• BMB Reports
• /
• 제55권7호
• /
• pp.316-322
• /
• 2022

Ubiquitin is relatively modest in size but involves almost entire cellular signaling pathways. The primary role of ubiquitin is maintaining cellular protein homeostasis. Ubiquitination regulates the fate of target proteins using the proteasome- or autophagy-mediated degradation of ubiquitinated substrates, which can be either intracellular or foreign proteins from invading pathogens. Legionella, a gram-negative intracellular pathogen, hinders the host-ubiquitin system by translocating hundreds of effector proteins into the host cell's cytoplasm. In this review, we describe the current understanding of ubiquitin machinery from Legionella. We summarize structural and biochemical differences between the host-ubiquitin system and ubiquitin-related effectors of Legionella. Some of these effectors act much like canonical host-ubiquitin machinery, whereas others have distinctive structures and accomplish non-canonical ubiquitination via novel biochemical mechanisms.

• 한국안광학회지
• /
• 제3권1호
• /
• pp.93-101
• /
• 1998

본 연구는 발생과정에 따른 흰쥐 각막의 변화를 주사 및 투과형 전자현미경으로 관찰하였다. 생후 1일된 안검이 개검되지 않은 흰쥐의 각막 60안, 생후 10주된 성체 흰쥐의 각막 40안을 적출하여 각막의 변화를 비교 연구 하였다. 연령증가에 따라 각막의 미세구조의 변화가 나타났으며 각막의 상피는 오각형의 모양이며, 세포간 경계는 분명하였으나 성장할수록 탈락세포는 짙은 전자밀도를 나타냈으며, 새로 생성된 세포는 밝은 전자밀도를 나타내어 명암의 차이가 뚜렷하였다. 보우만층은 연령의 증가에 따라 콜라겐섬유가 불균질한 구조에서 균질한 구조로 변화하였다. 실질층의 각막세포는 세포 소기관의 밀도가 성체로 갈수록 감소하였고, 콜라겐층은 연령증가에 따라 종횡으로 평행배열을 나타내었다. 데스멧층은 성체로 갈수록 "banded layer"에서 "non-banded layer"의 형태로 변화하였으며 층의 두께가 현저히 두꺼워진것이 관찰되었다. 내피층은 단층으로 구성되어 있으며, 성체로 갈수록 내피 세포수는 감소하는 반면 감소된 세포수의 자리는 세포 크기가 확대됨으로써 보상되었다.

• 한국동물위생학회지
• /
• 제30권3호
• /
• pp.429-436
• /
• 2007

This study was performed to make helpful standard for discrimination of cows from heifers by uterine and ovarian section inspection. A total of 3,736 heifers and 249 cows were inspected from January to November 2006 in Karak Market Slaughter house. Firstly, it was obvious that non-corpus albicans were observed in almost heifers(3,597/3,736, 96.3%), but there were distinctive corpus albicans in all cows (249/249 100%). Secondly, another evident was that the length and diameter of the horn in uterus was below 30mm in 94.5% (3,267/3,736) heifers, but above 30mm in 90.4% (225/245) cows, and it was easy to distinguish between right and left horn by difference of size in 87.6% (218/249) cows. Thirdly the diameters of pelvic cavity was below 220mm in 96.8% (3,615/3,736) heifers, but was over 200mm in 85.1% (212/249) cows. Fourthly another difference was found in second sacrum union condition and 13th thoracic vertebral process's states. In case of heifers, it was distinctive five lines in each second sacrum, but it was non-distinctive or united in the same each lines of the sacrum in cows. Fifthly in the results of 13th thoracic vertebral colors, the ratio between red color and white color was 7 : 3 in heifers (3,385/3,736, 90.6%), but that was 2 : 8 in cows (199/249, 79.9%). Consequently, it was possible to use the method which discriminated cows from heifers by uterine and ovarian section inspection in large scaled field slaughter house.

