• Journal of Biomedical Engineering Research
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• v.28 no.2
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• pp.199-204
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• 2007

In digital radiography, to improve the contrast of digital radiography image, the multi-scale nonlinear amplification algorithm based on unsharp masking is one of the major image enhancement algorithms. In this paper, we used the Laplacian pyramid to decompose a digital radiography(DR) image. In our simulation, the DR image was decomposed into seven layers and the coefficients of the each layer was amplified with nonlinear function. We also imported a noise containment algorithm to limit noise amplification. To enhance the contrast of image, we proposed a new adaptive non-linear gain amplification coefficients. As a result of having applied to some clinical data, a detail visibility was improved significantly without unacceptable noise boosting. Images that acquired with the proposed adaptive non-linear gain coefficients have shown superior quality to those that applied similar gain control method and expected to be accepted in the clinical applications.

• Earthquakes and Structures
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• v.4 no.5
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• pp.557-585
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• 2013

The recent huge earthquake ground motion records in Japan result in the reconsideration of seismic design forces for nuclear power stations from the view point of seismological research. In addition, the seismic design force should be defined also from the view point of structural engineering. In this paper it is shown that one of the occurrence mechanisms of such large acceleration in recent seismic records (recorded in or near massive structures and not free-field ground motions) is due to the interaction between a massive building and its surrounding soil which induces amplification of local mode in the surface soil. Furthermore on-site investigation after earthquakes in the nuclear power stations reveals some damages of soil around the building (cracks, settlement and sand boiling). The influence of plastic behavior of soil is investigated in the context of interaction between the structure and the surrounding soil. Moreover the amplification property of the surface soil is investigated from the seismic records of the Suruga-gulf earthquake in 2009 and the 2011 off the Pacific coast of Tohoku earthquake in 2011. Two methods are introduced for the analysis of the non-stationary process of ground motions. It is shown that the non-stationary Fourier spectra can detect the temporal change of frequency contents of ground motions and the displacement profile integrated from its acceleration profile is useful to evaluate the seismic behavior of the building and the surrounding soil.

• Earthquakes and Structures
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• v.17 no.2
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• pp.191-204
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• 2019

Near-field earthquake records including long-period high-amplitude velocity pulses can cause large isolation system displacements leading to buckling or rupture of isolators. In such cases, providing supplemental damping in the isolation system has been proposed as a solution. However, it is known that linear viscous dampers can reduce base displacements in case of near-field earthquakes but at the potential expense of increased superstructure response in case of far-field earthquakes. But can non-linear dampers with different levels of non-linearity offer a superior seismic performance? In order to answer this question, the effectiveness of non-linear viscous dampers in reducing isolator displacements and its effects on the superstructure response are investigated. A comparison with linear viscous dampers via time history analysis is done using a base-isolated benchmark building model under historical near-field and far-field earthquake records for a wide range of different levels of non-linearity and supplemental damping. The results show that the non-linearity level and the amount of supplemental damping play important roles in reducing base displacements effectively. Although use of non-linear supplemental dampers may cause superstructure response amplification in case of far-field earthquakes, this negative effect may be avoided or even reduced by using appropriate combinations of non-linearity level and supplemental damping.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2006.10a
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• pp.134-143
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• 2006

