• 대한한방내과학회지
• /
• 제36권3호
• /
• pp.436-445
• /
• 2015

Objectives The purpose of this study is to report the clinical effects of immuno pharmacopuncture and herbal medicine Simmidojeok-san on chronic non-bacterial prostatitis. Methods The patient was treated with Simmidojeok-san ; 0.2 cc of V pharmacopuncture injection was given into Jeonyang and 0.6 cc of V pharmacopuncture injection was administered into Hoeeum (CV1). National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and Numerous Rating Scale (NRS) were used to assess treatment effect. Results NIH-CPSI and NRS decreased after treatment. Conclusions The herbal medicine Simmidojeok-san and V pharmacopuncture therapy are effective in treating chronic non-bacterial prostatitis.

• KSBB Journal
• /
• 제27권5호
• /
• pp.295-300
• /
• 2012

Matured dendritic cells (DCs) begin migration with their release from the bone marrow (BM) into the blood and subsequent traffic into peripheral lymphoid and non-lymphoid tissues. Throughout this long movement, migrating DCs must apply specialized skills to reach their target destination. Non-invasive in vivo cell-tracking techniques are necessary to advance immune cell-based therapies. In this study, we used a DiD cell-tracking solution for in vivo dendritic cell tracking in naive mice. We tracked DiD (non-invasive fluorescence dye)-labeled mature dendritic cells using the Near Infrared (NIR) imaging system in normal mice. We examined the immunophenotype of DiD-labeled cells compared with non-labelled mature DCs, and obtained time-serial images of NIR-DC trafficking after mouse footpad injection. In conclusion, we confirmed that DiD-labeled DCs migrated into the popliteal lymph node 24 h after the footpad injection. Here, these data suggested that the cell tracking system with the stable fluorescence dye DiD was useful as a cell tracking tool to advance dendritic cell-based immunotherapy.

• 한국어병학회지
• /
• 제18권1호
• /
• pp.59-66
• /
• 2005

In the present paper, the immunostimulatory effects of Korean mistletoe (Viscum album Coloratum) on the non-specific immune responses of Japanese eel (Anguilla japonica) were examined. Eel were innoculated with mistletoe, Freund's complete adjuvant (FCA), or phosphate-buffered saline (PBS) as a control into their peritoneal cavities. The number of nitrobule tetrazolium (NBT)-positive cells in the head kidney of fish was significantly increased by the second day post-injection of mistletoe. ROI products were more enhanced in mistletoe-injected fish kidney leucocytes than in FCA-injected ones. The level of lysozyme activity detected in the serum of fish 2 days after injection with mistletoe was also significantly higher than that found in the serum of the control fish. The appropriate concentration of mistletoe to induce the highest level of serum lysozyme activity was revealed to 1000${\mu}g$/200 g of fish. In phagocytic activity assay, mistletoe-sensitized eel kidney phagocytes captured more zymosan than did the control fish. Korean mistletoe appeared to be a good activator of the non-specific immune responses of Japanese eel.

