between the berberine and HP14.

• Earthquakes and Structures
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• v.15 no.5
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• pp.565-581
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• 2018

This paper proposes a new analytical formulation for computing the seismic input at various levels of a structure in terms of floor response spectra. The approach, which neglects the dynamic interaction between primary structure and secondary element, is particularly useful for the seismic assessment of secondary and non-structural elements. The proposed formulation has a robust theoretical basis and it is based on few meaningful dynamic parameters of the main building. The method has been validated in the linear and nonlinear behavior of the main building through results coming from both experimental tests (available in literature) and parametric numerical analyses. The conditions, for which the Floor Spectrum Approach and its simplified assumptions are valid, have been derived in terms of specific interval ratios between the mass of the secondary element and the participant mass of the main structure. Finally, a practice-oriented formulation has been derived, which could be easily implementable also at code level.

• Journal of Gynecologic Oncology
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• v.29 no.6
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• pp.99.1-99.11
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• 2018

Objective: The present study is to evaluate the biological functions of long non-coding RNA (lncRNA), X-inactive specific transcript, X-inactive specific transcript (XIST) in human epithelial ovarian cancer (EOC). Methods: XIST was upregulated in EOC cell lines, CAOV3 and OVCAR3 cells by lentiviral transduction. The effects of XIST overexpression on cancer cell proliferation, invasion, chemosensitivity and in vivo tumor growth were investigated, respectively. Possible sponging interaction between XIST and human microRNA hsa-miR-214-3p was further evaluated. Furthermore, hsa-miR-214-3p was overexpressed in XIST-upregulated CAOV3 and OVCAR3 cells to evaluate its effect on XIST-mediated EOC regulation. Results: Lentivirus-mediated XIST upregulation had significant anticancer effects in CAOV3 and OVCAR3 cells by suppressing cancer cell proliferation, invasion, increasing cisplatin chemosensitivity and inhibiting in vivo tumor growth. Hsa-miR-214-3p was confirmed to directly bind XIST, and inversely downregulated in XIST-upregulated EOC cells. In EOC cells with XIST upregulation, secondary lentiviral transduction successfully upregulated hsa-miR-214-3p expression. Subsequently, hsa-miR-214-3p upregulation functionally reversed the anticancer effects of XIST-upregulation in EOC. Conclusion: Upregulation of lncRNA XIST may suppress EOC development, possibly through sponging effect to induce hsa-miR-214-3p downregulation