• 기술혁신학회지
• /
• 제9권3호
• /
• pp.451-470
• /
• 2006

본 연구는 사원 개인을 분석단위로 사원제안제도의 활용에 영향을 미치는 요인을 살펴보았다. 또한 사원제안제도가 지금까지 제조업 중심으로 이루어져 왔지만 최근 서비스업을 중심으로 비제조업에도 사원제안제도가 확산됨에 따라 업종별 차이도 분석하였다. 연구 가설은 Unsworth(2001)의 개인 창의성 분류와 Frese et al.(1999)의 사원제안제도 일반 모형에서 도출하였다. 자동차 조립업체와 은행을 대상으로 자료를 수집하였고 PLS로 통계분석을 실시하였다. 연구결과를 보면 Frese et al.(1999)의 일반모형은 대체로 지지되었으며 업종간 유의한 차이를 발견하지는 못하였다. 그러나 모형 내부 변수들의 상관관계의 정도는 유의한 통계적 차이를 보였다. 이를 바탕으로 비제조업의 사원제안제도 활용에 대한 제언을 제시하였다.

• 한국지구과학회지
• /
• 제25권3호
• /
• pp.142-151
• /
• 2004

This study was designed to determine whether visitor behavior at science museums differs across various exhibit styles and between Family and Non Family groups. Eight exhibits in the natural history sections of the national science museum located in Daejeon were identified to have distinctive characteristics and styles. At each selected exhibit, visitor behavior was observed for an hour. An average of eighty people stopped by each exhibit. Descriptive analyses of visitors behaviors showed that: 1) families spent more time than non-family visitors; 2) families paid more attention to exhibits, for instance, they talked and commented about the exhibits; 3) exhibit characteristics related to holding power and attention span; 4) families more frequently visited exhibits related to school curriculum rather than ones that looked attractive, fun or novel. Visitors did not play with sensory simulation types of exhibits as much as expected. This implicates that exhibit style does not guarantee long visitors holding time and attracting power. Non-significant results are explained in terms of environmental and exhibit-related factors. Several potential factors including visitor factors, setting factors, and exhibit factors are discussed and explored with topics proposed for future study.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제39권4호
• /
• pp.175-181
• /
• 2013

Objectives: This retrospective study was performed to evaluate the clinical impact of diabetes mellitus on the prognosis in secondary space infection. Materials and Methods: Medical records, radiographic images, computed tomography, and microbial studies of 51 patients (25 diabetic patients and 26 non-diabetic patients) were reviewed. Patients were diagnosed as secondary fascial space infections with odontogenic origin and underwent treatment at Chonnam National University Hospital, in Department of Oral and Maxillofacial Surgery, from January 2007 to February 2009. Results: Compared to patients without diabetes, patients with diabetes were presented with the following characteristics: older age (diabetic patients: 62.9 years, non-diabetic patients, 47.8 years), more spaces involved (diabetic patients, 60%; non-diabetic patients, 27.3%), more intense treatment, longer hospitalization (diabetic patients, 28.9 days; non-diabetic patients, 15.4 days), higher white blood cell and C-reactive protein values, higher incidence of complication (diabetic patients, 40%; non-diabetic patients, 7.7%), and distinctive main causative microorganisms. Conclusion: These results suggest that the prognosis of diabetic patients is poorer than that of non-diabetic patients in secondary space infections since they had greater incidence rates of involved spaces, abnormal hematologic findings, more complications, and additional procedures, such as tracheostomy.

• 한국한의학연구원논문집
• /
• 제13권3호
• /
• pp.165-178
• /
• 2007

This article explores how non-dominant medical practitioners shape their own self-images and the identity of relevant medicine and in what ways fashioning of self-images and accompanying modalities of medical practice informs the social evolution of the medicines at specific times and over specific places, by means of the historical configuration of osteopathy and chiropractic in the UK and the US. Attention is directed onto motivations and pursuits for professional recognition and actual strategies and activities of non-dominant medicines and its practitioners by turning to historical instances such as osteopathy and chiropractic in the UK and the US, not least drawing focus on professional desires with regard to circumstances it faces within and without. Some non-dominant medicines as a way with which to acquire and protect the exclusive monopoly of its knowledge and practical skills, adopted various forms of professionalism project, as dominant biomedical groups pressed up non-dominant medicines by virtue of marginalizing tactics. Meanwhile, non-dominant medicines took somewhat distinctive professionalisation strategies from each other. Strategies they took were diversified depending on medical philosophy, healing modality, the degree of occupational solidarity embodied as forms of medical organisation, and especially vocational aspiration and prospect. Change of socio-medical culture and the state's policy seems to have wielded critical influenceon the determination of the ups and downs of non-dominant medicines. From the perspective of long-term time span, dominant biomedicine eventually did not have much influence on the ups and downs of marginalized medicines in so far as in the case of osteopathy and chiropractic in Englandand the U. S.

