• Journal of Radiation Protection and Research
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• 제20권3호
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• pp.155-162
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• 1995

비전리방사선에 대한 방호의 관점에서 현재의 검출 및 측정기술을 검토하였다. 특히 전파와 자외선을 중심으로 노출계측량, 측정기기 및 측정 시 고려사항을 설명하였다. 전파장에 대해서는 실제 파원별로 출력밀도의 수준을 요약하여 실무에 참고가 되게 하였다. 대체로 비 전리방사선의 측정에는 아직 큰 오차가 있으므로 늘어나는 비 전리방사선원과 이로 인한 유해한 건강영향에 대한 대중의 관심을 고려하면 비 전리방사선 측정기술의 개발수요는 크다.

• 한국산업보건학회지
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• 제25권1호
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• pp.27-35
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• 2015

Objectives: To investigate safety and health management, conditions in factories or facilities handling radiation-generating devices and radioactive isotopes were reviewed in terms of regulations of radiation safety control in Korea. Radiation exposure levels generated at those facilities were directly measured and evaluated for establishing an effective safety and health management plan. Methods: Government organizations with laws and systems of radiation safety and health were investigated and compared. There are three laws governing radiation-related employment such as occupational safety and health acts, nuclear safety acts, and medical service acts. We inspected 12 workplaces as research objects:four workplaces that manufacture and assemble semiconductor devices, three non-destructive inspection workplaces that perform inspections on radiation penetration, and five workplaces in textile and tire manufacturing. Monitoring of radiation exposure was performed through two methods. Spatial and surface monitoring using real-time radiation instruments was performed on each site handling radiation generating devices and radioactive isotopes in order to identify radiation leakage. Results: According to the occupational safety and health act, there is no legal obligation to measure ionizing radiation and set dose limits. This can cause confusion in the application of the laws, because the scopes and contents are different from each other. Surface dose rates in radiation generating devices such as implanters, thickness gages and accelerators, which were registered according to nuclear safety acts, using surveymeters, and seven of 36 facilities(19.4%) exceeded the international standards for surface radiation dose of $10{\mu}Sv/hr$. Conclusions: The results showed that occupational health and safety acts require a separate provision for measuring and assessing the radiation exposure of workers performing radiation work. Like noise, ionizing radiation will also periodically be controlled by including it in the object factors of work-environment measurement.

• 환경생물
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• 제21권4호
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• pp.321-327
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• 2003

Differences between the principles for the radiological protection of man and the environment are compared. The derived levels of exposure for man and biota recommended by the international agencies with dose rates for chronic radiation producing effects at different levels of biological organization were given in terms of the biological effects. Cytogenetic effects on plants after an exposure to ionizing radiation at low doses alone and in combination with other factors are discussed. A wide range of experimental data were analysed and the general conclusions were extracted to cover the topics such as non-linearity of dose response, synergistic and antagonistic effects of the combined exposure of different factors, radiation-induced genomic instability, and the phenomena of radioadaptation.

• 방사선산업학회지
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• 제5권1호
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• pp.7-13
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• 2011

The present study has been performed to compare the physiological analysis of monocot model plant (rice) in response to ionizing irradiations (cosmic-ray, gamma-ray, and Ion beam). Ionizing radiations were implanted into monocot model plant (rice) seed. After irradiation, the seeds were planted in the plastic pots for a growth period of one month. Thereafter, the morphological and physiological characteristics including malondealdehyde (MDA) and chlorophyll content, activities of antioxidant enzymes in irradiation samples were investigated. We are confirmed that the activity level of MDA and chlorophyll content were not changed by ionizing irradiation samples. However, the free radical contents were increased in all irradiated plants. And the activities of SOD, POD, and APX were significantly increased by irradiation compared with non-irradiation plant.

• Journal of Radiation Protection and Research
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• 제20권3호
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• pp.201-213
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• 1995

비이온화방사선(NIR)에 대한 방어는 증가되는 관심의 주제가 되고 있지만, 방사선의 유형이나 그 적용간의 의존되는 아주 다른 개념의 사용은 이 분야에서의 통일된 방법의 자료편집에 어려움을 주고 있다. 이 논문의 주된 목적은 비 이온화방사선 방어의 목적으로 확실하게 사용하는 개념, 양, 단위 및 전문용어를 제공하기 위해서이다. 그 외에 방사선방어의 표준과 피폭한도를 양으로 나타내는데 사용되는 특별한 개념과 주어진 양들의 체계적인 분류와 비교를 요약하고 또 논하였다.

• Nuclear Engineering and Technology
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• 제54권1호
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• pp.283-292
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• 2022

Advanced radiation applications have been widely used and extended to many fields. As a result of this fact, choosing an appropriate shielding material based on the radiation application has become vital. In this regard, the integration of elements into polymer composites has been investigated and contributed to the quantity and quality of radiation shielding materials. This study reports photon attenuation parameters and electromagnetic shielding effectiveness of a novel polymer composite prepared with a matrix reinforced with three different proportions (5, 10, and 15 wt%) of niobium content. Addition of Nb dopant improves both photon attenuation and electromagnetic shielding effectiveness for the investigated composites. Therefore, Nb(15%) polymer composite with highest concentration has been found to be the best absorber for ionizing and non-ionizing radiations. Consequently, the performed analyzes provide evidences that the prepared Nb-reinforced polymer composite could be effectively used as photon radiation attenuator and electromagnetic shielding material.