• 대한수의학회지
• /
• 제14권1호
• /
• pp.59-71
• /
• 1974

The studies were conducted on the allergic skin reaction of bovine eurytremiasis. In order to confirm the appearance of allergic skin reaction in this disease, a protein fraction of Eurytrema SPP(EPF) was extracted, and it's antigenicity was studied by means of intradermal reaction on the rabbits, goats and bovine. Rabbits used in this studies were divided into three groups: the first group was sensitized with EPF, the second group was sensitized with EPF, and the third group was served as control which is consisted with 5 non-sensitized and 2 saline injected rabbits. Three healthy native goats and bovine also used. Among these, 86 cases were eurytremiasis, 31 cases were fascioliasis and 71 cases non-infected. A protein fraction was also made from adult worm of Fasciola SPP(FPF) and tested the cross reaction between these two different fluke infestations. The results obtained were as follow: 1. Intradermal reaction was appeared in the infected cattle(bovine eurytremiasis) as well as in the EPF sensitized rabbits and goats. 2. In the EPF sensitized rabbits, the wheal of the intradermal reaction reacted the maximum size (increased wheal size of 5.0 to 9.0 mm) in 40 to 60 minutes and erythema in 60 minutes after intradermal injection of EPF antigen. In the EPF sensitized goats, the size of wheal reacted the maximum(increased wheal size of 5.5 to 8.0 mm) in 30 to 40 minutes, and then disappeared in 120 to 180 minutes after injection of EPF antgen. On the contrary, in the control groups of rabbits and goats, the wheal (7.0 mm) produced following antigen injection reached only to 7.5 to 8.5 mm. in 10 minutes without developing erythema, and then perished in 40 to 60 minutes after injection of EPF antigen. In the infected cattle, the wheal of the intradermal reaction reached the maximal sizes(increased wheal size of 4.0 to 11.0 mm) in 15 to 20 minutes and perished in 60 to 90 minutes after injection of EPF antigen. 3. It would be standardized that the positive reaction is above 4.0 mm, the negative below 2.0 mm and the suspective is 3.0 mm of the infected cattle. In the results of intradermal reaction, 87.2%(75 of 86 cases) was positive, 4.7%(4 of 86 cases) negative and 8.1% (7 of 86 cases) was suspective. However, in the non-infected control cattle, the wheal produced following injection disappeared in 30 to 40 minutes without increasing the wheal size in the most subjects or with incresing only to 1.0 to 2.0 mm in a few cattle. 4. In the results of intradermal reaction which were reciprocally tested in EPF sensitized rabbits by FPF antigen and in FPF sensitized. rabbits by EPF antigen, there were cross reacted. In the 31 cases if fascioliasis tested by EPF antigen, 11 cases were not specifically reacted with EPF antigen. Judging from the results of cross reaction in experimental rabbits and natural bovine fascioliasis, it would be expected when both EPF and EPF antigens are given intracutaneously on the same bovine patients of eurytremiasis or fascioliasis, the former antigen will produce the larger wheal in eurytremiasis, while the latter antigen will produce also the larger wheal in fascioliasis.

• Journal of Mechanical Science and Technology
• /
• 제16권7호
• /
• pp.999-1008
• /
• 2002

The spray structures and distribution characteristics of liquid and vapor phases in non-evaporating and evaporating Gasoline Direct Injection (GDI) fuel sprays were investigated using Laser Induced Exciplex Fluorescence (LIEF) technique. Dopants were 2% fluorobenzene and 9% DEMA (diethyl-methyl-amine) in 89% solution of hexane by volume. In order to study internal structure of the spray, droplet size and velocity under non-evaporating condition were measured by Phase Doppler Anemometry (PDA). Liquid and vapor phases were visualized at different moments after the start of injection. Experimental results showed that the spray could be divided into two regions by the fluorescence intensity of liquid phase: cone and mixing regions. Moreover, vortex flow of vapor phase was found in the mixing region. About 5㎛ diameter droplets were mostly distributed in the vortex flow region. Higher concentration of vapor phase due to vaporization of these droplets was distributed in this region. Particularly, higher concentration of vapor phase and lower one were balanced within the measurement area at 2ms after the start of injection.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2005년도 제24회 춘계학술대회논문집
• /
• pp.405-408
• /
• 2005

혼합챔버 내에서 패브리-초킹(Fabri-chocking)이 발생한다는 가정을 이용하여 이차목을 갖는 환형분사 초음속 이젝터의 이론 해석을 수행하였다. 부유동 압력을 예측하기 위해 혼합챔버 입구에서 패브리-초킹면 사이를 비혼합이론(non-mixing theory)을 이용하여 계산하였다. 혼합챔버의 수축각에 의해 발생하는 깔때기 모양의 경사충격파를 이차원 경사충격파로 모사하였고, 패브리-초킹면의 주유동에만 영향을 미친다고 가정하였다. 그 결과 혼합챔버의 수축각이 4도보다 작은 조건에서 실험값을 잘 예측하는 것을 확인하였다.