• 한국산업보건학회지
• /
• 제29권1호
• /
• pp.82-97
• /
• 2019

Objective: In this study, in order to investigate the relationship between leadership type and job satisfaction, the types of leadership in medical institutions are divided into transformational leadership, servant leadership and authentic leadership. In addition medical staff and non-medical staff are classified according to their job characteristics, and middle managers and operators are classified according to position. Methods: For this purpose, 589 questionnaires were applied to the medical institutions in Seoul and Gyunggi-do, and empirically analyzed with multiple regression. Results: The results of this study are first, among gender, medical or non-medical staff, position and career experience, men, non-medical staffs, and middle managers showed higher leadership, job engagement, and job satisfaction. Second, servant leadership and authentic leadership have significant positive relationships with job engagement. In the case of medical staff, only servant leadership has a positive effect on job engagement, while in the case of non-medical staff, both servant leadership and authentic leadership have significant influence on job engagement. Job satisfaction was found to have a statistically significant effect of servant leadership and authentic leadership in medical staff and non-medical staff. Third, in the case of middle managers, servant leadership showed a statistically significant effect only on job satisfaction, while servant leadership and authentic leadership had statistically significant effects on job engagement and job satisfaction of operators. Conclusions: This study suggests the possibility and applicability of authentic leadership in addition to transformational leadership and servant leadership in hospital organizations. Also, by identifying differences in the effects on organizational effectiveness, it is also suggested the need for research on identifying leadership factors that reflect strictly distinctive job characteristics.

• 복식
• /
• 제60권6호
• /
• pp.1-10
• /
• 2010

The cultures and traditions of Asia has the roots so deep and it is the origin of inspiration. Therefore, it is easy to find a different inspiration when designing, expecially for Western designers who are seeking European tradition and its comparison. The most distinctive feature of the Asian look is non-structural and has no clear form close to the structure of the body or mathematical ratio, but is steric with 2-Dimensional planed textiles, and has a flexible, non-structural formative characteristic related to the movable body. This is base on the vision of the universe that regards the parts as the whole. From this research, generally studying about the Asian look and its non-structural formative characteristics. The study looked closely into the aesthetic value of non-structural formative characteristics formation, with basis on the large dress regulation system of the western reasoning and rationalism and mechanism. At first, my study pointed on the dressing functionalism or Neo-classism considering emotions, Anti-Western aspect observing surrealism dressing and expressionism dressing. Second, with men and women showing similar outer shape without the equivalent element such from wearing a corset, the sexism is abolished. Finally, the designers’ inner intention of art is being delivered, from the aspect that the expression of art, size and no waste of fabric shows effort of communicating with the world, giving value to the possibility of continuance.

• Journal of Nutrition and Health
• /
• 제41권4호
• /
• pp.327-340
• /
• 2008

This study was designed to investigate the correlation between nutrition status and cardiovascular disease in type 2 diabetes patients with metabolic syndrome. The subjects were 66 patients and divided into Non MS (a group without metabolic syndrome, n = 37) and MS (a group with metabolic syndrome, n = 29). The percentage of patients accompanying metabolic syndrome was 43.9% and family history such as DM, skipping meal and eating speed were higher in MS (P < 0.05) The average values of BMI, body fat (%), waist circumference were significantly higher in patients of MS than that of Non MS. For hamatological values, MS showed higher FRS, HOMA-IR, LDL-Cholesterol, CRP. Percentage of FRS was 21.63% in MS that is relatively higher in comparison with 16.81% in Non MS. Moreover, the incidence of cardiovascular disease appeared 13.8% in MS that is higher than 2.7% in Non MS. The intake of sodium and vitamin E were higher, but the intake of fat, vitamin A and zinc were lower in MS than in Non MS. Close correlations were elucidated among FRS, occurrence of cardiovascular disease, weight, waist circumference, Total-Cholesterol, LDLCholesterol, sodium in both groups. In conclusion, cardiovascular disease risk factors would be higher in type 2 diabetes patients with metabolic syndrome and there were distinctive patterns that were associated with hamatological values, nutrition intake risk factors. This result should be considered when designing nutrition study and intervetion programs.