Out of all types of motions the critical motions leading to capsize is roll. The dynamic amplification in case of roll motion may be large for ships as roll natural frequency generally falls within the frequency range of wave energy spectrum typical used for estimation of motion spectrum. Roll motion is highly non-linear in nature. Den are various representations of non-linear damping and restoring available in literature. In this paper an uncoupled non-linear roll equations with three representation of damping and cubic restoring term is solved using a perturbation technique. Damping moment representations are linear plus quadratic velocity damping, angle dependant damping and linear plus cubic velocity dependant damping. Numerical value of linear damping coefficient is almost same for all types but non-linear damping is different. Linear and non-linear damping coefficients are obtained form free roll decay tests. External rolling moment is assumed as deterministic with sinusoidal form. Maximum roll amplitude of non-linear roll equation with various representations of damping is calculated using analytical procedure and compared with experimental results, which are obtained form forced tests in regular waves by varying frequency with three wave heights. Experiments indicate influence of non-linearity at resonance frequency. Both experiment and analytical results indicates increase in maximum roll amplitude with wave slope at resonance. Analytical results are compared with experiment results which indicate maximum roll amplitude analytically obtained with angle dependent and cubic velocity damping are equal and difference from experiments with these damping are less compared to non-linear equation with quadratic velocity damping.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.36 no.3
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• pp.121-128
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• 2020

In this paper, the ASCE 7 equivalent static approach for seismic design of non-structural elements is critically evaluated based on the measured floor acceleration data, theory of structural dynamics, and linear/nonlinear dynamic analysis of three-dimensional building models. The analysis of this study on the up-to-date database of the instrumented buildings in California clearly reveals that the measured database does not well corroborate the magnitude and the profile of the floor acceleration as proposed by ASCE 7. The basic flaws in the equivalent static approach are illustrated using elementary structural dynamics. Based on the linear and nonlinear dynamic analyses of three-dimensional case study buildings, it is shown that the magnitude and distribution of the PFA (peak floor acceleration) can significantly be affected by the supporting structural characteristics such as fundamental period, higher modes, structural nonlinearity, and torsional irregularity. In general, the equivalent static approach yields more conservative acceleration demand as building period becomes longer, and the PFA distribution in long-period buildings tend to become constant along the building height due to the higher mode effect. Structural nonlinearity was generally shown to reduce floor acceleration because of its period-lengthening effect. Torsional floor amplification as high as 250% was observed in the building model of significant torsional irregularity, indicating the need for inclusion of the torsional amplification to the equivalent static approach when building torsion is severe. All these results lead to the conclusion that, if permitted, dynamic methods which can account for supporting structural characteristics, should be preferred for rational seismic design of non-structural elements.

• Journal of the Earthquake Engineering Society of Korea
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• v.20 no.5
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• pp.301-310
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• 2016

There are differences in seismic behavior between non-skewed bridges and skewed bridges due to in-plane rotations caused by pounding between the skewed deck and its abutments during strong earthquake. Many advances have been made in developing design codes and guidelines for dynamic analyses of non-skewed bridges. However, there remain significant uncertainties with regard to the structural response of skewed bridges caused by unusual seismic response characteristics. The purpose of this study is performing non-linear time history analysis of the bridges using abutment-soil interaction model considering pounding between the skewed deck and its abutments, and analyzing global seismic behavior characteristics of the skewed bridges to assess the possibility of unseating. Refined bridge model with abutment back fill, shear key and elastomeric bearing was developed using non-linear spring element. In order to evaluate the amplification of longitudinal and transverse displacement response, non-linear time history analysis was performed for single span bridges. Far-fault and near-fault ground motions were used as input ground motions. According to each parameter, seismic behavior of skewed bridges was evaluated.

• Journal of the Earthquake Engineering Society of Korea
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• v.17 no.6
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• pp.279-291
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• 2013

The seismic damage of non-structural components, such as communication facilities, causes direct economic losses as well as indirect losses which result from social chaos occurring with downtime of communication and financial management network systems. The current Korean seismic code, KBC2009, prescribes the design criteria and requirements of non-structural components based on their elastic response. However, it is difficult for KBC to reflect the dynamic characteristics of structures where non-structural components exist. In this study, both linear and nonlinear time history analyses of structures with various analysis parameters were carried out and floor acceleration spectra obtained from analyses were compared with both ground acceleration spectra used for input records of the analyses and the design floor acceleration spectrum proposed by National Radio Research Agency. Also, this study investigates to find out the influence of structural dynamic characteristics on the floor acceleration spectra. The analysis results show that the acceleration amplification is observed due to the resonance phenomenon and such amplification increases with the increase of building heights and with the decrease of structure's energy dissipation capacities.