• 대한약침학회지
• /
• 제13권1호
• /
• pp.5-14
• /
• 2010

Objectives : This study was performed to examine the anticancer effect of mountain ginseng Pharmacopuncture(MGP) to the nude mouse of lung carcinoma induced by NCI-H460 human nonsmall lung cancer cells. Methods : Human lung cancer (NCI-H460) cells were cultured and applied to evaluate anti-tumor activity in nude mice. After confirmed tumor growth in mice, MGP was treated per 0.1ml/kg dose to intraperitoneal and intravenous injection everyday for four weeks. And checked the changes in body weights, tumor volume, mean survival time and percent, increase in life span, histo-pathological findings, organ weights, and blood chemistry levels. Results : The results of in vivo study showed that MGP may have potential as growth inhibitor of solid tumor induced NCI-H460 without marked side effects. MGP inhibited dosage-dependently the growth of NCI-H460 cell-transplanted solid tumor compared with the control group. And mean survival time of MGP treated group was prolonged comparing with control group. Generally the group of intravenous injection is more effective than intraperitoneal injection. Conclusion : These results were suggested that MGP may be a useful anticancer agent for therapy of human lung cancer. And follow study need for the certain evidence.

• 한국산학기술학회논문지
• /
• 제4권3호
• /
• pp.183-188
• /
• 2003

본 연구는 Connector Mold의 Termina (리브)에 가스 모임으로 인한 미성형 및 웰드라인이 생성되어 이를 방지하기 위해 과다한 사출압력, 금형온도 및 수지온도를 높이므로 Burr둥의 불량현상이 발생하게된다. 따라서 연구에서는 진공성형시스템을 응용한 Connector Mold를 개발하기 위하여 사출성형의 중요한 인자가 되는 용융수지온도, 금형온도, 냉각조건을 최적 조건에서 진공압을 체계적으로 제어함으로 각 캐비티의 깊은 글 부분의 미충전 부분을 진공화 하여 충전불량을 해소하면서, 싸이클 시간을 단축시킬 수 있는 진공시스템을 연구개발 성형가공에 적용함으로 우수한 제품과 생산성 향상의 효과를 얻을 수 있다.

• 한국추진공학회지
• /
• 제9권1호
• /
• pp.61-66
• /
• 2005

혼합챔버 내에서 패브리 초킹(Fabri choking)이 발생한다는 가정을 이용하여 이차목을 갖는 환형분사 초음속 이젝터의 이론 해석을 수행하였다. 부유동 압력을 예측하기 위해 혼합챔버 입구에서 패브리 초킹면 사이를 비혼합 이론(non mixing theory)을 이용하여 계산하였다. 혼합챔버의 수축각에 의해 발생하는 깔때기 모양의 경사충격파를 이차원 경사충격파로 모사하였고, 패브리 초킹면의 주유동에만 영향을 미친다고 가정하였다. 또한 패브리 초킹면의 주유동 압력과 부유동 압력이 같다는 물리적인 제한조건을 사용하였다. 그 결과 혼합챔버의 수축각이 4도보다 작은 조건에서 실험값을 잘 예측하는 것을 확인하였다.

• Archives of Plastic Surgery
• /
• 제37권3호
• /
• pp.245-249
• /
• 2010

Purpose: High-pressure injection injury is caused by accidental injection of the high-pressure injection devices in industry. The initial benign appearance of the wound fools patients into delays in an adequate treatment. And it can result in disastrous outcomes such as necrosis and amputation. To avoid the poor prognosis, the injuries require a prompt surgical intervention. The purpose of this article is to recognize the poor outcome of the highpressure injection injury and to introduce an adequate treatment in need. Methods: We have 4 cases of the high-pressure injection injuries in the hand from April, 2005 to March, 2009. Average age is 39 years (30 - 49 years old), 2 cases are the palm of dominant hand, 1 case is the thumb of dominant hand, and 1 case is the palm of non-dominant hand, respectively. We followed up these patients for 20 months on average. In 3 cases, the immediate, aggressive surgical intervention was carried out, but the other one was delayed in early adequate treatment. The wounds were covered by local advancement flap, anterolateral thigh free flap, conservative treatment with antibiotics and dressing. Results: No pathogens after culture were found nor any findings of fracture in imaging study. Conservative treatment, local advancement flap and anterolateral thigh free flap for the open wound resulted in a desirable aesthetic outcome. In a long-term follow up, functional capability of the patient was also satisfactory. Conclusion: Upon initial evaluation, most high-pressure injection injuries present as innocuous wounds with very few symptoms and result in delaying the proper management. And the majority of high-pressure injection injuries will produce significant morbidity to the hand, amputation. And the initial aggressive surgical debridement was needed to prevent the poor outcome. The key to success in treating high-pressure injection injuries of the hand is the prompt aggressive surgical intervention.