• Tuberculosis and Respiratory Diseases
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• 제71권4호
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• pp.259-265
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• 2011

Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, gefitinib and erlotinib, are effective therapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor somatic mutations in EGFR. The mutations are, however, only found in about 30% of Asian NSCLC patients and all patients ultimately develop resistance to these agents. Ionizing radiation has been shown to induce autophosphorylation of EGFR and activate its downstream signaling pathways. In the present study, we have tested whether the effect of gefitinib treatment can be enhanced after ionizing radiation. Methods: We compared the PC-9 and A549 cell line with its radiation-resistant derivatives after gefitinib treatment with cell proliferation and apoptosis assay. We also analyzed the effect of gefitinib after ionizing radiation in PC-9, A549, and NCI-H460 cells. Cell proliferation was determined by MTT assay and induction of apoptosis was evaluated by flow cytometry. Caspase 3 activation and PARP cleavage were evaluated by western blot analysis. Results: PC-9 cells having mutated EGFR and their radiation-resistant cells showed no significant difference in cell viability. However, radiation-resistant A549 cells were more sensitive to gefitinib than were their parental cells. This was attributable to an increased induction of apoptosis. Gefitinib-induced apoptosis increased significantly after radiation in cells with wild type EGFR including A549 and NCI-H460, but not in PC-9 cells with mutated EGFR. Caspase 3 activation and PARP cleavage accompanied these findings. Conclusion: The data suggest that gefitinib-induced apoptosis could increase after radiation in cells with wild type EGFR, but not in cells with mutated EGFR.

• Radiation Oncology Journal
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• 제33권3호
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• pp.256-260
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• 2015

Purpose: Mefenamic acid (MEF) as a non-steroidal anti-inflammatory drug is used as a medication for relieving of pain and inflammation. Radiation-induced inflammation process is involved in DNA damage and cell death. In this study, the radioprotective effect of MEF was investigated against genotoxicity induced by ionizing radiation in human blood lymphocytes. Materials and Methods: Peripheral blood samples were collected from human volunteers and incubated with MEF at different concentrations (5, 10, 50, or $100{\mu}M$) for two hours. The whole blood was exposed to ionizing radiation at a dose 1.5 Gy. Lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis blocked binucleated lymphocyte. Results: A significant decreasing in the frequency of micronuclei was observed in human lymphocytes irradiated with MEF as compared to irradiated lymphocytes without MEF. The maximum decreasing in frequency of micronuclei was observed at $100{\mu}M$ of MEF (38% decrease), providing maximal protection against ionizing radiation. Conclusion: The radioprotective effect of MEF is probably related to anti-inflammatory property of MEF on human lymphocytes.

• 한국환경농학회지
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• 제24권1호
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• pp.61-65
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• 2005

This study was to evaluate whether ionizing gamma radiation could be applied to break the dormancy of a potato minituber. The respiration rate of the minitubers was significantly affected by the storage temperature and a low dose gamma radiation. Ionizing radiation of 8 Gy enhanced the respiration rate of the potato tuber stored at $10^{\circ}C$ for 20 days. The potato tuber subjected to 4 and 8 Gy after 40 days storage at 10 and $20^{\circ}C$ exhibited higher respiration rates compared to the control (non-irradiated), but not at st. However, the ionizing radiation did not exhibit on significant effect on the respiration rate of the potato tuber stored for 60 days. It was observed that minitubers stored for 20 days had significant response to the storage temperature in terms of the total sugar content the higher the storage temperature, the lower the total sugar content. It was measured that the reducing sugar content was increased under the storage conditions both 5 and $10^{\circ}C$ for 40 days, but not to $20^{\circ}C$. The total sugar contents in the minituber stored for 60 days were similar to those stored for 40 days. The data was discussed on the relationships among the storage duration, temperature and ionizing radiation.

• Journal of Radiation Protection and Research
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• 제20권3호
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• pp.143-154
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• 1995

최근에 정자기장을 사용하는 새로운 기술이 개발되어 인체가 정자기장에 노출될 가능성이 커지게 되어 건강에 영향을 줄 우려도 증가되었다. 여러 나라에서 정부를 비롯한 권위 있는 기관들이 주로 자기공명 영상법(MRI)이나 고에너지물리학에서의 입자가속기와 같은 특수 용도를 위해 노출한도를 제시해 왔다. 산업적인 면과 의학에서의 정자기장의 응용이 앞으로 더 많아져서 직업적이거나 일반공중이거나 간에 노출 가능성이 증가되고, 또 정자기장(static magnetic field)에 영향을 받는 강자성(强磁性) 이식조직 이나 전자장치를 부착한 사람들의 수도 증가하고 있으므로 국제적인 노출한도에 대한 지침이 필요하게 되었다. 본고에서는 비 이온화방사선(NIR)에 대한 국제방사선방어학회/비이온방사선방어위원회(IRPA/ICNIRP)의 제반지침을 검토하기 위하여 이 IRPA/ICNIRP(이전의 INIRC의 것도 포함)의 기본지침 중 정자기장에 대한 노출한도에 관한 지침을 택하여 논하였다.