• Geomechanics and Engineering
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• v.16 no.4
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• pp.435-448
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• 2018

In order to make reliable earthquake-resistant design of civil engineering structures, one of the most important considerations in a region with high seismicity is to pay attention to the local soil condition of regions. It is aimed in the current study at specifying dynamic soil characteristics of Kirikkale city center conducting the 1-D equivalent linear and non-linear site response analyses. Due to high vulnerability and seismicity of the city center of Kirikkale surrounded by active many faults, such as the North Anatolian Fault (NAF), the city of Kirikkale is classified as highly earthquake-prone city. The first effort to determine critical site response parameter is to perform the seismic hazard analyses of the region through the earthquake record catalogues. The moment magnitude of the city center is obtained as $M_w=7.0$ according to the recorded probability of exceedance of 10% in the last 50 years. Using the data from site tests, the 1-D equivalent linear (EL) and nonlinear site response analyses (NL) are performed with respect to the shear modulus reduction and damping ratio models proposed in literature. The important engineering parameters of the amplification ratio, predominant site period, peak ground acceleration (PGA) and spectral acceleration values are predicted. Except for the periods between the period of T=0.2-1.0 s, the results from the NL are obtained to be similar to the EL results. Lower spectral acceleration values are estimated in the locations of the city where the higher amplification ratio is attained or vice-versa. Construction of high-rise buildings with modal periods higher than T=1.0 s are obtained to be suitable for the city of Kirikkale. The buildings at the city center are recommended to be assessed with street survey rapid structural evaluation methods so as to mitigate seismic damages. The obtained contour maps in this study are estimated to be effective for visually characterizing the city in terms of the considered parameters.

• Journal of Microbiology and Biotechnology
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• v.30 no.5
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• pp.662-667
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• 2020

Epidermal growth factor receptor (EGFR) mutations are not only genetic markers for diagnosis but also biomarkers of clinical-response against tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Among the EGFR mutations, the in-frame deletion mutation in EGFR exon 19 kinase domain (EGFR exon 19-del) is the most frequent mutation, accounting for about 45% of EGFR mutations in NSCLCs. Development of sensitive method for detecting the EGFR mutation is highly required to make a better screening for drug-response in the treatment of NSCLC patients. Here, we developed a fluorometric tandem gene amplification assay for sensitive detection of low-abundance EGFR exon 19-del mutant genomic DNA. The method consists of pre-amplification with PCR, thermal cycling of ligation by Taq ligase, and subsequent rolling circle amplification (RCA). PCR-amplified DNA from genomic DNA samples was used as splint DNA to conjugate both ends of linear padlock DNA, generating circular padlock DNA template for RCA. Long stretches of ssDNA harboring multiple copies of G-quadruplex structure was generated in RCA and detected by thioflavin T (ThT) fluorescence, which is specifically intercalated into the G-quadruplex, emitting strong fluorescence. Sensitivity of tandem gene amplification assay for detection of the EGFR exon 19-del from gDNA was as low as 3.6 pg, and mutant gDNA present in the pooled normal plasma was readily detected as low as 1% fraction. Hence, fluorometric detection of low-abundance EGFR exon 19 deletion mutation using tandem gene amplification may be applicable to clinical diagnosis of NSCLC patients with appropriate TKI treatment.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2006.11a
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• pp.127-134
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• 2006

Based on a weakly non-Gaussian theory the occurrence probability of freak waves is formulated in terms of the number of waves in a time series and the surface elevation kurtosis. Finite kurtosis gives rise to a significant enhancement of freak wave generation in comparison with the linear narrow banded wave theory. For fixed number of waves, the estimated amplification ratio of freak wave occurrence due to the deviation from the Gaussian theory is 50% - 300%. The results of the theory are compared with laboratory and field data.